{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:20:11Z","timestamp":1787887211346,"version":"build-2784847793"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteoporosis is a metabolic bone disease characterized by dysregulated osteoclast activity, resulting in increased bone degradation and compromised bone microarchitecture. While the interconnection between osteoclast differentiation and cellular energy metabolism has become increasingly recognized, the role of pyrimidine metabolism in this process remains largely undefined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Integrative multi-omics analyses were performed to characterize transcriptional and metabolic alterations during receptor activator of nuclear factor-\u03baB ligand (RANKL)-induced osteoclast differentiation. The effects of uridine (UD) on osteoclast development and resorptive function were assessed in vitro using RAW264.7 cells and bone marrow-derived macrophages (BMMs). In vivo effects of UD on bone loss were evaluated in an ovariectomized (OVX) mouse model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Integrative analyses revealed distinct metabolic remodeling during osteoclast differentiation and identified UD as a pivotal metabolite that showed a significant decline upon RANKL stimulation. Experimental evidence indicated that exogenous UD supplementation significantly suppressed osteoclast development and resorptive function, along with a reduction in the expression of nuclear factor of activated T cells c1 (NFATc1) and cathepsin K (CTSK). In OVX mice, UD administration improved trabecular microarchitecture, reduced osteoclast burden, and mitigated bone loss. Mechanistically, UD inhibited phosphoinositide 3-kinase\/protein kinase B (PI3K\/Akt) phosphorylation, facilitated Forkhead box O (FoxO) nuclear translocation, and suppressed reactive oxygen species (ROS) accumulation, thereby preventing NFATc1 activation and nuclear import.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Collectively, this research identifies a novel metabolic\u2013signaling interplay linking pyrimidine metabolism with osteoclast differentiation and highlights UD as a promising metabolic regulator for the treatment and prevention of osteoporosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1767279","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:27:31Z","timestamp":1777264051000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Uridine inhibits ROS-mediated osteoclast differentiation and alleviates osteoporosis via modulation of PI3K\/Akt\u2013FoxO signaling"],"prefix":"10.3389","volume":"17","author":[{"given":"Sijie","family":"Bian","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]},{"name":"Anhui Public Health Clinical Center","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianhui","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]},{"name":"Anhui Public Health Clinical Center","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]},{"name":"Anhui Public Health Clinical Center","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]},{"name":"Anhui Public Health Clinical Center","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianliang","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]},{"name":"Anhui Public Health Clinical Center","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]},{"name":"Anhui Public Health Clinical Center","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faxue","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]},{"name":"Anhui Public Health Clinical Center","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingkai","family":"Xue","sequence":"additional","affiliation":[{"name":"Experimental Center of Clinical Research, Scientific Research Department, The First Affiliated Hospital of Anhui University of Chinese Medicine","place":["Hefei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Huo","sequence":"additional","affiliation":[{"name":"Experimental Center of Clinical Research, Scientific Research Department, The First Affiliated Hospital of Anhui University of Chinese Medicine","place":["Hefei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The First Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]},{"name":"Anhui Public Health Clinical Center","place":["Hefei, China"]},{"name":"School of Basic Medical Sciences, Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2025.103244","article-title":"Criteria for osteoporosis diagnosis: a systematic review and meta-analysis of osteoporosis diagnostic studies with DXA and QCT","volume":"83","author":"Yang","year":"2025","journal-title":"EClinicalMedicine"},{"key":"B2","doi-asserted-by":"publisher","first-page":"ITC1","DOI":"10.1001\/jama.2020.2923","article-title":"Osteoporosis","volume":"177","author":"Ensrud","year":"2024","journal-title":"Ann