{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:49:37Z","timestamp":1782276577910,"version":"3.54.5"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"\n Background<\/jats:title>\n The mobilization of peripheral blood stem cells(PBSC) needs daily injection of granulocyte colony stimulating factor (G-CSF), which brings inconvenience to healthy donors. Can pegylated granulocyte colony-stimulating factor (Peg-G-CSF) solve this problem by single dose injection?<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This multicenter, randomized controlled study was conducted from May 2018 to April 2019. Eligible donors were randomly selected to received treatment with 12 mg Peg-G-CSF on day 1 or 10 \u00b5g\/kg\/d G-CSF consecutively from day 1. PBSC apheresis of the donors was conducted on day 5. The primary endpoint was the percentage of donors who collected \u22654\u00d710\n 6<\/jats:sup>\n CD34\n +<\/jats:sup>\n cells\/kg recipient weight after single apheresis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Eighty (83.3%) of 96 donors in the Peg-G-SCF group and 76 (79.2%) of 96 donors in the G-CSF group collected \u22654\u00d710\n 6<\/jats:sup>\n CD34\n +<\/jats:sup>\n cells\/kg recipient weight. The peak value of circulating CD34\n +<\/jats:sup>\n cell count occurred on day 5 in both groups. The median yield of CD34\n +<\/jats:sup>\n cell collected in the Peg-G-CSF group was comparable to that in the G-CSF group by a single apheresis procedure. Moreover, the incidence of side effects in both groups was similarly, no significant difference was observed in engraftment, graft-versus-host disease (GVHD) or survival between the two groups of recipients. By multivariate analysis, The CD34\n +<\/jats:sup>\n cell count on the fifth day was the variable that may have significantly affected the CD34\n +<\/jats:sup>\n yield.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Mobilization via a single injection of Peg-G-CSF can match traditional G-CSF mobilization in terms of efficacy and safety and is expected to provide a better alternative to traditional G-CSF mobilization.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n www.chictr.org.cn<\/jats:ext-link>\n , identifier ChiCTR1800015716\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1737252","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:43:46Z","timestamp":1782276226000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of the single-dose pegylated G-CSF vs. daily G-CSF for peripheral blood stem cells mobilization in donors: a multicenter, randomized controlled trial"],"prefix":"10.3389","volume":"17","author":[{"given":"Jiali","family":"Li","sequence":"first","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Zhou","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, 920th Hospital of Joint Logistics Support Force","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Preventive Medicine, Army Military Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanbin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, 920th Hospital of Joint Logistics Support Force","place":["Kunming, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Second Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Rao","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixi","family":"Xiang","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichun","family":"Gao","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Yao","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyan","family":"Kong","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Gao","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[{"name":"Medical Center of Hematology, Institute of Science Innovation for Blood Ecology and Intelligent Cells, The Second Affiliated Hospital of Army Medical University","place":["Chongqing, China"]},{"name":"Chongqing Key Laboratory of Hematology and Microenvironment","place":["Chongqing, China"]},{"name":"State Key Laboratory of Trauma and Chemical Poisoning, Army Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1200","article-title":"G-CSF as immune regulator in T cells espressing the G-CSF receptor: implications for transplantation and autoimmune disease","volume":"102","author":"Franzke","year":"2003","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(89)90711-3","article-title":"Granulocyte-macrophage colony-stimulating factor to harvest circulating haemopoietic stem cells for autotransplantation","volume":"2","author":"Gianni","year":"1989","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2007.08.002","article-title":"Mobilization of peripheral blood stem cells","volume":"37","author":"Arslan","year":"2007","journal-title":"Transfus Apher Sci"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-200304000-00002","article-title":"Pegfilgrastim: using pegylation technology to improve neutropenia support in cancer patients","volume":"14","author":"Molineux","year":"2003","journal-title":"Anticancer Drugs"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21550","article-title":"Pegylated granulocyte-colony stimulating factor versus non-pegylated granulocyte-colony stimulating factor for peripheral blood stem cell mobilization: a systematic