{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T07:06:31Z","timestamp":1771830391474,"version":"3.50.1"},"reference-count":154,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    (Kp) is a multidrug-resistant (MDR) pathogen responsible for severe infections such as pneumonia, sepsis, and urinary tract infections. Its pathogenicity includes both bacterial virulence factors and host-driven inflammatory responses thereby complicating treatment outcomes. Herbal compounds (phytochemicals) have recently gained attention as promising dual-action therapeutic agents that target both infection and inflammation. Phytochemicals such as curcumin, berberine, quercetin, resveratrol, and several medicinal plant extracts have demonstrated an integrated ability to mitigate both infection as well as host inflammation in preclinical studies. Their ability to attenuate virulence, reduce oxidative stress, and regulate host immune signaling positions them as potential candidates for adjunctive therapy against Kp infections. Furthermore, phytochemical-antibiotic combinations demonstrate synergistic effects, enhancing bacterial clearance and reducing antibiotic dosage requirements. Overall, the dual action of phytochemicals makes them as valuable candidates for integrative therapies against\n                    <jats:italic>Kp<\/jats:italic>\n                    infections and related inflammatory diseases. Unlike the prior reviews, the present review uniquely focusses the dual antibacterial and immunomodulatory actions of plant-derived compounds against Kp. It adds a novel perspective integrating the therapeutic promise of phytochemicals with a systematic analysis of their translational limitations. Further, it provides a rational framework to guide future development of phytochemicals as potent and clinically viable therapeutics against Kp infections.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1767981","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T06:30:18Z","timestamp":1771828218000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual action of herbal compounds in Klebsiella pneumoniae infection and associated inflammatory diseases"],"prefix":"10.3389","volume":"17","author":[{"given":"Uzma","family":"Saqib","sequence":"first","affiliation":[{"name":"School of Life Sciences, Devi Ahilya Vishwavidyalaya","place":["Indore (MP), India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakina","family":"Ratlamwala","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Devi Ahilya Vishwavidyalaya","place":["Indore (MP), India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhi","family":"Kibe","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Devi Ahilya Vishwavidyalaya","place":["Indore (MP), India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirza S.","family":"Baig","sequence":"additional","affiliation":[{"name":"Mehta Family School of Biosciences & Biomedical Engineering, Indian Institute of Technology Indore (IITI)","place":["Indore, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnan","family":"Hajela","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Devi Ahilya Vishwavidyalaya","place":["Indore (MP), India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadhana","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences","place":["Patna, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/biology13020078","article-title":"General overview of klebsiella pneumonia: epidemiology and the role of siderophores in its pathogenicity","volume":"13","author":"Abbas","year":"2024","journal-title":"Biol (Basel)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1128\/cmr.11.4.589","article-title":"Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors","volume":"11","author":"Podschun","year":"1998","journal-title":"Clin Microbiol Rev"},{"key":"B3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1111\/joim.13007","article-title":"Hypervirulent Klebsiella pneumoniae - clinical and molecular perspectives","volume":"287","author":"Choby","year":"2020","journal-title":"J Intern Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801550","article-title":"Changes in prevalence of health care-associated infections in U.S","volume":"379","author":"Magill","year":"2018","journal-title":"Hospitals. N Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1050396","article-title":"Host defense against the infection of Klebsiella pneumoniae: New strategy to kill the bacterium in the era of antibiotics? Front","volume":"12","author":"Liang","year":"2022","journal-title":"Cell Infect Microbiol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e9896","DOI":"10.1371\/journal.pone.0009896","article-title":"Cooperative interactions between TLR4 and TLR9 regulate interleukin 23 and 17 production in a murine model of gram negative bacterial pneumonia","volume":"5","author":"Bhan","year":"2010","journal-title":"PloS One"},{"key":"B7","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12964-025-02149-4","article-title":"An examination of the LPS-TLR4 immune response through the analysis of molecular structures and protein\u2013protein interactions","volume":"23","author":"Luo","year":"2025","journal-title":"Cell Commun Signal"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.651664","article-title":"Bergenin Monohydrate Attenuates Inflammatory Response via MAPK and NF-\u03baB Pathways Against Klebsiella pneumonia Infection","volume":"12","author":"Tang","year":"2021","journal-title":"Front Pharmacol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2024.2439509","article-title":"Klebsiella pneumoniae capsular polysaccharide: Mechanism in regulation of