{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:10:40Z","timestamp":1778735440687,"version":"3.51.4"},"reference-count":86,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allergic diseases represent a growing global health burden, and B cells have emerged as central yet incompletely defined regulators of IgE-mediated immunity and tolerance. There is currently a lack of bibliometric research on allergic diseases and B cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Records were retrieved from the Science Citation Index Expanded of the Web of Science Core Collection (WoSCC) and PubMed. After applying language, time, and article-type restrictions, 3, 084 WoSCC articles and 71 PubMed-indexed clinical trials were included. CiteSpace (v6.4.R1), VOSviewer (v1.6.20), and Excel were used to analyze publication and citation trends, journals, countries, institutions, authors, keyword co-occurrence, and burst terms, and to visualize co-authorship and thematic networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Annual publications and citations increased steadily, indicating sustained academic interest. Output was concentrated in leading allergy and immunology journals and in institutions from Europe and the United States, although contributions from other regions have increased over time. Keyword clustering identified stable cores around \u2018food allergy, \u2018 \u2018asthma, \u2018 and \u2018plasma cells, \u2018 while burst and overlay analyses highlighted \u2018regulatory B cells\u2019 and \u2018innate lymphoid cells\u2019 as emerging research hotspots. These bibliometric patterns indicate growing attention to tissue-associated B-cell biology, immune regulation, and allergen immunotherapy. PubMed clinical-trial records further suggest increasing translational interest in B-cell-related interventions for allergic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Over the past 20 years, research on allergic diseases and B cells has evolved from descriptive immunoglobulin E (IgE) associations toward a tissue- and systems-level exploration of B-cell biology. This bibliometric analysis delineates research hotspots and translational themes, Future progress will require large, multicenter studies with standardized B-cell phenotyping and functional endpoints to support precision medicine in allergy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1760388","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:26:49Z","timestamp":1778732809000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Studies on allergic diseases and B cells in the past 20 years: a bibliometric analysis via CiteSpace and VOSviewer"],"prefix":"10.3389","volume":"17","author":[{"given":"Weiyuan","family":"Mai","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Maoming Maternal and Child Health Hospital","place":["Maoming, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Maoming Maternal and Child Health Hospital","place":["Maoming, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanlin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Maoming Maternal and Child Health Hospital","place":["Maoming, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangshen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery, Maoming Maternal and Child Health Hospital","place":["Maoming, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Maoming Maternal and Child Health Hospital","place":["Maoming, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2025.128254","article-title":"The role of the oral microbiota in allergic diseases: Current understandings and future trends","volume":"299","author":"Zhang","year":"2025","journal-title":"Microbiol Res"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111825","article-title":"The role of Interleukin-21 (IL-21) in allergic disorders: Biological insights and regulatory mechanisms","volume":"134","author":"Saadh","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/cea.70118","article-title":"Allergic rhinitis in China: Trends, challenges and implications over the past two decades","volume":"55","author":"Wang","year":"2025","journal-title":"Clin Exp Allergy"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/apa.70362","article-title":"Health-related quality of life in children, 1\u201312 years old, with food allergy in Sweden","author":"Nordh","year":"2025","journal-title":"Acta Paediatr"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/all.70122","article-title":"Prolonged IL-33 exposure switches the secreted mast cell cytokine profile from pro-inflammatory to pro-tolerant","author":"Teufelberger","year":"2025","journal-title":"Allergy"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2025.104683","article-title":"Assessment of clinical efficacy and safety of sublingual immunotherapy for house dust mite-induced allergic pharyngitis with rhinitis","volume":"46","author":"Qiu","year":"2025","journal-title":"Am J Otolaryngol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/all.70150","article-title":"B-cell repertoire of children