{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T08:21:32Z","timestamp":1772180492700,"version":"3.50.1"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004329","name":"The Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["P3-0427, J3-4497"],"award-info":[{"award-number":["P3-0427, J3-4497"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2018-05619"],"award-info":[{"award-number":["2018-05619"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["FKZ01KU1909A"],"award-info":[{"award-number":["FKZ01KU1909A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011758","name":"Ministrstvo za visoko \u0161olstvo, znanost in tehnologijo","doi-asserted-by":"publisher","award":["C3330-19-252012, RIUM"],"award-info":[{"award-number":["C3330-19-252012, RIUM"]}],"id":[{"id":"10.13039\/501100011758","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Patients with severe asthma may benefit from targeted biological therapies. However, personalized therapy in children and adolescents with asthma, based on individual susceptibility to molecular mechanisms addressed by different biologicals is underdeveloped. Here, we established a functional\n                      <jats:italic>in vitro<\/jats:italic>\n                      model, to study the differential responses of asthma patients to omalizumab (an IgE targeting biological) therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      White blood cells isolated from asthmatic children and adolescents were pre-treated with omalizumab. Next, basophil activation and degradation were used to assess the\n                      <jats:italic>in vitro<\/jats:italic>\n                      patient\u2019s response to omalizumab after exposure to patient-specific allergens. In parallel, basophils-specific whole RNA sequencing was used to screen for differentially expressed genes associated with an\n                      <jats:italic>in vitro<\/jats:italic>\n                      response to omalizumab. The results of the screen were first confirmed in an\u00a0independent cohort of patients, and finally compared to the clinically relevant data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>in vitro<\/jats:italic>\n                      basophil activation + degradation test may be used to study the differential response to omalizumab in patients. The differentially expressed genes in the basophils of the better vs. the poor\/non-responders are associated primarily with defense against viruses. The low\n                      <jats:italic>RSAD2<\/jats:italic>\n                      expression correlates with poor response to omalizumab\n                      <jats:italic>in vitro<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      We describe an\n                      <jats:italic>in vitro<\/jats:italic>\n                      test to study the differential response to omalizumab in patients.\n                      <jats:italic>RSAD2<\/jats:italic>\n                      may be a biomarker for response to omalizumab in asthma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1744735","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:51:46Z","timestamp":1772175106000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A functional cell model using basophil activation test to study molecular mechanisms and biomarkers of response to omalizumab treatment in patients with asthma"],"prefix":"10.3389","volume":"17","author":[{"given":"Boris","family":"Gole","sequence":"first","affiliation":[{"name":"Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor","place":["Maribor, Slovenia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa","family":"Gori\u010dan","sequence":"additional","affiliation":[{"name":"Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor","place":["Maribor, Slovenia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregor","family":"Jezernik","sequence":"additional","affiliation":[{"name":"Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor","place":["Maribor, Slovenia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Gorenjak","sequence":"additional","affiliation":[{"name":"Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor","place":["Maribor, Slovenia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Bizjak","sequence":"additional","affiliation":[{"name":"Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor","place":["Maribor, Slovenia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vojko","family":"Berce","sequence":"additional","affiliation":[{"name":"Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor","place":["Maribor, Slovenia"]},{"name":"Department of Pediatrics, University Medical Center Maribor","place":["Maribor, Slovenia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maja","family":"Skerbinjek Kavalar","sequence":"additional","affiliation":[{"name":"Ambulanta \u010cebelica","place":["Maribor, Slovenia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kabesch","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology and Allergy, University Children\u2019s Hospital Regensburg (KUNO)","place":["Regensburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Mel\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Education S\u00f6dersjukhuset, Karolinska Institutet","place":["Stockholm, Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Korneliusz","family":"Golebski","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam University Medical Center, University of Amsterdam","place":["Amsterdam, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelius M.","family":"van Drunen","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Amsterdam University Medical Center, University of Amsterdam","place":["Amsterdam, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke Hilse","family":"Maitland-van der Zee","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam University Medical Center, University of Amsterdam","place":["Amsterdam, Netherlands"]},{"name":"Department of Pediatric Pulmonology, Emma Children\u2019s Hospital, Amsterdam University Medical Center, University of Amsterdam","place":["Amsterdam, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Reinartz","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Tergooi Hospitals","place":["Hilversum, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne J. H.","family":"Vijverberg","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Amsterdam University Medical Center, University of