{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:11:07Z","timestamp":1779343867956,"version":"3.51.4"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Systemic sclerosis (SSc) is an autoimmune disease. In the types of SSc, lcSSc presents with milder symptoms and poses challenges for early diagnosis. Therefore, the identification of biomarkers for earlier diagnosis and the discovery of potential therapeutic targets are of greater significance. This study aims to explore the relationship between competing endogenous RNA (ceRNA) networks, cuproptosis, and lcSSc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      RNA sequencing was performed to profile differentially expressed RNAs in blood samples from lcSSc patients and healthy controls. The potential ceRNA network targeting relationships were then examined using a dual-luciferase reporter assay. Subsequently, a series of\n                      <jats:italic>in vitro<\/jats:italic>\n                      experiments utilizing primary CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells. These experiments, which included phenotypic assays and molecular analyses, demonstrated the occurrence of cuproptosis. Finally, these findings were validated\n                      <jats:italic>in vivo<\/jats:italic>\n                      in a mouse model through analyses of skin tissues using H&amp;amp;E staining, Masson staining, Immunofluorescence, qPCR, and Western blotting.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TTLL7-IT1\/hsa-miR-29c-3p\/GLS was constructed using bioinformatic analysis of lcSSc. CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells from patients with lcSSc exhibited elevated copper ion levels and reduced glutaminase(GLS) expression, accompanied by alterations in their phenotype and cuproptosis-related proteins. These phenotypic and protein expression changes were reversed by cuproptosis inhibition. Furthermore, cuproptosis exacerbates fibrosis and vascular pathology. Animal experiments further revealed that in bleomycin-induced mouse models, both inhibition of copper ions and GLS overexpression reduced dermal thickness, collagen deposition, fibrotic factor expression, and CD31\/\u03b1-SMA co-localization in the skin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In summary, our findings reveal a functional interaction between cuproptosis and ceRNA networks: TTLL7-IT1\/hsa-miR-29c-3p\/GLS influences cuproptosis and lcSSc progression, providing new insights into the pathogenesis of lcSSc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1722661","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:45:14Z","timestamp":1779342314000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of TTLL7-IT1\/Hsa-miR-29c-3p\/GLS with limited cutaneous systemic sclerosis and exploration of the underlying mechanisms"],"prefix":"10.3389","volume":"17","author":[{"given":"Xin","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Center for Big Data and Population Health of Institute Health and Medicine, Institute Health and Medicine, HeFei Comprehensive National Science Center (IHM), The First Affiliated Hospital of Anhui Medical University, Rheumatology and Immunology Department, Clinical College of Anhui Medical University, Key Laboratory of Public Health Social Governance, Philosophy and Social Sciences of Anhui Province","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanyu","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University, Rheumatology and Immunology Department","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danni","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Center for Big Data and Population Health of Institute Health and Medicine, Institute Health and Medicine, HeFei Comprehensive National Science Center (IHM), The First Affiliated Hospital of Anhui Medical University, Rheumatology and Immunology Department, Clinical College of Anhui Medical University, Key Laboratory of Public Health Social Governance, Philosophy and Social Sciences of Anhui Province","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Chronic Non-Communicable Diseases Prevention and Control Fei Xi County Centre for Disease Control and Prevention","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Liang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Anhui Medical University, Institute of Dermatology and Department of Dermatology, Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Center for Big Data and Population Health of Institute Health and Medicine, Institute Health and Medicine, HeFei Comprehensive National Science Center (IHM), The First Affiliated Hospital of Anhui Medical University, Rheumatology and Immunology Department, Clinical College of Anhui Medical University, Key Laboratory of Public Health Social Governance, Philosophy and Social Sciences of Anhui Province","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Center for Big Data and Population Health of Institute Health and Medicine, Institute Health and Medicine, HeFei Comprehensive National Science Center (IHM), The First Affiliated Hospital of Anhui Medical University, Rheumatology and Immunology Department, Clinical College of Anhui Medical University, Key Laboratory of Public Health Social Governance, Philosophy and Social Sciences of Anhui Province","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiejie","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Public