{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:25:17Z","timestamp":1777890317391,"version":"3.51.4"},"reference-count":187,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Autoimmune rheumatic diseases (ARDs), often characterized by pain, constitute a diverse group of autoimmune conditions involving inflammation-mediated injuries to bones, joints, surrounding connective tissues, and occasionally other organs. RNA methylation is a key epitranscriptomic modification that regulates gene expression by influencing stability, splicing, nuclear translocation and degradation. Recent studies have highlighted the crucial role of RNA modification in the pathogenesis and progression of various ARDs. RNA modification affects critical biologic processes of ARDs, such as inflammation, immune response. This review systematically explores the landscape of RNA modification in ARDs, elucidating its regulatory roles and therapeutic implications, including rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, primary Sj\u00f6gren\u2019s syndrome, systemic sclerosis. The intricate mechanisms of RNA modification can lead to the development of novel diagnostic biomarkers and therapeutic strategies, ultimately improving patient outcomes.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1779307","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:35:24Z","timestamp":1777613724000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["RNA methylation in autoimmune rheumatic diseases: mechanisms and therapeutic potential"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuyao","family":"Wang","sequence":"first","affiliation":[{"name":"Experimental Research Center, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanhui","family":"Song","sequence":"additional","affiliation":[{"name":"Experimental Research Center, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujin","family":"Xue","sequence":"additional","affiliation":[{"name":"The First Clinical Medical School, Shaanxi University of Chinese Medicine","place":["Xianyang, Shaanxi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoya","family":"Li","sequence":"additional","affiliation":[{"name":"The Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences\/Peking Union Medical College","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiping","family":"Cheng","sequence":"additional","affiliation":[{"name":"Clinical Medical College, Jiangxi University of Chinese Medicine","place":["Nanchang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meijie","family":"Liu","sequence":"additional","affiliation":[{"name":"Experimental Research Center, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Experimental Research Center, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghua","family":"Pan","sequence":"additional","affiliation":[{"name":"Experimental Research Center, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Experimental Research Center, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danping","family":"Fan","sequence":"additional","affiliation":[{"name":"Experimental Research Center, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.003","article-title":"Comprehensive analysis of mRNA methylation reveals enrichment in 3\u2019 UTRs and near stop codons","volume":"149","author":"Meyer","year":"2012","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11112","article-title":"Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.045","article-title":"Dynamic RNA modifications in gene expression regulation","volume":"169","author":"Roundtree","year":"2017","journal-title":"Cell"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-090413-025405","article-title":"The pivotal regulatory landscape of RNA modifications","volume":"15","author":"Li","year":"2014","journal-title":"Annu Rev Genom Hum G"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105937","article-title":"RNA methylation and cancer treatment","volume":"174","author":"Yang","year":"2021","journal-title":"Pharmacol Res"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00652-9","article-title":"Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases","volume":"17","author":"Szekanecz","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-024-09003-4","article-title":"Methylation of T and B lymphocytes in autoimmune rheumatic diseases","volume":"66","author":"Deng","year":"2024","journal-title":"Clin Rev Allerg Immu"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiae087","article-title":"N6-methyladenosine promotes TNF mRNA degradation in CD4+ T lymphocytes","volume":"116","author":"van Vroonhoven","year":"2024","journal-title":"J Leukocyte Biol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.755691","article-title":"The emerging role of m6A modification in regulating the immune system and autoimmune diseases","volume":"9","author":"Wang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2147\/jir.s431076","article-title":"The m6A\/m1A\/m5C-related methylation modification patterns and immune landscapes in rheumatoid arthritis and osteoarthritis revealed by microarray and single-cell transcriptome","volume":"16","author":"Zheng","year":"2023","journal-title":"J Inflammation Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16030","article-title":"Potential medicinal value of N6-methyladenosine in autoimmune diseases and tumours","volume":"182","author":"Geng","year":"2023","journal-title":"Brit J Pharmacol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1030","article-title":"MODOMICS: a database of RNA modification pathways. 