{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T06:02:02Z","timestamp":1774245722713,"version":"3.50.1"},"reference-count":85,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Low-grade systemic inflammation is seen in type 2 diabetes mellitus (T2DM), which is also considered the underlying mechanism for the occurrence of major complications observed in these patients. In developing countries like India, prediabetes\/insulin resistance is often overlooked. Specialized pro-resolving mediators (SPMs) are a family of anti-inflammatory lipid molecules that are needed to resolve inflammation to maintain immune balance and prevent complications due to DM. Treg cells are a subset of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells that express IL-2 receptor alpha chain CD25 and FOXP3 transcription factor to maintain immune tolerance during diabetes. In this context, the role of resolvins in the regulatory function of Treg cells assumes significance in the prevention and management of diabetic complications. In the current review, we explore the functions of Tregs and resolvins and their potential implications in managing insulin resistance, obesity, and type 2 diabetes.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1748000","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T05:20:37Z","timestamp":1774243237000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Role play of regulatory T cells and resolvins in type 2 diabetes"],"prefix":"10.3389","volume":"17","author":[{"given":"Sandhya","family":"Krishnan","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Biomedical Sciences and Technology, Sri Ramachandra Institute of Higher Education and Research","place":["Chennai, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shriraam","family":"Mahadevan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Sri Ramachandra Medical College","place":["Chennai, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanuman Prasad","family":"Sharma","sequence":"additional","affiliation":[{"name":"Scientist \u2013 II Bioanalytics Facility, Centralized Core Research Facility, All India Institute of Medical Sciences (AIIMS)","place":["New Delhi, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Undurti Narasimha","family":"Das","sequence":"additional","affiliation":[{"name":"UND Life Sciences","place":["Battle Ground, WA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaviarasan","family":"Kuppan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Biomedical Sciences and Technology, Sri Ramachandra Institute of Higher Education and Research","place":["Chennai, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-021-00927-y","article-title":"The many faces of diabetes. 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