{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:01:17Z","timestamp":1793062877496,"version":"4.5.0"},"reference-count":139,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3503501, 2023YFC3503504"],"award-info":[{"award-number":["2023YFC3503501, 2023YFC3503504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174314"],"award-info":[{"award-number":["82174314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2025-JYB-XJSJJ005"],"award-info":[{"award-number":["2025-JYB-XJSJJ005"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The immunometabolic checkpoint axis formed by the IDO1\/AhR pathway and the HIF-1\u03b1 pathway, which functionally antagonize each other via their competition for the shared transcriptional partner aryl hydrocarbon receptor nuclear translocator (ARNT), profoundly regulates the pathogenesis and progression of autoimmune diseases. Following activation of the aryl hydrocarbon receptor (AhR) by kynurenine (Kyn), a tryptophan metabolite generated by IDO1, the activated AhR and hypoxia-induced HIF-1\u03b1 intensely compete for the limited pool of ARNT protein. This competition results in the formation of two distinct transcriptional complexes: AhR\/ARNT and HIF-1\u03b1\/ARNT. These complexes drive opposing immune programs. The AhR\/ARNT complex promotes immune tolerance by facilitating Treg cell differentiation, inducing a tolerogenic phenotype in dendritic cells, promoting M2 macrophage polarization, and sustaining the survival of long-lived plasma cells. Conversely, the HIF-1\u03b1\/ARNT complex enhances glycolysis and amplifies inflammation, driving Th17 cell differentiation, activating the pro-inflammatory functions of dendritic cells, promoting M1 macrophage polarization, and stimulating plasmablast proliferation. In autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), and membranous nephropathy (MN), dysregulation of this axis is characterized by excessive HIF-1\u03b1 signaling and relative insufficiency of the IDO1\/AhR pathway. This imbalance leads to the monopolization of ARNT by the HIF-1\u03b1 pathways, consequently exacerbating Treg\/Th17 imbalance, autoantibody production, and tissue damage. Targeting this axis, for instance through combined HIF-1\u03b1 inhibitors and IDO1\/AhR pathway agonists, holds promise as a novel metabolic intervention strategy for autoimmune diseases.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1772536","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:44:33Z","timestamp":1772779473000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The IDO1\/AhR-HIF-1\u03b1 metabolic axis: ARNT competition as a central antagonistic switch in autoimmune pathogenesis"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhaocheng","family":"Dong","sequence":"first","affiliation":[{"name":"Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Dai","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University","place":["Beijing, China"]},{"name":"Shunyi Branch, Beijing Traditional Chinese Medicine Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University","place":["Beijing, China"]},{"name":"Beijing Hospital of Integrated Traditional Chinese and Western Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine","place":["Beijing, China"]},{"name":"Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangzi","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Rui","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoli","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianggen","family":"Zhong","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1073971","article-title":"Emerging role of hypoxia-inducible factor-1alpha in inflammatory autoimmune diseases: A comprehensive review","volume":"13","author":"Tang","year":"2022","journal-title":"Front Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00551","article-title":"Aryl hydrocarbon receptor and kynurenine: recent advances in autoimmune disease research","volume":"5","author":"Nguyen","year":"2014","journal-title":"Front Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"101573","DOI":"10.1016\/j.arr.2022.101573","article-title":"Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process","volume":"75","author":"Salminen","year":"2022","journal-title":"Ageing Res Rev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01889","article-title":"Regulatory T cell metabolism in the hepatic microenvironment","volume":"8","author":"Wawman","year":"2017","journal-title":"Front Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"115371","DOI":"10.1016\/j.bcp.2022.115371","article-title":"Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR\/ARNT signaling pathway","volume":"208","author":"Sondermann","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-012-6650-y","article-title":"Formation of an N-formylkynurenine-derived