2017 update","volume":"46","author":"Boccaletto","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/s41419-020-2686-7","article-title":"N6-methyladenosine (m6A) methylation in ischemia-reperfusion injury","volume":"11","author":"Yao","year":"2020","journal-title":"Cell Death Dis"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1753808","article-title":"Blood-based epigenetic biomarkers in rheumatoid arthritis: current knowledge and future perspectives","volume":"17","author":"Mo\u0142o\u0144","year":"2026","journal-title":"Front Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-023-2526-2","article-title":"Dynamic RNA methylation modifications and their regulatory role in mammalian development and diseases","volume":"67","author":"Yang","year":"2024","journal-title":"Sci China Life Sci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-020-00295-8","article-title":"The epitranscriptome beyond m6A","volume":"22","author":"Wiener","year":"2021","journal-title":"Nat Rev Genet"},{"key":"B17","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct Tar"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3891","article-title":"Roles of rRNA N-methyladenosine modification in the function of ribosomes","volume":"41","author":"Yang","year":"2023","journal-title":"Cell Biochem Funct"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/srep42271","article-title":"AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells","volume":"7","author":"Ueda","year":"2017","journal-title":"Sci Rep-Uk"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-024-01530-8","article-title":"SERRATE drives phase separation behaviours to regulate m6A modification and miRNA biogenesis","volume":"26","author":"Zhong","year":"2024","journal-title":"Nat Cell Biol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nature14234","article-title":"N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions","volume":"518","author":"Liu","year":"2015","journal-title":"Nature"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0387-x","article-title":"Novel insights into m6A modification in circular RNA and implications for immunity","volume":"17","author":"Paramasivam","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8351-1","article-title":"Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex","volume":"534","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"852","DOI":"10.3410\/f.1163652.625421","article-title":"The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms","volume":"13","author":"Huang","year":"2022","journal-title":"Cell Death Dis"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/nature19342","article-title":"m6A RNA methylation promotes XIST-mediated transcriptional repression","volume":"537","author":"Patil","year":"2016","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.02.015","article-title":"Zc3h13 regulates nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal","volume":"69","author":"Wen","year":"2018","journal-title":"Mol Cell"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.05.048","article-title":"Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5\u2019 sites","volume":"8","author":"Schwartz","year":"2014","journal-title":"Cell Rep"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.05.003","article-title":"The U6 snRNA m6A methyltransferase METTL16 regulates SAM synthetase intron retention","volume":"169","author":"Pendleton","year":"2017","journal-title":"Cell"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz619","article-title":"The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112","volume":"47","author":"van Tran","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1038\/ncomms2822","article-title":"FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA","volume":"4","author":"Fu","year":"2013","journal-title":"Nat Commun"},{"key":"B31","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol Cell"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.150126","article-title":"Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat Cell Biol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1101\/2020.06.03.131441","article-title":"Context-dependent functional compensation between Ythdf m6A reader proteins","volume":"34","author":"Lasman","year":"2020","journal-title":"Gene Dev"},{"key":"B34","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.canlet.2021.04.020","article-title":"METTL3 enhances the stability of MALAT1 with the assistance of HuR via m6A modification and activates NF-\u03baB to promote the Malignant progression of IDH-wildtype glioma","volume":"511","author":"Chang","year":"2021","journal-title":"Cancer Lett"},{"key":"B35","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/j.cell.2015.10.012","article-title":"5\u2019 UTR m6A promotes cap-independent translation","volume":"163","author":"Meyer","year":"2015","journal-title":"Cell"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl765","article-title":"Identification of human tRNA: m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA)","volume":"34","author":"Brzezicha","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.08.061","article-title":"YccW is the m5C methyltransferase specific for 23S rRNA nucleotide 1962","volume":"383","author":"Purta","year":"2008","journal-title":"J Mol Biol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1007\/bf02887186","article-title":"Developmental mRNA m5C landscape and regulatory innovations of massive m5C modification of maternal mRNAs in animals","volume":"13","author":"Liu","year":"2022","journal-title":"Nat Commun"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.2210\/pdb6jv5\/pdb","article-title":"5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons","volume":"119","author":"Zhang","year":"2022","journal-title":"P Natl Acad Sci USA"},{"key":"B40","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/s41419-023-05781-5","article-title":"Long noncoding RNA DIAPH2-AS1 promotes neural invasion of gastric cancer via stabilizing NSUN2 to enhance the m5C modification of NTN1","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis"},{"key":"B41","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s40364-020-00225-0","article-title":"Advances in RNA cytosine-5 methylation: detection, regulatory mechanisms, biological functions and links to cancer","volume":"8","author":"Xue","year":"2020","journal-title":"biomark Res"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201591382","article-title":"The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis","volume":"34","author":"Tuorto","year":"2015","journal-title":"EMBO