{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T05:59:47Z","timestamp":1780898387058,"version":"3.54.1"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kidney renal clear cell carcinoma (KIRC) has a poor clinical prognosis, and its tumor progression and immunotherapy response are closely associated with genomic aberrations and immune microenvironment disorders. This study aimed to identify key prognostic biomarkers and potential therapeutic targets for KIRC via multi-omics integrative analysis and preliminary experimental validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Multi-omics data including transcriptome, methylation, copy number variation (CNV), and immune infiltration data of KIRC were integrated from public databases, and further validated by single-cell RNA sequencing (scRNA-seq), two-sample Mendelian randomization (TSMR), in silico gene knockout, and quantitative PCR (qPCR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results demonstrated that CRHBP was a core downregulated prognostic biomarker in KIRC, with stage-dependent low expression and favorable survival predictive value (OS HR\u00a0=\u00a00.42, 95%CI: 0.395\u20130.45, P&amp;lt;0.05). ScRNA-seq revealed a compartmentalized CRHBP expression pattern and its differential regulation by immune checkpoint blockade (ICB) treatment and gender. TSMR confirmed the causal risk effect of testicular-derived UCN2 on KIRC, and UCN2 negatively correlated with tumor angiogenesis and hypoxia. Molecular docking screened dabrafenib as a promising candidate drug targeting CRHBP\/UCN2 (binding affinity: -11.55\/-17.23 kcal\/mol). In silico knockout of CRHBP altered SRGN\/TYROBP expression and inhibited cytokine production. QPCR verified decreased CRHBP expression in human KIRC tissues and elevated UCN2 expression in mouse KIRC tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The CRHBP-UCN2 axis critically regulates KIRC prognosis and immune microenvironment remodeling. CRHBP serves as a reliable prognostic biomarker and a potential anticancer peptide target, while dabrafenib is a promising therapeutic agent for KIRC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1732965","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T05:33:51Z","timestamp":1780896831000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-omics analysis of kidney renal cell carcinoma in silico with preliminary in vivo validation"],"prefix":"10.3389","volume":"17","author":[{"given":"Tingyu","family":"Su","sequence":"first","affiliation":[{"name":"Department of Nephrology, First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases","place":["Beijing, China"]},{"name":"Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases","place":["Beijing, China"]},{"name":"Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine (zyyzdxk-2023310)","place":["Beijing, China"]},{"name":"Department of Nephrology, the Eighth Medical Center of People's Liberation Army General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Section of Health, No. 94804 Unit of the Chinese People\u2019s Liberation Army","place":["Shanghai, China"]},{"name":"Resident Standardization Training Cadet Corps, Air Force Medical Center","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, the Ninth Medical Center of People's Liberation Army (PLA) General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiubin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, the Third Medical Center of People's Liberation Army General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Nephrology, the Eighth Medical Center of People's Liberation Army General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, First Medical Center of Chinese People's Liberation Army (PLA) General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases","place":["Beijing, China"]},{"name":"Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases","place":["Beijing, China"]},{"name":"Key Laboratory of Digital Intelligent TCM for the Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine (zyyzdxk-2023310)","place":["Beijing, China"]},{"name":"Department of Nephrology, the Eighth Medical Center of People's Liberation Army General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s13046-023-02742-w","article-title":"Traf2 promotes m2-polarized tumor-associated macrophage infiltration, angiogenesis and cancer progression by inhibiting autophagy in clear c ell renal cell carcinoma","volume":"42","author":"Xu","year":"2023","journal-title":"J Exp Clin Cancer Res CR"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.981764","article-title":"Multi-omics pan-cancer study of cuproptosis core gene FDX1 and its role in kidney renal clear cell carcinoma","volume":"13","author":"Xu","year":"2022","journal-title":"Front Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7269","article-title":"Metastatic pathway-specific transcriptome analysis identifies mfsd4 as a putative tumor suppressor and biomarker for hepatic metastasis in p atients with gastric