synthesis, virulence, and pathogenicity","volume":"15","author":"Xu","year":"2024","journal-title":"Virulence"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/165974","article-title":"Cytokines in sepsis: potent immunoregulators and potential therapeutic targets\u2014An updated view","volume":"2013","author":"Schulte","year":"2013","journal-title":"Mediators Inflammation"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e16710","DOI":"10.1111\/jocd.16710","article-title":"Efficacy and safety of topical application of plant-based products on skin aging in healthy individuals: A systematic review and meta-analysis of randomized controlled trials","volume":"24","author":"Cheng","year":"2025","journal-title":"J Cosmet Dermatol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28020887","article-title":"Major phytochemicals: recent advances in health benefits and extraction method","volume":"28","author":"Kumar","year":"2023","journal-title":"Molecules"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.22377\/ijgp.v10i1.600","article-title":"Role of phytochemicals as immunomodulatory agents: A review","volume":"10","author":"Brindha","year":"2016","journal-title":"Int J Green Pharm (IJGP)"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmpp.2025.102668","article-title":"Sustainable futures: Allyl isothiocyanate in agro-industry and food science","volume":"138","author":"Priyadharshini","year":"2025","journal-title":"Physiol Mol Plant Pathol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering9090470","article-title":"Anticancer activity, mechanism, and delivery of allyl isothiocyanate","volume":"9","author":"Tarar","year":"2022","journal-title":"Bioengineering"},{"key":"B16","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1186\/s12866-020-01995-1","article-title":"Resveratrol enhances the antimicrobial effect of polymyxin B on Klebsiella pneumoniae and Escherichia coli isolates with polymyxin B resistance","volume":"20","author":"Liu","year":"2020","journal-title":"BMC Microbiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1080\/21553769.2015.1089949","article-title":"Antiproliferative activities of several plant extracts from Turkey on rat brain tumor and human cervix carcinoma cell lines","volume":"9","author":"Sahin Yagl\u0131oglu","year":"2016","journal-title":"Front Life Sci"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-020-10082-6","article-title":"Investigation of the cytotoxicity of bioinspired coumarin analogues towards human breast cancer cells","volume":"25","author":"Gkionis","year":"2021","journal-title":"Mol Diversity"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.17305\/bb.2026.13776","article-title":"Synergistic effect of the rifaximin-berberine combination against Klebsiella pneumoniae: RfaH targeting supported by MD simulation","author":"Ashraf","year":"2026","journal-title":"Biomol Biomed"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19056583","article-title":"Berberine enhances the antibacterial activity of selected antibiotics against coagulase-negative staphylococcus strains in vitro","volume":"19","author":"Wojtyczka","year":"2014","journal-title":"Molecules"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6252","article-title":"Berberine and barberry (Berberis vulgaris): A clinical review","volume":"33","author":"Imenshahidi","year":"2019","journal-title":"Phytother Res"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.106170","article-title":"Mahanimbine isolated from Murraya koenigii inhibits P-glycoprotein involved in lung cancer chemoresistance","volume":"129","author":"Mondal","year":"2022","journal-title":"Bioorganic Chem"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16119651","article-title":"Biological activity of carbazole alkaloids and essential oil of murraya koenigii against antibiotic resistant microbes and cancer cell lines","volume":"16","author":"Nagappan","year":"2011","journal-title":"Molecules"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15225488","article-title":"The promise of piperine in cancer chemoprevention","volume":"15","author":"Benayad","year":"2023","journal-title":"Cancers (Basel)"},{"key":"B25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3390\/suschem4010005","article-title":"Innovative green approach for extraction of piperine from black pepper based on response surface methodology","volume":"4","author":"Lwamba","year":"2023","journal-title":"Sustain Chem"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/separations10010021","article-title":"Evaluation of antimicrobial activity and cytotoxicity effects of extracts of piper nigrum L","volume":"10","author":"Alves","year":"2023","journal-title":"Piperine. Separations"},{"key":"B27","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s00284-025-04456-y","article-title":"Anti-bacterial properties of propolis: A comprehensive review","volume":"82","author":"Rana","year":"2025","journal-title":"Curr Microbiol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e00158","DOI":"10.1002\/cbdv.202500158","article-title":"A promising antibacterial inhibition of propolis extracts against carbapenem-resistant bacteria isolated from clinical samples","volume":"22","author":"Eserta\u015f","year":"2025","journal-title":"Chem Biodiversity"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2025.106526","article-title":"Propolis: A comprehensive review on the nature\u2019s polyphenolic wonder","volume":"183","author":"Balasubramaniam","year":"2025","journal-title":"Fitoterapia"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.795150","article-title":"Quercetin rejuvenates sensitization of