{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:30:58Z","timestamp":1773815458818,"version":"3.50.1"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acute lung injury (ALI), characterized by diffuse alveolar damage and inflammation, can trigger secondary enteritis through systemic interactions, aligning with the established lung-gut axis concept\u2014a bidirectional communication system underpinned by shared mechanisms including inflammation, oxidative stress, and barrier dysfunction; however, the molecular links remain unclear, and vitamin E\u2019s role in this axis lacks systematic investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>By integrating GeneCards database screening, protein\u2013protein interaction (PPI) network, and pathway analyses,<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>we identified 34 \u201cALI\u2013Enteritis \u2229 Vitamin E\u201d related core genes. In an LPS-induced ALI mouse model, vitamin E alleviated lung pathology while repairing intestinal mucosal barrier through modulating M1\/M2 macrophage polarization and suppressing excessive neutrophil recruitment. This study first systematically delineates molecular commonalities between ALI and enteritis, identifies 34 shared therapeutic targets, and demonstrates vitamin E\u2019s coordinated multi-organ protection via targeting these pathways,<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>offering novel insights into the \u201clung\u2013intestine axis\u201d and a scientific basis for its nutritional-immunomodulatory intervention in multi-organ injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1762374","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:37:06Z","timestamp":1773812226000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated network pharmacology and in vivo evidence reveal vitamin E\u2019s multi-organ protective effects in acute lung injury and secondary enteritis"],"prefix":"10.3389","volume":"17","author":[{"given":"Jinhai","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Shangyu People\u2019s Hospital of Shaoxing, Shaoxing University","place":["Shaoxing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiongdan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of The First Clinical Medical School, Hainan Medical University","place":["Haikou, China"]},{"name":"Hainan Academy of Medicine Sciences","place":["Haikou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanlong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shangyu People\u2019s Hospital of Shaoxing, Shaoxing University","place":["Shaoxing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shangyu People\u2019s Hospital of Shaoxing, Shaoxing University","place":["Shaoxing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiwei","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Shaoxing People\u2019s Hospital","place":["Shaoxing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifang","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shangyu People\u2019s Hospital of Shaoxing, Shaoxing University","place":["Shaoxing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00010.2008","article-title":"Animal models of acute lung injury","volume":"295","author":"Matute-Bello","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.1016\/j.celrep.2020.02.013","article-title":"Gut dysbiosis during influenza contributes to pulmonary pneumococcal superinfection through altered short-chain fatty acid production","volume":"30","author":"Sencio","year":"2020","journal-title":"Cell Rep"},{"key":"B3","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nrmicro.2016.142","article-title":"Emerging pathogenic links between microbiota and the gut-lung axis","volume":"15","author":"Budden","year":"2017","journal-title":"Nat Rev 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