{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:59:12Z","timestamp":1793350752610,"version":"4.5.0"},"reference-count":163,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The stimulator of interferon genes (STING) pathway plays a unique role in antitumor immunity, bridging innate and adaptive immune responses to initiate a sustained and highly effective antitumor immune response. However, due to the widespread expression of the STING pathway and the lack of clearly distinguishable physiological and pathological features, its excessive or systemic activation can trigger severe adverse effects, such as cytokine storms, thereby limiting its clinical applicability. With the development of nanotechnology, stimuli-responsive nanoplatforms designed based on tumor microenvironment (TME) signals (such as pH, glutathione, reactive oxygen species, hypoxia, and enzymes) and exogenous stimuli (including light, ultrasound, radiation, and magnetic fields) provide a promising strategy for the precise activation of the STING pathway. These nanoplatforms can achieve tumor-specific and controllable STING activation, thereby minimizing off-target toxicity, and can be combined with chemotherapy, radiotherapy, or photodynamic therapy to produce multimodal synergistic antitumor effects. Here, we provide a systematic overview of stimuli-responsive nanoplatforms for STING activation, highlighting their design strategies and how they can reverse immunosuppressive TME through STING pathway activation. Additionally, we discuss the challenges facing their clinical translation and outline future directions, aiming to provide a foundation for further research in this field. In conclusion, stimuli-responsive STING-activating nanoplatforms demonstrate significant potential in antitumor therapy and may serve as a novel therapeutic strategy.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1714249","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:19:16Z","timestamp":1769411956000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Stimuli-responsive nanoplatforms for precision activation of the STING pathway in cancer immunotherapy"],"prefix":"10.3389","volume":"17","author":[{"given":"Dongming","family":"Bi","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu Sichuan, China"]},{"name":"Department of Laboratory Medicine, Deyang Hospital Affiliated Hospital of Chengdu University of Traditional Chinese Medicine","place":["Deyang Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyan","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongming","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Yaan People\u2019s Hospital","place":["Ya an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Deyang Hospital Affiliated Hospital of Chengdu University of Traditional Chinese Medicine","place":["Deyang Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s12943-025-02366-y","article-title":"Enhancing radiotherapy-induced anti-tumour immunity via nanoparticle-mediated sting agonist synergy","volume":"24","author":"Zeng","year":"2025","journal-title":"Mol Cancer"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1472772","article-title":"Advances in targeting tumor microenvironment for immunotherapy","volume":"15","author":"Wang","year":"2024","journal-title":"Front Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-019-0155-1","article-title":"Challenges in assessing solid tumor responses to immunotherapy","volume":"27","author":"Chai","year":"2020","journal-title":"Cancer Gene Ther"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0308-z","article-title":"Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges","volume":"17","author":"Martin","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-022-00468-w","article-title":"The cgas-sting pathway and cancer","volume":"3","author":"Samson","year":"2022","journal-title":"Nat Cancer"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01872-3","article-title":"The balance of sting signaling orchestrates immunity in cancer","volume":"25","author":"Lanng","year":"2024","journal-title":"Nat Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0244-x","article-title":"Molecular mechanisms and cellular functions of cgas-sting signalling","volume":"21","author":"Hopfner","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-024-01624-2","article-title":"Universal sting mimic boosts antitumour immunity via preferential activation of tumour control signalling pathways","volume":"19","author":"Wang","year":"2024","journal-title":"Nat Nanotechnol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-023-01361-0","article-title":"The development of sting agonists and emerging results as a cancer immunotherapy","volume":"25","author":"Hines","year":"2023","journal-title":"Curr Oncol Rep"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29133121","article-title":"Agonists and inhibitors of the cgas-sting pathway","volume":"29","author":"Yu","year":"2024","journal-title":"Molecules"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.03.054","article-title":"Nano-delivery of sting agonists: unraveling the potential of immunotherapy","volume":"197","author":"Zhang","year":"2025","journal-title":"Acta Biomater"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S436373","article-title":"Platelet-based nanoparticles with stimuli-responsive for anti-tumor therapy","volume":"18","author":"Yang","year":"2023","journal-title":"Int J Nanomed"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/med.22016","article-title":"Cgas-sting pathway agonists are promising vaccine adjuvants","volume":"44","author":"Tian","year":"2024","journal-title":"Med Res Rev"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.111647","article-title":"Sting activation and overcoming the challenges associated with sting agonists using adc (Antibody-drug conjugate) and other delivery systems","volume":"128","author":"Vasiyani","year":"2025","journal-title":"Cell Signall"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2025-011572","article-title":"Phase 1 first-in-human dose-escalation study of imsa101, a novel