colistin-resistant escherichia coli and klebsiella pneumoniae clinical isolates to colistin","volume":"9","author":"Lin","year":"2021","journal-title":"Front Chem"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1038\/s41598-017-02548-9","article-title":"Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil","volume":"7","author":"Ishida","year":"2017","journal-title":"Sci Rep"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104120","article-title":"Demonstration of bactericidal and synergistic activity of quercetin with meropenem among pathogenic carbapenem resistant Escherichia coli and Klebsiella pneumoniae","volume":"143","author":"Pal","year":"2020","journal-title":"Microbial Pathogenesis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbe1603030","article-title":"Quercetin, the potential powerful flavonoid for human and food: A review","volume":"16","author":"Baqer","year":"2024","journal-title":"Front Biosci (Elite Ed)"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2025.100926","article-title":"A comprehensive review on Kaempferol as a therapeutic flavonoid against ESKAPE and multiple drug-resistant bacteria: Recent advances and challenges","author":"Setyawan","year":"2026","journal-title":"Phytomedicine"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02265-22","article-title":"The antibacterial activity of kaempferol combined with colistin against colistin-resistant gram-negative bacteria","volume":"10","author":"Zhou","year":"2022","journal-title":"Microbiol Spectr"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232315054","article-title":"Kaempferol: antimicrobial properties, sources, clinical, and traditional applications","volume":"23","author":"A","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262110414","article-title":"Synergistic effects of curcumin and antibiotics against drug-sensitive and multidrug-resistant mycobacterium tuberculosis","volume":"26","author":"Lara-Espinosa","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25158136","article-title":"Efficacy of curcumin-mediated antimicrobial photodynamic therapy on candida spp.-A systematic review","volume":"25","author":"Kubizna","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2021-0222","article-title":"Characterization of virulence factors and antibacterial activity of curcumin in hypervirulent klebsiella pneumoniae","volume":"17","author":"Karami-Zarandi","year":"2022","journal-title":"Future Microbiol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/foods6100092","article-title":"Curcumin: A review of its\u2019 Effects on human health","volume":"6","author":"Hewlings","year":"2017","journal-title":"Foods"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1458267","article-title":"Synergistic combination of baicalein and rifampicin against Staphylococcus aureus biofilms","volume":"15","author":"Muniyasamy","year":"2024","journal-title":"Front Microbiol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117488","article-title":"Revealing active constituents within traditional Chinese Medicine used for treating bacterial pneumonia, with emphasis on the mechanism of baicalein against multi-drug resistant Klebsiella pneumoniae","volume":"321","author":"Qin","year":"2024","journal-title":"J Ethnopharmacology"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2023.100326","article-title":"An updated review of Chinese skullcap (Scutellaria baicalensis): Emphasis on phytochemical constituents and pharmacological attributes","volume":"9","author":"Chanchal","year":"2023","journal-title":"Pharmacol Res - Modern Chin Med"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.116028","article-title":"Naringin alleviates pneumonia caused by Klebsiella pneumoniae infection by suppressing NLRP3 inflammasome","volume":"170","author":"Jing","year":"2024","journal-title":"BioMed Pharmacother"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115940","article-title":"Therapeutic effect and safety evaluation of naringin on klebsiella pneumoniae in mice","volume":"24","author":"Zhao","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28155623","article-title":"Phytochemical properties, extraction, and pharmacological benefits of naringin: A review","volume":"28","author":"Shilpa","year":"2023","journal-title":"Molecules"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2020.08.006","article-title":"Prenylated phenolics as promising candidates for combination antibacterial therapy: Morusin and kuwanon G","volume":"28","author":"Aelenei","year":"2020","journal-title":"Saudi Pharm J"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2004.10.001","article-title":"In vitro activity of three different antimicrobial agents against ESBL producing Escherichia coli and Klebsiella pneumoniae blood isolates","volume":"160","author":"Kizirgil","year":"2005","journal-title":"Microbiological Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3390\/nu17091539","article-title":"Inhibition mechanism of mulberry prenylated flavonoids sanggenone D\/kuwanon G against \u03b1-glucosidase and the regulation of glucose via GLUT4 pathway","volume":"17","author":"Wu","year":"2025","journal-title":"Nutrients"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156085","article-title":"Insights into the anticancer effects of galangal and galangin: A comprehensive review","volume":"135","author":"Wu","year":"2024","journal-title":"Phytomedicine"},{"key":"B51","doi-asserted-by":"publisher","first-page":"74","DOI":"10.14715\/cmb\/","article-title":"Synergistic antibacterial effect of apigenin with \u00ce2-lactam antibiotics and modulation of bacterial resistance by a possible membrane effect