Health and Health Management, Clinical College of Anhui Medical University","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Public Health and Health Management, Clinical College of Anhui Medical University","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijing","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Public Health, Anhui Medical University","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaye","family":"Fei","sequence":"additional","affiliation":[{"name":"School of Public Health, Anhui Medical University","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyuan","family":"Bao","sequence":"additional","affiliation":[{"name":"Clinical Medicine in the 5 + 3 Integrated Program, Anhui Medical University","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangrui","family":"Xia","sequence":"additional","affiliation":[{"name":"Clinical Medicine in the 5 + 3 Integrated Program, Anhui Medical University","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Center for Big Data and Population Health of Institute Health and Medicine, Institute Health and Medicine, HeFei Comprehensive National Science Center (IHM), The First Affiliated Hospital of Anhui Medical University, Rheumatology and Immunology Department, Clinical College of Anhui Medical University, Key Laboratory of Public Health Social Governance, Philosophy and Social Sciences of Anhui Province","place":["Hefei, Anhui, China"]},{"name":"The First Affiliated Hospital of Anhui Medical University, Rheumatology and Immunology Department","place":["Hefei, Anhui, China"]},{"name":"Department of Public Health and Health Management, Clinical College of Anhui Medical University","place":["Hefei, Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/bor.0000000000001063","article-title":"A scoping review of the epidemiology of systemic sclerosis and its organ manifestations: 2018-2024","volume":"37","author":"Good","year":"2025","journal-title":"Curr Opin Rheumatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"855\u2013866","DOI":"10.1002\/acr.25504","article-title":"Geographic clustering of systemic sclerosis in areas of environmental pollution","volume":"77","author":"Kosarek","year":"2025","journal-title":"Arthritis Care Res"},{"key":"B3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.4078\/jrd.2024.0129","article-title":"Pathogenesis of systemic sclerosis: an integrative review of recent advances","volume":"32","author":"Son","year":"2025","journal-title":"J Rheumatic Dis"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12917","article-title":"Abnormalities in endothelial form of nitric oxide synthase is pathogenic in limited cutaneous systemic sclerosis","volume":"18","author":"Jia","year":"2019","journal-title":"J Cosmetic Dermatol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.11817\/j.issn.1672-7347.2023.220621","article-title":"Role of ceRNA network in inflammatory cells of rheumatoid arthritis","volume":"48","author":"He","year":"2023","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban = J Cent South Univ Med Sci"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1383186","article-title":"Construction of competing endogenous RNA networks in systemic lupus erythematosus by integrated analysis","volume":"11","author":"He","year":"2024","journal-title":"Front Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.70003","article-title":"The role of non-coding RNA in systemic sclerosis: from mechanism to translation","volume":"16","author":"Zhu","year":"2025","journal-title":"Wiley Interdiscip Rev RNA"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2147\/dnnd.s491211","article-title":"Integrated transcriptome analysis reveals molecular subtypes and ceRNA networks in multiple sclerosis","volume":"14","author":"Ji","year":"2024","journal-title":"Degenerative Neurological Neuromuscular Dis"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2147\/jir.s431603","article-title":"An important role in novel immune mechanism and diagnostic model of ankylosing spondylitis: the ceRNA-ADRB2 network","volume":"16","author":"Huang","year":"2023","journal-title":"J Inflammation Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1125183","article-title":"Bioinformatics-integrated screening of systemic sclerosis-specific expressed markers to identify therapeutic targets","volume":"14","author":"Jin","year":"2023","journal-title":"Front Immunol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1111812","article-title":"Identification of lncRNA-miRNA-mRNA networks in circulating exosomes as potential biomarkers for systemic sclerosis","volume":"10","author":"Sun","year":"2023","journal-title":"Front Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15811","article-title":"Localized scleroderma: actual insights and new biomarkers","volume":"61","author":"Snarskaya","year":"2022","journal-title":"Int J Dermatol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2025.103422","article-title":"miR-143-3p boosts extracellular vesicles to improve the dermal fibrosis of localized scleroderma","volume":"153","author":"Jin","year":"2025","journal-title":"J Autoimmun"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1157196","article-title":"Cuproptosis-related gene identification and immune infiltration analysis in systemic lupus erythematosus","volume":"14","author":"Li","year":"2023","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1204926","article-title":"Verification