{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:14:39Z","timestamp":1784632479727,"version":"3.55.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Chronic antigen exposure drives CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell exhaustion; however, strategies to maintain a long-lived, functional CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell population under chronic stimulation remain unclear. In this study, we demonstrate that overexpression of nitric oxide synthase\u2013interacting protein (NOSIP) enhances the persistence of antigen-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells under chronic antigen stimulation. Notably, NOSIP overexpression preserved a less differentiated CX3CR1\n                    <jats:sup>neg<\/jats:sup>\n                    subset and inhibited its progression toward an apoptosis-prone CX3CR1\n                    <jats:sup>hi<\/jats:sup>\n                    state, which was associated with reducing cell death and promoting long-term persistence. In a tumor model, NOSIP-overexpressing CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells exhibited improved tumor control, indicating that NOSIP-mediated persistence confers superior antitumor capacity. Furthermore, NOSIP overexpression increased the responsiveness of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells to programmed death-ligand 1 blockade, suggesting that NOSIP may represent a promising therapeutic target.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1755657","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:32:43Z","timestamp":1782102763000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["NOSIP overexpression promotes long-term persistence of CD8+ T cells during chronic infection"],"prefix":"10.3389","volume":"17","author":[{"given":"Shihui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Hospital","place":["Kanazawa, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshikatsu","family":"Tamai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Hospital","place":["Kanazawa, Japan"]},{"name":"Department of Molecular Genetics, Graduate School of Medical Science, Kanazawa University","place":["Kanazawa, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Shinzawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Graduate School of Medical Science, Kanazawa University","place":["Kanazawa, Japan"]},{"name":"Center for Biomedical Research and Education, Kanazawa University","place":["Kanazawa, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotaro","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Graduate School of Medical Science, Kanazawa University","place":["Kanazawa, 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Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Kurachi","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Graduate School of Medical Science, Kanazawa University","place":["Kanazawa, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Koura","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Graduate School of Medical Science, Kanazawa University","place":["Kanazawa, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eishiro","family":"Mizukoshi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Hospital","place":["Kanazawa, Japan"]},{"name":"Department of Gastroenterology, Kanazawa Medical University","place":["Kanazawa, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kurachi","sequence":"additional","affiliation":[{"name":"Department 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