{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:14:11Z","timestamp":1770963251530,"version":"3.50.1"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tezepelumab, an anti-thymic stromal lymphopoietin (TSLP) monoclonal antibody, reduces exacerbations across asthma phenotypes, but its role in status asthmaticus and near-fatal exacerbations requiring veno-venous extracorporeal membrane oxygenation (VV-ECMO) is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>We report three patients (17, 22, 57 years) with therapy-refractory hypercapnic respiratory failure initiated on VV-ECMO who received tezepelumab 210 mg within 24 h. Tidal volume and minute ventilation increased within 24\u201372 h, permitting decannulation by days 12\u201315 and ventilator weaning by days 17\u201328. Two patients had elevated IgE; one had normal blood eosinophils\/IgE. No immediate drug-related adverse events occurred. Follow-up demonstrated lung-function recovery; one patient required escalation of maintenance therapy for persistent symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this small series, adjunctive tezepelumab during VV-ECMO\u2013supported status asthmaticus appeared safe and potentially beneficial adjunctive therapy during near-fatal asthma requiring VV-ECMO. Randomized controlled studies are needed to determine the impact of TSLP inhibition on recovery time, ventilation duration, and mortality in this setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1722963","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T05:22:44Z","timestamp":1770960164000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Tezepelumab as rescue therapy in near-fatal asthma requiring extracorporeal membrane oxygenation"],"prefix":"10.3389","volume":"17","author":[{"given":"Gani","family":"Oruqaj","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Justus Liebig University","place":["Giessen, Germany"]},{"name":"Universities of Giessen and Marburg Lung Center, German Center for Lung Research","place":["Giessen, Germany"]},{"name":"Interdisciplinary Extracorporeal Membrane Oxygenation (ECMO) Center, Interdisciplinary Center for Intensive Care Medicine, University Hospital Giessen","place":["Giessen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Bewersdorff","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Justus Liebig University","place":["Giessen, Germany"]},{"name":"Universities of Giessen and Marburg Lung Center, German Center for Lung Research","place":["Giessen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Detlef","family":"Litzlbauer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Giessen","place":["Giessen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Wolff","sequence":"additional","affiliation":[{"name":"Interdisciplinary Extracorporeal Membrane Oxygenation (ECMO) Center, Interdisciplinary Center for Intensive Care Medicine, University Hospital Giessen","place":["Giessen, Germany"]},{"name":"Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Justus Liebig University Giessen","place":["Giessen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Sander","sequence":"additional","affiliation":[{"name":"Interdisciplinary Extracorporeal Membrane Oxygenation (ECMO) Center, Interdisciplinary Center for Intensive Care Medicine, University Hospital Giessen","place":["Giessen, Germany"]},{"name":"Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, Justus Liebig University Giessen","place":["Giessen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Seeger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Justus Liebig University","place":["Giessen, Germany"]},{"name":"Universities of Giessen and Marburg Lung Center, German Center for Lung Research","place":["Giessen, 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