{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T07:02:42Z","timestamp":1772434962805,"version":"3.50.1"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031928","name":"Affiliated Hospital of Guizhou Medical University","doi-asserted-by":"publisher","award":["\u8d44\u52a9\u7f16\u53f7I-2020-24, Gyfybsky-2024-37"],"award-info":[{"award-number":["\u8d44\u52a9\u7f16\u53f7I-2020-24, Gyfybsky-2024-37"]}],"id":[{"id":"10.13039\/100031928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["\u5343\u79d1\u548c\u57fa\u91d1\u4f1a-ZK [2023] 355\u53f7"],"award-info":[{"award-number":["\u5343\u79d1\u548c\u57fa\u91d1\u4f1a-ZK [2023] 355\u53f7"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Eosinophilic granulomatosis with polyangiitis (EGPA) represents a systemic necrotizing vasculitis characterized by prominent peripheral eosinophilia. Concomitant plasma cell dyscrasias in the context of EGPA remain exceedingly rare in clinical literature. This paper presents a case of a 49-year-old female patient with recurrent diarrhea, rash, fever, and wheezing. The patient was initially diagnosed with multiple myeloma (MM) due to significant elevation of M protein and immature plasma cells in the bone marrow. However, chemotherapy failed to alleviate her condition, while standardized EGPA treatment achieved disease control. This case of EGPA with clinical manifestations of MM prompts us to consider whether the clinical presentation should follow Occam\u2019s razor or Hickam\u2019s dictum. Ultimately, we hypothesize that EGPA-induced eosinophil (EOS) perturbs the bone marrow hematopoietic niche. Through the Th2-mediated cytokine milieu, this microenvironment may trigger a reactive, \u201cpseudo-malignant\u201d expansion of plasma cells.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1751926","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T06:32:40Z","timestamp":1772433160000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Eosinophilic granulomatosis with polyangiitis coexisting with multiple myeloma: independent entities or coexistence? 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