against methicillin resistant Staphylococcus aureus","volume":"62","author":"Akilandeswari","year":"2016","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1900","article-title":"A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.)","volume":"20","author":"McKay","year":"2006","journal-title":"Phytother Res"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12091469","article-title":"The direction of the antibacterial effect of rutin hydrate and amikacin","volume":"12","author":"Miklasi\u0144ska-Majdanik","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"B54","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12906-015-0580-0","article-title":"Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus","volume":"15","author":"Amin","year":"2015","journal-title":"BMC Complement Altern Med"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2021.10.006","article-title":"Health benefits and limitations of rutin - A natural flavonoid with high nutraceutical value","volume":"46","author":"Semwal","year":"2021","journal-title":"Phytochem Lett"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29051093","article-title":"Effects and mechanisms of luteolin, a plant-based flavonoid, in the prevention of cancers via modulation of inflammation and cell signaling molecules","volume":"29","author":"Almatroodi","year":"2024","journal-title":"Molecules"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28062609","article-title":"Luteolin 4\u2032-neohesperidoside inhibits clinically isolated resistant bacteria in vitro and in vivo","volume":"28","author":"El-Shiekh","year":"2023","journal-title":"Molecules"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c03741","article-title":"Daidzein from Dietary Supplement to a Drug Candidate: An Evaluation of Potential","volume":"8","author":"Ubaid","year":"2023","journal-title":"ACS Omega"},{"key":"B59","doi-asserted-by":"publisher","first-page":"66","DOI":"10.5582\/ddt.2013.v7.2.66","article-title":"Antimicrobial action mechanism of flavonoids from Dorstenia species","volume":"7","author":"Paul Dzoyem","year":"2013","journal-title":"Drug Discoveries Ther"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S515798","article-title":"Daidzein-decorated gold nanoparticles as a novel antimicrobial strategy against carbapenem-resistant enterobacteriaceae","volume":"20","author":"Pan","year":"2025","journal-title":"Int J Nanomedicine"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/3268136","article-title":"Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits","volume":"2021","author":"Sharifi-Rad","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201000438","article-title":"Extraction and isolation of catechins from tea","volume":"33","author":"Vuong","year":"2010","journal-title":"J Sep Sci"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.12.058","article-title":"Evaluation of antibacterial and modifying action of catechin antibiotics in resistant strains","volume":"115","author":"Gomes","year":"2018","journal-title":"Microbial Pathogenesis"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14011802","article-title":"The combination of catechin and epicatechin gallate from fructus crataegi potentiates \u03b2-lactam antibiotics against methicillin-resistant staphylococcus aureus (MRSA) in vitro and in vivo","volume":"14","author":"Qin","year":"2013","journal-title":"Int J Mol Sci"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3945\/an.113.005603","article-title":"Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action","volume":"5","author":"Alam","year":"2014","journal-title":"Adv Nutr"},{"key":"B66","volume-title":"Exploring microorganisms: recent advances in applied microbiology","author":"Mendez-Vilas","year":"2018"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1453426","article-title":"Licochalcone A: a review of its pharmacology activities and molecular mechanisms","volume":"15","author":"Liu","year":"2024","journal-title":"Front Pharmacol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.amolm.2025.100066","article-title":"Chalcone-related small molecules as potent antibacterial and antifungal agents: Design, synthesis, In vitro, and computational approaches","volume":"5","author":"Hussen","year":"2025","journal-title":"Aspects Mol Med"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-008-0012-7","article-title":"Synergistic effects of the combination of galangin with gentamicin against methicillin-resistant Staphylococcus aureus","volume":"46","author":"Lee","year":"2008","journal-title":"J Microbiol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2004.09.018","article-title":"Galangin expresses bactericidal activity against multiple-resistant bacteria: MRSA, Enterococcus spp. and Pseudomonas aeruginosa","volume":"240","author":"Pepeljnjak","year":"2004","journal-title":"FEMS Microbiol Lett"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.105112","article-title":"Clove essential oil and eugenol: A review of their significance and uses","volume":"62","author":"Silva","year":"2024","journal-title":"Food Bioscience"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.10.005","article-title":"In vitro efficacy of eugenol in inhibiting single and mixed-biofilms of drug-resistant strains of Candida albicans and Streptococcus mutans","volume":"54","author":"Jafri","year":"2019","journal-title":"Phytomedicine"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.1099150","article-title":"Complete genome analysis of Bacillus subtilis derived from yaks and its probiotic characteristics","volume":"9","author":"Li","year":"2023","journal-title":"Front Vet