with atopic dermatitis exhibits altered IgE maturation associated with allergic food sensitization","author":"Gill","year":"2025","journal-title":"Allergy"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.06.023","article-title":"Dupilumab treatment decreases MBC2s, correlating with reduced IgE levels in pediatric atopic dermatitis","volume":"154","author":"Starrenburg","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2025.145099","article-title":"Insights into food allergy mechanisms and the anti-allergic potential of natural polyphenols in regulating Fc\u03f5RI-mediated mast cell degranulation","volume":"490","author":"Li","year":"2025","journal-title":"Food Chem"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2025.106850","article-title":"Antigen-presenting cells orchestrate mixed inflammatory endotypes in atopic dermatitis","volume":"188","author":"Wang","year":"2025","journal-title":"Int J Biochem Cell Biol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2025.110561","article-title":"Origin, functions, heterogeneity and associated diseases of B-1 cells","volume":"280","author":"Shen","year":"2025","journal-title":"Clin Immunol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/jimmun\/vkaf273","article-title":"Ubiquitination of MHC class II molecules regulates B-cell development and response to antigens in mice","author":"Raymond","year":"2025","journal-title":"J Immunol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2147\/jaa.S544136","article-title":"Iron deficiency drives Th2-mediated immunity in pediatric atopic dermatitis through DNA hypermethylation and TIGIT suppression in IL-10-producing Breg cells","volume":"18","author":"Gao","year":"2025","journal-title":"J Asthma Allergy"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2025.05.006","article-title":"Genetic contributions to epigenetic-defined endotypes of allergic phenotypes in children","volume":"112","author":"Thompson","year":"2025","journal-title":"Am J Hum Genet"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/all.16220","article-title":"Allergen-specific B cell responses in oral immunotherapy-induced desensitization, remission, and natural outgrowth in cow's milk allergy","volume":"80","author":"Satitsuksanoa","year":"2025","journal-title":"Allergy"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-025-00444-y","article-title":"Exosomes derived from M2 macrophages regulate airway inflammation by modulating epithelial cell proliferation and apoptosis","volume":"22","author":"Ren","year":"2025","journal-title":"J Inflammation-Lond"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01079-w","article-title":"B-cell-derived IL-10 promotes allergic sensitization in asthma regulated by Bcl-3","volume":"20","author":"Qian","year":"2023","journal-title":"Cell Mol Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2018.10.5.428","article-title":"Autoimmune responses in severe asthma","volume":"10","author":"Mukherjee","year":"2018","journal-title":"Allergy Asthma Immunol Res"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.03.042","article-title":"CD23 surface density on B cells is associated with IgE levels and determines IgE-facilitated allergen uptake, as well as activation of allergen-specific T cells","volume":"139","author":"Selb","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/all.12911","article-title":"Ontogeny of human IgE-expressing B cells and plasma cells","volume":"72","author":"Ramadani","year":"2017","journal-title":"Allergy"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.875492","article-title":"Unmet medical needs in chronic, non-communicable inflammatory skin diseases","volume":"9","author":"Ujiie","year":"2022","journal-title":"Front Med"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1159\/000487402","article-title":"Rituximab in refractory chronic spontaneous urticaria: An encouraging therapeutic approach","volume":"31","author":"Combalia","year":"2018","journal-title":"Skin Pharmacol Physiol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2021-0325","article-title":"Mechanisms of allergen immunotherapy supporting its disease-modifying effect","volume":"14","author":"Bumbacea","year":"2022","journal-title":"Immunotherapy"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/antib10040049","article-title":"Allergen-specific IgE and IgG4 as biomarkers for immunologic changes during subcutaneous allergen immunotherapy","volume":"10","author":"Nikolov","year":"2021","journal-title":"Antibodies"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154288","article-title":"Relevance of pathogenetic mechanisms to clinical effectiveness of B-cell-depleting monoclonal antibodies in multiple sclerosis","volume":"11","author":"Massacesi","year":"2022","journal-title":"J Clin Med"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109673","article-title":"The adaptor protein APS modulates BCR signalling in mature B cells","volume":"73","author":"Dondi","year":"2020","journal-title":"Cell