{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:55:16Z","timestamp":1781502916630,"version":"3.54.1"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006321","name":"National Institutes of Natural Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This case report describes the potential clinical benefit and safety of ozone major blood ozonation (O\n                      <jats:sub>3<\/jats:sub>\n                      -MBO) in the treatment of glucocorticoid (GC)-dependent dermatomyositis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The patient received an initial 15-day daily course of O\n                      <jats:sub>3<\/jats:sub>\n                      -MBO (at a concentration of 80 \u03bcg\/mL), followed by repeated cycles of 15-day treatment alternating with 15-day rest periods over approximately 15 months. Laboratory parameters and cutaneous lesion status were continuously monitored during the treatment period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the case presented, the patient added 15 days of O\n                      <jats:sub>3<\/jats:sub>\n                      -MBO therapy and 15 days of rest as adjunctive therapy without increasing the hormone dosage, which was associated with reductions in serum levels of CK, AST, and ALT, healed the skin ulcers on the shoulders, normalized the skin, reduced the facial edema, and was associated with reduced corticosteroid-related side effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      O\n                      <jats:sub>3<\/jats:sub>\n                      -MBO may serve as a valuable adjunctive treatment for patients with corticosteroid dependence or refractory dermatological symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1767266","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:36:20Z","timestamp":1781501780000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ozone major blood ozonation in the management of dermatomyositis: a case report"],"prefix":"10.3389","volume":"17","author":[{"given":"Yunbo","family":"Xie","sequence":"first","affiliation":[{"name":"Ozone Biomedical Research Institute, School of Clinical and Basic Medical Sciences of Shandong First Medical University & Shandong Academy of Medical Science","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Cui","sequence":"additional","affiliation":[{"name":"Ozone Biomedical Research Institute, School of Clinical and Basic Medical Sciences of Shandong First Medical University & Shandong Academy of Medical Science","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Liu","sequence":"additional","affiliation":[{"name":"Shandong Jiangang Hospital Management Co., Ltd., Huaiyin Jiangang Hospital","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Song","sequence":"additional","affiliation":[{"name":"Ozone Biomedical Research Institute, School of Clinical and Basic Medical Sciences of Shandong First Medical University & Shandong Academy of Medical Science","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.1016\/0190-9622(91)70153-S","article-title":"Amyopathic dermatomyositis (dermatomyositis sin\u00e9 myositis). 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