{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:12:03Z","timestamp":1776229923688,"version":"3.50.1"},"reference-count":74,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Endometriosis (EMS) is a common gynecological disease that seriously affects women\u2019s health and quality of life. However, the detailed dynamic cellular and molecular mechanisms underlying EMS pathogenesis remain largely unknown. This study establishes a novel diagnostic model to distinguish ectopic endometrium (EC) from eutopic endometrium (EU) samples. This study elucidated the critical role of low-density lipoprotein receptor-related protein 1 (LRP1) in EMS pathogenesis through integrated multi-omics analyses. Our comprehensive approach began with merging three GEO datasets (GSE7305, GSE11691, GSE25628), identifying 1,404 differentially expressed genes (DEGs) and 489 co-expressed genes with the brown module using weighted gene co-expression network analysis (WGCNA). A machine learning algorithm identified 30 hub genes, among which LRP1 exhibited the highest diagnostic performance. Immune profiling revealed a strong positive correlation between LRP1 and M2 macrophage infiltration (r=0.62, p&amp;lt;0.001), while Mendelian randomization analysis confirmed a causal relationship (OR = 1.35, 95%CI:1.13-1.61, p=0.001). Single-cell RNA sequencing demonstrated LRP1 is predominantly expressed in fibroblasts and monocytes, orchestrating cell-cell communication through the MIF signaling pathway, particularly through CD74\/CXCR4 interactions. Experimental validation confirmed significantly elevated LRP1 expression in ectopic lesions at both mRNA (p&amp;lt;0.01) and protein levels. Mechanistically, LRP1 may promote the progression of EMS by enhancing cell migration, invasion, and proliferation through the MIF signaling pathway. Collectively, these findings identified LRP1 as a central regulator of EMS progression through immunomodulation and intercellular crosstalk, offering novel diagnostic and therapeutic potential.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1735221","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:37:48Z","timestamp":1776227868000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["LRP1 as a potential diagnostic and immunomodulatory target in endometriosis: evidence from multi-omics and single-cell analyses"],"prefix":"10.3389","volume":"17","author":[{"given":"Chengmao","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00389-5","article-title":"Endometriosis is a chronic systemic disease: clinical challenges and novel innovations","volume":"397","author":"Taylor","year":"2021","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.02.047","article-title":"Research priorities for endometriosis differ among patients, clinicians, and researchers","volume":"222","author":"Brady","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew293","article-title":"World Endometriosis Society consensus on the classification of endometriosis","volume":"32","author":"Johnson","year":"2017","journal-title":"Hum Reprod"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00441-015-2339-9","article-title":"Oxidative stress and oocyte quality: ethiopathogenic mechanisms of minimal\/mild endometriosis-related infertility","volume":"364","author":"Da Broi","year":"2016","journal-title":"Cell Tissue Res"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-4","article-title":"Endometriosis and physical exercises: a systematic review","volume":"12","author":"Bonocher","year":"2014","journal-title":"Reprod Biol Endocrinol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoac009","article-title":"ESHRE guideline: endometriosis","volume":"2022","author":"Becker","year":"2022","journal-title":"Hum Reprod Open"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S119724","article-title":"Self-management and psychological-sexological interventions in patients with endometriosis: strategies, outcomes, and integration into clinical care","volume":"9","author":"Buggio","year":"2017","journal-title":"Int J women\u2019s Health"},{"key":"B8","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41419-023-06182-4","article-title":"Macrophages originated IL-33\/ST2 inhibits ferroptosis in endometriosis via the ATF3\/SLC7A11 axis","volume":"14","author":"Wu","year":"2023","journal-title":"Cell Death Dis"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1701700","article-title":"New lessons about endometriosis - somatic mutations and disease heterogeneity","volume":"376","author":"Montgomery","year":"2017","journal-title":"N Engl J Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e36339","DOI":"10.1097\/MD.0000000000036339","article-title":"Diagnostic value of the combination of circulating serum miRNAs and CA125 in endometriosis","volume":"102","author":"Chen","year":"2023","journal-title":"Medicine"},{"key":"B11","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1152\/physrev.00033.2007","article-title":"LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies","volume":"88","author":"Lillis","year":"2008","journal-title":"Physiol Rev"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.04.012","article-title":"Functional changes of immune cells: signal of immune tolerance of the ectopic lesions in endometriosis","volume":"43","author":"Voltolini Velho","year":"2021","journal-title":"Reprod Biomed Online"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/art.40080","article-title":"Inhibition of shedding of low-density lipoprotein receptor-related protein 1 reverses cartilage matrix degradation in osteoarthritis","volume":"69","author":"Yamamoto","year":"2017","journal-title":"Arthritis Rheumatol (Hoboken N.J.)"