Signal"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2023.102286","article-title":"Cytokine-mediated STAT-dependent pathways underpinning human B-cell differentiation and function","volume":"81","author":"Tangye","year":"2023","journal-title":"Curr Opin Immunol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11121832","article-title":"Targeting STAT3 and STAT5 in tumor-associated immune cells to improve immunotherapy","volume":"11","author":"Verdeil","year":"2019","journal-title":"Cancers"},{"key":"B29","doi-asserted-by":"publisher","first-page":"95","DOI":"10.22452\/mjlis.vol23no2.6","article-title":"Bibliometric analysis of Central European journals in the Web of Science and JCR Social Science Edition","volume":"23","author":"Bucher","year":"2018","journal-title":"Malaysian J Library Inf Sci"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000029213","article-title":"Using the forest plot to compare citation achievements in bibliographic and meta-analysis studies since 2011 using data on PubMed Central: A retrospective study","volume":"101","author":"Wu","year":"2022","journal-title":"Med Baltimore"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1488559","article-title":"Research hotspots of irisin in the nervous system: A bibliometric study and visualization analysis via CiteSpace","volume":"17","author":"Wang","year":"2025","journal-title":"Front Aging Neurosci"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-025-08741-w","article-title":"Distribution of trial registry numbers within full-text of PubMed Central articles: Implications for linking trials to publications and indexing trial publication types","volume":"26","author":"Holt","year":"2025","journal-title":"Trials"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/all.12697","article-title":"A regulatory CD9+ B-cell subset inhibits HDM-induced allergic airway inflammation","volume":"70","author":"Braza","year":"2015","journal-title":"Allergy"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7859","article-title":"Transcriptomics reveals apigenin alleviates airway inflammation and epithelial cell apoptosis in allergic asthma via MAPK pathway","volume":"37","author":"Yu","year":"2023","journal-title":"Phytother Res"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s11121-023-01543-z","article-title":"Open science standards at journals that inform evidence-based policy","volume":"24","author":"Grant","year":"2023","journal-title":"Prev Sci"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2021.101519","article-title":"Proportion versus absolute counts of B cell populations in the assessment of immunological profiles of kidney transplant recipients","volume":"70","author":"Gama","year":"2022","journal-title":"Transpl Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/cia2.12156","article-title":"Clinical and pathological differences between skin-limited IgM\/IgG vasculitis and skin-limited IgA vasculitis","volume":"4","author":"Kawamura","year":"2021","journal-title":"J Cutaneous Immunol Allergy"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14880","article-title":"Analysis of IL-10 and IL-35 in dipeptidyl peptidase-4 inhibitor-related bullous pemphigoid","volume":"32","author":"Kokubu","year":"2023","journal-title":"Exp Dermatol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2024.107602","article-title":"Addressing missing outcome data in randomised controlled trials: A methodological scoping review","volume":"143","author":"Medcalf","year":"2024","journal-title":"Contemp Clin Trials"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1324","article-title":"Epigenetic programming underpins B-cell dysfunction in peanut and multi-food allergy","volume":"10","author":"Imran","year":"2021","journal-title":"Clin Transl Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01277","article-title":"B cell intrinsic mechanisms constraining IgE memory","volume":"8","author":"Laffleur","year":"2017","journal-title":"Front Immunol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.2147\/jaa.S393683","article-title":"Specific IgE response and omalizumab responsiveness in severe allergic asthma","volume":"16","author":"Tajiri","year":"2023","journal-title":"J Asthma Allergy"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2019.109674","article-title":"Anti-IgE treatment in allergic rhinitis","volume":"127","author":"Muluk","year":"2019","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2020.100129","article-title":"Nasal IgE in subjects with allergic and non-allergic rhinitis","volume":"13","author":"Eckrich","year":"2020","journal-title":"World Allergy Organ J"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino15.300","article-title":"Serum allergen-specific IgE, allergic rhinitis severity, and age","volume":"54","author":"Ciprandi","year":"2016","journal-title":"Rhinology"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adi0944","article-title":"Type 2-polarized memory B cells hold allergen-specific IgE memory","volume":"16","author":"Koenig","year":"2024","journal-title":"Sci