fluorophore and its use for measuring indoleamine 2,3-dioxygenase 1 activity","volume":"405","author":"Tomek","year":"2013","journal-title":"Anal Bioanal Chem"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00388","article-title":"IDO and kynurenine metabolites in peripheral and CNS disorders","volume":"11","author":"Huang","year":"2020","journal-title":"Front Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4137\/IJTR.S11737","article-title":"Exploitation of the IDO pathway in the therapy of rheumatoid arthritis","volume":"6","author":"Williams","year":"2013","journal-title":"Int J Tryptophan Res"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.3390\/biom10091280","article-title":"Amino acid metabolism in rheumatoid arthritis: friend or foe","volume":"10","author":"Panfili","year":"2020","journal-title":"Biomolecules"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.5114\/reum\/19175","article-title":"The kynurenine pathway in patients with rheumatoid arthritis during tumor necrosis factor alpha inhibitors treatment","volume":"62","author":"Witoszynska-Sobkowiak","year":"2024","journal-title":"Reumatologia"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02762","article-title":"Hypoxia inducible factor 1alpha inhibits the expression of immunosuppressive tryptophan-2,3-dioxygenase in glioblastoma","volume":"10","author":"Mohapatra","year":"2019","journal-title":"Front Immunol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.609490","article-title":"Targeting indoleamine 2,3-dioxygenase in cancer models using the novel small molecule inhibitor NTRC 3883-0","volume":"11","author":"Grobben","year":"2020","journal-title":"Front Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40360-022-00564-8","article-title":"Interaction between AhR and HIF-1 signaling pathways mediated by ARNT\/HIF-1beta","volume":"23","author":"Zhang","year":"2022","journal-title":"BMC Pharmacol Toxicol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00172.2015","article-title":"Activation of aryl hydrocarbon receptor mediates suppression of hypoxia-inducible factor-dependent erythropoietin expression by indoxyl sulfate","volume":"310","author":"Asai","year":"2016","journal-title":"Am J Physiol Cell Physiol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13638","article-title":"AhR activation promotes Treg cell generation by enhancing Lkb1-mediated fatty acid oxidation via the Skp2\/K63-ubiquitination pathway","volume":"169","author":"Zhang","year":"2023","journal-title":"Immunology"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1002\/eji.201747121","article-title":"AhR activation increases IL-2 production by alloreactive CD4(+) T cells initiating the differentiation of mucosal-homing Tim3(+) Lag3(+) Tr1 cells","volume":"47","author":"Ehrlich","year":"2017","journal-title":"Eur J Immunol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84431","article-title":"HIF1alpha and metabolic reprogramming in inflammation","volume":"126","author":"Corcoran","year":"2016","journal-title":"J Clin Invest"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2023.03.013","article-title":"The Warburg effect: a signature of mitochondrial overload","volume":"33","author":"Wang","year":"2023","journal-title":"Trends Cell Biol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2021.03.003","article-title":"Modeling the energy metabolism in immune cells","volume":"68","author":"Schuster","year":"2021","journal-title":"Curr Opin Biotechnol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00775","article-title":"Metabolic control of dendritic cell functions: digesting information","volume":"10","author":"Wculek","year":"2019","journal-title":"Front Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3390\/cells7070068","article-title":"Metabolic stress in the immune function of T cells, macrophages and dendritic cells","volume":"7","author":"Domblides","year":"2018","journal-title":"Cells"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1250684","DOI":"10.1126\/science.1250684","article-title":"mTOR- and HIF-1alpha-mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Cheng","year":"2014","journal-title":"Science"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell Res"},{"key":"B24","doi-asserted-by":"publisher","first-page":"168370","DOI":"10.1016\/j.jmb.2023.168370","article-title":"Per-ARNT-sim (PAS) domains in basic helix-loop-helix (bHLH)-PAS transcription factors and coactivators: structures and mechanisms","volume":"436","author":"Daffern","year":"2024","journal-title":"J Mol Biol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2014.05.001","article-title":"Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1alpha signaling node","volume":"218","author":"Vorrink","year":"2014","journal-title":"Chem Biol