cyclic di-nucleotide sting agonist, for patients with advanced solid tumor Malignancies","volume":"13","author":"Jacoby","year":"2025","journal-title":"J Immunotherapy Cancer"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-21-1963","article-title":"Phase I dose-escalation trial of miw815 (Adu-S100), an intratumoral sting agonist, in patients with advanced\/metastatic solid tumors or lymphomas","volume":"28","author":"Meric-Bernstam","year":"2022","journal-title":"Clin Cancer Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1200\/JCO.2019.37.15_suppl.2507","article-title":"Phase ib study of miw815 (Adu-S100) in combination with spartalizumab (Pdr001) in patients (Pts) with advanced\/metastatic solid tumors or lymphomas","volume":"37","author":"Meric-Bernstam","year":"2019","journal-title":"J Clin Oncol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26189008","article-title":"Stinging cancer: development, clinical application, and targeted delivery of sting agonists","volume":"26","author":"Nerdinger","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2025.111914","article-title":"Sting agonists: A range of eminent mediators in cancer immunotherapy","volume":"134","author":"Wen","year":"2025","journal-title":"Cell Signall"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112695","article-title":"Sting agonists as cancer therapeutics","volume":"13","author":"Amouzegar","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.35.0660","article-title":"Randomized phase iii placebo-controlled trial of carboplatin and paclitaxel with or without the vascular disrupting agent vadimezan (Asa404) in advanced non-small-cell lung cancer","volume":"29","author":"Lara","year":"2011","journal-title":"J Clin Oncol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e09890","DOI":"10.1002\/advs.202509890","article-title":"Emerging cgas-sting agonist-based nanotherapeutics: mechanistic insights and applications in cancer combination therapy","volume":"12","author":"Wang","year":"2025","journal-title":"Adv Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.05.042","article-title":"A next-generation sting agonist msa-2: from mechanism to application","volume":"371","author":"Yang","year":"2024","journal-title":"J Controlled Rele"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c07498","article-title":"Antitumor effect of platinum-modified sting agonist msa-2","volume":"9","author":"Wang","year":"2024","journal-title":"ACS Omega"},{"key":"B25","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s13045-022-01363-8","article-title":"Combination of oral sting agonist msa-2 and anti-tgf-\u03b2\/pd-L1 bispecific antibody ym101: A novel immune cocktail therapy for non-inflamed tumors","volume":"15","author":"Yi","year":"2022","journal-title":"J Hematol Oncol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-24-2824","article-title":"Intratumoral or subcutaneous mk-2118, a noncyclic dinucleotide sting agonist, with or without pembrolizumab, for advanced or metastatic solid tumors or lymphomas","volume":"31","author":"Luke","year":"2025","journal-title":"Clin Cancer Res"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-010511","article-title":"Phase I dose-escalation and pharmacodynamic study of sting agonist E7766 in advanced solid tumors","volume":"13","author":"Luke","year":"2025","journal-title":"J Immunotherapy Cancer"},{"key":"B28","doi-asserted-by":"publisher","first-page":"19","DOI":"10.21147\/j.issn.1000-9604.2023.01.04","article-title":"Mn-based cgas-sting activation for tumor therapy","volume":"35","author":"Huang","year":"2023","journal-title":"Chin J Cancer Res = Chung-Kuo Yen Cheng Yen Chiu"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10051072","article-title":"The role of the metabolism of zinc and manganese ions in human cancerogenesis","volume":"10","author":"Rozenberg","year":"2022","journal-title":"Biomedicines"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/exp.20220001","article-title":"Recent progress of metal-based nanomaterials with anti-tumor biological effects for enhanced cancer therapy","volume":"3","author":"Lei","year":"2023","journal-title":"Explor (Beijing China)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s13045-021-01155-6","article-title":"Combine and conquer: manganese synergizing anti-tgf-\u03b2\/pd-L1 bispecific antibody ym101 to overcome immunotherapy resistance in non-inflamed cancers","volume":"14","author":"Yi","year":"2021","journal-title":"J Hematol Oncol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e2205409","DOI":"10.1002\/adma.202205409","article-title":"Manganese-based tumor immunotherapy","volume":"35","author":"Zhang","year":"2023","journal-title":"Adv Mater (Deerfield Beach Fla)"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-23-0118","article-title":"Phase I study of synb1891, an engineered E. Coli nissle strain expressing sting agonist, with and without atezolizumab in advanced Malignancies","volume":"29","author":"Luke","year":"2023","journal-title":"Clin Cancer Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/s42003-021-02004-5","article-title":"Exosting, an extracellular vesicle loaded with sting agonists, promotes tumor immune surveillance","volume":"4","author":"Jang","year":"2021","journal-title":"Commun Biol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12539","article-title":"Immunologic tumor microenvironment modulators for turning cold tumors hot","volume":"44","author":"Khosravi","year":"2024","journal-title":"Cancer Commun (Lon Eng)"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14112346","article-title":"Tumor microenvironment-based stimuli-responsive nanoparticles for controlled release of drugs in cancer therapy","volume":"14","author":"Zhou","year":"2022","journal-title":"Pharmaceutics"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113846","article-title":"Nano-immunomodulator amplifies sting activation in tumor-associated macrophages for cancer immunotherapy","volume":"383","author":"Liang","year":"2025","journal-title":"J Controlled rel"},{"key":"B38","doi-asserted-by":"publisher","first-page":"270009","DOI":"10.1002\/exp.70009","article-title":"Cancer