{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:21:51Z","timestamp":1792588911387,"version":"4.5.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Emotional distress (ED) is closely associated with the progression of triple-negative breast cancer (TNBC). Xiaoyao San (XYS), a classical Chinese herbal prescription traditionally used for mood regulation, has demonstrated potential therapeutic efficacy in emotion-related breast cancer. However, the molecular mechanisms through which XYS mitigates ED-induced TNBC (ED-TNBC) remain insufficiently characterized. This study aimed to investigate the therapeutic effects of XYS on ED-TNBC and elucidate its underlying molecular mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A TNBC mouse model subjected to chronic unpredictable mild stress (CUMS) was developed to simulate ED-TNBC conditions. The therapeutic efficacy of XYS at varying doses was evaluated through behavioral assessments and tumor growth analyses. Multi-omics analyses integrating network pharmacology, bioinformatics, and molecular dynamics simulations were employed to identify principal active constituents and key molecular targets of XYS. Transcriptomic profiling,\n                      <jats:italic>in vivo<\/jats:italic>\n                      and\n                      <jats:italic>in vitro<\/jats:italic>\n                      functional assays, and molecular biology experiments were conducted to delineate the molecular mechanisms underlying XYS-mediated regulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      High-dose XYS markedly alleviated depression-like behaviors and suppressed ED-TNBC tumor progression, with no evident adverse effects observed. Transcriptomic and molecular analyses revealed that XYS enhanced CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell infiltration and cytotoxic activity through activation of Cxcl9. The active constituents of XYS were found to bind directly to the transcription factor Rela. Subsequent experiments verified that Cxcl9 secretion from TNBC cells depends on Rela activity. In addition, XYS upregulated Rela expression and promoted its nuclear translocation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      XYS directly targets and activates the intratumoral Rela\/NF-\u03baB\u2013Cxcl9 axis, promoting CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cell infiltration and activation, thereby inhibiting the growth of ED-TNBS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1762492","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:45:58Z","timestamp":1770273958000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Xiaoyao San alleviates emotional distress - induced TNBC growth through augmenting intratumoral CD8+T cell infiltration mediated by Rela\/NF-kB-Cxcl9 axis"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuqi","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, Guangdong, China"]},{"name":"Chinese Medicine Guangdong Laboratory","place":["Hengqin, Guangdong, China"]},{"name":"Key Laboratory of Chinese Medicinal Resource from Lingnan, Ministry of Education, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, Guangdong, China"]},{"name":"Chinese Medicine Guangdong Laboratory","place":["Hengqin, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, Guangdong, China"]},{"name":"Chinese Medicine Guangdong Laboratory","place":["Hengqin, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, Guangdong, China"]},{"name":"Chinese Medicine Guangdong Laboratory","place":["Hengqin, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, Guangdong, China"]},{"name":"Chinese Medicine Guangdong Laboratory","place":["Hengqin, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juexiao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, Guangdong, China"]},{"name":"Chinese Medicine Guangdong Laboratory","place":["Hengqin, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, Guangdong, China"]},{"name":"Chinese Medicine Guangdong Laboratory","place":["Hengqin, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, Guangdong, China"]},{"name":"Chinese Medicine Guangdong Laboratory","place":["Hengqin, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, Guangdong, China"]},{"name":"Chinese Medicine Guangdong Laboratory","place":["Hengqin, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, Guangdong, China"]},{"name":"Chinese Medicine Guangdong Laboratory","place":["Hengqin, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, Guangdong, China"]},{"name":"Chinese Medicine Guangdong Laboratory","place":["Hengqin, Guangdong, China"]},{"name":"Key Laboratory of Chinese Medicinal Resource from Lingnan, Ministry of Education, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Bai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chinese Medicinal Resource from Lingnan, Ministry of Education, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Breast, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, Guangdong, China"]},{"name":"Chinese Medicine Guangdong Laboratory","place":["Hengqin, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"428-440.e5","DOI":"10.1016\/j.ccell.2019.02.001","article-title":"Genomic and transcriptomic landscape of triple-negative breast cancers: subtypes and treatment