cancer","volume":"7","author":"Kanda","year":"2016","journal-title":"Oncotarget"},{"key":"B4","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1186\/s12935-024-03562-4","article-title":"Crhbp, a novel multiple cancer biomarker connected with better prognos is and anti-tumorigenicity","volume":"24","author":"Yoo","year":"2024","journal-title":"Cancer Cell Int"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11538","article-title":"Mpp7 promotes the migration and invasion of breast cancer cells via eg fr\/akt signaling","volume":"45","author":"Liao","year":"2021","journal-title":"Cell Biol Int"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/cells12242854","article-title":"Natural killer t (nkt) cells in autoimmune hepatitis: Current evidence from basic and clinical research","volume":"12","author":"Poddighe","year":"2023","journal-title":"Cells"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1016\/j.immuni.2022.10.002","article-title":"Tumor-associated macrophages expressing the transcription factor irf8 promote t cell exhaustion in cancer","volume":"55","author":"Nixon","year":"2022","journal-title":"Immunity"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102952","article-title":"Relb-activated gpx4 inhibits ferroptosis and confers tamoxifen resista nce in breast cancer","volume":"68","author":"Xu","year":"2023","journal-title":"Redox Biol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.70389\/pjs.100082","article-title":"Transparency in the reporting of artificial intelligence \u2013 the titan guideline","volume":"2","author":"Riaz A","year":"2025","journal-title":"Premier J Sci"},{"key":"B10","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1371\/journal.pmed.1001216","article-title":"Reporting recommendations for tumor marker prognostic studies (remark): Explanation and elaboration","volume":"10","author":"Altman","year":"2012","journal-title":"BMC Med"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.607224","article-title":"Ythdf1 is a potential pan-cancer biomarker for prognosis and immunothe rapy","volume":"11","author":"Hu","year":"2021","journal-title":"Front Oncol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","article-title":"Ualcan: An update to the integrated cancer data analysis platform","volume":"25","author":"Chandrashekar","year":"2022","journal-title":"Neoplasia (New York NY)"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1607","article-title":"A roadmap to generate renewable protein binders to the human proteome","volume":"8","author":"Colwill","year":"2011","journal-title":"Nat Methods"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac558","article-title":"Gsca: An integrated platform for gene set cancer analysis at genomic, pharmacogenomic and immunogenomic levels","volume":"24","author":"Liu","year":"","journal-title":"Briefings Bioinf"},{"key":"B15","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"Gsva: Gene set variation analysis for microarray and rna-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2023","journal-title":"BMC Bioinf"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.4974","article-title":"Role of the gut-brain axis in the shared genetic etiology between gast rointestinal tract diseases and psychiatric disorders: A genome-wide p leiotropic analysis","volume":"80","author":"Gong","year":"2023","journal-title":"JAMA Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2021.02.003","article-title":"Dna copy number variation: Main characteristics, evolutionary signific ance, and pathological aspects","volume":"44","author":"P\u00f6s","year":"2021","journal-title":"Biomed J"},{"key":"B18","doi-asserted-by":"publisher","first-page":"D1268","DOI":"10.1093\/nar\/gkaa1104","article-title":"Methhc 2.0: Information repository of dna methylation and gene expression in human cancer","volume":"49","author":"Huang","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1151","article-title":"Methhc: A database of dna methylation and gene expression in human cancer","volume":"43","author":"Huang","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.27","article-title":"Cognitive decline in parkinson disease","volume":"13","author":"Aarsland","year":"","journal-title":"Nat Rev Neurol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.exphem.2018.09.004","article-title":"The human cell atlas bone marrow single-cell interactive web portal","volume":"68","author":"Hay","year":"","journal-title":"Exp Hematol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.ccell.2025.05.009","article-title":"Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma","volume":"39","author":"Bi","year":"2021","journal-title":"Cancer Cell"},{"key":"B23","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.bioactmat.2023.09.019","article-title":"Profibrogenic macrophage-targeted delivery of mitochondrial protector via exosome formula for alleviating pulmonary fibrosis","volume":"32","author":"Zhang","year":"2024","journal-title":"Bioact Mater"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2024.1429437","article-title":"Analyses