immunotherapy based on the bidirectional reprogramming of the tumor microenvironment by a \u201cBrakes off\/step on the accelerator\u201d Core-shell manganese phosphate\/sipd-L1 modulator","volume":"5","author":"Xia","year":"2025","journal-title":"Explor (Beijing China)"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e2311291","DOI":"10.1002\/adma.202311291","article-title":"Octadecyl gallate and lipid-modified mnse(2) nanoparticles enhance radiosensitivity in esophageal squamous cell carcinoma and promote radioprotection in normal tissues","volume":"36","author":"Li","year":"2024","journal-title":"Adv Mater (Deerfield Beach Fla)"},{"key":"B40","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1186\/s12951-025-03473-0","article-title":"Fucoidan-decorated metal-zoledronic acid nanocomplexes suppress tumor metastasis by inducing ferroptotic cell death and enhancing cancer immunotherapy","volume":"23","author":"Tsai","year":"2025","journal-title":"J Nanobiotechnol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat Rev Drug Discovery"},{"key":"B42","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1186\/s12951-025-03608-3","article-title":"Multifunctional nanoagent for enhanced cancer radioimmunotherapy via pyroptosis and cgas-sting activation","volume":"23","author":"Xu","year":"2025","journal-title":"J Nanobiotechnol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jconrel.2024.01.033","article-title":"Risedronate-functionalized manganese-hydroxyapatite amorphous particles: A potent adjuvant for subunit vaccines and cancer immunotherapy","volume":"367","author":"Zhang","year":"2024","journal-title":"J Controlled rel"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e10610","DOI":"10.1002\/btm2.10610","article-title":"Curcumin\/L-ohp co-loaded hap for cgas-sting pathway activation to enhance the natural immune response in colorectal cancer","volume":"9","author":"Xiao","year":"2024","journal-title":"Bioeng Trans Med"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/polym14050936","article-title":"Ph-responsive nanocarriers in cancer therapy","volume":"14","author":"AlSawaftah","year":"2022","journal-title":"Polymers (Basel)"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S496873","article-title":"Enhanced cancer immunotherapy by bacterial cytoplasmic membranes coated nanovaccines for co-delivery of ovalbumin antigen and immune adjuvants to dendritic cells in lymph nodes","volume":"20","author":"Zhao","year":"2025","journal-title":"Int J Nanomed"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1039\/d0nh00446d","article-title":"Immunostimulatory silica nanoparticle boosts innate immunity in brain tumors","volume":"6","author":"Bielecki","year":"2021","journal-title":"Nanoscale Horizons"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.02.003","article-title":"A homologous-targeting cgas-sting agonist multimodally activates dendritic cells for enhanced cancer immunotherapy","volume":"177","author":"Wang","year":"2024","journal-title":"Acta Biomater"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c10352","article-title":"Biomineralized mno(2) nanoplatforms mediated delivery of immune checkpoint inhibitors with sting pathway activation to potentiate cancer radio-immunotherapy","volume":"17","author":"Deng","year":"2023","journal-title":"ACS Nano"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c02309","article-title":"Universal fe\/mn nanoadjuvant with T1\/T2 mri self-navigation and gas generation for ideal vaccines with precise tracking","volume":"17","author":"Huang","year":"2023","journal-title":"ACS Nano"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1039\/d4tb02108h","article-title":"Mnco(3)-au nanoparticles to enable catalytic tumor inhibition with immune activation","volume":"13","author":"Yao","year":"2025","journal-title":"J Mater Chem B"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.Can-23-3511","article-title":"Ionizable sting-activating nanoadjuvants enhance tumor immunogenicity and potentiate immunotherapy efficacy in solid tumors","volume":"84","author":"Xian","year":"2024","journal-title":"Cancer Res"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.137326","article-title":"Biodegradable nano-immune agonist for enhanced immunotherapy of melanoma via the synergistic action of cuproptosis and cgas-sting enhanced immune response","volume":"690","author":"Li","year":"2025","journal-title":"J Colloid Interface Science"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1039\/d5nr01093d","article-title":"A zif-8-based dual-modal smart responsive nanoplatform for overcoming radiotherapy resistance in advanced tumors","volume":"17","author":"Feng","year":"2025","journal-title":"Nanoscale"},{"key":"B55","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12951-025-03229-w","article-title":"Metal-organic framework nanoparticles activate cgas-sting pathway to improve radiotherapy sensitivity","volume":"23","author":"Hu","year":"2025","journal-title":"J Nanobiotechnol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122695","article-title":"Integration of sting activation and cox-2 inhibition via steric-hindrance effect tuned nanoreactors for cancer chemoimmunotherapy","volume":"311","author":"Zhang","year":"2024","journal-title":"Biomaterials"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S459710","article-title":"Smart nanoplatforms responding to the tumor microenvironment for precise drug delivery in cancer therapy","volume":"19","author":"Wang","year":"2024","journal-title":"Int J Nanomed"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-018-0342-5","article-title":"Endosomolytic polymersomes increase the activity of cyclic dinucleotide sting agonists to enhance cancer immunotherapy","volume":"14","author":"Shae","year":"2019","journal-title":"Nat nanotechnol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c04471","article-title":"A cancer nanovaccine for co-delivery of peptide neoantigens and optimized combinations of sting and tlr4 agonists","volume":"18","author":"Baljon","year":"2024","journal-title":"ACS