{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:29:08Z","timestamp":1773815348998,"version":"3.50.1"},"reference-count":85,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Sprouty2 (Spry2) acts as a modulator of the MAPK-ERK signaling pathway by exerting both positive and negative regulation in a highly context- and cell type-specific manner. While its role in controlling the migration of non-immune cells in growth factor-dependent contexts is well established and continuously expanding, its function as a modulator of immune cell responses has only recently begun to emerge. Spry2 appears to critically and differentially influence B- and T-cell responses, consistent with its cell type-specific nature. However, its role in dendritic cells (DCs) remains unexplored. DCs serve as the cellular link between innate and adaptive immunity, and hence, DCs rely on their ability to navigate through different tissues and migrate to distinct target locations to initiate and coordinate effective immune responses. In the present study, we show that Spry2 expression is regulated during bone marrow-derived (BM)DC maturation and established a CD11c-specific Spry2 knockout mouse model to analyze the\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    immune functions of Spry2-deficient DCs. Unexpectedly, we found that its complete absence does not alter essential DC immune functions. Spry2-deficient DCs display intact DC differentiation\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    , efficient CCR7-driven migration and effective lymph node homing\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Furthermore, we demonstrate that Spry2-deficient DCs retain an unaltered ability to stimulate CD8\n                    <jats:sup>+<\/jats:sup>\n                    T-cell activation and proliferation, ultimately resulting in normal CD8\n                    <jats:sup>+<\/jats:sup>\n                    T-cell effector differentiation during acute viral infection. Collectively, our findings shed light on the function of Spry2 in DCs, thereby extending and reinforcing current knowledge of its diverse immunomodulatory functions.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1761675","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:36:18Z","timestamp":1773812178000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Intact lymph node homing and CD8+ T-cell priming abilities of Sprouty2-deficient dendritic cells"],"prefix":"10.3389","volume":"17","author":[{"given":"Nadine","family":"Anslinger","sequence":"first","affiliation":[{"name":"Institute of Cell Biology and Immunology Thurgau (BITG) at the University of Konstanz","place":["Kreuzlingen, Switzerland"]},{"name":"Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guerric P. B.","family":"Samson","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Immunology Thurgau (BITG) at the University of Konstanz","place":["Kreuzlingen, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Purvanov","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Immunology Thurgau (BITG) at the University of Konstanz","place":["Kreuzlingen, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Basler","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Immunology Thurgau (BITG) at the University of Konstanz","place":["Kreuzlingen, Switzerland"]},{"name":"Department of Biology, University of Konstanz","place":["Konstanz, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel F.","family":"Legler","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology and Immunology Thurgau (BITG) at the University of Konstanz","place":["Kreuzlingen, Switzerland"]},{"name":"Department of Biology, University of Konstanz","place":["Konstanz, Germany"]},{"name":"Theodor Kocher Institute, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80919-8","article-title":"sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the drosophila airways","volume":"92","author":"Hacohen","year":"1998","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00241-X","article-title":"Cloning and expression pattern of a mouse homologue of Drosophila sprouty in the mouse embryo","volume":"81","author":"de Maximy","year":"1999","journal-title":"Mech 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