{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T05:05:33Z","timestamp":1779771933981,"version":"3.53.1"},"reference-count":159,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To review the evolving shift in peri-implantitis research from traditional mechanical debridement toward host-modulatory and immunopharmacological concepts, focusing on molecular pathogenesis, candidate therapeutic targets, and advanced drug delivery systems requiring further validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A comprehensive literature review was conducted to synthesize current evidence on the osteoimmunology of peri-implantitis, including findings from single-cell RNA sequencing, studies on host-modulation therapies, and developments in nanotechnology-based delivery platforms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Peri-implantitis is increasingly recognized as an immunologically complex condition, with descriptive single-cell studies suggesting cell-interaction patterns such as the CXCL13+ fibroblast-CXCR2+ neutrophil axis. Candidate therapeutic strategies include targeted anti-cytokine biologics, specialized pro-resolving mediators (SPMs), and macrophage-directed approaches, but most remain preclinical or early translational. Advanced delivery systems such as stimuli-responsive hydrogels and exosome-based platforms may support localized treatment, while machine-learning models show promise for risk stratification but require prospective clinical validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Emerging immunopharmacological strategies, together with biomarker diagnostics and artificial intelligence, may help move peri-implantitis management toward more proactive and personalized care, provided that their mechanistic relevance and clinical utility are validated in rigorous studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1748582","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T04:44:11Z","timestamp":1779770651000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Precision immunopharmacology in peri-implantitis management: from molecular mechanisms to advanced therapeutic strategies"],"prefix":"10.3389","volume":"17","author":[{"given":"Yong","family":"Chen","sequence":"first","affiliation":[{"name":"School of Dentistry, Hainan Medical University","place":["Haikou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Dentistry, Hainan Medical University","place":["Haikou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MingWang","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Dentistry, Hainan Medical University","place":["Haikou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhuLing","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Dentistry, Hainan Medical University","place":["Haikou, China"]},{"name":"Department of Health Management Center, The First Affiliated Hospital of Hainan Medical University","place":["Haikou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2012.02557.x","article-title":"Implant survival and complications. 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