Nano"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-020-00675-9","article-title":"Prolonged activation of innate immune pathways by a polyvalent sting agonist","volume":"5","author":"Li","year":"2021","journal-title":"Nat Biomed Eng"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1584245","article-title":"Synergistic chemo-immunotherapy for osteosarcoma via a ph-responsive multi-component nanoparticle system","volume":"16","author":"Li","year":"2025","journal-title":"Front Pharmacol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1080\/17435889.2025.2508133","article-title":"Rationally designed anti-autophagy nanosystems for reversing the immunosuppressive network in the tumor environment","volume":"20","author":"Zhang","year":"2025","journal-title":"Nanomed (Lond)"},{"key":"B63","doi-asserted-by":"publisher","first-page":"e2403143","DOI":"10.1002\/adhm.202403143","article-title":"Enhanced tumor immunotherapy by triple amplification effects of nanomedicine on the sting signaling pathway in dendritic cells","volume":"14","author":"Wang","year":"2025","journal-title":"Adv Healthc Mat"},{"key":"B64","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jconrel.2022.03.006","article-title":"Self-degradable poly(\u03b2-amino ester)S promote endosomal escape of antigen and agonist","volume":"345","author":"Liu","year":"2022","journal-title":"J Controlled Rele"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c07123","article-title":"Mn(2+)\/cpg oligodeoxynucleotides codecorated black phosphorus nanosheet platform for enhanced antitumor potency in multimodal therapy","volume":"18","author":"Ling","year":"2024","journal-title":"ACS Nano"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01215","article-title":"Multifunctional calcium-manganese nanomodulator provides antitumor treatment and improved immunotherapy via reprogramming of the tumor microenvironment","volume":"17","author":"Luo","year":"2023","journal-title":"ACS Nano"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c09405","article-title":"Logic \u201cand gate circuit\u201d-based gasdermin protein expressing nanoplatform induces tumor-specific pyroptosis to enhance cancer immunotherapy","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"B68","doi-asserted-by":"publisher","first-page":"e2403201","DOI":"10.1002\/smll.202403201","article-title":"Chondroitin sulfate-modified hydroxyapatite for caspase-1 activated induced pyroptosis through ca overload\/er stress\/sting\/irf3 pathway in colorectal cancer","volume":"20","author":"Chen","year":"2024","journal-title":"Small (Weinheim an der Bergstrasse Germany)"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c14102","article-title":"Reprogramming the tolerogenic immune response against pancreatic cancer metastases by lipid nanoparticles delivering a sting agonist plus mutant kras mrna","volume":"19","author":"Xu","year":"2025","journal-title":"ACS Nano"},{"key":"B70","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.jconrel.2024.10.049","article-title":"Oxygen self-supplying nanoradiosensitizer activates cgas-sting pathway to enhance radioimmunotherapy of triple negative breast cancer","volume":"376","author":"Wang","year":"2024","journal-title":"J Controlled Rele"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.5c00333","article-title":"Bsa-ldhs-cgamp in situ sensitization of osteosarcoma: enhancing antitumor efficacy with cd40 agonist antibodies","volume":"11","author":"Yan","year":"2025","journal-title":"ACS Biomater Sci Eng"},{"key":"B72","doi-asserted-by":"publisher","first-page":"e2309562","DOI":"10.1002\/adma.202309562","article-title":"Ultrathin clay nanoparticles-mediated mutual reinforcement of ferroptosis and cancer immunotherapy","volume":"36","author":"Liu","year":"2024","journal-title":"Adv Mater (Deerfield Beach Fla)"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.3c02941","article-title":"Manganese-enriched zinc peroxide functional nanoparticles for potentiating cancer immunotherapy","volume":"23","author":"Zhou","year":"2023","journal-title":"Nano Lett"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c00969","article-title":"Biodegradable mno-based nanoparticles with engineering surface for tumor therapy: simultaneous fenton-like ion delivery and immune activation","volume":"16","author":"Sun","year":"2022","journal-title":"ACS Nano"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110189","article-title":"Biomineralization-inspired synthesis of autologous cancer vaccines for personalized metallo-immunotherapy","volume":"27","author":"Li","year":"2024","journal-title":"iScience"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c00322","article-title":"A hybrid manganese nanoparticle simultaneously eliminates cancer stem cells and activates sting pathway to potentiate cancer immunotherapy","volume":"19","author":"Wu","year":"2025","journal-title":"ACS Nano"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100566","article-title":"Nir responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the sting-dependent innate antitumor immunity","volume":"19","author":"Li","year":"2023","journal-title":"Mater Today Bio"},{"key":"B78","doi-asserted-by":"publisher","first-page":"e2500141","DOI":"10.1002\/adhm.202500141","article-title":"Synergistic provoking of pyroptosis and sting pathway by multifunctional manganese-polydopamine nano-immunomodulator for enhanced renal cell carcinoma immunotherapy","volume":"14","author":"Du","year":"2025","journal-title":"Adv Healthc Mat"},{"key":"B79","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12951-025-03186-4","article-title":"Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cgas-sting activation for enhancing triple-negative breast cancer immunotherapy","volume":"23","author":"Zhou","year":"2025","journal-title":"J Nanobiotechnol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2024.101797","article-title":"A dual-sting-activating nanosystem expands cancer immunotherapeutic temporal window","volume":"5","author":"Wang","year":"2024","journal-title":"Cell Rep