Interact"},{"key":"B26","doi-asserted-by":"publisher","first-page":"3653","DOI":"10.3390\/ijms20153653","article-title":"bHLH-PAS proteins: their structure and intrinsic disorder","volume":"20","author":"Kolonko","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1421346","article-title":"Aryl hydrocarbon receptor: current perspectives on key signaling partners and immunoregulatory role in inflammatory diseases","volume":"15","author":"Bahman","year":"2024","journal-title":"Front Immunol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8297","article-title":"Loss of HIF-1alpha in macrophages attenuates AhR\/ARNT-mediated tumorigenesis in a PAH-driven tumor model","volume":"7","author":"Henke","year":"2016","journal-title":"Oncotarget"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1056267","article-title":"Transcriptional regulation of innate lymphoid cells and T cells by aryl hydrocarbon receptor","volume":"14","author":"Helm","year":"2023","journal-title":"Front Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2021.1105","article-title":"Ongoing clinical trials in aging-related tissue fibrosis and new findings related to ahR pathways","volume":"13","author":"Yu","year":"2022","journal-title":"Aging Dis"},{"key":"B31","doi-asserted-by":"publisher","first-page":"6840271","DOI":"10.1155\/2023\/6840271","article-title":"AhR and HIF-1alpha signaling pathways in benign meningioma under hypoxia","author":"Perepechaeva","year":"2023","journal-title":"Int J Cell Biol 2023"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.3390\/genes15091167","article-title":"In silico exploration of AHR-HIF pathway interplay: implications for therapeutic targeting in ccRCC","volume":"15","author":"Gregoris","year":"2024","journal-title":"Genes (Basel)"},{"key":"B33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1161\/01.RES.0000153188.68898.ac","article-title":"Innate immunity and angiogenesis","volume":"96","author":"Frantz","year":"2005","journal-title":"Circ Res"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3416","DOI":"10.3390\/ijms22073416","article-title":"HIF-1alpha and pro-inflammatory signaling improves the immunomodulatory activity of MSC-derived extracellular vesicles","volume":"22","author":"Gomez-Ferrer","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B35","doi-asserted-by":"publisher","first-page":"9394","DOI":"10.1038\/s41467-024-53593-8","article-title":"HIF1alpha-regulated glycolysis promotes activation-induced cell death and IFN-gamma induction in hypoxic T cells","volume":"15","author":"Shen","year":"2024","journal-title":"Nat Commun"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.143","article-title":"IDO1 in cancer: a Gemini of immune checkpoints","volume":"15","author":"Zhai","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.835711","article-title":"T lymphocyte exhaustion during human and experimental visceral leishmaniasis","volume":"13","author":"Costa-Madeira","year":"2022","journal-title":"Front Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.711772","article-title":"T-cell exhaustion status under high and low levels of hypoxia-inducible factor 1alpha expression in glioma","volume":"12","author":"Liu","year":"2021","journal-title":"Front Pharmacol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003613","article-title":"Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets","volume":"186","author":"Michalek","year":"2011","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00115","article-title":"Differential regulation of human treg and th17 cells by fatty acid synthesis and glycolysis","volume":"10","author":"Cluxton","year":"2019","journal-title":"Front Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"e20221751","DOI":"10.1084\/jem.20221751","article-title":"Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitis","volume":"220","author":"Kim","year":"2023","journal-title":"J Exp Med"},{"key":"B43","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.cmet.2022.02.015","article-title":"The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming","volume":"34","author":"Hochrein","year":"2022","journal-title":"Cell Metab"},{"key":"B44","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3390\/cells8020104","article-title":"Control of the antitumor immune response by cancer metabolism","volume":"8","author":"Domblides","year":"2019","journal-title":"Cells"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e006728","DOI":"10.1136\/jitc-2023-006728","article-title":"Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2\/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes","volume":"11","author":"Solvay","year":"2023","journal-title":"J Immunother Cancer"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006615","article-title":"The role of STAT3 and AhR in the differentiation of CD4+ T cells into Th17 and Treg