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.08.043","article-title":"Unfavorable lipid profile in women with endometriosis","volume":"93","author":"Melo","year":"2010","journal-title":"Fertil Steril"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiosc.2022.08.004","article-title":"Bioinformatics in bioscience and bioengineering: Recent advances, applications, and perspectives","volume":"134","author":"Uesaka","year":"2022","journal-title":"J Biosci Bioeng"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15649","article-title":"Integration of single-cell and bulk transcriptomics reveals immune-related signatures in keloid","volume":"22","author":"Wang","year":"2023","journal-title":"J Cosmet Dermatol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v10.i33.12116","article-title":"Single-cell RNA-sequencing combined with bulk RNA-sequencing analysis of peripheral blood reveals the characteristics and key immune cell genes of ulcerative colitis","volume":"10","author":"Dai","year":"2022","journal-title":"World J Clin Cases"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high-density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj021","article-title":"The gene ontology (GO) project in 2006","volume":"34","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3715","article-title":"Toward understanding the origin and evolution of cellular organisms","volume":"28","author":"Kanehisa","year":"2019","journal-title":"Protein Sci"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa970","article-title":"KEGG: integrating viruses and cellular organisms","volume":"49","author":"Kanehisa","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"B28","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/s41467-022-28421-6","article-title":"Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer","volume":"13","author":"Liu","year":"2022","journal-title":"Nat Commun"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1216585","article-title":"Machine learning-based integration develops a neutrophil-derived signature for improving outcomes in hepatocellular carcinoma","volume":"14","author":"Gong","year":"2023","journal-title":"Front Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"6817","DOI":"10.1038\/s41598-023-34021-1","article-title":"Identification of oxidative stress-related genes differentially expressed in Alzheimer\u2019s disease and construction of a hub gene-based diagnostic model","volume":"13","author":"Zhang","year":"2023","journal-title":"Sci Rep"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00064","article-title":"Immune and stroma related genes in breast cancer: A comprehensive analysis of tumor microenvironment based on the cancer genome atlas (TCGA) database","volume":"7","author":"Xu","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky311","article-title":"GeneMANIA update 2018","volume":"46","author":"Franz","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1177\/03000605211042975","article-title":"Integrative analysis of ferroptosis-related genes in ulcerative colitis","volume":"49","author":"Cui","year":"2021","journal-title":"J Int Med Res"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700378-JLR200","article-title":"Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome","volume":"48","author":"Watkins","year":"2007","journal-title":"J Lipid Res"},{"key":"B35","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1007\/s11033-024-09406-8","article-title":"SIRT1 and ZNF350 as novel biomarkers for osteoporosis: a bioinformatics analysis and experimental validation","volume":"51","author":"Zhu","year":"2024","journal-title":"Mol Biol Rep"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1162458","article-title":"Unveiling the key genes, environmental toxins, and drug exposures in modulating the severity of ulcerative colitis: a comprehensive analysis","volume":"14","author":"Wang","year":"2023","journal-title":"Front Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e18266","DOI":"10.1111\/jcmm.18266","article-title":"and scRNA-seq to explore the molecular mechanisms governing the distinct efferocytosis activities of a macrophage subpopulation in PDAC","volume":"28","author":"Zhu","year":"2024","journal-title":"J Cell Mol Med"},{"key":"B38","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12974-020-01752-1","article-title":"Autonomic nervous system and inflammation interaction in endometriosis-associated