Transl Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00723-0","article-title":"IgG1 memory B cells keep the memory of IgE responses","volume":"8","author":"He","year":"2017","journal-title":"Nat Commun"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.reval.2021.10.012","article-title":"From B-cell self-control to therapeutic approaches, could B-cell intrinsic strategies temper IgE responses and IgE memory","volume":"62","author":"Cogn\u00e9","year":"2022","journal-title":"Rev Fr Allergol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-019-0324-z","article-title":"Dendritic cells license regulatory B cells to produce IL-10 and mediate suppression of antigen-specific CD8 T cells","volume":"17","author":"Boldison","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.11.7215","article-title":"Cutting edge:: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway","volume":"179","author":"El Kasmi","year":"2007","journal-title":"J Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002465","article-title":"Immunological effects of sublingual immunotherapy: Clinical efficacy is associated with modulation of programmed cell death ligand 1, IL-10, and IgG4","volume":"185","author":"Piconi","year":"2010","journal-title":"J Immunol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545524","article-title":"Bcl-3 puts the brakes on contact hypersensitivity","volume":"45","author":"Weighardt","year":"2015","journal-title":"Eur J Immunol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00715","article-title":"Non-classical B cell memory of allergic IgE responses","volume":"10","author":"Saunders","year":"2019","journal-title":"Front Immunol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1250719","article-title":"SpiB regulates the expression of B-cell-related genes and increases the longevity of memory B cells","volume":"14","author":"Horiuchi","year":"2023","journal-title":"Front Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.09.009","article-title":"Endogenous IL-10 maintains immune tolerance but IL-10 gene transfer exacerbates autoimmune cholangitis","volume":"95","author":"Hsueh","year":"2018","journal-title":"J Autoimmun"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301770","article-title":"Nanomedicine for T-cell mediated immunotherapy","volume":"36","author":"Li","year":"2024","journal-title":"Adv Mater"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2025.118442","article-title":"Down-regulation of Fc\u03f5RI expression on mast cells leads anti-allergic effect","volume":"132","author":"Tanaka","year":"2026","journal-title":"Bioorg Med Chem"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/cells14120900","article-title":"Advances in food allergy immunotherapy: Current strategies and role of antibodies isotypes","volume":"14","author":"Garcia-Carmona","year":"2025","journal-title":"Cells"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.02.015","article-title":"The B-cell antigen receptor of IgE-switched plasma cells regulates memory IgE responses","volume":"146","author":"Schmitt","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.03.001","article-title":"Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract","volume":"58","author":"Nelson","year":"2025","journal-title":"Immunity"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.5414\/alx02300e","article-title":"Mechanisms in AIT: insights 2021","volume":"45","author":"Satitsuksanoa","year":"2022","journal-title":"Allergologie"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1111\/all.14222","article-title":"Structure of intact IgE and the mechanism of ligelizumab revealed by electron microscopy","volume":"75","author":"Jensen","year":"2020","journal-title":"Allergy"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1097\/aci.0000000000000774","article-title":"Basophil activation test in food allergy: Is it ready for real-time","volume":"21","author":"Keswani","year":"2021","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1111\/imr.70031","article-title":"Structural and functional insights into IgE receptor interactions and disruptive inhibition","volume":"331","author":"Eggel","year":"2025","journal-title":"Immunol Rev"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1080\/1547691x.2025.2507311","article-title":"The interaction between the expression of CD23 molecule on B- lymphocytes and the level of specific IgE against molecular components of pollen in atopic dermatitis patients with and without dupilumab therapy","volume":"22","author":"Celakovsk\u00e1","year":"2025","journal-title":"J Immunotoxicol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13377","article-title":"Antibody feedback regulation","volume":"328","author":"Heyman","year":"2024","journal-title":"Immunol Rev"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1339171","article-title":"IgG in the control of Fc\u03f5RI activation: A battle on multiple