cells","volume":"96","author":"Liu","year":"2017","journal-title":"Med (Baltimore)"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1038\/s41467-024-45473-y","article-title":"Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17\/Treg cell balance axis","volume":"15","author":"Jia","year":"2024","journal-title":"Nat Commun"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.033","article-title":"Control of T(H)17\/T(reg) balance by hypoxia-inducible factor 1","volume":"146","author":"Dang","year":"2011","journal-title":"Cell"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00292","article-title":"TCR-signaling events in cellular metabolism and specialization","volume":"6","author":"Chisolm","year":"2015","journal-title":"Front Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"730","DOI":"10.3390\/ijms19030730","article-title":"The balance of th17 versus treg cells in autoimmunity","volume":"19","author":"Lee","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110278","article-title":"HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells","volume":"208","author":"Shi","year":"2011","journal-title":"J Exp Med"},{"key":"B52","doi-asserted-by":"publisher","first-page":"107688","DOI":"10.1016\/j.intimp.2021.107688","article-title":"Costunolide ameliorates colitis via specific inhibition of HIF1alpha\/glycolysis-mediated Th17 differentiation","volume":"97","author":"Lv","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.it.2020.11.001","article-title":"Tolerogenic dendritic cells in autoimmunity and inflammatory diseases","volume":"42","author":"Morante-Palacios","year":"2021","journal-title":"Trends Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.immuni.2022.05.013","article-title":"Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication","volume":"55","author":"Gargaro","year":"2022","journal-title":"Immunity"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16086","article-title":"Indoleamine 2,3-dioxygenase 1 (IDO1): an up-to-date overview of an eclectic immunoregulatory enzyme","volume":"289","author":"Pallotta","year":"2022","journal-title":"FEBS J"},{"key":"B56","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1016\/j.immuni.2021.09.005","article-title":"Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity","volume":"54","author":"Sharma","year":"2021","journal-title":"Immunity"},{"key":"B57","doi-asserted-by":"publisher","first-page":"217321","DOI":"10.1016\/j.canlet.2024.217321","article-title":"Single-cell RNA-sequencing of human spleens reveals an IDO-1(+) tolerogenic dendritic cell subset in pancreatic cancer patients that is absent in normal individuals","volume":"607","author":"Mundry","year":"2024","journal-title":"Cancer Lett"},{"key":"B58","doi-asserted-by":"publisher","first-page":"234","DOI":"10.3892\/etm.2023.11933","article-title":"Gain\u2212of\u2212function of IDO in DCs inhibits T cell immunity by metabolically regulating surface molecules and cytokines","volume":"25","author":"Wang","year":"2023","journal-title":"Exp Ther Med"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01973","article-title":"Engagement of nuclear coactivator 7 by 3-hydroxyanthranilic acid enhances activation of aryl hydrocarbon receptor in immunoregulatory dendritic cells","volume":"10","author":"Gargaro","year":"2019","journal-title":"Front Immunol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.7.4697","article-title":"Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function","volume":"180","author":"Jantsch","year":"2008","journal-title":"J Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s10020-023-00690-x","article-title":"Interferon-gamma regulates immunosuppression in septic mice by promoting the Warburg effect through the PI3K\/AKT\/mTOR pathway","volume":"29","author":"Fu","year":"2023","journal-title":"Mol Med"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.05.014","article-title":"Succinate based polymers drive immunometabolism in dendritic cells to generate cancer immunotherapy","volume":"358","author":"Inamdar","year":"2023","journal-title":"J Control Release"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1353787","article-title":"Involvement of tumor immune microenvironment metabolic reprogramming in colorectal cancer progression, immune escape, and response to immunotherapy","volume":"15","author":"Nicolini","year":"2024","journal-title":"Front Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izae022","article-title":"TolDC restores the balance of th17\/treg via aryl hydrocarbon receptor to attenuate colitis","volume":"30","author":"Wang","year":"2024","journal-title":"Inflammation Bowel Dis"},{"key":"B65","doi-asserted-by":"publisher","first-page":"173090","DOI":"10.1016\/j.ejphar.2020.173090","article-title":"Macrophage M1\/M2 