review and meta-analysis","volume":"32","author":"Kuan","year":"2017","journal-title":"J Clin Apher"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03579.x","article-title":"Pegfilgrastim- versus filgrastim-based autologous hematopoietic stem cell mobilization in the setting of preemptive use of plerixafor: efficacy and cost analysis","volume":"52","author":"Costa","year":"2012","journal-title":"Transfusion"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705675","article-title":"Efficient mobilization of peripheral blood stem cells following CAD chemotherapy and a single dose of pegylated G-CSF in patients with multiple myeloma","volume":"39","author":"Fruehauf","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704702","article-title":"Successful transplantation of peripheral blood stem cells mobilized by chemotherapy and a single dose of pegylated G-CSF in patients with multiple myeloma","volume":"35","author":"Steidl","year":"2005","journal-title":"Bone Marrow Transplant"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2011.170","article-title":"Novel agents and approaches for stem cell mobilization in normal donors and patients","volume":"47","author":"Bakanay","year":"2012","journal-title":"Bone Marrow Transplant"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4299","article-title":"Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL","volume":"107","author":"Morris","year":"2006","journal-title":"Blood"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01598","article-title":"Is it better to mobilize hematopoietic stem cells with pegfilgrastim in healthy donors during allogeneic hematopoietic stem cell transplantation","volume":"10","author":"Li","year":"2020","journal-title":"Front Oncol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.05.003","article-title":"Peripheral blood progenitor cell mobilization for autologous and allogeneic hematopoietic cell transplantation: guidelines from the American Society for Blood and Marrow Transplantation","volume":"20","author":"Duong","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"B13","article-title":"Single-dose pegfilgrastim for the mobilization of allogeneic CD34+ peripheral blood progenitor cells in healthy family and unrelated donors","volume":"90","author":"Kroschinsky","year":"2005","journal-title":"Haematologica"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.144691","article-title":"Human umbilical cord blood-derived stromal cells, a new resource in the suppression of acute graft-versus-host disease in haploidentical stem cell transplantation in sublethally irradiated mice","volume":"286","author":"Zhang","year":"2011","journal-title":"J Biol Chem"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.12.001","article-title":"National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report","volume":"21","author":"Jagasia","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0204-7","article-title":"EBMT-NIH-CIBMTR Task Force position statement on standardized terminology & guidance for graft-versus-host disease assessment","volume":"53","author":"Schoemans","year":"2018","journal-title":"Bone Marrow Transplant"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217264","article-title":"Consensus on the monitoring, treatment, and prevention of leukaemia relapse after allogeneic haematopoietic stem cell transplantation in China: 2024 update","volume":"605","author":"Wang","year":"2024","journal-title":"Cancer Lett"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3842-1","article-title":"Refining the role of pegfilgrastim (a long-acting G-CSF) for prevention of chemotherapy-induced febrile neutropenia: consensus guidance recommendations","volume":"25","author":"Aapro","year":"2017","journal-title":"Support Care Cancer"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-472x(99)00112-5","article-title":"A new form of Filgrastim with sustained duration in vivo and enhanced ability to mobilize PBPC in both mice and humans","volume":"27","author":"Molineux","year":"1999","journal-title":"Exp Hematol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-008-0675-5","article-title":"Single-dose pegfilgrastim is comparable to daily filgrastim in mobilizing peripheral blood stem cells: a case-matched study in patients with lymphoproliferative malignancies","volume":"88","author":"Putkonen","year":"2009","journal-title":"Ann Hematol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-014-1507-0","article-title":"Successful peripheral blood stem cell mobilization using pegfilgrastim in allogeneic stem cell transplantation","volume":"99","author":"Chanswangphuwana","year":"2014","journal-title":"Int J Hematol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000004880","article-title":"Efficacy and safety of single-dose pegfilgrastim for CD34+ cell mobilization in healthy volunteers: a phase 2 study","volume":"108","author":"Goto","year":"2024","journal-title":"Transplantation"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2006.03.001","article-title":"Allogeneic stem cell transplantation with peripheral blood stem cells mobilized by pegylated G-CSF","volume":"12","author":"Hill","year":"2006","journal-title":"Biol Blood