Med"},{"key":"B81","doi-asserted-by":"publisher","first-page":"e2500882","DOI":"10.1002\/advs.202500882","article-title":"Smart organic-inorganic copolymer nanoparticles distinguish between microglia and cancer cells for synergistic immunotherapy in glioma","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.07.039","article-title":"A polymeric nanoplatform enhances the cgas-sting pathway in macrophages to potentiate phagocytosis for cancer immunotherapy","volume":"373","author":"Li","year":"2024","journal-title":"J Controlled Rele"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.7150\/thno.107200","article-title":"Ph-responsive nano-vaccine combined with anti-pd-1 antibodies for enhanced immunotherapy of breast cancer","volume":"15","author":"Wang","year":"2025","journal-title":"Theranostics"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c10202","article-title":"A ph-responsive and guanidinium-rich nanoadjuvant efficiently delivers sting agonist for cancer immunotherapy","volume":"19","author":"Lu","year":"2025","journal-title":"ACS Nano"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.753472","article-title":"Pharmacological activation of cgas for cancer immunotherapy","volume":"12","author":"Garland","year":"2021","journal-title":"Front Immunol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"e2304845","DOI":"10.1002\/adma.202304845","article-title":"Tumor microenvironment-responsive nanoparticles amplifying sting signaling pathway for cancer immunotherapy","volume":"36","author":"Liu","year":"2024","journal-title":"Adv Mater (Deerfield Beach Fla)"},{"key":"B87","doi-asserted-by":"publisher","first-page":"e2400421","DOI":"10.1002\/adhm.202400421","article-title":"A manganese-based nanodriver coordinates tumor prevention and suppression through sting activation in glioblastoma","volume":"13","author":"Zhang","year":"2024","journal-title":"Adv Healthc Mat"},{"key":"B88","doi-asserted-by":"publisher","first-page":"e2209910","DOI":"10.1002\/adma.202209910","article-title":"Acid-ionizable iron nanoadjuvant augments sting activation for personalized vaccination immunotherapy of cancer","volume":"35","author":"Chen","year":"2023","journal-title":"Adv Mater (Deerfield Beach Fla)"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.01.019","article-title":"Manganese-based multifunctional nanoplatform for dual-modal imaging and synergistic therapy of breast cancer","volume":"141","author":"Zhu","year":"2022","journal-title":"Acta Biomater"},{"key":"B90","doi-asserted-by":"publisher","first-page":"e2104037","DOI":"10.1002\/adma.202104037","article-title":"Zns@Bsa nanoclusters potentiate efficacy of cancer immunotherapy","volume":"33","author":"Cen","year":"2021","journal-title":"Adv Mater (Deerfield Beach Fla)"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c11374","article-title":"Self-assembled sting-activating coordination nanoparticles for cancer immunotherapy and vaccine applications","volume":"18","author":"Sun","year":"2024","journal-title":"ACS Nano"},{"key":"B92","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12943-023-01831-w","article-title":"Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis","volume":"22","author":"Ren","year":"2023","journal-title":"Mol Cancer"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c12237","article-title":"Activating the cgas-sting pathway by manganese-based nanoparticles combined with platinum-based nanoparticles for enhanced ovarian cancer immunotherapy","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121856","article-title":"Activating cgas-sting pathway with ros-responsive nanoparticles delivering a hybrid prodrug for enhanced chemo-immunotherapy","volume":"290","author":"Cao","year":"2022","journal-title":"Biomaterials"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100675","article-title":"Combination of ido inhibitors and platinum(Iv) prodrugs reverses low immune responses to enhance cancer chemotherapy and immunotherapy for osteosarcoma","volume":"20","author":"Xiang","year":"2023","journal-title":"Mater Today Bio"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1080\/1061186x.2024.2365243","article-title":"Lipo\/tk-cdn\/tpp\/Y6 nanoparticles inhibit cutaneous melanoma formation","volume":"32","author":"Xiao","year":"2024","journal-title":"J Drug Targ"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c20103","article-title":"Dendrimer-mediated generation of a metal-phenolic network for antibody delivery to elicit improved tumor chemo\/chemodynamic\/immune therapy","volume":"17","author":"Wang","year":"2025","journal-title":"ACS Appl Mater Interfaces"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113601","article-title":"Multifunctional nanoparticle-mediated targeting of metabolic reprogramming and DNA damage response pathways to treat drug-resistant triple-negative breast cancer","volume":"381","author":"Zhu","year":"2025","journal-title":"J Controlled Rele"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123199","article-title":"Manganese-coordinated nanoparticles loaded with chk1 inhibitor dually activate cgas-sting pathway and enhance efficacy of immune checkpoint therapy","volume":"319","author":"Huang","year":"2025","journal-title":"Biomaterials"},{"key":"B100","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1186\/s12951-023-02132-6","article-title":"Tumor microenvironment-responsive DNA-based nanomedicine triggers innate sensing for enhanced immunotherapy","volume":"21","author":"Li","year":"2023","journal-title":"J Nanobiotechnol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"e2308762","DOI":"10.1002\/adma.202308762","article-title":"Targeting DNA damage and repair machinery via delivering wee1 inhibitor and platinum (Iv) prodrugs to stimulate sting pathway for maximizing chemo-immunotherapy in bladder cancer","volume":"36","author":"Wang","year":"2024","journal-title":"Adv Mater (Deerfield Beach Fla)"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113942","article-title":"A cgas-sting pathway activating cobalt(Iii) cyclam prodrug for combined chemotherapy and immunotherapy of breast