polarization","volume":"877","author":"Yunna","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.3390\/ijms20082023","article-title":"TET1 Knockdown Inhibits Porphyromonas gingivalis LPS\/IFN-gamma-Induced M1 Macrophage Polarization through the NF-kappaB Pathway in THP-1 Cells","volume":"20","author":"Huang","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B67","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s10020-023-00702-w","article-title":"Leptin\/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages","volume":"29","author":"Wang","year":"2023","journal-title":"Mol Med"},{"key":"B68","doi-asserted-by":"publisher","first-page":"100041","DOI":"10.1016\/j.cytox.2020.100041","article-title":"Macrophages as host, effector and immunoregulatory cells in leishmaniasis: Impact of tissue micro-environment and metabolism","volume":"2","author":"Bogdan","year":"2020","journal-title":"Cytokine X"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23865","article-title":"HIF-1alpha expression regulates the bactericidal capacity of phagocytes","volume":"115","author":"Peyssonnaux","year":"2005","journal-title":"J Clin Invest"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100587","article-title":"HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment","volume":"207","author":"Corzo","year":"2010","journal-title":"J Exp Med"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e17167","article-title":"Hypoxia inducible factor-1alpha is an important regulator of macrophage biology","volume":"9","author":"Qiu","year":"2023","journal-title":"Heliyon"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801710","article-title":"Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor","volume":"182","author":"Acosta-Iborra","year":"2009","journal-title":"J Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"115350","DOI":"10.1016\/j.celrep.2025.115350","article-title":"Hexokinase 2-mediated metabolic stress and inflammation burden of liver macrophages via histone lactylation in MASLD","volume":"44","author":"Li","year":"2025","journal-title":"Cell Rep"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160865","article-title":"Deletion of hypoxia-inducible factor-1alpha in myeloid lineage exaggerates angiotensin II-induced formation of abdominal aortic aneurysm","volume":"131","author":"Takahara","year":"2017","journal-title":"Clin Sci (Lond)"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40364-020-00251-y","article-title":"Metabolic reprogramming in macrophage responses","volume":"9","author":"Liu","year":"2021","journal-title":"biomark Res"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.7150\/thno.51144","article-title":"AhR activation attenuates calcium oxalate nephrocalcinosis by diminishing M1 macrophage polarization and promoting M2 macrophage polarization","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.965941","article-title":"The key player in the pathogenesis of environmental influence of systemic lupus erythematosus: Aryl hydrocarbon receptor","volume":"13","author":"Wu","year":"2022","journal-title":"Front Immunol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1466779","article-title":"Integrated analyses reveal IDO1 as a prognostic biomarker coexpressed with PD-1 on tumor-associated macrophages in esophageal squamous cell carcinoma","volume":"15","author":"Peng","year":"2024","journal-title":"Front Pharmacol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1502615","article-title":"Tolerogenic phenotype of IFN-gamma-induced IDO+ Dendritic cells is maintained via an autocrine IDO-kynurenine\/ahR-IDO loop","volume":"197","author":"Li","year":"2016","journal-title":"J Immunol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.51241","article-title":"The IFN-gamma-IDO1-kynureine pathway-induced autophagy in cervical cancer cell promotes phagocytosis of macrophage","volume":"17","author":"Yang","year":"2021","journal-title":"Int J Biol Sci"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1282653","article-title":"IFN-gamma lowers tumor growth by increasing glycolysis and lactate production in a nitric oxide-dependent manner: implications for cancer immunotherapy","volume":"14","author":"Chattopadhyay","year":"2023","journal-title":"Front Immunol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.02.009","article-title":"Interferon gamma induces reversible metabolic reprogramming of M1 macrophages to sustain cell viability and pro-inflammatory activity","volume":"30","author":"Wang","year":"2018","journal-title":"EBioMedicine"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2013.0040","article-title":"DMOG ameliorates IFN-gamma-induced intestinal barrier dysfunction by suppressing PHD2-dependent HIF-1alpha degradation","volume":"34","author":"Wang","year":"2014","journal-title":"J Interferon Cytokine Res"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1224102","article-title":"Crosstalk