{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T18:12:20Z","timestamp":1770660740943,"version":"3.49.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/QUI-OUT\/3143\/2021, 2020.08240.BD, 2020.10155.BD"],"award-info":[{"award-number":["PTDC\/QUI-OUT\/3143\/2021, 2020.08240.BD, 2020.10155.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013276","name":"Interreg","doi-asserted-by":"publisher","award":["0072_IBEROS_MAIS_1_E"],"award-info":[{"award-number":["0072_IBEROS_MAIS_1_E"]}],"id":[{"id":"10.13039\/100013276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Type 1 Diabetes (T1D) is a high-incidence chronic autoimmune disease, with patients requiring lifelong insulin therapy. In the most severe cases, pancreas transplantation (PTA) arises as the first choice of treatment for these patients in the hope of achieving insulin independence. However, the long-term success of PTA is hindered by ischemia-reperfusion injury (IRI) and immune rejection, both of which limit graft survival. To address these challenges, we have developed multifunctional theranostic nanoparticles (t-PLGA NPs) co-encapsulating Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    and MnO NPs, along with cyclosporine A, an immunosuppressive drug. These immunomodulating NPs serve as dual contrast agent for MRI, while generating oxygen to combat hypoxia during IRI. The t-PLGA NPs exhibit efficient drug encapsulation and sustained release, enhancing immunosuppression while minimizing systemic toxicity.\n                    <jats:italic>In vitro<\/jats:italic>\n                    studies also demonstrated the NPs\u2019 ability to suppress the immune system, validating the NPs\u2019 potential to prevent graft rejection. The combination of imaging and therapeutic properties makes this platform highly promising for improving PTA outcomes in T1D patients.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1746407","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:23:03Z","timestamp":1770614583000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional theranostic magnetic PLGA nanoparticles encapsulating cyclosporine A: addressing challenges in pancreas transplantation for type 1 diabetes"],"prefix":"10.3389","volume":"17","author":[{"given":"C\u00e1tia Vieira","family":"Rocha","sequence":"first","affiliation":[{"name":"International Iberian Nanotechnology Laboratory","place":["Braga, Portugal"]},{"name":"Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS), University of Santiago de Compostela","place":["Santiago de Compostela, 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