of cuproptosis-related diagnostic model associated with immune infiltration in rheumatoid arthritis","volume":"14","author":"Jiang","year":"2023","journal-title":"Front Endocrinol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf0529","article-title":"Copper induces cell death by targeting lipoylated TCA cycle proteins","volume":"375","author":"Tsvetkov","year":"2022","journal-title":"Sci (New York NY)"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/nu12061894","article-title":"Selenium and copper as biomarkers for pulmonary arterial hypertension in systemic sclerosis","volume":"12","author":"Sun","year":"2020","journal-title":"Nutrients"},{"key":"B18","doi-asserted-by":"publisher","first-page":"139","DOI":"10.12688\/wellcomeopenres.20080.2","article-title":"Respiratory tract lining fluid copper content contributes to pulmonary oxidative stress in patients with systemic sclerosis","volume":"9","author":"Fr\u00f8lich","year":"2024","journal-title":"Wellcome Open Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1515\/bmc-2021-0023","article-title":"NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: potential cross talk with circulating miRNAs","volume":"13","author":"Posadino","year":"2022","journal-title":"Biomol Concepts"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102812","article-title":"Crosstalk between oxidative stress, mitochondrial dysfunction, chromosome instability, and the activation of the cGAS-STING\/IFN pathway in systemic sclerosis","volume":"110","author":"Waseem","year":"2025","journal-title":"Ageing Res Rev"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.111239","article-title":"Cuproptosis in microsatellite stable colon cancer cells affects the cytotoxicity of CD8(+)T through the WNT signaling pathway","volume":"403","author":"Zeng","year":"2024","journal-title":"Chem Biol Interact"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1481129","article-title":"IAPP blocks anti-breast cancer function of CD8(+)T cells via targeting cuproptosis","volume":"15","author":"Guo","year":"2024","journal-title":"Front Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.imlet.2017.10.002","article-title":"Current perspectives on the role of CD8+ T cells in systemic sclerosis","volume":"195","author":"Fuschiotti","year":"2018","journal-title":"Immunol Lett"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.83009","article-title":"Identification of three cuproptosis-specific expressed genes as diagnostic biomarkers and therapeutic targets for atherosclerosis","volume":"20","author":"Chen","year":"2023","journal-title":"Int J Med Sci"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"van den Hoogen","year":"2013","journal-title":"Arthritis Rheumatism"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.5301\/jsrd.5000231","article-title":"Standardization of the modified Rodnan skin score for use in clinical trials of systemic sclerosis","volume":"2","author":"Khanna","year":"2017","journal-title":"J Scleroderma Related Disord"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2022.05.010","article-title":"A novel NUTM2A-AS1\/miR-769-5p axis regulates LPS-evoked damage in human dental pulp cells via the TLR4\/MYD88\/NF-\u03baB signaling","volume":"20","author":"Li","year":"2025","journal-title":"J Dental Sci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112152-20230717-00015","article-title":"Non-small cell lung cancer-derived exosomal circular RNA circEZH2 activates fibroblasts by regulating the miR-495-3p \/ TPD52 axis and NF-\u03baB pathway","volume":"46","author":"Xing","year":"2024","journal-title":"Zhonghua Zhong Liu Za Zhi [Chinese J Oncology]"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00856","article-title":"The emerging epigenetic role of CD8+T cells in autoimmune diseases: a systematic review","volume":"10","author":"Deng","year":"2019","journal-title":"Front Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1016\/j.cell.2018.10.001","article-title":"Distinct regulation of Th17 and Th1 cell differentiation by glutaminase-dependent metabolism","volume":"175","author":"Johnson","year":"2018","journal-title":"Cell"},{"key":"B31","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1097\/shk.0000000000002370","article-title":"Diminished expression of GLS in CD4 + T cells serves as a prognostic indicator associated with cuproptosis in septic patients","volume":"62","author":"Yang","year":"2024","journal-title":"Shock (Augusta Ga)"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0002-9629(24)00592-5","article-title":"A positive feedback loop exists between estradiol and IL-6 and contributes to dermal fibrosis","volume":"25","author":"Baker Frost","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200994R","article-title":"STAT6 suppression prevents bleomycin-induced dermal fibrosis","volume":"37","author":"Huang","year":"2023","journal-title":"FASEB J"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-023-05499-9","article-title":"Serum IL-17 and TNF\u03b1 as prognostic biomarkers in systemic sclerosis patients: a prospective study","volume":"44","author":"Kosa\u0142ka-W\u0119giel","year":"2024","journal-title":"Rheumatol Int"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.825567","article-title":"IL-13 and IL-33 serum levels are increased in systemic sclerosis patients with interstitial