between hypoxic cellular micro-environment and the immune system: a potential therapeutic target for infectious diseases","volume":"14","author":"Akinsulie","year":"2023","journal-title":"Front Immunol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/nature19334","article-title":"Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system","volume":"537","author":"Cho","year":"2016","journal-title":"Nature"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601401","article-title":"Germinal center hypoxia potentiates immunoglobulin class switch recombination","volume":"197","author":"Abbott","year":"2016","journal-title":"J Immunol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/s41467-017-02683-x","article-title":"Hypoxia-inducible factor-1alpha is a critical transcription factor for IL-10-producing B cells in autoimmune disease","volume":"9","author":"Meng","year":"2018","journal-title":"Nat Commun"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.15698\/cst2018.04.133","article-title":"New insights into the key role of HIF-1alpha in IL-10-producing B cells","volume":"2","author":"Meng","year":"2018","journal-title":"Cell Stress"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.MR0618-227R","article-title":"Innate-like B cell subsets during immune responses: Beyond antibody production","volume":"105","author":"Romero-Ramirez","year":"2019","journal-title":"J Leukoc Biol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"7638365","DOI":"10.1155\/2020\/7638365","article-title":"The potential role of regulatory B cells in idiopathic membranous nephropathy","volume":"2020","author":"Dong","year":"2020","journal-title":"J Immunol Res"},{"key":"B92","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.1016\/j.immuni.2021.10.005","article-title":"Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses","volume":"54","author":"Lightman","year":"2021","journal-title":"Immunity"},{"key":"B93","doi-asserted-by":"publisher","first-page":"107815","DOI":"10.1016\/j.celrep.2020.107815","article-title":"CD28 regulates metabolic fitness for long-lived plasma cell survival","volume":"31","author":"Utley","year":"2020","journal-title":"Cell Rep"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006404","article-title":"Hypoxia-inducible factor-1alpha plays roles in Epstein-Barr virus\u2019s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter","volume":"13","author":"Kraus","year":"2017","journal-title":"PloS Pathog"},{"key":"B95","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12929-016-0281-0","article-title":"Hypoxia and its implications in rheumatoid arthritis","volume":"23","author":"Quinonez-Flores","year":"2016","journal-title":"J BioMed Sci"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.696802","article-title":"WTD attenuating rheumatoid arthritis via suppressing angiogenesis and modulating the PI3K\/AKT\/mTOR\/HIF-1alpha pathway","volume":"12","author":"Ba","year":"2021","journal-title":"Front Pharmacol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1002\/art.39608","article-title":"Critical role of glucose metabolism in rheumatoid arthritis fibroblast-like synoviocytes","volume":"68","author":"Garcia-Carbonell","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxab021","article-title":"Metabolites as drivers and targets in rheumatoid arthritis","volume":"208","author":"Hanlon","year":"2022","journal-title":"Clin Exp Immunol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"e193054","DOI":"10.1172\/jci.insight.193054","article-title":"Rheumatoid arthritis synovial fibroblasts modulate T cell activation","volume":"10","author":"Romoff","year":"2025","journal-title":"JCI Insight"},{"key":"B100","doi-asserted-by":"publisher","first-page":"uxaf035","DOI":"10.1093\/cei\/uxaf035","article-title":"Engaging PD-1 rescuesregulatory T cell function and inhibits inflammatory T cells in rheumatoid arthritis","volume":"219","author":"Chowdhury","year":"2025","journal-title":"Clin Exp Immunol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040165","article-title":"Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy","volume":"200","author":"Ehrenstein","year":"2004","journal-title":"J Exp Med"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1002\/art.20499","article-title":"CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid","volume":"50","author":"van Amelsfort","year":"2004","journal-title":"Arthritis Rheum"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2022.05.003","article-title":"Increased HIF-1alpha expression in T cells and associated with enhanced Th17 pathway in systemic lupus erythematosus","volume":"121","author":"Liao","year":"2022","journal-title":"J Formos Med Assoc"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2021.02.019","article-title":"HIF-1alpha and