{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T05:54:06Z","timestamp":1774936446851,"version":"3.50.1"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["\u4e0d\u300232302886, \u4e0d\u300232160832"],"award-info":[{"award-number":["\u4e0d\u300232302886, \u4e0d\u300232160832"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["\u7f16\u53f72025YQ030"],"award-info":[{"award-number":["\u7f16\u53f72025YQ030"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Inflammasomes are an essential component of the innate immune response against pathogen infections. However, the molecular mechanism regulating the inflammasome signaling in response to gangrenous\n                    <jats:italic>Clostridium perfringens<\/jats:italic>\n                    (\n                    <jats:italic>C. perfringens<\/jats:italic>\n                    ) infection remains elusive. We herein report the unexpected discovery that IFI204 (the murine homolog of human IFI16)\u2013dependent STING protects against\n                    <jats:italic>C. perfringens<\/jats:italic>\n                    gas gangrene via enhancing NLRP3 inflammasome signaling. In the\n                    <jats:italic>C. perfringens<\/jats:italic>\n                    gas gangrene model, compared with wild-type (WT) mice,\n                    <jats:italic>Sting<\/jats:italic>\n                    deficiency (\n                    <jats:italic>\n                      Sting\n                      <jats:sup>-\/-<\/jats:sup>\n                    <\/jats:italic>\n                    ) mice displayed an increased susceptibility to\n                    <jats:italic>C. perfringens<\/jats:italic>\n                    soft tissue infection, with more bacterial colonization, severe muscle damage, and higher mortality rates. Obviously,\n                    <jats:italic>Sting<\/jats:italic>\n                    deficiency leads to the defect of inflammasome signaling activation and bacterial killing and clearance. STING promotes inflammasome signaling activation in an IFI204-dependent manner. Crucially, the IFI204-STING axis enhances NLRP3 inflammasome signaling activation, which, in turn, facilitates pathogen elimination and host defense. Our findings highlight STING acts as a positive regulator in defense of\n                    <jats:italic>C. perfringens<\/jats:italic>\n                    infection and present it as a potential target for anti-infection drug development.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1715595","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:17:39Z","timestamp":1774930659000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["IFI204-STING drives protective innate immunity against gangrenous Clostridium perfringens infection via regulation of NLRP3 signaling"],"prefix":"10.3389","volume":"17","author":[{"given":"Ming-Yue","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University","place":["Hohhot, 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