Intern Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.4771393","article-title":"The global, regional, and national burden attributable to low bone mineral density, 1990-2020: an analysis of a modifiable risk factor from the Global Burden of Disease Study 2021","volume":"7","year":"2025","journal-title":"Lancet Rheumatol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01736","article-title":"Discovery of an orally active PDE1 inhibitor for disease-modifying treatment of postmenopausal osteoporosis via dual anabolic-antiresorptive mechanisms","volume":"68","author":"Abbasi","year":"2025","journal-title":"J Med Chem"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-023-00838-y","article-title":"Racial\/ethnic differences in bone mineral density for osteoporosis","volume":"21","author":"Wu","year":"2023","journal-title":"Curr Osteoporos Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4437","DOI":"10.1038\/s41467-025-59719-w","article-title":"FABP4 inhibition suppresses bone resorption and protects against postmenopausal osteoporosis in ovariectomized mice","volume":"16","author":"Xie","year":"2025","journal-title":"Nat Commun"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.5435\/jaaos-d-24-00311","article-title":"Osteoporosis evaluation and management in spine surgery","volume":"32","author":"Girdler","year":"2024","journal-title":"J Am Acad Orthop Surg"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.244","article-title":"Mechanistic advances in osteoporosis and anti-osteoporosis therapies","volume":"4","author":"Wang","year":"2023","journal-title":"MedComm (2020)"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)02646-5","article-title":"Drug therapy for osteoporosis in older adults","volume":"399","author":"Reid","year":"2022","journal-title":"Lancet"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-024-07059-8","article-title":"Impact of osteoporosis and osteoporosis medications on fracture healing: a narrative review","volume":"35","author":"Chandran","year":"2024","journal-title":"Osteoporos Int"},{"key":"B11","doi-asserted-by":"publisher","first-page":"157401","DOI":"10.1016\/j.phymed.2025.157401","article-title":"Okanin attenuates ovariectomy-induced bone loss in mice model through inhibition of IKK\u03b2-mediated NF-\u03baB p65 phosphorylation","volume":"148","author":"Shi","year":"2025","journal-title":"Phytomedicine"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2025.101426","article-title":"Crebanine protects against ovariectomy-induced bone loss by targeting Sirt1 to interfere with NF-\u03baB acetylation and ROS activity","volume":"16","author":"Zhang","year":"2025","journal-title":"J Pharm Anal"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113871","article-title":"Fraxin inhibits ovariectomized-induced bone loss and osteoclastogenesis by suppressing ROS activity","volume":"147","author":"Zhou","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s41419-025-07965-7","article-title":"Targeting Irgm1 to combat osteoporosis: suppressing ROS and restoring bone remodeling","volume":"16","author":"Cui","year":"2025","journal-title":"Cell Death Dis"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115589","article-title":"Sofalcone inhibits osteoclastogenesis through Keap1\/Nrf2 signaling activation and mitigates ovariectomy-induced bone loss","volume":"166","author":"Liang","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8503","article-title":"Salvianolic acid A mitigates osteoporotic bone loss by repressing reactive oxygen species via the Nrf2-HO-1 pathway","volume":"39","author":"Qiu","year":"2025","journal-title":"Phytother Res"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.34133\/research.0784","article-title":"Visomitin attenuates pathological bone loss by reprogramming osteoclast metabolism via the STAT3\/LDHB axis","volume":"8","author":"Yuan","year":"2025","journal-title":"Res (Wash D C)"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103667","article-title":"Targeting mitochondria in bone and cartilage diseases: a narrative review","volume":"83","author":"Mendelsohn","year":"2025","journal-title":"Redox Biol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/s41580-023-00649-0","article-title":"FOXO transcription factors as mediators of stress adaptation","volume":"25","author":"Rodriguez-Colman","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41420-025-02760-x","article-title":"Activation of a FOXO3-induced cell cycle arrest regulates ferroptosis","volume":"11","author":"Huang","year":"2025","journal-title":"Cell Death Discov"},{"key":"B21","doi-asserted-by":"publisher","first-page":"7144","DOI":"10.1038\/s41467-024-51542-z","article-title":"FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species","volume":"15","author":"Song","year":"2024","journal-title":"Nat