{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T08:00:10Z","timestamp":1772006410643,"version":"3.50.1"},"reference-count":7,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Caplan syndrome is a rare disorder characterized by the coexistence of pneumoconiosis and rheumatoid arthritis (RA), primarily observed in individuals with silica or coal dust exposure. Data on disease behavior in the context of incomplete or irregular immunosuppressive therapy remain limited. This case report describes a 56-year-old man with a history of mixed dust exposure and smoking who presented with recurrent fever, chest pain, and polyarthralgia. Despite being diagnosed and treated for pulmonary tuberculosis and cryptococcosis, his respiratory and articular symptoms persisted. Serological tests revealed persistently elevated rheumatoid factor (RF) and anticitrullinated peptide antibody (ACPA), while a lung biopsy demonstrated chronic inflammation with carbon deposition, confirming Caplan syndrome. Retrospective analysis indicated that elevations of RF and ACPA preceded observable radiological and pathological changes. Notably, inflammatory markers continued to rise significantly even after infections were controlled and despite only episodic glucocorticoid use. This case highlights the importance of early serological monitoring and comprehensive management in high-risk patients and underscores that, rather than being viewed merely as complications, infections in autoimmune contexts should be recognized as potential triggers and aggravators of immune dysregulation, warranting heightened vigilance in both diagnosis and management.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1715034","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:04:09Z","timestamp":1772003049000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: The entanglement of infection and autoimmunity: a case of Caplan syndrome"],"prefix":"10.3389","volume":"17","author":[{"given":"Zilin","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"West China Clinical Medical College, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"West China School of Medicine, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, West China Hospital, Sichuan University","place":["Chengdu, China"]},{"name":"West China Clinical Medical College, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajia","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2010.02.004","article-title":"Rheumatoid pneumoconiosis (Caplan\u2019s syndrome)","volume":"21","author":"Schreiber","year":"2010","journal-title":"Eur J Intern Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(73)90209-X","article-title":"Rheumatoid pneumoconiosis. Documentation of onset and pathogenic considerations","volume":"55","author":"Benedek","year":"1973","journal-title":"Am J Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.98.2.334","article-title":"The lungs and pleura in rheumatoid arthritis","volume":"98","author":"Morgan","year":"1966","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"102962","DOI":"10.1016\/j.jaut.2022.102962","article-title":"Infectious diseases, autoantibodies, and autoimmunity","volume":"137","author":"Johnson","year":"2023","journal-title":"J Autoimmun"},{"key":"B5","doi-asserted-by":"publisher","first-page":"997","DOI":"10.2217\/imt.11.86","article-title":"Cryptococcus neoformans galactoxylomannan is a potent negative immunomodulator, inspiring new approaches in anti-inflammatory immunotherapy","volume":"3","author":"Vecchiarelli","year":"2011","journal-title":"Immunotherapy."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28756","article-title":"Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis","volume":"116","author":"Rangel-Moreno","year":"2006","journal-title":"J Clin Invest."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1156995","article-title":"Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica","volume":"320","author":"Dostert","year":"2008","journal-title":"Science."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1715034\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:04:11Z","timestamp":1772003051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1715034\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":7,"alternative-id":["10.3389\/fimmu.2026.1715034"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1715034","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"article-number":"1715034"}}