{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:29:15Z","timestamp":1789475355052,"version":"build-2803163510"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease primarily affecting intertriginous regions, and emerging evidence suggests that systemic autoinflammation (\u201cmetainflammation\u201d) contributes to its clinical heterogeneity. We report two cases of HS in patients of Moroccan origin with overlapping autoinflammatory features. The first case involves a 42-year-old man with HS since 2012, Hurley stage II, treated with adalimumab since 2019 and achieving an IHS4-70, who developed Beh\u00e7et\u2019s disease-like systemic manifestations in 2025; genetic testing revealed a heterozygous\n                    <jats:italic>MEFV<\/jats:italic>\n                    variant, and HLA typing included\n                    <jats:italic>A02<\/jats:italic>\n                    ,\n                    <jats:italic>A68<\/jats:italic>\n                    ,\n                    <jats:italic>B15<\/jats:italic>\n                    ,\n                    <jats:italic>B45<\/jats:italic>\n                    ,\n                    <jats:italic>C02<\/jats:italic>\n                    , and\n                    <jats:italic>C06<\/jats:italic>\n                    . The second case involves a 40-year-old man with HS since age 22, Hurley stage II, with persistent oral aphthosis; he achieved IHS4-70 on secukinumab in 2025 and responded to adjunctive colchicine for mucosal lesions, with HLA typing showing\n                    <jats:italic>B18<\/jats:italic>\n                    ,\n                    <jats:italic>B51<\/jats:italic>\n                    ,\n                    <jats:italic>C07<\/jats:italic>\n                    , and\n                    <jats:italic>C15<\/jats:italic>\n                    . These cases illustrate the interplay between HLA subtypes, autoinflammatory gene variants, and systemic inflammation in HS, highlighting a potential autoinflammatory HS subtype. Population-specific genetic factors, particularly in North African populations, may influence disease severity, systemic manifestations, and therapeutic response. Taken together, these observations support the concept that HS, in certain genetically predisposed individuals, may represent a systemic autoinflammatory\/metainflammatory disease, underscoring the relevance of personalized therapeutic strategies.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1775443","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:22:29Z","timestamp":1773984149000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hidradenitis suppurativa with systemic autoinflammatory features in patients of Moroccan origin: case report and implications for personalized medicine"],"prefix":"10.3389","volume":"17","author":[{"given":"J\u00e9r\u00f4me","family":"Lurel","sequence":"first","affiliation":[{"name":"Department of Dermatology, H\u00f4pitaux Universitaires de G\u00e9n\u00e8ve (HUG)","place":["Geneva, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadwa","family":"El Aissoug","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Notre Dame de Gr\u00e2ce, Gosselies, Universit\u00e9 Libre de Bruxelles (ULB)","place":["Rabat, Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima-Zahra","family":"Hammoud","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mohamed V University of Rabat, Ibn Sina University Hospital","place":["Rabat, Morocco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dillon","family":"Mintoff","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Mater Dei Hospital","place":["Msida, Malta"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Benhadou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, H\u00f4pital Universitaire de Bruxelles (H.U.B.), Centres Universitaires de Bruxelles (CUB) H\u00f4pital Erasme, Universit\u00e9 libre de Bruxelles (ULB)","place":["Brussels, Belgium"]},{"name":"European Hidradenitis Suppurativa Foundation e.V","place":["Dessau, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02965","article-title":"Hidradenitis suppurativa: a systematic review integrating inflammatory pathways into a cohesive pathogenic model","volume":"9","author":"Vossen","year":"2018","journal-title":"Front Immunol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13175211","article-title":"Evidence on hidradenitis suppurativa as an autoinflammatory skin disease","volume":"13","author":"D\u2019Onghia","year":"2024","journal-title":"J Clin Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad182","article-title":"Obesity and hidradenitis suppurativa: targeting 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