{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:03:13Z","timestamp":1793120593661,"version":"4.5.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017638","name":"Ministry of Health of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017638","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>During the COVID-19 pandemic, adenoviral vector-based Sputnik V vaccine was used to vaccinate the civilian population of 74 countries worldwide. As part of laboratory monitoring of the effectiveness of the Sputnik V vaccine, a decrease in effectiveness was detected against Omicron BA.5 and XBB variants. XBB variant quickly displaced all previously circulating variants, so the antigen composition of the Sputnik V vaccine was changed to the XBB variant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Gam-COVID-Vac XBB (Sputnik V XBB) vaccine was developed, manufactured, and stored by Gamaleya NRCEM (Moscow, Russia). Two open prospective clinical study of the safety, reactogenicity and immunogenicity of the Sputnik V XBB vaccine was conducted in 50 adult participants over 18 years old and 50 adolescent participants 12\u201317 years old (ClinicalTrials.gov Identifier: NCT06068569 and NCT06068556). Immunogenicity study included ELISA assay for detection glycoprotein S of the Omicron XBB variant and neutralization assay with viable SARS-CoV-2 virus Omicron \u0425\u0412\u0412.1.5, \u0425\u0412\u0412.1.9.1, \u0425\u0412\u0412.1.16, EG.5.1, \u0412\u0410.2.86, JN.1, KS.1, XFG.3, NY.2 and PY.2 variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Safety profile of the Sputnik V XBB vaccine was consistent with the previous formulation, and no new safety concerns were reported. There were no cases of serious AEs. Seroconversion of antigen-specific IgG on day 42 was 100% in adults and 87.5% in adolescents. We showed robust NtAb response to circulating SARS-CoV-2 variants (\u0425\u0412\u0412.1.5, \u0425\u0412\u0412.1.9.1, \u0425\u0412\u0412.1.16, EG.5.1, \u0412\u0410.2.86, JN.1, KS.1, XFG.3, NY.2 and PY.2) in vaccinated adults and adolescents, seroconversion rate of NtAb against any circulating variant was 96% in adults and 94% in adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of the clinical trials demonstrated a favorable safety profile and a high level of immunogenicity of Sputnik V XBB in adults and adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>\n                      , identifiers NCT06068569 and NCT06068556.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1736771","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:55:52Z","timestamp":1774518952000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Sputnik V update: safety and neutralizing antibodies in healthy adults and adolescents"],"prefix":"10.3389","volume":"17","author":[{"given":"Inna V.","family":"Shuliakova","sequence":"first","affiliation":[{"name":"N.F. Gamalei Federal Research Centre for Epidemiology and Microbiology, Ministry of Health Russian Federation","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria M.","family":"Grousova","sequence":"additional","affiliation":[{"name":"N.F. Gamalei Federal Research Centre for Epidemiology and Microbiology, Ministry of Health Russian Federation","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna A.","family":"Iliukhina","sequence":"additional","affiliation":[{"name":"N.F. Gamalei Federal Research Centre for Epidemiology and Microbiology, Ministry of Health Russian Federation","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina S.","family":"Dzharullaeva","sequence":"additional","affiliation":[{"name":"N.F. Gamalei Federal Research Centre for Epidemiology and Microbiology, Ministry of Health Russian Federation","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezhda L.","family":"Lubenets","sequence":"additional","affiliation":[{"name":"N.F. Gamalei Federal Research Centre for Epidemiology and Microbiology, Ministry of Health Russian Federation","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria K.","family":"Ordzhonikidze","sequence":"additional","affiliation":[{"name":"N.F. Gamalei Federal Research Centre for Epidemiology and Microbiology, Ministry of Health Russian Federation","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima M.","family":"Izhaeva","sequence":"additional","affiliation":[{"name":"N.F. Gamalei Federal Research Centre for Epidemiology and Microbiology, Ministry of Health Russian Federation","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina S.","family":"Erokhova","sequence":"additional","affiliation":[{"name":"N.F. Gamalei Federal Research Centre for Epidemiology and Microbiology, Ministry of Health Russian Federation","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya D.","family":"Zorkov","sequence":"additional","affiliation":[{"name":"N.F. Gamalei Federal Research Centre for Epidemiology and Microbiology, Ministry of Health Russian Federation","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin V.","family":"Azizyan","sequence":"additional","affiliation":[{"name":"N.F. 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