Sci"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120765","article-title":"Multi-target therapeutics of geraniin from Geranium wilfordii Maxim. and related species: Mechanisms and applications","volume":"356","author":"Cai","year":"2026","journal-title":"J Ethnopharmacol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"95","DOI":"10.4172\/2161-0444.1000332","article-title":"Anti-infective Properties and Time-Kill Kinetics of Phyllanthus muellerianus and its Major Constituent, Geraniin","volume":"6","author":"Boakye","year":"2016","journal-title":"Medicinal Chemistry: Curr Res"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2018.08.001","article-title":"Linalool bioactive properties and potential applicability in drug delivery systems","volume":"171","author":"Pereira","year":"2018","journal-title":"Colloids Surf B Biointerfaces"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.635016","article-title":"Combinatorial antimicrobial efficacy and mechanism of linalool against clinically relevant klebsiella pneumoniae","volume":"12","author":"Yang","year":"2021","journal-title":"Front Microbiol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2024.106051","article-title":"A comprehensive review on the pharmacological prospects of Terpinen-4-ol: From nature to medicine and beyond","volume":"176","author":"Prerna","year":"2024","journal-title":"Fitoterapia"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217472","article-title":"First evidence of a combination of terpinen-4-ol and \u03b1-terpineol as a promising tool against ESKAPE pathogens","volume":"27","author":"Johansen","year":"2022","journal-title":"Molecules"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1080\/22311866.2022.2154264","article-title":"Terpinen-4-ol, An Active Constituent of Kewda Essential Oil, Mitigates Biofilm Forming Ability of Multidrug Resistant Staphylococcus aureus and Klebsiella pneumoniae","volume":"12","author":"Cheruvanachari","year":"2022","journal-title":"J Biologically Active Products Nat"},{"key":"B81","volume-title":"Extraction, production and analysis techniques for menthol: A review","author":"Batool","year":"2018"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00420","article-title":"Sub-MICs of Mentha piperita essential oil and menthol inhibits AHL mediated quorum sensing and biofilm of Gram-negative bacteria","volume":"6","author":"Husain","year":"2015","journal-title":"Front Microbiol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jafr.2024.101570","article-title":"Chemical composition and citral content of essential oil of lemongrass (Cymbopogon citratus (DC.) Stapf) leaf waste prepared with various production methods","volume":"19","author":"Khasanah","year":"2025","journal-title":"J Agric Food Res"},{"key":"B84","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.phymed.2017.08.016","article-title":"Citral, a monoterpenoid aldehyde interacts synergistically with norfloxacin against methicillin resistant Staphylococcus aureus","volume":"34","author":"Gupta","year":"2017","journal-title":"Phytomedicine"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1088\/1757-899X\/1053\/1\/012118","article-title":"A brief review on the characteristics, extraction and potential industrial applications of citronella grass (Cymbopogon nardus) and lemongrass (Cymbopogon citratus) essential oils","volume":"1053","author":"Kumoro","year":"2021","journal-title":"IOP Conf Series: Materials Sci Eng"},{"key":"B86","doi-asserted-by":"publisher","first-page":"106","DOI":"10.4172\/2471-2663.1000106","article-title":"Antimicrobial activity of citronella essential oil on antimicro bial drug resistant bacteria from veterinary clinical cases","volume":"1","author":"Singh","year":"2015","journal-title":"Clin Med Biochem Open Access"},{"key":"B87","doi-asserted-by":"publisher","first-page":"e20250277","DOI":"10.1590\/0001-3765202520250277","article-title":"Bactericidal effect of citronellal and molecular docking with KPC-2 of Klebsiella pneumoniae and PBP2A of Staphylococcus aureus. An","volume":"97","author":"Silva","year":"2025","journal-title":"Acad Bras Ci\u00eanc"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.22159\/ijpps.2022v14i10.45766","article-title":"KAFUR (C. CAMPHORA L.)-AN UPDATED REVIEW OF ITS ETHNOPHARMACOLOGY, PHYTOCHEMISTRY AND PHARMACOLOGY review article","volume":"14","author":"Usmani","year":"2022","journal-title":"Int J Pharm Pharm Sci"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2021.113080","article-title":"Carvone and its pharmacological activities: A systematic review","volume":"196","author":"Pina","year":"2022","journal-title":"Phytochemistry"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2011.02363.x","article-title":"Inhibitory effects of various essential oils and individual components against extended-spectrum beta-lactamase (ESBL) produced by Klebsiella pneumoniae and their chemical compositions","volume":"76","author":"Orhan","year":"2011","journal-title":"J Food Sci"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6109","article-title":"Thymol, thyme, and other plant sources: Health and potential uses","volume":"32","author":"Salehi","year":"2018","journal-title":"Phytother Res"},{"key":"B92","volume-title":"Thymol: antibacterial, antifungal and antioxidant activities","author":"Braga","year":"2005"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1487083","article-title":"Thymol and carvacrol against Klebsiella: anti-bacterial, anti-biofilm, and synergistic activities\u2014a systematic review","volume":"15","author":"Farhadi","year":"2024","journal-title":"Front Pharmacol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"198","DOI":"10.14715\/cmb\/2023.69.3.29","article-title":"Evaluating