strategies","volume":"35","author":"Jiang","year":"2019","journal-title":"Cancer Cell"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.86085","article-title":"VEGFA\/NRP-1\/GAPVD1 axis promotes progression and cancer stemness of triple-negative breast cancer by enhancing tumor cell-macrophage crosstalk","volume":"20","author":"Wang","year":"2024","journal-title":"Int J Biol Sci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e2310266","DOI":"10.1002\/advs.202310266","article-title":"Chronic stress-induced and tumor derived SP1+ Exosomes polarizing IL-1\u03b2+ Neutrophils to increase lung metastasis of breast cancer","volume":"12","author":"Zhang","year":"2024","journal-title":"Advanced Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B5","doi-asserted-by":"publisher","first-page":"6314","DOI":"10.3390\/ijms25126314","article-title":"Beyond psychotropic: potential repurposing of fluoxetine toward cancer therapy","volume":"25","author":"Kadasah","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13058-017-0928-0","article-title":"Selective serotonin reuptake inhibitor use and breast cancer survival: a population-based cohort study","volume":"20","author":"Busby","year":"2018","journal-title":"Breast Cancer Research: BCR"},{"key":"B7","doi-asserted-by":"publisher","first-page":"eadj7808","DOI":"10.1126\/scitranslmed.adj7808","article-title":"Interferon-induced senescent CD8+ T cells reduce anti-PD1 immunotherapy efficacy in early triple-negative breast cancer","volume":"17","author":"Fu","year":"2025","journal-title":"Sci Trans Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12929-025-01165-3","article-title":"CD24a knockout results in an enhanced macrophage- and CD8+ T cell-mediated anti-tumor immune responses in tumor microenvironment in a murine triple-negative breast cancer model","volume":"32","author":"Chan","year":"2025","journal-title":"J BioMed Sci"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13933","article-title":"Depressive disorder affects TME and hormonal changes promoting tumour deterioration development","volume":"175","author":"Dong","year":"2025","journal-title":"Immunology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s12906-025-04860-8","article-title":"Molecular mechanisms of the Xiao-chai-hu-tang on chronic stress-induced colorectal cancer growth based on an integrated network pharmacology and RNA sequencing approach with experimental validation","volume":"25","author":"Yao","year":"2025","journal-title":"BMC Complement Med Ther"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e002045","DOI":"10.1136\/jitc-2020-002045","article-title":"CXCL9-expressing tumor-associated macrophages: new players in the fight against cancer","volume":"9","author":"Marcovecchio","year":"2021","journal-title":"J Immunother Cancer"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1112811","article-title":"A meta-analysis of chemokines in vitiligo: Recruiting immune cells towards melanocytes","volume":"14","author":"Speeckaert","year":"2023","journal-title":"Front Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"885-900.e10","DOI":"10.1016\/j.ccell.2019.05.004","article-title":"Cooperation between constitutive and inducible chemokines enables T cell engraftment and immune attack in solid tumors","volume":"35","author":"Dangaj","year":"2019","journal-title":"Cancer Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1186\/s12916-025-04263-z","article-title":"Multi-omics analysis uncovers predictive biomarkers for the efficacy and outcomes of chemoimmunotherapy in advanced unresectable biliary tract cancers","volume":"23","author":"Ni","year":"2025","journal-title":"BMC Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1038\/s42003-024-07341-9","article-title":"EZH2 elicits CD8+ T-cell desert in esophageal squamous cell carcinoma via suppressing CXCL9 and dendritic cells","volume":"7","author":"Zhu","year":"2024","journal-title":"Commun Biol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e2250281","DOI":"10.1002\/eji.202250281","article-title":"The IFN-\u03b3-CXCL9\/CXCL10-CXCR3 axis in vitiligo: Pathological mechanism and treatment","volume":"54","author":"Liu","year":"2024","journal-title":"Eur J Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155427","article-title":"Uncovering the effect and mechanism of Jiawei Xiaoyao Wan in treating breast cancer complicated with depression based on network pharmacology and experimental analysis","volume":"128","author":"Bai","year":"2024","journal-title":"Phytomedicine"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157221","article-title":"Xiaoyao San's dual efficacy in NAFLD and depression: Unraveling the mechanisms via network pharmacology and multi-omics","volume":"147","author":"Liu","year":"2025","journal-title":"Phytomedicine"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120534","article-title":"Network pharmacology-guided lipidomics and molecular docking reveals the involvement of sphingolipid metabolism and HIF-1 signaling in Xiaoyao San's blood-nourishing mechanism against depression","volume":"354","author":"Gong","year":"2025","journal-title":"J ethnopharmacology"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1004-0412.2025.04.046","article-title":"The influence of