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Through diverse mechanisms, Tregs potently inhibit anti-tumor immunity, thereby driving tumor progression and contributing to therapeutic resistance, which collectively correlates with poor clinical outcomes. This review systematically outlines the biological features and regulatory networks of Tregs in GBM, with particular emphasis on emerging strategies designed to target these cells. We discuss approaches such as Treg depletion, interference with their recruitment, functional reprogramming, and combination immunotherapies. Furthermore, we critically assess the translational progress and clinical limitations of these approaches, including challenges related to target specificity, immune adaptation, and treatment-related toxicities. By synthesizing mechanistic insights with therapeutic prospects, this review aims to inform future directions in precision immunotherapy and inspire multidisciplinary efforts toward effective Treg-targeting regimens for GBM.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1759023","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:06:01Z","timestamp":1775801161000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Targeting regulatory T cells in glioblastoma: from mechanistic insights to novel immunotherapeutic strategies"],"prefix":"10.3389","volume":"17","author":[{"given":"Jingwen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oncology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science","place":["Xiangyang, 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