the synergistic potency of essential oils and antibiotics against klebsiella pneumoniae BLSE strains","volume":"69","author":"Bariz","year":"2023","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16040521","article-title":"Comparative cytotoxicity of menthol and eucalyptol: an in vitro study on human gingival fibroblasts","volume":"16","author":"Puig-Herreros","year":"2024","journal-title":"Pharmaceutics"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2003.1432","article-title":"Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial","volume":"97","author":"Juergens","year":"2003","journal-title":"Respir Med"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26195914","article-title":"Pharmacological and therapeutic potential of myristicin: A literature review","volume":"26","author":"Seneme","year":"2021","journal-title":"Molecules"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1467460","article-title":"Essential oils as capsule disruptors: enhancing antibiotic efficacy against multidrug-resistant Klebsiella pneumoniae","volume":"15","author":"El-Demerdash","year":"2024","journal-title":"Front Microbiol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2006.10.001","article-title":"Antibacterials and modulators of bacterial resistance from the immature cones of Chamaecyparis lawsoniana","volume":"68","author":"Smith","year":"2007","journal-title":"Phytochemistry"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113520","article-title":"Biological activities of organic extracts and specialized metabolites from different parts of Cryptomeria japonica (Cupressaceae) \u2013 A critical review","volume":"206","author":"Lima","year":"2023","journal-title":"Phytochemistry"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2023.105811","article-title":"Insights into the preventive actions of natural compounds against Klebsiella pneumoniae infections and drug resistance","volume":"173","author":"Saifi","year":"2024","journal-title":"Fitoterapia"},{"key":"B102","doi-asserted-by":"publisher","first-page":"26240","DOI":"10.1074\/jbc.A116.508892","article-title":"MyD88 adapter-like (Mal) is phosphorylated by Bruton\u2019s tyrosine kinase during TLR2 and TLR4 signal transduction","volume":"291","author":"Gray","year":"2016","journal-title":"J Biol Chem"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11051156","article-title":"Insights into antimicrobial and anti-inflammatory applications of plant bioactive compounds","volume":"11","author":"Mitropoulou","year":"2023","journal-title":"Microorganisms"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-025-02716-4","article-title":"Emergence of resistance to novel \u03b2-lactam\/\u03b2-lactamase inhibitor combinations in KPC-producing Klebsiella pneumoniae: clinical and genomic insights from consecutive bloodstream infections","author":"Boattini","year":"2025","journal-title":"Infection"},{"key":"B105","doi-asserted-by":"publisher","first-page":"e0170125","DOI":"10.1371\/journal.pone.0170125","article-title":"Differences in inflammatory response induced by two representatives of clades of the pandemic ST258 klebsiella pneumoniae clonal lineage producing KPC-type carbapenemases","volume":"12","author":"Castronovo","year":"2017","journal-title":"PloS One"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.3390\/microbiolres16050090","article-title":"The presence of an ESBL-encoding plasmid reported during a klebsiella pneumoniae nosocomial outbreak in the United Kingdom","volume":"16","author":"Fordham","year":"2025","journal-title":"Microbiol Res"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2025.107399","article-title":"Emerging challenges in Klebsiella pneumoniae: Antimicrobial resistance and novel approach","volume":"202","author":"Shah","year":"2025","journal-title":"Microbial Pathogenesis"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad428","article-title":"Infectious Diseases Society of America 2023 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections","author":"Tamma","year":"2023","journal-title":"Clin Infect Dis"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2024.09.031","article-title":"In vitro activity of cefepime-enmetazobactam on carbapenem-resistant Gram negatives","volume":"31","author":"Bonnin","year":"2025","journal-title":"Clin Microbiol Infect"},{"key":"B110","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1186\/s13643-024-02695-x","article-title":"Efficiency of combination therapy versus monotherapy for the treatment of infections due to carbapenem-resistant Gram-negative bacteria: a systematic review and meta-analysis","volume":"13","author":"Lai","year":"2024","journal-title":"Syst Rev"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.01.014","article-title":"Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria","volume":"25","author":"Kortright","year":"2019","journal-title":"Cell Host Microbe"},{"key":"B112","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12992-024-01046-8","article-title":"AMR and Sustainable Development Goals: at a crossroads","volume":"20","author":"Aslam","year":"2024","journal-title":"Global Health"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.glmedi.2024.100081","article-title":"Antimicrobial resistance: Impacts, challenges, and future prospects","volume":"2","author":"Ahmed","year":"2024","journal-title":"J Medicine Surgery Public Health"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1489317","article-title":"Systematic review of multidrug-resistant Klebsiella pneumoniae in the Arabian Peninsula: molecular epidemiology and resistance