{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:41:42Z","timestamp":1776235302744,"version":"3.50.1"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Primary Sj\u00f6gren\u2019s syndrome (pSS) is a common autoimmune disease, with the minor salivary gland (MSG) being the main affected tissue; however, its pathogenesis remains unclear. Although changes in long noncoding RNA (lncRNA) expression have been reported in pSS, their biological functions are uncertain, despite the regulatory roles suggested. Therefore, it would be meaningful to systematically investigate the gene expression of lncRNAs in pSS for their regulatory roles and possible contribution to the disease development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Deep stranded total transcriptome sequencing was performed on MSG samples from 92 patients with pSS and 34 non-Sj\u00f6gren\u2019s syndrome (non-SS) controls. Differentially expressed genes between pSS and non-SS were identified, and a genome-wide competing endogenous RNA (ceRNA) network was constructed based on shared miRNA binding sites and gene\u2013expression correlations. The regulatory roles of lncRNAs in dysregulated pathways in pSS were assessed by examining expression changes of interacting lncRNAs and coding genes.\n                      <jats:italic>In vitro<\/jats:italic>\n                      overexpression experiments in a salivary gland cell line were performed to evaluate the regulatory roles of three selected lncRNAs as ceRNAs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Genome-wide coding and noncoding gene expression correlation analysis suggests the regulatory function of lncRNAs in pSS. LncRNA could regulate coding gene expression via ceRNA mechanisms. The genome-wide ceRNA network comprising 3,035 lncRNAs and 10,838 coding genes was constructed. Eight lncRNAs were predicted to play essential roles on coding gene expression changes in pSS. The regulatory effect for three of the eight key lncRNAs\u2014BISPR, LINC00926, and HCP5\u2014were validated by\n                      <jats:italic>in vitro<\/jats:italic>\n                      experiment and their expression was correlated with clinical features of pSS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Systematic analysis of coding and lncRNA expression in MSG samples suggests a genome-wide regulatory role for lncRNAs in pSS. We constructed, for the first time, a genome-wide ceRNA network. This ceRNA network can be used to infer lncRNA functions based on their interacting coding genes. The gene regulatory roles of three lncRNAs were validated. Our study suggests that lncRNAs contribute significantly to coding gene expression changes in pSS via ceRNA mechanisms, and the identified regulatory lncRNA candidates could be useful for diagnosis, sub-classification, and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1751195","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:41:28Z","timestamp":1776231688000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome-wide gene expression analysis suggests an important regulatory role of lncRNAs in primary Sj\u00f6gren\u2019s syndrome"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhongshan","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Genomic Medicine, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Changzheng Hospital, Naval Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiazheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Changzheng Hospital, Naval Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Changzheng Hospital, Naval Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Genomic Medicine, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihe","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Second Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Genomic Medicine, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwei","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Lishui People\u2019s Hospital","place":["Lishui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Genomic Medicine, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Genomic Medicine, Wenzhou Medical University","place":["Wenzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41584-023-00932-6","article-title":"Genetics and epigenetics of primary Sjogren syndrome: Implications for future therapies","volume":"19","author":"Thorlacius","year":"2023","journal-title":"Nat Rev Rheumatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2017.04.018","article-title":"Genetics of Sjogren\u2019s syndrome","volume":"182","author":"Teos","year":"2017","journal-title":"Clin Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1702514","article-title":"Primary Sjogren\u2019s syndrome","volume":"378","author":"Mariette","year":"2018","journal-title":"N Engl J Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key330","article-title":"Genetics and epigenetics in primary Sjogren\u2019s syndrome","volume":"60","author":"Imgenberg-Kreuz","year":"2021","journal-title":"Rheumatol (Oxford)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"23292","DOI":"10.1038\/s41598-021-01324-0","article-title":"Integrative epigenomics in Sjogren s syndrome reveals novel pathways and a strong interaction between the Hla, autoantibodies and the interferon signature","volume":"11","author":"Teruel","year":"2021","journal-title":"Sci Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1002\/art.42265","article-title":"Variability of primary Sjogren\u2019s syndrome is driven by interferon-alpha and interferon-alpha blood levels are associated with the class Ii Hla-Dq locus","volume":"74","author":"Trutschel","year":"2022","journal-title":"Arthritis Rheumatol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.1038\/s41467-022-30773-y","article-title":"Genome-wide