{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:55:14Z","timestamp":1792252514238,"version":"4.4.0"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunction, immune dysregulation, and microbial imbalance. Increasing evidence suggests that vitamin D, a secosteroid hormone with pleiotropic effects, plays a key role in modulating the pathogenesis of AD. This review provides a comprehensive overview of the molecular mechanisms through which vitamin D influences skin integrity and immune function, focusing on vitamin D receptor-mediated pathways, genetic and epigenetic modifiers, and the interplay with immune cells and microbiota. We also examine the epidemiological correlations between vitamin D deficiency and AD prevalence, diagnostic considerations including biomarkers and serum 25-hydroxyvitamin D evaluation, and therapeutic strategies involving systemic and topical vitamin D interventions. The review further discusses ongoing controversies regarding optimal dosing and evaluates the limitations of current clinical evidence. Finally, emerging research directions, such as vitamin D\u2013microbiota\u2013skin axis and personalized vitamin D therapy, are proposed as promising avenues for advancing AD management.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1739412","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T09:37:12Z","timestamp":1774863432000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular insights into the role of vitamin D in atopic dermatitis: pathogenesis, diagnosis, and emerging therapies"],"prefix":"10.3389","volume":"17","author":[{"given":"Pengyue","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Shengjing Hospital of China Medical University","place":["Shenyang, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Dermatology and 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