patterns","volume":"16","author":"Idrees","year":"2025","journal-title":"Front Microbiol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1021\/bm2017959","article-title":"Molecular spectroscopy evidence of berberine binding to DNA: comparative binding and thermodynamic profile of intercalation","volume":"13","author":"Li","year":"2012","journal-title":"Biomacromolecules"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.1c00642","article-title":"Hormesis Effect of Berberine against Klebsiella pneumoniae Is Mediated by Up-Regulation of the Efflux Pump KmrA","volume":"84","author":"Li","year":"2021","journal-title":"J Nat Prod"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2021.105121","article-title":"Antioxidant and antibacterial study of 10 flavonoids revealed rutin as a potential antibiofilm agent in Klebsiella pneumoniae strains isolated from hospitalized patients","volume":"159","author":"Wang","year":"2021","journal-title":"Microbial Pathogenesis"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151119552","article-title":"Antimicrobial activity of isothiocyanates from cruciferous plants against methicillin-resistant Staphylococcus aureus (MRSA)","volume":"15","author":"Dias","year":"2014","journal-title":"Int J Mol Sci"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030624","article-title":"Isothiocyanates: an overview of their antimicrobial activity against human infections","volume":"23","author":"Romeo","year":"2018","journal-title":"Molecules"},{"key":"B120","article-title":"Synergistic effect of propolis extract and antibiotics on multi-resist klebsiella pneumoniae strain isolated from wound","volume":"43","author":"Taher","year":"2015","journal-title":"Adv Life Sci Technol"},{"key":"B121","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/B978-0-443-15383-9.00005-6","article-title":"Chapter 4 - Synergistic effects of plant extracts for antimicrobial therapy","volume-title":"Herbal formulations, phytochemistry and pharmacognosy, drug discovery update","author":"Khodaie","year":"2024"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2024.e00347","article-title":"Berberine inhibits NLRP3 inflammasome activation and proinflammatory macrophage M1 polarization to accelerate peripheral nerve regeneration","volume":"21","author":"Sun","year":"2024","journal-title":"Neurotherapeutics"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.3390\/plants11192623","article-title":"Bioactivity and therapeutic potential of kaempferol and quercetin: new insights for plant and human health","volume":"11","author":"Jan","year":"2022","journal-title":"Plants (Basel)"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00369","article-title":"Curcumin represses NLRP3 inflammasome activation via TLR4\/myD88\/NF-\u03baB and P2X7R signaling in PMA-induced macrophages","volume":"7","author":"Kong","year":"2016","journal-title":"Front Pharmacol"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e29361","article-title":"Baicalin reduces inflammation to inhibit lung cancer via targeting SOCS1\/NF-\u03baB\/STAT3 axis","volume":"10","author":"Guo","year":"2024","journal-title":"Heliyon"},{"key":"B126","doi-asserted-by":"publisher","first-page":"e44107","DOI":"10.1371\/journal.pone.0044107","article-title":"Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells","volume":"7","author":"Zong","year":"2012","journal-title":"PloS One"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.onano.2023.100170","article-title":"Antimicrobial activity of nanoformulations of carvacrol and thymol: New trend and applications","volume":"13","author":"Hajibonabi","year":"2023","journal-title":"OpenNano"},{"key":"B128","doi-asserted-by":"publisher","first-page":"20824","DOI":"10.1038\/s41598-021-00249-y","article-title":"Antimicrobial activity and mode of action of 1,8-cineol against carbapenemase-producing Klebsiella pneumoniae","volume":"11","author":"Moo","year":"2021","journal-title":"Sci Rep"},{"key":"B129","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.jtcme.2019.02.006","article-title":"Andrographis paniculata extract inhibit growth, biofilm formation in multidrug resistant strains of Klebsiella pneumoniae","volume":"10","author":"Sah","year":"2019","journal-title":"J Tradit Complement Med"},{"key":"B130","volume-title":"The efficacy of herbs against Klebsiella pneumoniae with special reference to polyherbal formulation: An update","author":"Barik","year":"2014"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042134","article-title":"Plant-origin components: new players to combat antibiotic resistance in klebsiella pneumoniae","volume":"25","author":"Luna-Pineda","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt8239","article-title":"A plant peptide with dual activity against multidrug-resistant bacterial and fungal pathogens","volume":"11","author":"Chen","year":"2025","journal-title":"Sci Adv"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.3390\/plants11111429","article-title":"Anti-Biofilm and Associated Anti-Virulence Activities of Selected Phytochemical Compounds against Klebsiella pneumoniae","volume":"11","author":"Adeosun","year":"2022","journal-title":"Plants (Basel)"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/j.crbiot.2023.100152","article-title":"Anti-inflammatory activity of phytochemicals from medicinal plants and their nanoparticles: A review","volume":"6","author":"Gonfa","year":"2023","journal-title":"Curr Res Biotechnol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2025.e02644","article-title":"Effectiveness of African herbal preparations against multidrug-resistant Klebsiella pneumoniae: A systematic