traditional Chinese medicine Xiaoyao SAN combined with hot compress on the depressive state and immune function of postoperative breast cancer patients","volume":"46","author":"Yingfang","year":"2025","journal-title":"Jilin Med J"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/891893","article-title":"Prescription pattern of chinese herbal products for breast cancer in Taiwan: a population-based study","volume":"2012","author":"Lai","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1050337","article-title":"Modified xiaoyao san combined with chemotherapy for breast cancer: A systematic review and meta-analysis of randomized controlled trials","volume":"13","author":"Pan","year":"2023","journal-title":"Front Oncol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S390602","article-title":"10-gingerol enhances the effect of taxol in triple-negative breast cancer via targeting ADRB2 signaling","volume":"17","author":"Liang","year":"2023","journal-title":"Drug Design Dev Ther"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120389","article-title":"Jiawei Yanghe Decoction augments intratumoral CD8+ TIL infiltration and enhances radiotherapy efficacy in non-small cell lung cancer through CXCR3 ligand-mediated chemotaxis","volume":"353","author":"Shen","year":"2025","journal-title":"J ethnopharmacology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13098-022-00886-x","article-title":"New insights into the role of empagliflozin on diabetic renal tubular lipid accumulation","volume":"14","author":"Sun","year":"2022","journal-title":"Diabetol Metab Syndr"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.156405","article-title":"Modified Shenqi Dihuang Decoction inhibits prostate cancer metastasis by disrupting TCA cycle energy metabolism via NF-kB\/p65-mediated OGDH regulation","volume":"138","author":"Zhang","year":"2025","journal-title":"Phytomedicine"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1210\/me.2014-1102","article-title":"Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells","volume":"28","author":"Lee","year":"2014","journal-title":"Mol Endocrinol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2828","DOI":"10.3390\/plants14182828","article-title":"Network pharmacology, molecular docking and molecular dynamics studies to predict the molecular targets and mechanisms of action of melissa officinalis phytoconstituents in type-2 diabetes mellitus","volume":"14","author":"Ononamadu","year":"2025","journal-title":"Plants (Basel)"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.24660","article-title":"CHARMM-GUI 10 years for biomolecular modeling and simulation","volume":"38","author":"Jo","year":"2016","journal-title":"J Comput Chem"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4067","article-title":"CHARMM36m: an improved force field for folded and intrinsically disordered proteins","volume":"14","author":"Huang","year":"2016","journal-title":"Nat Methods"},{"key":"B32","doi-asserted-by":"publisher","first-page":"194501","DOI":"10.1063\/5.0050841","article-title":"Three- and four-site models for heavy water: SPC\/E-HW, TIP3P-HW, and TIP4P\/2005-HW","volume":"154","author":"Linse","year":"2021","journal-title":"J Chem Phys"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-5-367","article-title":"ACPYPE - anteChamber PYthon parser interfacE","volume":"5","author":"Sousa da Silva","year":"2012","journal-title":"BMC Res Notes"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1113","article-title":"JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles","volume":"50","author":"Castro-Mondragon","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"B35","doi-asserted-by":"publisher","first-page":"7619","DOI":"10.3390\/ijms21207619","article-title":"CC chemokines in a tumor: A review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands","volume":"21","author":"Korbecki","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2024.101063","article-title":"Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer","volume":"73","author":"Ou","year":"2024","journal-title":"Drug Resist Updat"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.19852\/j.cnki.jtcm.2025.03.016","article-title":"Clinical effect of Shugan Jieyu San for improving liver function and alleviating depression in patients with triple negative breast cancer","volume":"45","author":"Yang","year":"2025","journal-title":"J Traditional Chin Med = Chung I Tsa Chih Ying Wen Pan"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-00865-6","article-title":"Prognostic value of depression and anxiety on breast cancer recurrence and mortality: a systematic review and meta-analysis of 282,203 patients","volume":"25","author":"Wang","year":"2020","journal-title":"Mol Psychiatry"},{"key":"B39","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3390\/healthcare7030107","article-title":"Correlation of clinicopathological characteristics of breast carcinoma and depression","volume":"7","author":"Ilic","year":"2019","journal-title":"Healthcare (Basel)"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e12402","DOI":"10.1111\/cpr.12402","article-title":"Fluoxetine induces autophagic cell death via eEF2K-AMPK-mTOR-ULK complex axis in triple negative breast