Amsterdam","place":["Amsterdam, Netherlands"]},{"name":"Department of Pediatric Pulmonology, Emma Children\u2019s Hospital, Amsterdam University Medical Center, University of Amsterdam","place":["Amsterdam, Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uro\u0161","family":"Poto\u010dnik","sequence":"additional","affiliation":[{"name":"Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor","place":["Maribor, Slovenia"]},{"name":"Laboratory for Biochemistry, Molecular Biology and Genomics, Faculty for Chemistry and Chemical Engineering, University of Maribor","place":["Maribor, Slovenia"]},{"name":"Department for Science and Research, University Medical Center Maribor","place":["Maribor, Slovenia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S1526054225000636","DOI":"10.1016\/j.prrv.2025.06.003","article-title":"Choosing biologic therapy in children with severe asthma","author":"Gupta","year":"2025","journal-title":"Paediatr Respir Rev"},{"key":"B2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.5334\/aogh.2416","article-title":"Pediatric asthma: A global epidemic","volume":"85","author":"Serebrisky","year":"2019","journal-title":"Ann Glob Health"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-023-00589-4","article-title":"Developments in the management of severe asthma in children and adolescents: focus on dupilumab and tezepelumab","volume":"25","author":"Van Dijk","year":"2023","journal-title":"Pediatr Drugs"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200216050-00009","article-title":"Anti-IgE monoclonal antibody E25, E25, Humanised anti-IgE MAb, IGE 025, Monoclonal antibody E25, Olizumab, Xolair, rhuMAb-E25","volume":"16","author":"Omalizumab","year":"2002","journal-title":"BioDrugs"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1753466618810192","DOI":"10.1177\/1753466618810192","article-title":"Omalizumab, the first available antibody for biological treatment of severe asthma: more than a decade of real-life effectiveness","volume":"12","author":"Pelaia","year":"2018","journal-title":"Ther Adv Respir Dis"},{"key":"B6","doi-asserted-by":"publisher","first-page":"138099","DOI":"10.1016\/j.ijbiomac.2024.138099","article-title":"IgE-Fc\u03f5RI protein\u2013protein interaction as a therapeutic target against allergic asthma: An updated review","volume":"284","author":"Liu","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3390\/jpm15080370","article-title":"Established and emerging asthma biomarkers with a focus on biologic trials: A narrative review","volume":"15","author":"Lavere","year":"2025","journal-title":"J Pers Med"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/all.14662","article-title":"Basophils and their effector molecules in allergic disorders","volume":"76","author":"Miyake","year":"2021","journal-title":"Allergy"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.27206","article-title":"Basophil FceRI expression\u2014A management tool in anti-IgE treatment of allergic asthma","volume":"59","author":"Rubak","year":"2024","journal-title":"Pediatr Pulmonol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S505951","article-title":"Utility of the basophil reactivity test in the clinical management of people with severe uncontrolled asthma","volume":"18","author":"Garc\u00eda R\u00f3denas","year":"2025","journal-title":"J Asthma Allergy"},{"key":"B11","doi-asserted-by":"publisher","first-page":"121822","DOI":"10.1016\/j.lfs.2023.121822","article-title":"The expression IL1B correlates negatively with the clinical response to adalimumab in Crohn\u2019s disease patients: An ex vivo approach using peripheral blood mononuclear cells","volume":"326","author":"Gole","year":"2023","journal-title":"Life Sci"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2017.38.4046","article-title":"In vitro impact of anti-immunoglobulin E monoclonal antibodies, including omalizumab on whole blood basophil histamine release: Assessment of direct induction of basophil histamine release and evaluation of modulation of allergen-induced basophil histamine release","volume":"38","author":"Kowal","year":"2017","journal-title":"Allergy Asthma Proc"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-023-02402-y","article-title":"Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers","volume":"129","author":"Ntafoulis","year":"2023","journal-title":"Br J Cancer"},{"key":"B14","volume-title":"Allergic asthma","year":"2025"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60203-7","article-title":"Health of the world\u2019s adolescents: a synthesis of internationally comparable data","volume":"379","author":"Patton","year":"2012","journal-title":"Lancet"},{"key":"B16","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3390\/cells11010117","article-title":"MFUM-brTNBC-1, a newly established patient-derived triple-negative breast cancer cell line: molecular characterisation, genetic stability, and comprehensive comparison with commercial breast cancer cell lines","volume":"11","author":"Skok","year":"2021","journal-title":"Cells"},{"key":"B17","doi-asserted-by":"publisher","first-page":"5449","DOI":"10.1038\/s41598-021-84909-z","article-title":"Omics data integration identifies ELOVL7 and MMD gene regions as novel loci for adalimumab response in patients with Crohn\u2019s disease","volume":"11","author":"Gorenjak","year":"2021","journal-title":"Sci Rep"},{"key":"B18","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/all.14747","article-title":"Basophil activation test: Mechanisms and considerations for use in clinical trials and clinical practice","volume":"76","author":"Santos","year":"2021","journal-title":"Allergy"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1159\/000542428","article-title":"Biological effects and clinical application of the anti-immunoglobulin E antibody","volume":"186","author":"Zhang","year":"2024","journal-title":"Int Arch Allergy Immunol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.33696\/immunology.2.031","article-title":"Basophil activation tests BAT: degranulation, cytometry and chemotaxis in drug allergy","volume":"2","author":"Irigoyen-Coria","year":"2020","journal-title":"J Cell Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/cea.13066","article-title":"Double-blind placebo-controlled trial of the effect of omalizumab on basophils in chronic urticaria patients","volume":"48","author":"J\u00f6rg","year":"2018","journal-title":"Clin Exp Allergy"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000815","article-title":"Pulmonary