pain","volume":"17","author":"Wei","year":"2020","journal-title":"J Neuroinflammation"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew303","article-title":"mRNA levels of low-density lipoprotein receptors are overexpressed in the foci of deep bowel endometriosis","volume":"32","author":"Gibran","year":"2017","journal-title":"Hum Reprod"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"B41","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1053\/j.ajkd.2023.01.449","article-title":"Integrated analysis of blood and urine biomarkers to identify acute kidney injury subphenotypes and associations with long-term outcomes","volume":"82","author":"Bhatraju","year":"2023","journal-title":"Am J Kidney Dis"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.05.021","article-title":"Atherosclerotic cardiovascular disease in women with endometriosis: a systematic review of risk factors and prospects for early surveillance","volume":"39","author":"Tan","year":"2019","journal-title":"Reprod Biomed Online"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/624540","article-title":"Low-density lipoproteins oxidation and endometriosis","volume":"2013","author":"Polak","year":"2013","journal-title":"Mediators Inflammation"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1021\/ja3067226","article-title":"Compound I is the reactive intermediate in the first monooxygenation step during conversion of cholesterol to pregnenolone by cytochrome P450scc: EPR\/ENDOR\/cryoreduction\/annealing studies","volume":"134","author":"Davydov","year":"2012","journal-title":"J Am Chem Soc"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2009.10.010","article-title":"Cancer associated fibroblasts in cancer pathogenesis","volume":"21","author":"Franco","year":"2010","journal-title":"Semin Cell Dev Biol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13164026","article-title":"Malignant transformation of postmenopausal endometriosis: A systematic review of the literature","volume":"13","author":"Giannella","year":"2021","journal-title":"Cancers (Basel)"},{"key":"B47","doi-asserted-by":"publisher","first-page":"e20202207","DOI":"10.1084\/jem.20202207","article-title":"Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A","volume":"218","author":"Nikolakopoulou","year":"2021","journal-title":"J Exp Med"},{"key":"B48","doi-asserted-by":"publisher","first-page":"2902","DOI":"10.1016\/j.devcel.2021.09.015","article-title":"Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation","volume":"56","author":"Bian","year":"2021","journal-title":"Dev Cell"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00025","article-title":"Cellular cholesterol distribution influences proteolytic release of the LRP-1 ectodomain","volume":"7","author":"Dekky","year":"2016","journal-title":"Front Pharmacol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2017.05.023","article-title":"FXII promotes proteolytic processing of the LRP1 ectodomain","volume":"1861","author":"Wujak","year":"2017","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23599","article-title":"LRP1 deficiency in microglia blocks neuro-inflammation in the spinal dorsal horn and neuropathic pain processing","volume":"67","author":"Brifault","year":"2019","journal-title":"Glia"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/biology11040513","article-title":"Role of betaglycan in TGF-\u03b2 Signaling and wound healing in human endometriotic epithelial cells and in endometriosis","volume":"11","author":"Mwaura","year":"2022","journal-title":"Biol (Basel)"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e29385","DOI":"10.1371\/journal.pone.0029385","article-title":"Low density lipoprotein receptor-related protein 1 dependent endosomal trapping and recycling of apolipoprotein E","volume":"7","author":"Laatsch","year":"2012","journal-title":"PLoS One"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111667","article-title":"The molecular mechanism of LRP1 in physiological vascular homeostasis and signal transduction pathways","volume":"139","author":"He","year":"2021","journal-title":"Biomedicine pharmacotherapy = Biomedecine pharmacotherapie"},{"key":"B55","doi-asserted-by":"publisher","first-page":"e28846","DOI":"10.1371\/journal.pone.0028846","article-title":"Macrophage LRP1 suppresses neo-intima formation during vascular remodeling by modulating the TGF-\u03b2 signaling pathway","volume":"6","author":"Muratoglu","year":"2011","journal-title":"PLoS One"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24225","article-title":"LRP1 expression in colon cancer predicts clinical outcome","volume":"9","author":"Boulagnon-Rombi","year":"2018","journal-title":"Oncotarget"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00211-9","article-title":"Endometriosis patients show an increased M2 response in the peritoneal CD14(+low)\/CD68(+low) macrophage subpopulation coupled with an increase in the T-helper 2 and T-regulatory cells","volume":"27","author":"Hudson","year":"2020","journal-title":"Reprod Sci"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2156-5","article-title":"LRP1 is