cancer","volume":"384","author":"Song","year":"2025","journal-title":"J Controlled Rele"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c06194","article-title":"A trisulfide bond containing biodegradable polymer delivering pt(Iv) prodrugs to deplete glutathione and donate H(2)S to boost chemotherapy and antitumor immunity","volume":"18","author":"Li","year":"2024","journal-title":"ACS Nano"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122905","article-title":"Biologically logic-gated trojan-horse strategy for personalized triple-negative breast cancer precise therapy by selective ferroptosis and sting pathway provoking","volume":"315","author":"Guo","year":"2025","journal-title":"Biomaterials"},{"key":"B105","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1038\/s41467-025-57718-5","article-title":"Supramolecular polyrotaxane-based nano-theranostics enable cancer-cell stiffening for enhanced T-cell-mediated anticancer immunotherapy","volume":"16","author":"Luo","year":"2025","journal-title":"Nat Commun"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.34133\/bmr.0048","article-title":"Amino acid metabolism-regulated nanomedicine for enhanced tumor immunotherapy through synergistic regulation of immune microenvironment","volume":"28","author":"Duan","year":"2024","journal-title":"Biomaterials Res"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.02.100","article-title":"Glutathione degradable manganese-doped polydopamine nanoparticles for photothermal therapy and cgas-sting activated immunotherapy of lung tumor","volume":"663","author":"Lin","year":"2024","journal-title":"J Colloid Interface Science"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101707","article-title":"Copper-coordination driven nano-frameworks for efficient colorectal cancer chemo-immunotherapy by suppression of cancer cell stemness","volume":"32","author":"Huang","year":"2025","journal-title":"Mater Today Bio"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1002\/exp.20230061","article-title":"Programmed initiation and enhancement of cgas\/sting pathway for tumour immunotherapy via tailor-designed znfe(2)O(4)-based nanosystem","volume":"3","author":"Yang","year":"2023","journal-title":"Explor (Beijing China)"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08174","article-title":"Manganese dioxide-entrapping dendrimers co-deliver protein and nucleotide for magnetic resonance imaging-guided chemodynamic\/starvation\/immune therapy of tumors","volume":"17","author":"Gao","year":"2023","journal-title":"ACS Nano"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1039\/d4tb02565b","article-title":"Decomposable sting nanoagonist-amplified oncolytic virotherapy through remodeling the immunosuppressive microenvironment of triple-negative breast cancer","volume":"13","author":"Mu","year":"2025","journal-title":"J Mater Chem B"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102000","article-title":"A mno(2)-based tumor-seeking nanoplatform for enhanced chemoimmunotherapy against 4t1 breast cancer","volume":"33","author":"Gong","year":"2025","journal-title":"Mater Today Bio"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122745","article-title":"Manganese-coordinated nanoparticle with high drug-loading capacity and synergistic photo-\/immuno-therapy for cancer treatments","volume":"312","author":"Chen","year":"2025","journal-title":"Biomaterials"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c12304","article-title":"Glutathione-responsive metal-organic-framework-derived mn(X)O(Y)\/(a\/R)Tio(2) nanoparticles for enhanced synergistic sonodynamic\/chemodynamic\/immunotherapy","volume":"19","author":"Yang","year":"2025","journal-title":"ACS Nano"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.04.040","article-title":"Mitochondria-targeted manganese-based mesoporous silica nanoplatforms trigger cgas-sting activation and sensitize anti pd-L1 therapy in triple-negative breast cancer","volume":"199","author":"Zhong","year":"2025","journal-title":"Acta Biomater"},{"key":"B116","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1186\/s12951-024-02859-w","article-title":"Redox-manipulating nanocarriers for anticancer drug delivery: A systematic review","volume":"22","author":"Meng","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113789","article-title":"Hypoxia-responsive albumin nanoparticles co-delivering banoxantrone and sting agonist enhance immunotherapy of high-intensity focused ultrasound","volume":"383","author":"Huang","year":"2025","journal-title":"J Controlled Rele"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.144962","article-title":"Carrier-free nanotherapeutics unleashed: ce6\/sipd-L1 co-delivery system synergizes photodynamic and rnai therapies to combat breast cancer","volume":"318","author":"Luo","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2024.127258","article-title":"Nanomotors activating both cgas-sting pathway and immune checkpoint blockade for tumor therapy and bioimaging","volume":"284","author":"Jing","year":"2025","journal-title":"Talanta"},{"key":"B120","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12951-021-01226-3","article-title":"Extracellular matrix-degrading sting nanoagonists for mild nir-ii photothermal-augmented chemodynamic-immunotherapy","volume":"20","author":"Zhan","year":"2022","journal-title":"J Nanobiotechnol"},{"key":"B121","doi-asserted-by":"publisher","first-page":"5773","DOI":"10.1038\/s41467-025-60927-7","article-title":"Engineering sting nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy","volume":"16","author":"Chen","year":"2025","journal-title":"Nat Commun"},{"key":"B122","doi-asserted-by":"publisher","first-page":"e2302895","DOI":"10.1002\/advs.202302895","article-title":"Cgas-sting pathway activation and systemic anti-tumor immunity induction via photodynamic nanoparticles with potent toxic platinum DNA intercalator against uveal melanoma","volume":"10","author":"Tao","year":"2023","journal-title":"Adv Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B123","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1186\/s12951-025-03353-7","article-title":"Drug-loaded