{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:26:14Z","timestamp":1787739974734,"version":"build-2784847793"},"reference-count":97,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Parasitic eosinophilic lung disease is characterized by eosinophil infiltration and dysregulated immune responses, posing significant challenges due to its complex immunoregulatory mechanisms which remain incompletely understood. This review explores the emerging role of IgE immune complexes (IgE ICs) in modulating eosinophilic immune responses, proposing a hypothetical signaling axis involving the NLRC4 inflammasome that may influence disease progression. We synthesize preliminary evidence from cellular models and discuss the potential implications of this pathway for parasitic eosinophilic lung disease. Integrating recent findings, we explore how IgE ICs interact with Toll-like receptor 2 (TLR2) and Fc epsilon receptor II (Fc\u03f5RII) to regulate eosinophil inflammatory responses, degranulation, and the expression of associated proteins. These interactions reveal a dual regulatory function of immune complexes in parasitic infections and related pulmonary disorders. By critically examining the available evidence for crosstalk between IgE ICs and the NLRC4 inflammasome, this review aims to provide a conceptual framework and hypothesis-generating perspectives for developing targeted immunotherapeutic strategies for parasitic eosinophilic lung disease. Importantly, we acknowledge that the mechanistic evidence for this axis is primarily derived from\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies and requires validation in physiologically relevant systems.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1776407","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:13:55Z","timestamp":1787739235000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Immunoregulatory mechanisms in parasitic eosinophilic lung disease: the role of IgE immune complexes and NLRC4 inflammasome"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuanchao","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, The Affiliated Hospital of Jiujiang University","place":["Jiujiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingyu","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, First Affiliated Hospital of Gannan Medical University","place":["Ganzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongbo","family":"Peng","sequence":"additional","affiliation":[{"name":"The First Clinical College, Gannan Medical University","place":["Ganzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Clinical College, Gannan Medical University","place":["Ganzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghui","family":"Xia","sequence":"additional","affiliation":[{"name":"The First Clinical College, Gannan Medical University","place":["Ganzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfa","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, First Affiliated Hospital of Gannan Medical University","place":["Ganzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanglin","family":"Fu","sequence":"additional","affiliation":[{"name":"The First Clinical College, Gannan Medical University","place":["Ganzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defa","family":"Huang","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, The First Affiliated Hospital of Gannan Medical University","place":["Ganzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuxiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, First Affiliated Hospital of Gannan Medical University","place":["Ganzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The Affiliated Hospital of Jiujiang University","place":["Jiujiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2020.10.005","article-title":"Hypersensitivity pneumonitis, allergic bronchopulmonary aspergillosis and other eosinophilic lung diseases","volume":"66","author":"Barry","year":"2020","journal-title":"Curr Opin Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.ccm.2025.07.007","article-title":"Eosinophilic lung diseases","volume":"43","author":"Cottin","year":"2023","journal-title":"Immunol Allergy Clin North 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