Commun"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.07.046","article-title":"Immunometabolism of macrophages in the bone microenvironment: a new perspective for bone healing therapy","volume":"82","author":"Wang","year":"2025","journal-title":"J Adv Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41413-025-00424-1","article-title":"Bone-derived factors mediate crosstalk between skeletal and extra-skeletal organs","volume":"13","author":"He","year":"2025","journal-title":"Bone Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41420-025-02510-z","article-title":"Role of ANT2 in mitochondrial function and cancer cell survival: a target for therapeutic intervention","volume":"11","author":"Bohacova","year":"2025","journal-title":"Cell Death Discov"},{"key":"B25","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s12964-025-02186-z","article-title":"Glucose- and glutamine-driven de novo nucleotide synthesis facilitates WSSV replication in shrimp","volume":"23","author":"Chen","year":"2025","journal-title":"Cell Commun Signal"},{"key":"B26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/ijms25137441","article-title":"The protective effect of uridine in a rotenone-induced model of Parkinson\u2019s disease: the role of the mitochondrial ATP-dependent potassium channel","volume":"25","author":"Mironova","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109910","article-title":"Dexmedetomidine alleviates oxidative stress and mitochondrial dysfunction in diabetic peripheral neuropathy via the microRNA-34a\/SIRT2\/S1PR1 axis","volume":"117","author":"Lin","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1360891","article-title":"Uridine and its role in metabolic diseases, tumors, and neurodegenerative diseases","volume":"15","author":"Yang","year":"2024","journal-title":"Front Physiol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1435295","article-title":"Causal inference study of plasma proteins and blood metabolites mediating the effect of obesity-related indicators on osteoporosis","volume":"16","author":"Huang","year":"2025","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3390\/nu15071694","article-title":"Integration of metabolomics and transcriptomics to reveal the metabolic characteristics of exercise-improved bone mass","volume":"15","author":"Hou","year":"2023","journal-title":"Nutrients"},{"key":"B31","doi-asserted-by":"publisher","first-page":"16456","DOI":"10.1038\/s41598-018-34574-6","article-title":"Integrative bone metabolomics-lipidomics strategy for pathological mechanism of postmenopausal osteoporosis mouse model","volume":"8","author":"Zhao","year":"2018","journal-title":"Sci Rep"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1038\/s41467-024-46602-3","article-title":"Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis","volume":"15","author":"Zhao","year":"2024","journal-title":"Nat Commun"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.11.004","article-title":"Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1 beta expression","volume":"10","author":"Son","year":"2020","journal-title":"Acta Pharm Sin B"},{"key":"B34","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1172\/jci143137","article-title":"Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells","volume":"131","author":"Yu","year":"2021","journal-title":"J Clin Invest"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1013403","article-title":"A novel combination therapy with uridine and praziquantel effectively alleviates schistosomiasis-induced hepatic fibrosis through promoting adipogenic differentiation","volume":"21","author":"Zhou","year":"2025","journal-title":"PloS Pathog"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155516","article-title":"Luteolin rescues postmenopausal osteoporosis elicited by OVX through alleviating osteoblast pyroptosis via activating PI3K-AKT signaling","volume":"128","author":"Chai","year":"2024","journal-title":"Phytomedicine"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00948-y","article-title":"The serine synthesis pathway drives osteoclast differentiation through epigenetic regulation of NFATc1 expression","volume":"6","author":"Stegen","year":"2024","journal-title":"Nat Metab"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/jbmr\/zjaf040","article-title":"Heme metabolism mediates RANKL-induced osteoclastogenesis via mitochondrial oxidative phosphorylation","volume":"40","author":"Qiu","year":"2025","journal-title":"J Bone Miner Res"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-023-00825-3","article-title":"Novel insights into osteoclast energy metabolism","volume":"21","author":"Ledesma-Colunga","year":"2023","journal-title":"Curr Osteoporos Rep"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.34133\/bmef.0084","article-title":"Spatially resolved multiomics: data analysis from monoomics to