{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:46:25Z","timestamp":1776746785916,"version":"3.51.2"},"reference-count":217,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>This review systematically summarizes the central roles and molecular mechanisms of the cytoskeletal system\u2014including actin filaments, microtubules (MT), intermediate filaments, and the Septin family\u2014in the regulation of autophagy. The cytoskeleton not only provides a structural framework and facilitates transport for the autophagic process but also acts as a dynamic signaling hub, participating in every stage from autophagosome formation and cargo recognition to targeted trafficking and autophagosome-lysosome fusion. Actin filaments regulate the initiation of autophagy through dynamic assembly, Arp2\/3-mediated nucleation, and mechanosensing. Microtubules drive the transport and localization of autophagosomes by relying on \u201cdynamic instability\u201d and the \u201ctubulin code\u201d. Intermediate filaments\u2014such as vimentin\u2014and septins influence autophagy flux by maintaining organelle integrity, forming molecular scaffolds, and establishing diffusion barriers on membranes. This review further discusses the functional implications of this regulatory network in diverse physiological and pathological neuroimmune contexts, including neurodegeneration and aging. Finally, we highlight that targeting the cytoskeleton\u2013autophagy interaction axis may offer novel therapeutic strategies for related diseases.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1732775","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:22:35Z","timestamp":1776745355000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytoskeleton-mediated autophagy regulation in neuroimmune contexts: molecular mechanisms and functional perspectives"],"prefix":"10.3389","volume":"17","author":[{"given":"Xingyu","family":"Cao","sequence":"first","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of Technology","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haolin","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science, Beijing University of 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