association study identifies Sjogren\u2019s risk loci with functional implications in immune and glandular cells","volume":"13","author":"Khatri","year":"2022","journal-title":"Nat Commun"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx135","article-title":"A new Mhc-linked susceptibility locus for primary Sjogren\u2019s syndrome: Mica","volume":"26","author":"Carapito","year":"2017","journal-title":"Hum Mol Genet"},{"key":"B9","doi-asserted-by":"publisher","first-page":"11154","DOI":"10.1038\/s41598-021-90569-w","article-title":"Gene expression alterations in salivary gland epithelia of Sjogren\u2019s syndrome patients are associated with clinical and histopathological manifestations","volume":"11","author":"Dela Cruz","year":"2021","journal-title":"Sci Rep"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3523","DOI":"10.1038\/s41467-021-23472-7","article-title":"A new molecular classification to drive precision treatment strategies in primary Sjogren\u2019s syndrome","volume":"12","author":"Soret","year":"2021","journal-title":"Nat Commun"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/art.21006","article-title":"Gene expression profiling of minor salivary glands clearly distinguishes primary Sjogren\u2019s syndrome patients from healthy control subjects","volume":"52","author":"Hjelmervik","year":"2005","journal-title":"Arthritis Rheum"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/art.27509","article-title":"Gene expression profile in the salivary glands of primary Sjogren\u2019s syndrome patients before and after treatment with rituximab","volume":"62","author":"Devauchelle-Pensec","year":"2010","journal-title":"Arthritis Rheumatism"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.10.024","article-title":"Small and long non-coding Rnas: Past, present, and future","volume":"187","author":"Chen","year":"2024","journal-title":"Cell"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding Rnas: Definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00193","article-title":"The role of long non-coding Rnas in the pathogenesis of Ra, Sle, and Ss","volume":"5","author":"Gao","year":"2018","journal-title":"Front Med (Lausanne)"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/biom10071044","article-title":"Long noncoding Rnas and circular Rnas in autoimmune diseases","volume":"10","author":"Lodde","year":"2020","journal-title":"Biomolecules"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4110\/in.2019.19.e4","article-title":"Potential implications of long noncoding Rnas in autoimmune diseases","volume":"19","author":"Hur","year":"2019","journal-title":"Immune Netw"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8091349","article-title":"Long non-coding Rnas modulate Sjogren\u2019s syndrome associated gene expression and are involved in the pathogenesis of the disease","volume":"8","author":"Dolcino","year":"2019","journal-title":"J Clin Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002672","article-title":"Dysregulated long non-coding Rna in Sjogren\u2019s disease impacts both interferon and adaptive immune responses","volume":"8","author":"Joachims","year":"2022","journal-title":"RMD Open"},{"key":"B20","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12865-021-00439-3","article-title":"Differential long non-coding Rna expression profile and function analysis in primary Sjogren\u2019s syndrome","volume":"22","author":"Chen","year":"2021","journal-title":"BMC Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"19629","DOI":"10.1038\/s41598-020-76701-2","article-title":"Lncrna and Mrna expression profile of peripheral blood mononuclear cells in primary Sjogren\u2019s syndrome patients","volume":"10","author":"Peng","year":"2020","journal-title":"Sci Rep"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.102358","article-title":"Lncrna Pvt1 links Myc to glycolytic metabolism upon Cd4(+) T cell activation and Sjogren\u2019s syndrome-like autoimmune response","volume":"107","author":"Fu","year":"2020","journal-title":"J Autoimmun"},{"key":"B23","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s13075-020-02248-2","article-title":"Identification of novel genes associated with dysregulation of B cells in patients with primary Sjogren\u2019s syndrome","volume":"22","author":"Inamo","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106992","article-title":"Lncrna Neat1 positively regulates Mapk signaling and is involved in the pathogenesis of Sjogren\u2019s syndrome","volume":"88","author":"Ye","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s13075-016-1005-2","article-title":"Long non-coding Rna expression profile in minor salivary gland of primary Sjogren\u2019s syndrome","volume":"18","author":"Shi","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.624614","article-title":"Predicted disease-specific immune infiltration patterns decode the potential mechanisms of long non-coding Rnas in primary Sjogren\u2019s syndrome","volume":"12","author":"Cheng","year":"2021","journal-title":"Front Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding Rnas and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14194564","article-title":"Insight into Lncrna- and Circrna-mediated Cernas: Regulatory network and implications in nasopharyngeal carcinoma-a narrative literature review","volume":"14","author":"Zhang","year":"2022","journal-title":"Cancers (Basel)"},{"key":"B29","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/s41420-022-01061-x","article-title":"The role of Lncrna-mediated Cerna regulatory networks in pancreatic cancer","volume":"8","author":"Xu","year":"2022","journal-title":"Cell Death Discov"},{"key":"B30","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13578-019-0302-2","article-title":"Lncrna