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Dysregulated TRIM expression or activity contributes to the pathogenesis of autoimmune diseases, including SLE, Sj\u00f6gren\u2019s syndrome, rheumatoid arthritis, psoriasis, inflammatory bowel diseases, and type I diabetes. This review summarizes the role of TRIM proteins in innate and adaptive immunity and their signaling axis linked to autoimmune and immune-related pathologies. It also focuses on the emerging therapeutic potential, targets and clinical strategies for targeting TRIM proteins.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1764253","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:10:17Z","timestamp":1770822617000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["TRIM proteins as emerging regulators of immune pathways: potential therapeutic targets in immune-related disorders"],"prefix":"10.3389","volume":"17","author":[{"given":"Bilal","family":"Jawed","sequence":"first","affiliation":[{"name":"Ente Ecclesiastico Ospedale Generale Regionale Francesco Miulli","place":["Acquaviva delle Fonti, Italy"]},{"name":"Universita degli Studi Gabriele d\u2019Annunzio Chieti Pescara","place":["Chieti, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimsha","family":"Kanwal","sequence":"additional","affiliation":[{"name":"Ente 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