J"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.09.098","article-title":"Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration","volume":"520","author":"Xue","year":"2019","journal-title":"Biochem Bioph Res Co"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.07.009","article-title":"NSUN2 is a glucose sensor suppressing cGAS\/STING to maintain tumorigenesis and immunotherapy resistance","volume":"35","author":"Chen","year":"2023","journal-title":"Cell Metab"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1466","article-title":"The m5 C methyltransferase NSUN2 promotes codon-dependent oncogenic translation by stabilising tRNA in anaplastic thyroid cancer","volume":"13","author":"Li","year":"2023","journal-title":"Clin Transl Med"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2357","article-title":"RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis","volume":"19","author":"Tuorto","year":"2012","journal-title":"Nat Struct Mol Biol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.molcel.2005.10.036","article-title":"Rapid tRNA decay can result from lack of nonessential modifications","volume":"21","author":"Alexandrov","year":"2006","journal-title":"Mol Cell"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.55","article-title":"5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader","volume":"27","author":"Yang","year":"2017","journal-title":"Cell Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100860","article-title":"NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation","volume":"7","author":"Tang","year":"2015","journal-title":"Aging (Albany NY)"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0361-y","article-title":"5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs","volume":"21","author":"Chen","year":"2019","journal-title":"Nat Cell Biol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.2.439","article-title":"Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA","volume":"29","author":"Dong","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/genes10020102","article-title":"Eukaryotic 5-methylcytosine (m5C) RNA methyltransferases: mechanisms, cellular functions, and links to disease","volume":"10","author":"Bohnsack","year":"2019","journal-title":"Genes-Basel"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/biom7010014","article-title":"Cross-talk between Dnmt2-dependent tRNA methylation and queuosine modification","volume":"7","author":"Ehrenhofer-Murray","year":"2017","journal-title":"Biomolecules"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac817","article-title":"Human NOP2\/NSUN1 regulates ribosome biogenesis through non-catalytic complex formation with box C\/D snoRNPs","volume":"50","author":"Liao","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1038\/s41419-021-04127-3","article-title":"NSUN2 modified by SUMO-2\/3 promotes gastric cancer progression and regulates mRNA m5C methylation","volume":"12","author":"Hu","year":"2021","journal-title":"Cell Death Dis"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-023-02707-5","article-title":"Peritoneal high-fat environment promotes peritoneal metastasis of gastric cancer cells through activation of NSUN2-mediated ORAI2 m5C modification","volume":"42","author":"Liu","year":"2023","journal-title":"Oncogene"},{"key":"B57","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41420-022-01294-w","article-title":"NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress","volume":"9","author":"Wang","year":"2023","journal-title":"Cell Death Discov"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004110","article-title":"NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly","volume":"10","author":"Metodiev","year":"2014","journal-title":"PloS Genet"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13434","article-title":"RNA cytosine methyltransferase NSUN5 promotes protein synthesis and tumorigenic phenotypes in glioblastoma","volume":"17","author":"Zhou","year":"2023","journal-title":"Mol Oncol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1193","article-title":"Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6","volume":"49","author":"Selmi","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B61","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/s42003-023-04680-x","article-title":"NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice","volume":"6","author":"Murakami","year":"2023","journal-title":"Commun Biol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205179","article-title":"Identification of m5c regulator-medicated methylation modification patterns for prognosis and immune microenvironment in glioma","volume":"15","author":"Xiao","year":"2023","journal-title":"Aging (Albany NY)"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae818","article-title":"3,N4-etheno-5-methylcytosine blocks TET1\u20133 oxidation but is repaired by ALKBH2, 3 and FTO","volume":"52","author":"Ma","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx354","article-title":"ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications","volume":"45","author":"Kawarada","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"B65","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/s41419-023-06008-3","article-title":"THOC3 interacts with YBX1 to promote lung squamous cell carcinoma progression through PFKFB4 mRNA modification","volume":"14","author":"Yu","year":"2023","journal-title":"Cell Death Dis"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2116251119","article-title":"FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation","volume":"119","author":"Yang","year":"2022","journal-title":"P Natl Acad Sci USA"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.58888","article-title":"Splicing factor SRSF2-centric gene regulation","volume":"17","author":"Li","year":"2021","journal-title":"Int J Biol Sci"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b04505","article-title":"YTHDF2 binds to 5-methylcytosine in RNA