indocyanine green J-aggregates activate metalloimmunotherapy for sustained photothermal therapy of hepatocellular carcinoma","volume":"23","author":"He","year":"2025","journal-title":"J Nanobiotechnol"},{"key":"B124","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1186\/s12951-025-03536-2","article-title":"An imaging-guided self-amplifying photo-immunotherapeutic nanoparticle for sting pathway activation and enhanced cancer therapy","volume":"23","author":"Chen","year":"2025","journal-title":"J Nanobiotechnol"},{"key":"B125","doi-asserted-by":"publisher","first-page":"eade6257","DOI":"10.1126\/sciadv.ade6257","article-title":"Single-dose injectable nanovaccine-in-hydrogel for robust immunotherapy of large tumors with abscopal effect","volume":"9","author":"Cheng","year":"2023","journal-title":"Sci Adv"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.05.029","article-title":"Targeted nanosensitizer-augmented sono-immunotherapy with sting agonist to remodel the immune microenvironment in hepatocellular carcinoma","volume":"199","author":"Yang","year":"2025","journal-title":"Acta Biomater"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c21493","article-title":"Ultrasound-responsive nanobubbles for breast cancer: synergistic sonodynamic, chemotherapy, and immune activation through the cgas-sting pathway","volume":"17","author":"Pu","year":"2025","journal-title":"ACS Appl Mater Interfaces"},{"key":"B128","doi-asserted-by":"publisher","first-page":"e10400","DOI":"10.1002\/btm2.10400","article-title":"Magnetic nanoparticles enhance the cellular immune response of dendritic cell tumor vaccines by realizing the cytoplasmic delivery of tumor antigens","volume":"8","author":"Huang","year":"2023","journal-title":"Bioeng Trans Med"},{"key":"B129","doi-asserted-by":"publisher","first-page":"4783","DOI":"10.1038\/s41467-025-59977-8","article-title":"Neoantigen enriched biomimetic nanovaccine for personalized cancer immunotherapy","volume":"16","author":"Li","year":"2025","journal-title":"Nat Commun"},{"key":"B130","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1186\/s12951-024-02747-3","article-title":"Metal ions-anchored bacterial outer membrane vesicles for enhanced ferroptosis induction and immune stimulation in targeted antitumor therapy","volume":"22","author":"Sun","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122687","article-title":"Tumor-derived nanovesicles enhance cancer synergistic chemo-immunotherapy by promoting cgas\/sting pathway activation and immunogenetic cell death","volume":"348","author":"Guo","year":"2024","journal-title":"Life Sci"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.12.034","article-title":"Engineered virus-mimicking nanovaccine with lymph node-tumor dual-targeting and sting-activating capacity for robust cancer immunotherapy","volume":"378","author":"Wang","year":"2025","journal-title":"J Ctrl Rel"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c03243","article-title":"Engineered nanovaccine targeting clec9a(+) dendritic cells remarkably enhances the cancer immunotherapy effects of sting agonist","volume":"21","author":"Gou","year":"2021","journal-title":"Nano Lett"},{"key":"B134","doi-asserted-by":"publisher","first-page":"4909","DOI":"10.1038\/s41467-020-18626-y","article-title":"Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis","volume":"11","author":"Rao","year":"2020","journal-title":"Nat Commun"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.7150\/thno.110841","article-title":"X-ray-responsive dissolving microneedles mediate sting pathway activation to potentiate cutaneous melanoma radio-immunotherapy","volume":"15","author":"Hu","year":"2025","journal-title":"Theranostics"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.12.030","article-title":"X-ray triggered bimetallic nanoassemblies as radiosensitizers and sting agonists for a cdt\/radio-immunotherapy strategy","volume":"192","author":"Chen","year":"2025","journal-title":"Acta Biomater"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16091216","article-title":"Targeted delivery of sting agonist via albumin nanoreactor boosts immunotherapeutic efficacy against aggressive cancers","volume":"16","author":"Miao","year":"2024","journal-title":"Pharmaceutics"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01447-7","article-title":"Investigation of the enhanced antitumour potency of sting agonist after conjugation to polymer nanoparticles","volume":"18","author":"Dosta","year":"2023","journal-title":"Nat Nanotechnol"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.04.032","article-title":"Ultra-small janus nanoparticle-induced activation of ferroptosis for synergistic tumor immunotherapy","volume":"181","author":"Wang","year":"2024","journal-title":"Acta Biomater"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101826","article-title":"Enhancing tumor immunotherapy with smart nanoparticles for reprogramming macrophages and blocking the cd47\/sirp\u03b1 Pathway","volume":"32","author":"Hussain","year":"2025","journal-title":"Mater Today Bio"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c09491","article-title":"Gelatin methacryloyl xerogel puncture implants loaded with cu(0.5)Mn(2.5)O(4) nanoparticles synergizes cuproptosis and sting activation for enhanced breast cancer immunotherapy","volume":"19","author":"Jiang","year":"2025","journal-title":"ACS Nano"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.2174\/1389450122666210114095614","article-title":"Endogenous enzyme-responsive nanoplatforms for anti-tumor therapy","volume":"22","author":"Lou","year":"2021","journal-title":"Curr Drug Targ"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.7150\/thno.104190","article-title":"Hypoxia-responsive nanoparticles for fluorescence diagnosis and therapy of cancer","volume":"15","author":"Zhang","year":"2025","journal-title":"Theranostics"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S433737","article-title":"Cell membrane-camouflaged nanoparticles mediated nucleic acids delivery","volume":"18","author":"Lin","year":"2023","journal-title":"Int