fronts","volume":"14","author":"Storni","year":"2024","journal-title":"Front Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207278109","article-title":"Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc\u03f5RI","volume":"109","author":"Dhaliwal","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/all.16448","article-title":"Transcriptomic profiles of the nasal mucosa following birch pollen provocation differ between birch pollen-allergic and non-allergic individuals","volume":"80","author":"Sudharson","year":"2025","journal-title":"Allergy"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2014.45","article-title":"Regulatory T cells and immune regulation of allergic diseases: Roles of IL-10 and TGF-\u03b2","volume":"15","author":"Palomares","year":"2014","journal-title":"Genes Immun"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12071162","article-title":"Allergic asthma in the era of personalized medicine","volume":"12","author":"Papapostolou","year":"2022","journal-title":"J Pers Med"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.5414\/alx01992","article-title":"Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: An EAACI position paper","volume":"41","author":"Jakwerth","year":"2018","journal-title":"Allergologie"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701690","article-title":"Functional and immunoreactive levels of IgG4 correlate with clinical responses during the maintenance phase of house dust mite immunotherapy","volume":"200","author":"Feng","year":"2018","journal-title":"J Immunol"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.5414\/alx02273e","article-title":"State of the art in AIT: The patients' perspective","volume":"45","author":"Joss\u00e9","year":"2022","journal-title":"Allergologie"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106806","article-title":"IL-10-producing B cells play important role in the pathogenesis of recurrent pregnancy loss","volume":"87","author":"Danaii","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s12016-024-08982-8","article-title":"Tissue-resident memory T cells in allergy","volume":"66","author":"Long","year":"2024","journal-title":"Clin Rev Allergy Immunol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1111\/all.16530","article-title":"Vaccine-induced anti-IgE antibodies neutralize free IgE but fail to bind and activate mast cell-displayed IgE","volume":"80","author":"Gharailoo","year":"2025","journal-title":"Allergy"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.11.006","article-title":"Two years of treatment with the recombinant grass pollen allergy vaccine BM32 induces a continuously increasing allergen-specific IgG4 response","volume":"50","author":"Eckl-Dorna","year":"2019","journal-title":"EBioMedicine"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12222","article-title":"Soluble IgE-binding factors in the serum of food-allergic patients: Possible pathophysiological role of soluble Fc\u03f5RI as protective factor","volume":"13","author":"Steinert","year":"2023","journal-title":"Clin Transl Allergy"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1111\/sji.13005","article-title":"A pilot study towards the immunological effects of omalizumab treatment used to facilitate oral immunotherapy in peanut-allergic adolescents","volume":"93","author":"van der Heiden","year":"2021","journal-title":"Scand J Immunol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.11.046","article-title":"Allergen-specific IgG+ memory B cells are temporally linked to IgE memory responses","volume":"146","author":"Hoof","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1093\/jimmun\/vkaf088","article-title":"PGI2 restricts trained ILC2 responses in allergic inflammation","volume":"214","author":"Zhou","year":"2025","journal-title":"J Immunol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2021.2010749","article-title":"Asthma biologic trial eligibility and real-world outcomes in the United States","volume":"59","author":"Lam","year":"2022","journal-title":"J Asthma"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.07.025","article-title":"IgD-activated mast cells induce IgE synthesis in B cells in nasal polyps","volume":"142","author":"Zhai","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1111\/all.14288","article-title":"CD23 expression on switched memory B cells bridges T-B cell interaction in allergic rhinitis","volume":"75","author":"Yao","year":"2020","journal-title":"Allergy"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2022.03.010","article-title":"Clostridium leptum induces the generation of interleukin-10+ regulatory B cells to alleviate airway inflammation in asthma","volume":"145","author":"Huang","year":"2022","journal-title":"Mol Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1760388\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:26:58Z","timestamp":1778732818000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1760388\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":86,"alternative-id":["10.3389\/fimmu.2026.1760388"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1760388","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]},"article-number":"1760388"}}