{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:18:12Z","timestamp":1774621092258,"version":"3.50.1"},"reference-count":121,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN -148372, PDI -190357"],"award-info":[{"award-number":["FDN -148372, PDI -190357"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    B cell receptor (BCR) signaling is required for the regulation of normal B lymphocyte development. However, many B cell lymphoma subtypes employ constitutive BCR signaling for transformation, survival, and growth. Here we report that mice expressing a POZ domain-deficient MIZ-1 (MIZ-1\n                    <jats:sup>\u0394POZ<\/jats:sup>\n                    ), a well-known binding partner of the oncogene MYC, exhibit reduced surface receptor expression on na\u00efve B cells and impaired BCR signaling. Transcriptomic and ChIP-seq analyses revealed that, in addition to autophagy related genes, MIZ-1 directly regulates genes involved in BCR signal transduction and actin cytoskeleton dynamics. Upon stimulation, MIZ-1\n                    <jats:sup>\u0394POZ<\/jats:sup>\n                    B cells show defective receptor clustering and impaired BCR-induced signal transduction via key signaling molecules such as SYK, RAF1, AKT and ERK. We demonstrate that these perturbations are associated with altered calcium flux and mitochondrial respiration. These defects upon BCR crosslinking specifically lead to decreased survival of follicular but not marginal zone B cells and impaired the expansion of MYC-dependent B cell lymphoma. Altogether, our data suggest that MIZ-1 is as a central integrator of BCR signaling which is essential for maintaining B cell function and keeping a balance between cell death and survival.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1758550","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:14:55Z","timestamp":1774617295000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["MIZ-1 controls transcriptional programs required for BCR signaling, actin dynamics, and na\u00efve B cell survival"],"prefix":"10.3389","volume":"17","author":[{"given":"Julie","family":"Ross","sequence":"first","affiliation":[{"name":"Institut de recherches cliniques de Montr\u00e9al (IRCM), Hematopoiesis and Cancer Unit","place":["Montr\u00e9al, QC, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva-Maria","family":"Piskor","sequence":"additional","affiliation":[{"name":"Institut de recherches cliniques de Montr\u00e9al (IRCM), Hematopoiesis and Cancer Unit","place":["Montr\u00e9al, QC, Canada"]},{"name":"Department of Medicine, Division of Clinical and Translational Research, McGill University","place":["Montreal, QC, Canada"]},{"name":"Department of Biochemistry, Center for Molecular Biomedicine (CMB), Friedrich Schiller University Jena","place":["Jena, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Joly-Beauparlant","sequence":"additional","affiliation":[{"name":"Bioinformatic platform, Faculty of Medicine, Universit\u00e9 Laval","place":["Qu\u00e9bec, QC, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia Paola Gabrielli","family":"Tabarez","sequence":"additional","affiliation":[{"name":"Institut de recherches cliniques de Montr\u00e9al (IRCM), Hematopoiesis and Cancer Unit","place":["Montr\u00e9al, QC, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elie","family":"El Ghorayeb","sequence":"additional","affiliation":[{"name":"Institut de recherches cliniques de Montr\u00e9al (IRCM), Hematopoiesis and Cancer Unit","place":["Montr\u00e9al, QC, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Droit","sequence":"additional","affiliation":[{"name":"Bioinformatic platform, Faculty of Medicine, Universit\u00e9 Laval","place":["Qu\u00e9bec, QC, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kosan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Center for Molecular Biomedicine (CMB), Friedrich Schiller University Jena","place":["Jena, 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