review","volume":"28","author":"Akorful","year":"2025","journal-title":"Sci Afr"},{"key":"B136","doi-asserted-by":"publisher","first-page":"27","DOI":"10.55544\/jrasb.4.3.4","article-title":"Comparing phytochemicals and conventional antibiotics: mechanisms, affinities, and therapeutic potential review","volume":"4","author":"Das","year":"2025","journal-title":"J Res Appl Sci Biotechnol"},{"key":"B137","doi-asserted-by":"publisher","first-page":"48","DOI":"10.9734\/ajrb\/2025\/v15i1350","article-title":"Therapeutic potentials of phytochemicals in combatting antimicrobial resistance (AMR)","volume":"15","author":"Popoola","year":"2025","journal-title":"Asian J Res Biochem"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1591534","article-title":"The neurobiology of plant-based therapeutics in women\u2019s reproductive health: mechanisms, efficacy, and clinical translation","volume":"12","author":"Liu","year":"2025","journal-title":"Front Nutr"},{"key":"B139","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s40203-025-00421-6","article-title":"Deciphering curcumin\u2019s differential inhibition of KPC-3, L2, and CTX-M-15 \u03b2-lactamases through binding energetics and structural dynamics","volume":"13","author":"Shirzadi","year":"2025","journal-title":"In Silico Pharmacol"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.3390\/biom15060774","article-title":"Exploring the therapeutic potential of natural compounds and plant extracts in human health","volume":"15","author":"Zeppa","year":"2025","journal-title":"Biomolecules"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodhyd.2022.108165","article-title":"Bioaccessibility and bioavailability of phytochemicals: Influencing factors, improvements, and evaluations","volume":"135","author":"Hu","year":"2023","journal-title":"Food Hydrocolloids"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11030322","article-title":"Antimicrobial potential of curcumin: therapeutic potential and challenges to clinical applications","volume":"11","author":"Hussain","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00487","article-title":"Nanocurcumin: A promising candidate for therapeutic applications","volume":"11","author":"Karthikeyan","year":"2020","journal-title":"Front Pharmacol"},{"key":"B144","article-title":"Chapter Six - Potential risks of phytonutrients associated with high-dose or long-term use","volume-title":"Phytonutrients in food, woodhead publishing series in food science, technology and nutrition","author":"S\u00fcntar","year":"2020"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2024.e02395","article-title":"A comprehensive review on medicinal plant extracts as antibacterial agents: Factors, mechanism insights and future prospects","volume":"26","author":"Zouine","year":"2024","journal-title":"Sci Afr"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.medidd.2025.100211","article-title":"Current demands for standardization of Indian medicinal plants: A critical review","volume":"27","author":"Kaundal","year":"2025","journal-title":"Med Drug Discov"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S499893","article-title":"From plant based therapy to plant-derived vesicle-like nanoparticles for cancer treatment: past, present and future","volume":"20","author":"An","year":"2025","journal-title":"Int J Nanomedicine"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215251","article-title":"Liposomes and phytosomes: Nanocarrier systems and their applications for the delivery of phytoconstituents","volume":"491","author":"Dutt","year":"2023","journal-title":"Coordination Chem Rev"},{"key":"B149","doi-asserted-by":"publisher","first-page":"16","DOI":"10.33545\/26646862.2025.v7.i1a.89","article-title":"Phytosomes as innovative delivery systems for phytochemicals: An updated review","volume":"7","author":"Purohit","year":"2025","journal-title":"Int J Pharm Res Dev"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157090","article-title":"Exploring the therapeutic potential of phytochemicals: challenges and strategies for clinical translation","volume":"145","author":"Kim","year":"2025","journal-title":"Phytomedicine"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200504-037SR","article-title":"Pharmacologic principles for combination therapy","volume":"2","author":"Toews","year":"2005","journal-title":"Proc Am Thorac Soc"},{"key":"B152","doi-asserted-by":"publisher","first-page":"24","DOI":"10.26438\/ijsrbs.v12i4.705","article-title":"Phytochemical-antibiotic synergy: exploring the antibacterial potential of calotropis procera in combination therapy","volume":"12","author":"Emmanuel","year":"2025","journal-title":"Int J Sci Res Biol Sci"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2025.126999","article-title":"Nanoparticle-enhanced drug delivery systems: An up-to-date review","volume":"424","author":"Chenxi","year":"2025","journal-title":"J Mol Liquids"},{"key":"B154","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3831\/KPI.2022.25.2.79","article-title":"Potential role of bioactive phytochemicals in combination therapies against antimicrobial activity","volume":"25","author":"Choudhury","year":"2022","journal-title":"J Pharmacopuncture"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1767981\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T06:30:21Z","timestamp":1771828221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1767981\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":154,"alternative-id":["10.3389\/fimmu.2026.1767981"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1767981","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]},"article-number":"1767981"}}