and modulates the maturation of ribosomal RNA","volume":"92","author":"Dai","year":"2020","journal-title":"Anal Chem"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.1038\/s41467-020-16722-7","article-title":"m5C modification of mRNA serves a DNA damage code to promote homologous recombination","volume":"11","author":"Chen","year":"2020","journal-title":"Nat Commun"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3390\/biom7010020","article-title":"m1A post-transcriptional modification in tRNAs","volume":"7","author":"Oerum","year":"2017","journal-title":"Biomolecules"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvy018","article-title":"rRNA adenine methylation requires T07A9.8 gene as rram-1 in Caenorhabditis elegans","volume":"163","author":"Yokoyama","year":"2018","journal-title":"J Biochem"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3508","article-title":"ARM-seq: AlkB-facilitated RNA methylation sequencing reveals a complex landscape of modified tRNA fragments","volume":"12","author":"Cozen","year":"2015","journal-title":"Nat Methods"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1102","article-title":"Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA","volume":"41","author":"Peifer","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.23.3650","article-title":"The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA","volume":"12","author":"Anderson","year":"1998","journal-title":"Gene Dev"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1261\/rna.5040605","article-title":"The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans","volume":"11","author":"Ozanick","year":"2005","journal-title":"Rna"},{"key":"B76","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1101\/202747","article-title":"Base-resolution mapping reveals distinct m1A methylome in nuclear- and mitochondrial-encoded transcripts","volume":"68","author":"Li","year":"2017","journal-title":"Mol Cell"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/nature24456","article-title":"The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution","volume":"551","author":"Safra","year":"2017","journal-title":"Nature"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.038","article-title":"ALKBH1-mediated tRNA demethylation regulates translation","volume":"167","author":"Liu","year":"2016","journal-title":"Cell"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2040","article-title":"Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome","volume":"12","author":"Li","year":"2016","journal-title":"Nat Chem Biol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1250","article-title":"Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs","volume":"47","author":"Chen","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1360\/012013-151","article-title":"Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm","volume":"71","author":"Wei","year":"2018","journal-title":"Mol Cell"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b01703","article-title":"Identification of YTH domain-containing proteins as the readers for N1-methyladenosine in RNA","volume":"90","author":"Dai","year":"2018","journal-title":"Anal Chem"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401493101","article-title":"Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II","volume":"101","author":"Mandal","year":"2004","journal-title":"P Natl Acad Sci USA"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.00540-18","article-title":"Distinct functions of the cap-binding complex in stimulation of nuclear mRNA export","volume":"39","author":"Sen","year":"2019","journal-title":"Mol Cell Biol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19124080","article-title":"7-methylguanosine modifications in transfer RNA (tRNA)","volume":"19","author":"Tomikawa","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz736","article-title":"Detection of internal N7-methylguanosine (m7G) RNA modifications by mutational profiling sequencing","volume":"47","author":"Enroth","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.040","article-title":"METTL1 promotes let-7 microRNA processing via m7G methylation","volume":"74","author":"Pandolfini","year":"2019","journal-title":"Mol Cell"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw637","article-title":"Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM","volume":"44","author":"Varshney","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.08.041","article-title":"RAM\/Fam103a1 is required for mRNA cap methylation","volume":"44","author":"Gonatopoulos-Pournatzis","year":"2011","journal-title":"Mol Cell"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1017\/s1355838200000364","article-title":"The crystal structure of yeast phenylalanine tRNA at 1.93 A resolution: a classic structure revisited","volume":"6","author":"Shi","year":"2000","journal-title":"Rna"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj491","article-title":"Accurate energies of hydrogen bonded nucleic acid base pairs and triplets in tRNA tertiary interactions","volume":"34","author":"Oliva","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1261\/rna.047910.114","article-title":"WBSCR22\/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA","volume":"21","author":"Haag","year":"2015","journal-title":"Rna"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.05.047","article-title":"QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism","volume":"186","author":"Zhao","year":"2023","journal-title":"Cell"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjae012","article-title":"Regulation of m6Am RNA modification and its implications in human diseases","volume":"16","author":"Jin","year":"2024","journal-title":"J Mol Cell Biol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032277","article-title":"Regulation of gene expression by m6Am RNA modification","volume":"24","author":"Cesaro","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B96","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s12935-023-03066-7","article-title":"PCIF1, the