lung disease","volume":"9","author":"Versace","year":"2022","journal-title":"Front Med"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.037","article-title":"Skin-resident effector memory CD8(+)CD28(-) T cells exhibit a profibrotic phenotype in patients with systemic sclerosis","volume":"137","author":"Li","year":"2017","journal-title":"J Invest Dermatol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00601","article-title":"IGFBP-5 promotes fibrosis via increasing its own expression and that of other pro-fibrotic mediators","volume":"9","author":"Nguyen","year":"2018","journal-title":"Front Endocrinol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2023.02.001","article-title":"Overcoming chemoresistance in non-angiogenic colorectal cancer by metformin via inhibiting endothelial apoptosis and vascular immaturity","volume":"13","author":"Li","year":"2023","journal-title":"J Pharm Anal"},{"key":"B39","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/s41419-023-05639-w","article-title":"Copper homeostasis and copper-induced cell death in the pathogenesis of cardiovascular disease and therapeutic strategies","volume":"14","author":"Chen","year":"2023","journal-title":"Cell Death Dis"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14102448","article-title":"Acquired \u03b1SMA expression in pericytes coincides with aberrant vascular structure and function in pancreatic ductal adenocarcinoma","volume":"14","author":"Natarajan","year":"2022","journal-title":"Cancers"},{"key":"B41","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1093\/eurheartj\/ehae707","article-title":"NAT10 promotes vascular remodelling via mRNA ac4C acetylation","volume":"46","author":"Yu","year":"2025","journal-title":"Eur Heart J"},{"key":"B42","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jdermsci.2025.02.001","article-title":"The role and mechanism of JAK2 inhibitor in endothelial mesenchymal transition in systemic sclerosis","volume":"117","author":"Luo","year":"2025","journal-title":"J Dermatol Sci"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3390\/life11070610","article-title":"New insights into profibrotic myofibroblast formation in systemic sclerosis: when the vascular wall becomes the enemy","volume":"11","author":"Romano","year":"2021","journal-title":"Life (Basel Switzerland)"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m603984200","article-title":"TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites","volume":"281","author":"Ikegami","year":"2006","journal-title":"J Biol Chem"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1249405","article-title":"The transcriptomics profiling of blood CD4 and CD8 T-cells in narcolepsy type I","volume":"14","author":"Khajavi","year":"2023","journal-title":"Front Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9635","article-title":"Long noncoding RNA CPS1-IT1 suppresses the metastasis of hepatocellular carcinoma by regulating HIF-1\u03b1 activity and inhibiting epithelial-mesenchymal transition","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"B47","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s13046-023-02847-2","article-title":"LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on GLUT1 and PKM2","volume":"42","author":"Wang","year":"2023","journal-title":"J Exp Clin Cancer Research: CR"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.779483","article-title":"A review on the role of SPRY4-IT1 in the carcinogenesis","volume":"11","author":"Ghafouri-Fard","year":"2021","journal-title":"Front Oncol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1194046","article-title":"A ceRNA network-mediated over-expression of cuproptosis-related gene SLC31A1 correlates with poor prognosis and positive immune infiltration in breast cancer","volume":"10","author":"Lian","year":"2023","journal-title":"Front Med"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14030553","article-title":"Advancing cancer treatment by targeting glutamine metabolism-a roadmap","volume":"14","author":"Halama","year":"2022","journal-title":"Cancers"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/s2665-9913(24)00282-0","article-title":"CD19-targeting CAR T-cell therapy in patients with diffuse systemic sclerosis: a case series","volume":"7","author":"Auth","year":"2025","journal-title":"Lancet Rheumatol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1097\/bor.0000000000001082","article-title":"Management of cutaneous manifestations of systemic sclerosis: current approaches and emerging therapies","volume":"37","author":"Bautista Sanchez","year":"2025","journal-title":"Curr Opin Rheumatol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"23971983251342697","DOI":"10.1177\/23971983251342697","article-title":"A systematic literature review of Janus kinase inhibitors for the treatment of systemic sclerosis","volume":"10","author":"Sener","year":"2025","journal-title":"J Scleroderma Related Disord"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1722661\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:45:18Z","timestamp":1779342318000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1722661\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":53,"alternative-id":["10.3389\/fimmu.2026.1722661"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1722661","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]},"article-number":"1722661"}}