function testing for the diagnosis of asthma in preschool children","volume":"22","author":"Chawes","year":"2022","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.07.021","article-title":"Retrospective study on the association of biomarkers with real-world outcomes of omalizumab-treated patients with allergic asthma","volume":"41","author":"Kavati","year":"2019","journal-title":"Clin Ther"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.07.026","article-title":"Long-term evaluation of response to omalizumab therapy in real life by a novel multimodular approach","volume":"123","author":"Singh","year":"2019","journal-title":"Ann Allergy Asthma Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/all.13302","article-title":"Response to omalizumab using patient enrichment criteria from trials of novel biologics in asthma","volume":"73","author":"Casale","year":"2018","journal-title":"Allergy"},{"key":"B30","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1080\/00325481.2017.1321945","article-title":"Predictors of response to therapy with omalizumab in patients with severe allergic asthma \u2013 a real life study","volume":"129","author":"Kallieri","year":"2017","journal-title":"Postgrad Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2317356","DOI":"10.1080\/07853890.2024.2317356","article-title":"Clinical characteristics of complete responders versus non-complete responders to omalizumab, benralizumab and mepolizumab in patients with severe asthma: a long-term retrospective analysis","volume":"56","author":"Basaga\u00f1a","year":"2024","journal-title":"Ann Med"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00894.x","article-title":"High sensitivity of basophils predicts side-effects in venom immunotherapy","volume":"60","author":"Kosnik","year":"2005","journal-title":"Allergy"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3390\/diagnostics14131403","article-title":"Basophil activation test predicts cetuximab anaphylaxis severity in alpha-gal igE-positive patients","volume":"14","author":"Kopa\u010d","year":"2024","journal-title":"Diagnostics"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/cea.70058","article-title":"Basophil activation and histamine release tests in relation to omalizumab response in peanut-allergic children","volume":"55","author":"Nielsen","year":"2025","journal-title":"Clin Exp Allergy"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700055","article-title":"Activation of human basophils by A549 lung epithelial cells reveals a novel igE-dependent response independent of allergen","volume":"199","author":"Schroeder","year":"2017","journal-title":"J Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01024.x","article-title":"IgE-receptor activation induces survival and Bfl-1 expression in human mast cells but not basophils","volume":"61","author":"Xiang","year":"2006","journal-title":"Allergy"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.02.005","article-title":"Accelerated dissociation of IgE-Fc\u03f5RI complexes by disruptive inhibitors actively desensitizes allergic effector cells","volume":"133","author":"Eggel","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s11882-018-0831-5","article-title":"Basophil activation test: old and new applications in allergy","volume":"18","author":"Hemmings","year":"2018","journal-title":"Curr Allergy Asthma Rep"},{"key":"B39","doi-asserted-by":"publisher","first-page":"348","DOI":"10.3390\/biomedicines9040348","article-title":"Immunological aspects related to viral infections in severe asthma and the role of omalizumab","volume":"9","author":"Menzella","year":"2021","journal-title":"Biomedicines"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201701-0120OC","article-title":"Effects of omalizumab on rhinovirus infections, illnesses, and exacerbations of asthma","volume":"196","author":"Esquivel","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.11.004","article-title":"Viperin: A multifunctional, interferon-inducible protein that regulates virus replication","volume":"10","author":"Seo","year":"2011","journal-title":"Cell Host Microbe"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.10.019","article-title":"The role of viperin in the innate antiviral response","volume":"426","author":"Helbig","year":"2014","journal-title":"J Mol Biol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61380-3","article-title":"Role of viral respiratory infections in asthma and asthma exacerbations","volume":"376","author":"Busse","year":"2010","journal-title":"Lancet"},{"key":"B44","doi-asserted-by":"publisher","first-page":"198408","DOI":"10.1016\/j.virusres.2021.198408","article-title":"Impact of human rhinoviruses on gene expression in pediatric patients with severe acute respiratory infection","volume":"300","author":"Abbasi","year":"2021","journal-title":"Virus Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"110964","DOI":"10.1016\/j.cellsig.2023.110964","article-title":"FGF10 attenuates allergic airway inflammation in asthma by inhibiting PI3K\/AKT\/NF-\u03baB pathway","volume":"113","author":"Peng","year":"2024","journal-title":"Cell Signal"},{"key":"B46","doi-asserted-by":"publisher","first-page":"111581","DOI":"10.1016\/j.intimp.2024.111581","article-title":"Radical S-adenosyl methionine domain-containing 2, a potential target of D-tryptophan in asthma treatment, regulates T helper cell type 1\/2 balance","volume":"129","author":"Wang","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41533-023-00330-1","article-title":"Key recommendations for primary care from the 2022 Global Initiative for Asthma (GINA) update","volume":"33","author":"Levy","year":"2023","journal-title":"NPJ Prim Care Respir Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.10.003","article-title":"2020 focused updates to the asthma management guidelines: A report from the national asthma education and prevention program coordinating committee expert panel working group","volume":"146","author":"Cloutier","year":"2020","journal-title":"J Allergy Clin Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1744735\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:51:48Z","timestamp":1772175108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1744735\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":48,"alternative-id":["10.3389\/fimmu.2026.1744735"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1744735","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]},"article-number":"1744735"}}