{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:27:37Z","timestamp":1775024857102,"version":"3.50.1"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Dendritic cell activation of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells at the immunological synapse is critical for immunity, but the structural organization of the dendritic cell side and its impact on T cell fate remain poorly defined. Using bone marrow-derived dendritic cells (BMDCs) as a model, we describe two stable subpopulations distinguished by their capacity to form morphologically distinct synapses. We demonstrate that this architectural divergence is governed by the differential expression of the co-stimulatory molecule CD70: CD70\n                    <jats:sup>high<\/jats:sup>\n                    BMDCs form spiky \u201cfirework\u201d synapses driven by a filopodia-based cytoskeletal program, while CD70\n                    <jats:sup>low<\/jats:sup>\n                    BMDCs form smooth \u201cpancake\u201d synapses. This structural dichotomy functionally dictates T cell programming. CD70\n                    <jats:sup>high<\/jats:sup>\n                    dendritic cells prime potent, terminally differentiated Tc1 effector cells. In contrast, IL-6-secreting CD70\n                    <jats:sup>low<\/jats:sup>\n                    dendritic cells generate memory T cells with a Tc17-like functional profile and robust recall capacity. Our work reveals that DC synapse architecture is a key determinant of T cell fate, linking the physical organization of the cell to distinct immunological outcomes.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1716644","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:27:09Z","timestamp":1775017629000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct dendritic cell cytoskeletal programs dictate synapse architecture and CD8+ T cell fate"],"prefix":"10.3389","volume":"17","author":[{"given":"Camille D.","family":"Clamagirand","sequence":"first","affiliation":[{"name":"Institute of Cell Biology and Immunology Thurgau (BITG), University of Konstanz","place":["Kreuzlingen, Switzerland"]},{"name":"Graduate School for Cellular and Biomedical Sciences, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Ratswohl","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Immunology Thurgau (BITG), University of Konstanz","place":["Kreuzlingen, Switzerland"]},{"name":"Department of Biology, University of Konstanz","place":["Konstanz, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc W.","family":"Schmid","sequence":"additional","affiliation":[{"name":"MWSchmid GmbH","place":["Glarus, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresia","family":"Eich","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Immunology Thurgau (BITG), University of Konstanz","place":["Kreuzlingen, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Anslinger","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Immunology Thurgau 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