miR-210 differential and lineage-specific expression in systemic lupus erythematosus","volume":"133","author":"Garchow","year":"2021","journal-title":"Mol Immunol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1435306","article-title":"The role of hypoxic microenvironment in autoimmune diseases","volume":"15","author":"Gong","year":"2024","journal-title":"Front Immunol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/cei.12256","article-title":"Increased 8-hydroxy-2\u2019-deoxyguanosine in plasma and decreased mRNA expression of human 8-oxoguanine DNA glycosylase 1, anti-oxidant enzymes, mitochondrial biogenesis-related proteins and glycolytic enzymes in leucocytes in patients with systemic lupus erythematosus","volume":"176","author":"Lee","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30140-X","article-title":"Remyelination in multiple sclerosis: from basic science to clinical translation","volume":"19","author":"Lubetzki","year":"2020","journal-title":"Lancet Neurol"},{"key":"B108","doi-asserted-by":"publisher","first-page":"106230","DOI":"10.1016\/j.nbd.2023.106230","article-title":"An overall view of the most common experimental models for multiple sclerosis","volume":"184","author":"Dedoni","year":"2023","journal-title":"Neurobiol Dis"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.741938","article-title":"Intranuclear delivery of HIF-1alpha-TMD alleviates EAE via functional conversion of TH17 cells","volume":"12","author":"Shin","year":"2021","journal-title":"Front Immunol"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9562.S12-004","article-title":"Metabolic control of th17 cell generation and CNS inflammation","author":"Yang","year":"2014","journal-title":"J Neurol Neurophysiol"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01256","article-title":"Co-treatments to boost IDO activity and inhibit production of downstream catabolites induce durable suppression of experimental autoimmune encephalomyelitis","volume":"11","author":"Lemos","year":"2020","journal-title":"Front Immunol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-022-01461-3","article-title":"Primary membranous nephropathy: an endless story","volume":"36","author":"Claudio","year":"2023","journal-title":"J Nephrol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500277","article-title":"Amino acid metabolism inhibits antibody-driven kidney injury by inducing autophagy","volume":"194","author":"Chaudhary","year":"2015","journal-title":"J Immunol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"e2404151","DOI":"10.1002\/advs.202404151","article-title":"Podocyte pathogenic bone morphogenetic protein-2 pathway and immune cell behaviors in primary membranous nephropathy","volume":"11","author":"Cai","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.574997","article-title":"Th17-immune response in patients with membranous nephropathy is associated with thrombosis and relapses","volume":"11","author":"Cremoni","year":"2020","journal-title":"Front Immunol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1159\/000353102","article-title":"Various roles of Th cytokine mRNA expression in different forms of glomerulonephritis","volume":"38","author":"Ifuku","year":"2013","journal-title":"Am J Nephrol"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01809","article-title":"Immunological pathogenesis of membranous nephropathy: focus on PLA2R1 and its role","volume":"10","author":"Liu","year":"2019","journal-title":"Front Immunol"},{"key":"B118","doi-asserted-by":"publisher","first-page":"102976","DOI":"10.1016\/j.autrev.2021.102976","article-title":"Course monitoring of membranous nephropathy: Both autoantibodies and podocytes require multidimensional attention","volume":"21","author":"Liu","year":"2022","journal-title":"Autoimmun Rev"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020091310","article-title":"Indoleamine 2,3-dioxygenase-1, a novel therapeutic target for post-vascular injury thrombosis in CKD","volume":"32","author":"Walker","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.770902","article-title":"Exploring the differences in molecular mechanisms and key biomarkers between membranous nephropathy and lupus nephritis using integrated bioinformatics analysis","volume":"12","author":"Dong","year":"2021","journal-title":"Front Genet"},{"key":"B121","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s41572-023-00476-9","article-title":"IgA nephropathy","volume":"9","author":"Stamellou","year":"2023","journal-title":"Nat Rev Dis Primers"},{"key":"B122","article-title":"Renal expression of hypoxia inducible factor-1alpha in patients with chronic kidney disease: a clinicopathologic study from nephrectomized kidneys","volume":"137","author":"Hung","year":"2013","journal-title":"Indian J Med