of single-cell and bulk rna sequencing combined with machine learning reveal the expression patterns of disrupted mitophagy in schizophrenia","volume":"15","author":"Yang","year":"2024","journal-title":"Front Psychiatry"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2023.2168554","article-title":"Genetic and epigenetic regulation of the innate immune response to gout","volume":"52","author":"de Lima","year":"2023","journal-title":"Immunol Invest"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/cells12101401","article-title":"Ginsentide tp1 protects hypoxia-induced dysfunction and er stress-linked apoptosis","volume":"12","author":"Dutta","year":"2023","journal-title":"Cells"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12345","article-title":"Tumor-associated macrophages in liver cancer: From mechanisms to therapy","volume":"42","author":"Cheng","year":"2022","journal-title":"Cancer Commun (Lond)"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.583084","article-title":"Tumor-associated macrophages in tumor immunity","volume":"11","author":"Pan","year":"2020","journal-title":"Front Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1111","article-title":"Genomics of drug sensitivity in cancer (gdsc): A resource for therapeutic biomarker discovery in cancer cells","volume":"41","author":"Yang","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10010","article-title":"Integrating heterogeneous drug sensitivity data from cancer pharmacogenomic studies","volume":"7","author":"Pozdeyev","year":"2016","journal-title":"Oncotarget"},{"key":"B31","doi-asserted-by":"publisher","first-page":"D1083","DOI":"10.1093\/nar\/gkaa968","article-title":"Cellminer cross-database (cellminercdb) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics","volume":"49","author":"Luna","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-15-0335","article-title":"Using cellminer 1.6 for systems pharmacology and genomic analysis of the nci-60","volume":"21","author":"Reinhold","year":"2015","journal-title":"Clin Cancer Res"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0312erratum","article-title":"High proliferation predicts pathological complete response to neoadjuvant chemotherapy in early breast cancer","volume":"21","author":"Alba","year":"2016","journal-title":"Oncologist"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.117864","article-title":"Deciphering csu pathogenesis: Network toxicologyand molecular dynamics of dotp exposure","volume":"291","author":"Cao","year":"2025","journal-title":"Ecotoxicol Environ Saf"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0684-4","article-title":"Complex genetic signatures in immune cells underlie autoimmunity and inform therapy","volume":"52","author":"Orr\u00f9","year":"2020","journal-title":"Nat Genet"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/med4.40","article-title":"Design and development of a multi-epitope vaccine for the prevention of latent tuberculosis infection","volume":"1","author":"Jiang","year":"2023","journal-title":"Med Adv"},{"key":"B37","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/id9.0000000000000104","article-title":"Development and evaluation of a promising biomarker for diagnosis of latent and active tuberculosis infection","volume":"4","author":"Peng","year":"2024","journal-title":"Infect Dis Immun"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1102578","article-title":"Bioinformatics analysis and consistency verification of a novel tuberculosis vaccine candidate hp13138pb","volume":"14","author":"Cheng","year":"2023","journal-title":"Front Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s43556-024-00177-z","article-title":"Construction of novel multi-epitope-based diagnostic biomarker hp16118p and its application in the differential diagnosis of mycobacterium tuberculosis latent infection","volume":"5","author":"Wang","year":"2024","journal-title":"Mol BioMed"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1280299","article-title":"A comprehensive approach to developing a multi-epitope vaccine against mycobacterium tuberculosis: From in silico design to in vitro immunization evaluation","volume":"14","author":"Jiang","year":"2023","journal-title":"Front Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11040856","article-title":"Pp19128r, a multiepitope vaccine designed to prevent latent tuberculosis infection, induced immune responses in silico and in vitro assays","volume":"11","author":"Jiang","year":"2023","journal-title":"Vaccines (Basel)"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109728","article-title":"Developing a multiepitope vaccine for the prevention of sars-cov-2 and monkeypox virus co-infection: A reverse vaccinology analysis","volume":"115","author":"Jiang","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"D900","DOI":"10.1093\/nar\/gky939","article-title":"Cancersea: A cancer single-cell state atlas","volume":"47","author":"Yuan","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.patter.2022.100434","article-title":"Sctenifoldknk: An efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation","volume":"3","author":"Osorio","year":"2022","journal-title":"Patterns (N Y)"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.11.043","article-title":"Matrix metalloproteinase-7 protects against acute kidney injury by priming renal tubules for survival and regeneration","volume":"95","author":"Fu","year":"2019","journal-title":"Kidney Int"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189953","article-title":"Therapeutic targeting of the gas6\/axl signaling pathway in cancer","volume":"22","author":"Tanaka","year":"","journal-title":"Int J Mol Sci"},{"key":"B47","doi-asserted-by":"publisher","first-page":"3112","DOI":"10.1038\/s41598-024-52387-8","article-title":"A pan-cancer analysis uncovering the function of crhbp in tumor immunity, prognosis and drug response: Especially its function in lihc","volume":"14","author":"Chen","year":"2024","journal-title":"Sci Rep"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2776","article-title":"Dynamic expression and regulation of the corticotropin-releasing hormone\/urocortin-receptor-binding protein system in the primate ovary during the menstrual cycle","volume":"91","author":"Xu","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"B49","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.peptides.2014.09.008","article-title":"Differential stress response in rats subjected to chronic mild stress is accompanied by changes in crh-family gene expression at the pituitary level","volume":"61","author":"Kolasa","year":"2014","journal-title":"Peptides"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2016.10.009","article-title":"Crh peptide evolution occurred in three phases: Evidence from characterizing sea lamprey crh system members","volume":"240","author":"Endsin","year":"2017","journal-title":"Gen Comp Endocrinol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00441-012-1450-4","article-title":"Expression of urocortin and corticotropin-releasing hormone receptors in the horse thyroid gland","volume":"350","author":"Squillacioti","year":"2012","journal-title":"Cell Tissue Res"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-199","article-title":"Reduced mRNA expression level of corticotropin-releasing hormone-binding protein is associated with aggressive human kidney cancer","volume":"13","author":"Tezval","year":"2013","journal-title":"BMC Cancer"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmd.2025.100113","article-title":"Physiologically based pharmacokinetic modeling of aldehyde oxidase drug-drug interactions mediated by erlotinib","volume":"53","author":"Heikkinen","year":"2025","journal-title":"Drug Metab Dispos"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaq1093","article-title":"PP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells","volume":"10","author":"Kauko","year":"2018","journal-title":"Sci Transl Med"},{"key":"B55","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1038\/s42003-022-03725-x","article-title":"ISX-9 potentiates CaMKII\u03b4-mediated BMAL1 activation to enhance circadian amplitude","volume":"5","author":"Li","year":"2022","journal-title":"Commun Biol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-12-2258","article-title":"First-in-human phase I trial of two schedules of OSI-930, a novel multikinase inhibitor, incorporating translational proof-of-mechanism studies","volume":"19","author":"Yap","year":"2013","journal-title":"Clin Cancer Res"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(12)60868-x","article-title":"Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial","volume":"380","author":"Hauschild","year":"2012","journal-title":"Lancet"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.19189","article-title":"Tumor-educated platelets: a review of current and potential applications in solid tumors","volume":"13","author":"Varkey","year":"2021","journal-title":"Cureus"},{"key":"B59","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jhep.2006.09.014","article-title":"IFN-gamma abrogates profibrogenic TGF-beta signaling in liver by targeting expression of inhibitory and receptor Smads","volume":"46","author":"Weng","year":"2007","journal-title":"J Hepatol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00323-22","article-title":"TGF-\u03b2\/IFN-\u03b3 antagonism in subversion and self-defense of phase II Coxiella burnetii-infected dendritic cells","volume":"91","author":"Matthiesen","year":"2023","journal-title":"Infect Immun"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1732965\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T05:33:53Z","timestamp":1780896833000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1732965\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":60,"alternative-id":["10.3389\/fimmu.2026.1732965"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1732965","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"article-number":"1732965"}}