{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:04:45Z","timestamp":1785438285211,"version":"3.56.0"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Segmental colitis associated with diverticulosis (SCAD) is a rare inflammatory condition limited to colonic segments affected by diverticulosis. Its coexistence with ulcerative colitis (UC) is extremely rare and poses a diagnostic and therapeutic challenge. We report the case of a 56-year-old woman with a history of sigmoidectomy for recurrent sigmoid diverticulitis, who subsequently developed SCAD in the residual diverticula adjacent to the anastomosis, along with concomitant left-sided UC. Despite treatment with mesalazine and vedolizumab and rectal healing of UC, SCAD was therapy-refractory. The use of the anti-TNF antibody adalimumab, intensified to 40 mg weekly, resulted in complete clinical, endoscopic, and histologic remission of both SCAD and UC. At five years of follow-up to date, the patient remains in sustained, steroid-free remission without adverse events. This case highlights the possible coexistence of SCAD and UC and suggests adalimumab as a promising and sustained treatment option in refractory SCAD, even in the setting of coexisting UC.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1764305","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:42:33Z","timestamp":1776231753000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Successful anti-TNF antibody therapy in steroid-dependent segmental colitis associated with diverticulosis and concomitant ulcerative colitis"],"prefix":"10.3389","volume":"17","author":[{"given":"Fotios","family":"Fousekis","sequence":"first","affiliation":[{"name":"First Department of Medicine, University Hospital Erlangen, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Deutsches Zentrum Immuntherapie (DZI)","place":["Erlangen, 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