multiomics","volume":"6","author":"Huan","year":"2025","journal-title":"BME Front"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-025-01402-7","article-title":"Uridine as a hub in cancer metabolism and RNA biology","volume":"57","author":"Choi","year":"2025","journal-title":"Exp Mol Med"},{"key":"B42","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.brainres.2017.09.010","article-title":"Uridine treatment protects against neonatal brain damage and long-term cognitive deficits caused by hyperoxia","volume":"1676","author":"Goren","year":"2017","journal-title":"Brain Res"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1039\/d0fo02533j","article-title":"Uridine attenuates obesity, ameliorates hepatic lipid accumulation and modifies the gut microbiota composition in mice fed with a high-fat diet","volume":"12","author":"Liu","year":"2021","journal-title":"Food Funct"},{"key":"B44","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3390\/ijms22189841","article-title":"Evaluating neuroprotective effects of uridine, erythropoietin, and therapeutic hypothermia in a ferret model of inflammation-sensitized hypoxic-ischemic encephalopathy","volume":"22","author":"Corry","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s44319-025-00520-7","article-title":"Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes","volume":"26","author":"Whyte","year":"2025","journal-title":"EMBO Rep"},{"key":"B46","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1186\/s12967-025-06708-8","article-title":"Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization","volume":"23","author":"Gao","year":"2025","journal-title":"J Transl Med"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2025.08.033","article-title":"Epimedin B attenuates ovariectomy-induced bone loss by suppressing osteoclastogenesis through decreasing ROS production and targeting ESR1","volume":"240","author":"Lai","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2024.10.012","article-title":"Moderate static magnetic field regulates iron metabolism and salvage bone loss caused by iron accumulation","volume":"50","author":"Zhen","year":"2025","journal-title":"J Orthopaedic Translation"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2025.06.043","article-title":"Idebenone attenuates RANKL-induced osteoclastogenesis and improves bone mass in ovariectomized mice","volume":"238","author":"Yu","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2025.156186","article-title":"Pharmacologically targeting fatty acid synthase-mediated de novo lipogenesis alleviates osteolytic bone loss by directly inhibiting osteoclastogenesis through suppression of STAT3 palmitoylation and ROS signaling","volume":"167","author":"Xiu","year":"2025","journal-title":"Metabolism"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2186112","article-title":"The role of autophagy in bone metabolism and clinical significance","volume":"19","author":"Wang","year":"2023","journal-title":"Autophagy"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1007\/s42765-025-00580-3","article-title":"Bienzyme-engineered fibrous membranes: A mitochondrial-targeted strategy to reverse bone loss in osteoporotic models","volume":"7","author":"Zhao","year":"2025","journal-title":"Adv Fiber Mater"},{"key":"B53","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41413-021-00142-4","article-title":"Endocrine role of bone in the regulation of energy metabolism","volume":"9","author":"Zhou","year":"2021","journal-title":"Bone Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.34133\/bmef.0036","article-title":"Making \u201cCASES\u201d for AI in medicine","volume":"5","author":"Wang","year":"2024","journal-title":"BME Front"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.149444","article-title":"3D printing of personalized magnesium composite bone tissue engineering scaffold for bone and angiogenesis regeneration","volume":"484","author":"Wang","year":"2024","journal-title":"Chem Eng J"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-0716-4217-7_1","article-title":"FOXO transcription factors: A brief overview","volume":"2871","author":"Link","year":"2025","journal-title":"Methods Mol Biol (Clifton NJ)"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2418023122","article-title":"Dnmt3a-mediated hypermethylation of FoxO3 promotes redox imbalance during osteoclastogenesis","volume":"122","author":"Zhang","year":"2025","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1767279\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:27:32Z","timestamp":1777264052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1767279\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":57,"alternative-id":["10.3389\/fimmu.2026.1767279"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1767279","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]},"article-number":"1767279"}}