{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:12:28Z","timestamp":1793812348035,"version":"4.6.1"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    OCA-B (OCT Coactivator from B cells) is highly expressed in B cells and is the first-identified tissue-specific transcriptional coactivator. Mechanistically, OCA-B is recruited to target genes through primary interactions with DNA-binding transcription factors OCT1\/OCT2, as well as secondary interactions with MEF2B, and its effector functions in activating transcription involve interactions with the Mediator coactivator complex. Physiologically, OCA-B plays an essential role in antigen-stimulated Germinal Center (GC) formation and transcription of secondary immunoglobulin (Ig) genes. OCA-B also regulates bone marrow and peripheral B cell development. While GC B cell-specific inactivation of\n                    <jats:italic>Oca-B<\/jats:italic>\n                    is sufficient to cause GC defects, OCA-B function in follicular T helper (Tfh) cells also plays an important role in GC reactions. In GC B cells, OCA-B\u2013dependent genes include known GC regulatory genes such as\n                    <jats:italic>Bcl6<\/jats:italic>\n                    ,\n                    <jats:italic>Mef2b<\/jats:italic>\n                    and\n                    <jats:italic>Irf4<\/jats:italic>\n                    . In CD4\n                    <jats:sup>+<\/jats:sup>\n                    memory T cells, OCA-B is required to maintain a subset of genes, including\n                    <jats:italic>Il2<\/jats:italic>\n                    , in a transcriptionally poised state, enabling their rapid and robust up-regulation upon repeated stimulation. Moreover, recent studies have indicated an essential role for OCA-B in B-cell malignancy and multiple autoimmune diseases, highlighting OCA-B as a potential therapeutic target for these diseases.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1764360","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:23:39Z","timestamp":1773897819000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Regulation of B cell development and lymphocyte function by transcriptional coactivator OCA-B"],"prefix":"10.3389","volume":"17","author":[{"given":"Xiangdong","family":"Lu","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, The Rockefeller University","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Roeder","sequence":"additional","affiliation":[{"name":"Laboratory of 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