Malat1 promotes osteoarthritis by modulating Mir-150-5p\/Akt3 axis","volume":"9","author":"Zhang","year":"2019","journal-title":"Cell Biosci"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103334","article-title":"Cerna in cancer: Possible functions and clinical implications","volume":"52","author":"Qi","year":"2015","journal-title":"J Med Genet"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2017.1319938","article-title":"Competitive endogenous Rna network: Potential implication for systemic lupus erythematosus","volume":"21","author":"Li","year":"2017","journal-title":"Expert Opin Ther Targets"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/biom9060206","article-title":"Differential plasma expression profiles of long non-coding Rnas reveal potential biomarkers for systemic lupus erythematosus","volume":"9","author":"Wu","year":"2019","journal-title":"Biomolecules"},{"key":"B34","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1186\/s12920-022-01416-4","article-title":"Construction and function analysis of the Lncrna-Mirna-Mrna competing endogenous Rna network in autoimmune hepatitis","volume":"15","author":"Li","year":"2022","journal-title":"BMC Med Genomics"},{"key":"B35","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1186\/s12967-021-03033-8","article-title":"Integrated analysis of competing endogenous Rna networks in peripheral blood mononuclear cells of systemic lupus erythematosus","volume":"19","author":"Song","year":"2021","journal-title":"J Transl Med"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/genes13040647","article-title":"Construction of a Cerna network related to rheumatoid arthritis","volume":"13","author":"Huang","year":"2022","journal-title":"Genes (Basel)"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1092","article-title":"Lncactdb 3.0: An updated database of experimentally supported Cerna interactions and personalized networks contributing to precision medicine","volume":"50","author":"Wang","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1248","article-title":"Starbase V2.0: Decoding Mirna-Cerna, Mirna-Ncrna and protein-Rna interaction networks from large-scale Clip-Seq data","volume":"42","author":"Li","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11637","article-title":"Comprehensive characterization of Lncrna-Mrna related Cerna network across 12 major cancers","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251399","article-title":"Crinet: A computational tool to infer genome-wide competing endogenous Rna (Cerna) interactions","volume":"16","author":"Kesimoglu","year":"2021","journal-title":"PloS One"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10891","article-title":"Construction and analysis of dysregulated Lncrna-associated Cerna network identified novel Lncrna biomarkers for early diagnosis of human pancreatic cancer","volume":"7","author":"Zhou","year":"2016","journal-title":"Oncotarget"},{"key":"B42","doi-asserted-by":"publisher","first-page":"10258","DOI":"10.1038\/s41598-023-37378-5","article-title":"Identification of hub genes and potential Cerna networks of diabetic cardiomyopathy","volume":"13","author":"Hou","year":"2023","journal-title":"Sci Rep"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv853","article-title":"The Mrna related Cerna-Cerna landscape and significance across 20 major cancer types","volume":"43","author":"Xu","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbw084","article-title":"A novel computational method for inferring competing endogenous interactions","volume":"18","author":"Sardina","year":"2017","journal-title":"Brief Bioinform"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.09.029","article-title":"Coding-independent regulation of the tumor suppressor Pten by competing endogenous Mrnas","volume":"147","author":"Tay","year":"2011","journal-title":"Cell"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S297081","article-title":"Comprehensive analysis of Lncrna-Mrna expression profiles and the Cerna network associated with pyroptosis in Lps-induced acute lung injury","volume":"14","author":"Luo","year":"2021","journal-title":"J Inflammation Res"},{"key":"B47","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/art.39859","article-title":"2016 American College of Rheumatology\/European League against Rheumatism classification criteria for primary Sjogren\u2019s syndrome: A consensus and data-driven methodology involving three international patient cohorts","volume":"69","author":"Shiboski","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1159\/000501896","article-title":"Association of Hla alleles with primary Sjogren syndrome in the South Tunisian population","volume":"29","author":"Charfi","year":"2020","journal-title":"Med Princ Pract"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.10.002","article-title":"Hla and Sjogren\u2019s syndrome susceptibility. A meta-analysis of worldwide studies","volume":"11","author":"Cruz-Tapias","year":"2012","journal-title":"Autoimmun Rev"},{"key":"B50","doi-asserted-by":"publisher","first-page":"15122","DOI":"10.1038\/s41598-019-51626-7","article-title":"Gene and Lncrna co-expression network analysis reveals novel Cerna network for triple-negative breast cancer","volume":"9","author":"Le","year":"2019","journal-title":"Sci Rep"},{"key":"B51","doi-asserted-by":"publisher","first-page":"16047","DOI":"10.1038\/nrdp.2016.47","article-title":"Sjogren syndrome","volume":"2","author":"Brito-Zeron","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1177\/0961203318801673","article-title":"Primary Sjogren\u2019s syndrome","volume":"27","author":"Bowman","year":"2018","journal-title":"Lupus"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00605-2","article-title":"Epithelial-immune