Res"},{"key":"B123","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/1471-2369-15-110","article-title":"Transplantation of endothelial progenitor cells in treating rats with IgA nephropathy","volume":"15","author":"Guo","year":"2014","journal-title":"BMC Nephrol"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.14712\/fb2019065020101","article-title":"Indoleamine 2,3-dioxygenase (IDO) regulates th17\/treg immunity in experimental IgA nephropathy","volume":"65","author":"Yang","year":"2019","journal-title":"Folia Biol (Praha)"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05960616","article-title":"Focal segmental glomerulosclerosis","volume":"12","author":"Rosenberg","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"B126","doi-asserted-by":"publisher","first-page":"eaay1620","DOI":"10.1126\/scitranslmed.aay1620","article-title":"Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis","volume":"12","author":"Chen","year":"2020","journal-title":"Sci Transl Med"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1271118","article-title":"Acriflavine, a HIF-1 inhibitor, preserves vision in an experimental autoimmune encephalomyelitis model of optic neuritis","volume":"14","author":"Anders","year":"2023","journal-title":"Front Immunol"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001628","article-title":"IDO upregulates regulatory T cells via tryptophan catabolite and suppresses encephalitogenic T cell responses in experimental autoimmune encephalomyelitis","volume":"185","author":"Yan","year":"2010","journal-title":"J Immunol"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1126\/science.1117634","article-title":"Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite","volume":"310","author":"Platten","year":"2005","journal-title":"Science"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem160","article-title":"The anti-allergic drug, N-(3\u2019,4\u2019-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis","volume":"46","author":"Inglis","year":"2007","journal-title":"Rheumatol (Oxford)"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02017","article-title":"Limited effect of indolamine 2,3-dioxygenase expression and enzymatic activity on lupus-like disease in B6.Nba2 mice","volume":"10","author":"Davison","year":"2019","journal-title":"Front Immunol"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2010.02432.x","article-title":"Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation","volume":"72","author":"Jager","year":"2010","journal-title":"Scand J Immunol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02833","article-title":"The aryl hydrocarbon receptor as an immune-modulator of atmospheric particulate matter-mediated autoimmunity","volume":"9","author":"O\u2019Driscoll","year":"2018","journal-title":"Front Immunol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1209613","article-title":"Modulation of immunity by tryptophan microbial metabolites","volume":"10","author":"Li","year":"2023","journal-title":"Front Nutr"},{"key":"B135","doi-asserted-by":"publisher","first-page":"520763","DOI":"10.1155\/2014\/520763","article-title":"Toward understanding the role of aryl hydrocarbon receptor in the immune system: current progress and future trends","author":"Hanieh","year":"2014","journal-title":"BioMed Res Int 2014"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00639","article-title":"The treg\/th17 axis: A dynamic balance regulated by the gut microbiome","volume":"6","author":"Omenetti","year":"2015","journal-title":"Front Immunol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.812974","article-title":"The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription","volume":"292","author":"Sakurai","year":"2017","journal-title":"J Biol Chem"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2017.02.004","article-title":"The aryl hydrocarbon receptor repressor - More than a simple feedback inhibitor of AhR signaling: Clues for its role in inflammation and cancer","volume":"2","author":"Vogel","year":"2017","journal-title":"Curr Opin Toxicol"},{"key":"B139","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/s41467-017-01799-4","article-title":"ER-associated degradation regulates Alzheimer\u2019s amyloid pathology and memory function by modulating gamma-secretase activity","volume":"8","author":"Zhu","year":"2017","journal-title":"Nat Commun"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1772536\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:44:37Z","timestamp":1772779477000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1772536\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,6]]},"references-count":139,"alternative-id":["10.3389\/fimmu.2026.1772536"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1772536","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,6]]},"article-number":"1772536"}}