cancer","volume":"51","author":"Sun","year":"2017","journal-title":"Cell Prolif"},{"key":"B41","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/s13058-025-02043-4","article-title":"Depression, antidepressant use, and breast cancer incidence in the Sister Study cohort","volume":"27","author":"D\u00edaz-Santana","year":"2025","journal-title":"Breast Cancer Research: BCR"},{"key":"B42","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1007\/s12032-025-02919-7","article-title":"Duloxetine inhibits breast cancer progression by suppressing AKT signaling and inducing Bax\/Bcl-2-mediated apoptosis","volume":"42","author":"Wang","year":"2025","journal-title":"Med Oncol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-025-07766-8","article-title":"Stage at diagnosis and breast cancer-specific mortality in breast cancer patients treated with antidepressants, anxiolytics, and antipsychotics: a population-based cohort study from Northern Ireland","volume":"213","author":"Baxter","year":"2025","journal-title":"Breast Cancer Res Treat"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.15887\/j.cnki.13-1389\/r.2016.15.041","article-title":"Observation on the clinical efficacy of Xiaoyao SAN combined with Capecitabine in the treatment of advanced triple-negative breast cancer","volume":"9","author":"Jianbo","year":"2016","journal-title":"J Clin Rational Drug Use"},{"key":"B45","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s13046-023-02696-z","article-title":"Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM\/CXCL1 signaling","volume":"42","author":"Zheng","year":"2023","journal-title":"J Exp Clin Cancer Research: CR"},{"key":"B46","doi-asserted-by":"publisher","first-page":"e00722","DOI":"10.1002\/advs.202500722","article-title":"Paracrine orchestration of tumor microenvironment remodeling induced by GLO1 potentiates lymph node metastasis in breast cancer","volume":"12","author":"Xie","year":"2025","journal-title":"Advanced Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B47","doi-asserted-by":"publisher","first-page":"6160","DOI":"10.1038\/s41467-023-41817-2","article-title":"Repressed Blautia-acetate immunological axis underlies breast cancer progression promoted by chronic stress","volume":"14","author":"Ye","year":"2023","journal-title":"Nat Commun"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e2207155","DOI":"10.1002\/advs.202207155","article-title":"BCAT2 shapes a noninflamed tumor microenvironment and induces resistance to anti-PD-1\/PD-L1 immunotherapy by negatively regulating proinflammatory chemokines and anticancer immunity","volume":"10","author":"Cai","year":"2023","journal-title":"Advanced Sci (Weinheim Baden-Wurttemberg Germany)"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2025.117157","article-title":"Baicalin promotes anti-tumor immunity in hepatocellular carcinoma through HIF-1\u03b1\/Lactate\/CXCL9 axis","volume":"241","author":"Yang","year":"2025","journal-title":"Biochem Pharmacol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2025.102164","article-title":"Spatial and genomic profiling of residual breast cancer after neoadjuvant chemotherapy unveil divergent fates for each breast cancer subtype","volume":"6","author":"Seo","year":"2025","journal-title":"Cell Rep Med"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-23-0281","article-title":"C-X-C motif chemokine ligand 9 correlates with favorable prognosis in triple-negative breast cancer by promoting immune cell infiltration","volume":"22","author":"Cao","year":"2023","journal-title":"Mol Cancer Ther"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2019.07.009","article-title":"Insights into the relationship between nucleolar stress and the NF-\u03baB pathway","volume":"35","author":"Chen","year":"2019","journal-title":"Trends Genet"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217772","article-title":"Macrophage polarization in cancer and beyond: from inflammatory signaling pathways to potential therapeutic strategies","volume":"625","author":"Bai","year":"2025","journal-title":"Cancer Letters"},{"key":"B54","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.semcdb.2017.08.004","article-title":"Cancer secretome and inflammation: The bright and the dark sides of NF-\u03baB","volume":"78","author":"Capece","year":"2017","journal-title":"Semin Cell Dev Biol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.743837","article-title":"Baicalein potentiated M1 macrophage polarization in cancer through targeting PI3K\u03b3\/ NF-\u03baB signaling","volume":"12","author":"He","year":"2021","journal-title":"Front In Pharmacol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.934","article-title":"CXCL9: evidence and contradictions for its role in tumor progression","volume":"5","author":"Ding","year":"2016","journal-title":"Cancer Med"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1762492\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:57:37Z","timestamp":1771927057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1762492\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":56,"alternative-id":["10.3389\/fimmu.2026.1762492"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1762492","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]},"article-number":"1762492"}}