cell interplay in primary Sjogren syndrome salivary gland pathogenesis","volume":"17","author":"Verstappen","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.20","article-title":"Peripheral blood gene expression profiling in Sjogren\u2019s syndrome","volume":"10","author":"Emamian","year":"2009","journal-title":"Genes Immun"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11082","article-title":"Gene expression profiles in primary Sjogren\u2019s syndrome with and without systemic manifestations","volume":"1","author":"Vitali","year":"2019","journal-title":"ACR Open Rheumatol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1186\/ar4081","article-title":"Systems analysis of primary Sjogren\u2019s syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model","volume":"14","author":"Horvath","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2019.01142","article-title":"Identifying key genes and functionally enriched pathways in Sjogren\u2019s syndrome by weighted gene co-expression network analysis","volume":"10","author":"Yao","year":"2019","journal-title":"Front Genet"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.31083\/j.jin2206136","article-title":"Identification of a Lncrna\/Circrna-Mirna-Mrna cerna network in Alzheimer\u2019s disease","volume":"22","author":"Su","year":"2023","journal-title":"J Integr Neurosci"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/s41419-020-03259-2","article-title":"Linc00426 accelerates lung adenocarcinoma progression by regulating Mir-455-5p as a molecular sponge","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2021.5236","article-title":"Lncrna Hcp5 acts as a cerna to regulate Ezh2 by sponging Mir-138-5p in cutaneous squamous cell carcinoma","volume":"59","author":"Zou","year":"2021","journal-title":"Int J Oncol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2023.2226492","article-title":"Lncrna Neat1 promotes Il-6 secretion in monocyte-derived dendritic cells via sponging Mir-365a-3p in systemic lupus erythematosus","volume":"18","author":"Xiang","year":"2023","journal-title":"Epigenetics"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3892\/or.2018.6296","article-title":"Construction of a cerna network reveals potential Lncrna biomarkers in rectal adenocarcinoma","volume":"39","author":"Zhang","year":"2018","journal-title":"Oncol Rep"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.11.151","article-title":"Comprehensive analysis of Lncrna-associated cerna network in colorectal cancer","volume":"508","author":"Yuan","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.663654","article-title":"Lncrna Hcp5 induces gastric cancer cell proliferation, invasion, and Emt processes through the Mir-186-5p\/Wnt5a axis under hypoxia","volume":"9","author":"Gao","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203155","article-title":"Long non-coding Rna Hcp5 functions as a sponge of Mir-29b-3p and promotes cell growth and metastasis in hepatocellular carcinoma through upregulating Dnmt3a","volume":"13","author":"Zhou","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2018-0432","article-title":"Long non-coding Rna Hcp5 serves as a cerna sponging Mir-17-5p and Mir-27a\/B to regulate the pathogenesis of childhood obesity via the Mapk signaling pathway","volume":"32","author":"Chen","year":"2019","journal-title":"J Pediatr Endocrinol Metab"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216463","article-title":"Linc00926 promotes progression of renal cell carcinoma via regulating Mir-30a-5p\/Sox4 axis and activating Ifngamma-Jak2-Stat1 pathway","volume":"578","author":"Du","year":"2023","journal-title":"Cancer Lett"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2023.110788","article-title":"Linc00426, a novel M(6)a-regulated long non-coding Rna, induces Emt in cervical cancer by binding to Zeb1","volume":"109","author":"Shen","year":"2023","journal-title":"Cell Signal"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3963","article-title":"Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis","volume":"10","author":"Zhang","year":"2021","journal-title":"Cancer Med"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-020-00267-4","article-title":"Lncrna Linc01857 promotes cell growth and diminishes apoptosis via Pi3k\/Mtor pathway and Emt process by regulating Mir-141-3p\/Map4k4 axis in diffuse large B-cell lymphoma","volume":"28","author":"Li","year":"2021","journal-title":"Cancer Gene Ther"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2025.153011","article-title":"Knockdown of long non-coding Rna Bispr attenuates the proinflammatory cytokine Il-6 production in human microglia","volume":"793","author":"Wang","year":"2025","journal-title":"Biochem Biophys Res Commun"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2024.10.013","article-title":"Lncrna Hcp5 regulates inflammation and oxidative stress of neonatal sepsis via modulating Mir-93-5p","volume":"66","author":"Qi","year":"2025","journal-title":"Pediatr Neonatol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41398-022-01971-5","article-title":"Long non-coding Rna Linc00926 regulates Wnt10b signaling pathway thereby altering inflammatory gene expression in Ptsd","volume":"12","author":"Bam","year":"2022","journal-title":"Transl Psychiatry"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1751195\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:41:31Z","timestamp":1776231691000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1751195\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":73,"alternative-id":["10.3389\/fimmu.2026.1751195"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1751195","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"article-number":"1751195"}}