{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:12:57Z","timestamp":1771485177780,"version":"3.50.1"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Ferroptosis is an iron-dependent, lipid peroxidation-driven form of programmed cell death that plays an important role in neurodegenerative, neoplastic, and autoimmune diseases. Recent studies in Rheumatoid arthritis (RA) have shown that iron metabolism disorders caused by iron overload and impaired transferrin function lead to the production of reactive oxygen species; ferroptosis-associated pathways, such as dysregulation of the System Xc\n                    <jats:sup>-<\/jats:sup>\n                    \/GPX4 axis dysregulation, NCOA4-mediated ferritin autophagy, endoplasmic reticulum stress and ferroptosis pathway crosstalk; as well as ferroptosis plays a regulatory role in a variety of immune cells, such as T-cells, B-cells, macrophages, etc., which collectively constitute a complex disease regulatory network in RA. Studies have shown that traditional Chinese medicine (TCM) and TCM therapeutics can alleviate RA-related symptoms and improve the disease progression and prognosis of RA by regulating iron metabolism, activating the Nrf2\/HO-1 antioxidant pathway, and removing abnormally proliferating synovial fibroblasts (FLS cells). The aim of this review is to comprehensively summarize the therapeutic potential of TCM for RA using ferroptosis as a therapeutic pathway. The aim is to provide a scientific basis for the clinical application of TCM in RA. In major scientific databases (including PubMed, Web of Science, ScienceDirect, and CNKI, covering literature published up to June 2025). The search strategy combines \u201cChinese medicine\u201d, \u201cTCM\u201d, \u201cferroptosis\u201d, and \u201crheumatoid arthritis\u201d, using Boolean operators (AND, OR). This review systematically elucidates the mechanistic underpinnings through which TCM mitigates RA by modulating ferroptosis pathways. This review highlights the potential that Chinese medicine holds in the treatment of RA. The use of ferroptosis as a therapeutic pivot provides new ideas for the treatment of RA and promotes the integration of Western and Chinese medicine.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1768013","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:42:07Z","timestamp":1771483327000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ferroptosis as a therapeutic nexus: traditional Chinese medicine interventions in rheumatoid arthritis"],"prefix":"10.3389","volume":"17","author":[{"given":"Ruibin","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University","place":["Xi\u2019an, China"]},{"name":"State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases","place":["Xi\u2019an, 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