Marrow Transplant"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705851","article-title":"Correlation between serum lactate dehydrogenase and stem cell mobilization","volume":"40","author":"Egan","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2012.05.019","article-title":"The difference in lactate dehydrogenase activity between pre- and post-mobilization periods is a good indicator of successful stem cell mobilization","volume":"48","author":"Donmez","year":"2013","journal-title":"Transfus Apher Sci"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1991.tb05803.x","article-title":"Lactate dehydrogenase (LDH) isoenzymes and proliferative activity of lymphoid cells--an immunocytochemical study","volume":"86","author":"Pan","year":"1991","journal-title":"Clin Exp Immunol"},{"key":"B27","article-title":"Spontaneous splenic rupture in a healthy allogeneic donor of peripheral-blood stem cell following the administration of granulocyte colony-stimulating factor (g-csf). A case report and review of the literature","volume":"91","author":"Nuamah","year":"2006","journal-title":"Haematologica"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10434","article-title":"Proteolytic cleavage of granulocyte colony-stimulating factor and its receptor by neutrophil elastase induces growth inhibition and decreased cell surface expression of the granulocyte colony-stimulating factor receptor","volume":"74","author":"Hunter","year":"2003","journal-title":"Am J Hematol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01240-4","article-title":"Mesenchymal stromal cells plus basiliximab, calcineurin inhibitor as treatment of steroid-resistant acute graft-versus-host disease: a multicenter, randomized, phase 3, open-label trial","volume":"15","author":"Zhao","year":"2022","journal-title":"J Hematol Oncol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s12026-010-8193-7","article-title":"Prevention of GVHD without losing GVL effect: windows of opportunity","volume":"49","author":"Zhang","year":"2011","journal-title":"Immunol Res"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2864","article-title":"Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance","volume":"103","author":"Morris","year":"2004","journal-title":"Blood"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.4.1841","article-title":"Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cells","volume":"174","author":"MacDonald","year":"2005","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2020.1709436","article-title":"The role of regulatory T cells in graft-versus-host disease management","volume":"13","author":"Whangbo","year":"2020","journal-title":"Expert Rev Hematol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-571125","article-title":"Regulatory B cells are enriched within the IgM memory and transitional subsets in healthy donors but are deficient in chronic GVHD","volume":"124","author":"Khoder","year":"2014","journal-title":"Blood"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003272","article-title":"Activation of natural killer T cells enhances the function of regulatory T-cell therapy in suppressing murine GVHD","volume":"5","author":"Hirai","year":"2021","journal-title":"Blood Adv"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.621935","article-title":"Allogeneic hematopoietic stem cell transplantation mobilized with pegylated granulocyte colony-stimulating factor ameliorates severe acute graft-versus-host disease through enrichment of monocytic myeloid-derived suppressor cells in the graft: a real world experience","volume":"12","author":"Li","year":"2021","journal-title":"Front Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00010.x","article-title":"Analysis of factors associated with low peripheral blood progenitor cell collection in normal donors","volume":"42","author":"de la Rubia","year":"2002","journal-title":"Transfusion"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16370","article-title":"Potentially modifiable predictors of cell collection efficiencies and product characteristics of allogeneic hematopoietic progenitor cell collections","volume":"61","author":"Pham","year":"2021","journal-title":"Transfusion"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2017.05.021","article-title":"Factors affecting hematopoietic stem cell mobilization and apheresis in allogeneic donors: the role of iron status","volume":"56","author":"Ozkurt","year":"2017","journal-title":"Transfus Apher Sci"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2005.07.007","article-title":"Factors affecting PBSC mobilization and collection in healthy donors","volume":"33","author":"Lysak","year":"2005","journal-title":"Transfus Apher Sci"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1737252\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:43:56Z","timestamp":1782276236000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1737252\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,24]]},"references-count":40,"alternative-id":["10.3389\/fimmu.2026.1737252"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1737252","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,24]]},"article-number":"1737252"}}