a master regulator of tau uptake and spread","volume":"580","author":"Rauch","year":"2020","journal-title":"Nature"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.509133","article-title":"LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein","volume":"288","author":"Mantuano","year":"2013","journal-title":"J OF Biol Chem"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e110434","DOI":"10.1371\/journal.pone.0110434","article-title":"Macrophage migration inhibitory factor is involved in ectopic endometrial tissue growth and peritoneal-endometrial tissue interaction in vivo: a plausible link to endometriosis development","volume":"9","author":"Rakhila","year":"2014","journal-title":"PLoS One"},{"key":"B61","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.fertnstert.2003.11.044","article-title":"Elevations in peritoneal fluid macrophage migration inhibitory factor are independent of the depth of invasion or stage of endometriosis","volume":"82","author":"Mahutte","year":"2004","journal-title":"Fertil Steril"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0417","article-title":"Macrophage migration inhibitory factor elicits an angiogenic phenotype in human ectopic endometrial cells and triggers the production of major angiogenic factors via CD44, CD74, and MAPK signaling pathways","volume":"95","author":"Veillat","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.2.8260","article-title":"Macrophage migration inhibitory factor is markedly expressed in active and early-stage endometriotic lesions","volume":"87","author":"Kats","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"B64","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1677\/joe.0.1790015","article-title":"Macrophage migration inhibitory factor: a neuroendocrine modulator of chronic inflammation","volume":"179","author":"Baugh","year":"2003","journal-title":"J Endocrinol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.07.499","article-title":"Effect of lupron vs norethindrone treatment on lipid profile of women with symptomatic endometriosis","volume":"104","author":"Charles","year":"2015","journal-title":"Fertility Sterility"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(92)90165-U","article-title":"The low density lipoprotein receptor-related protein\/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase","volume":"267","author":"Chappell","year":"1992","journal-title":"J OF Biol Chem"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.3c00728","article-title":"Coronal apoE protein combines with LRP1 to inactivate GSK3\u03b2 That mitigates silica nanoparticle-induced brain lesion","volume":"15","author":"Wei","year":"2024","journal-title":"ACS Chem Neurosci"},{"key":"B68","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1161\/ATVBAHA.124.321748","article-title":"ApoE receptor-2 R952Q variant in macrophages elevates soluble LRP1 to potentiate hyperlipidemia and accelerate atherosclerosis in mice","volume":"45","author":"Turkson","year":"2025","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"e173831","DOI":"10.1172\/jci.insight.173831","article-title":"Identification of LRP1+CD13+ human periosteal stem cells that require LRP1 for bone repair","volume":"9","author":"Jeong","year":"2024","journal-title":"JCI Insight"},{"key":"B70","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.fertnstert.2017.11.036","article-title":"Micro-RNA profile and proteins in peritoneal fluid from women with endometriosis: their relationship with sterility","volume":"109","author":"Mar\u00ed-Alexandre","year":"2018","journal-title":"Fertil Steril"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11102730","article-title":"Analysis of membrane type-1 matrix metalloproteinase (MT1-MMP, MMP14) in eutopic and ectopic endometrium and in serum and endocervical mucus of endometriosis","volume":"11","author":"Maoga","year":"2023","journal-title":"Biomedicines"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1475531","article-title":"MMP-9 as a clinical marker for endometriosis: a meta-analysis and bioinformatics analysis","volume":"15","author":"Huang","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B73","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.matbio.2022.08.007","article-title":"A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage","volume":"112","author":"Yamamoto","year":"2022","journal-title":"Matrix Biol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ajpath.2013.08.029","article-title":"LDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous system","volume":"184","author":"Gonias","year":"2014","journal-title":"Am J Pathol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1735221\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:37:57Z","timestamp":1776227877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1735221\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":74,"alternative-id":["10.3389\/fimmu.2026.1735221"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1735221","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"article-number":"1735221"}}