J Nanomed"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102343","article-title":"Cell membrane biomimetic nanoplatforms: A new strategy for immune escape and precision targeted therapy","volume":"35","author":"Feng","year":"2025","journal-title":"Mater Today Bio"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29030636","article-title":"Light-responsive and dual-targeting liposomes: from mechanisms to targeting strategies","volume":"29","author":"Agiba","year":"2024","journal-title":"Molecules"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.05.016","article-title":"Light-responsive nanomedicine for cancer immunotherapy","volume":"13","author":"Kang","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"B148","doi-asserted-by":"publisher","first-page":"e2403158","DOI":"10.1002\/advs.202403158","article-title":"Light-activated in situ vaccine with enhanced cytotoxic T lymphocyte infiltration and function for potent cancer immunotherapy","volume":"11","author":"An","year":"2024","journal-title":"Adv Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B149","doi-asserted-by":"publisher","first-page":"e2300153","DOI":"10.1002\/adhm.202300153","article-title":"Tumor therapy strategies based on microenvironment-specific responsive nanomaterials","volume":"12","author":"Zhang","year":"2023","journal-title":"Adv Healthc Mat"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.01.029","article-title":"Manganese dioxide-based in situ vaccine boosts antitumor immunity via simultaneous activation of immunogenic cell death and the sting pathway","volume":"194","author":"Peng","year":"2025","journal-title":"Acta Biomater"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.137632","article-title":"Self-oxygenating nanoplatform integrating crispr\/cas9 gene editing and immune activation for highly efficient photodynamic therapy","volume":"693","author":"Tian","year":"2025","journal-title":"J Colloid Interface Science"},{"key":"B152","doi-asserted-by":"publisher","first-page":"e2207200","DOI":"10.1002\/advs.202207200","article-title":"Dual-cascade activatable nanopotentiators reshaping adenosine metabolism for sono-chemodynamic-immunotherapy of deep tumors","volume":"10","author":"Zhan","year":"2023","journal-title":"Adv Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B153","doi-asserted-by":"publisher","first-page":"113565","DOI":"10.1016\/j.jconrel.2025.02.061","article-title":"Sting pathway activation with cisplatin polyprodrug nanoparticles for chemo-immunotherapy in ovarian cancer","volume":"381","author":"Fu","year":"2025","journal-title":"J Controlled Rele"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c15342","article-title":"Ph and redox dual-responsive nanoparticle with enhanced dendritic cell maturation for cancer therapy","volume":"16","author":"Yun","year":"2024","journal-title":"ACS Appl Mater Interfaces"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c03838","article-title":"In situ aggregated nanomanganese enhances radiation-induced antitumor immunity","volume":"16","author":"Xu","year":"2024","journal-title":"ACS Appl Mater Interfaces"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110150","article-title":"Mesoporous manganese nanocarrier target delivery metformin for the co-activation sting pathway to overcome immunotherapy resistance","volume":"27","author":"Dou","year":"2024","journal-title":"iScience"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121988","article-title":"Manganese-enriched photonic\/catalytic nanomedicine augments synergistic anti-tnbc photothermal\/nanocatalytic\/immuno-therapy via activating cgas-sting pathway","volume":"293","author":"Zheng","year":"2023","journal-title":"Biomaterials"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.113957","article-title":"Coordinated modulation of glucose metabolism and immunity via metal-drug nanovesicles for hepatocellular carcinoma therapy","volume":"384","author":"Kong","year":"2025","journal-title":"J Controlled Rele"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S436160","article-title":"A ph-sensitive nanoparticle as reactive oxygen species amplifier to regulate tumor microenvironment and potentiate tumor radiotherapy","volume":"19","author":"Jiang","year":"2024","journal-title":"Int J Nanomed"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1002\/exp.20220140","article-title":"Tumor microenvironment-responsive delivery nanosystems reverse immunosuppression for enhanced co gas\/immunotherapy","volume":"3","author":"Chen","year":"2023","journal-title":"Explor (Beijing China)"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2024.11.003","article-title":"Nuclear-targeted smart nanoplatforms featuring double-shell hollow mesoporous copper sulfide coated with manganese dioxide synergistically potentiate chemotherapy and immunotherapy in hepatocellular carcinoma cells","volume":"680","author":"Li","year":"2025","journal-title":"J Colloid Interface Sci"},{"key":"B162","doi-asserted-by":"publisher","first-page":"e2313029","DOI":"10.1002\/adma.202313029","article-title":"Decomposable nanoagonists enable nir-elicited cgas-sting activation for tandem-amplified photodynamic-metalloimmunotherapy","volume":"36","author":"Guo","year":"2024","journal-title":"Adv Mater (Deerfield Beach Fla)"},{"key":"B163","doi-asserted-by":"publisher","first-page":"e2302278","DOI":"10.1002\/advs.202302278","article-title":"Record-high ultrasound-sensitive no nanogenerators for cascade tumor pyroptosis and immunotherapy","volume":"10","author":"Bao","year":"2023","journal-title":"Adv Sci (Weinheim Baden-Wurttemberg Germany)"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1714249\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T07:19:18Z","timestamp":1769411958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1714249\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,26]]},"references-count":163,"alternative-id":["10.3389\/fimmu.2026.1714249"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1714249","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,26]]},"article-number":"1714249"}}