only methyltransferase of N6,2-O-dimethyladenosine","volume":"23","author":"Wu","year":"2023","journal-title":"Cancer Cell Int"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.26226\/morressier.5ebd45acffea6f735881b196","article-title":"METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing","volume":"48","author":"Goh","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/nature21022","article-title":"Reversible methylation of m6Am in the 5\u2019 cap controls mRNA stability","volume":"541","author":"Mauer","year":"2017","journal-title":"Nature"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0231-8","article-title":"FTO controls reversible m6Am RNA methylation during snRNA biogenesis","volume":"15","author":"Mauer","year":"2019","journal-title":"Nat Chem Biol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2024.10.004","article-title":"m6Am sequesters PCF11 to suppress premature termination and drive neuroblastoma differentiation","volume":"84","author":"An","year":"2024","journal-title":"Mol Cell"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1021\/ja505305z","article-title":"Tet-mediated formation of 5-hydroxymethylcytosine in RNA","volume":"136","author":"Fu","year":"2014","journal-title":"J Am Chem Soc"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1039\/c5cc07354e","article-title":"The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals","volume":"52","author":"Zhang","year":"2016","journal-title":"Chem Commun"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.457","article-title":"Epigenomic landscape of 5-hydroxymethylcytosine reveals its transcriptional regulation of lncRNAs in colorectal cancer","volume":"116","author":"Hu","year":"2017","journal-title":"Brit J Cancer"},{"key":"B104","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.1038\/s41467-020-16321-6","article-title":"DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification","volume":"11","author":"Lentini","year":"2020","journal-title":"Nat Commun"},{"key":"B105","doi-asserted-by":"publisher","first-page":"5775","DOI":"10.1038\/s41467-024-50161-y","article-title":"m3C32 tRNA modification controls serine codon-biased mRNA translation, cell cycle, and DNA-damage response","volume":"15","author":"Cui","year":"2024","journal-title":"Nat Commun"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab603","article-title":"Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6","volume":"49","author":"Mao","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac184","article-title":"Molecular basis for human mitochondrial tRNA m3C modification by alternatively spliced METTL8","volume":"50","author":"Huang","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00821-0","article-title":"Detection technologies for RNA modifications","volume":"54","author":"Zhang","year":"2022","journal-title":"Exp Mol Med"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25063098","article-title":"An overview of current detection methods for RNA methylation","volume":"25","author":"Sa\u011flam","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3453","article-title":"Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome","volume":"12","author":"Linder","year":"2015","journal-title":"Nat Methods"},{"key":"B111","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1038\/s41587-022-01587-6","article-title":"Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination","volume":"41","author":"Xiao","year":"2023","journal-title":"Nat Biotechnol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-8808-2_1","article-title":"Bisulfite sequencing of RNA for transcriptome-wide detection of 5-methylcytosine","volume":"1870","author":"Trixl","year":"2019","journal-title":"Methods Mol Biol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.03.036","article-title":"Transcriptome-wide mapping of internal N7-methylguanosine methylome in mammalian mRNA","volume":"74","author":"Zhang","year":"2019","journal-title":"Mol Cell"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0550-4","article-title":"Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA","volume":"16","author":"Zhou","year":"2019","journal-title":"Nat Methods"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-443-23947-2.00081-3","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.116066","article-title":"Emerging roles and mechanism of m6A methylation in rheumatoid arthritis","volume":"170","author":"Xu","year":"2024","journal-title":"BioMed Pharmacother"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1494873","article-title":"Emerging influence of RNA post-transcriptional modifications in the synovial homeostasis of rheumatoid arthritis","volume":"15","author":"Fatima","year":"2024","journal-title":"Front Immunol"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2024.114237","article-title":"Increased m6A RNA methylation and METTL3 expression may contribute to the synovitis progression of rheumatoid arthritis","volume":"442","author":"Su","year":"2024","journal-title":"Exp Cell Res"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00575.2022","article-title":"METTL14 promotes fibroblast-like synoviocytes activation via the LASP1\/SRC\/AKT axis in rheumatoid arthritis","volume":"324","author":"Li","year":"2023","journal-title":"Am J Physiol-Cell Ph"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3120391","article-title":"METTL3 attenuates LPS-induced inflammatory response in macrophages via NF-\u03baB signaling pathway","volume":"2019","author":"Wang","year":"2019","journal-title":"Mediat Inflammation"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5114697","article-title":"Identification of synovial fibroblast-associated neuropeptide genes and m6A factors in rheumatoid arthritis using single-cell analysis and machine learning","volume":"2022","author":"Xiao","year":"2022","journal-title":"Dis Markers"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167112","article-title":"METTL3 knockdown suppresses RA-FLS activation through m6A-YTHDC2-mediated regulation of AMIGO2","volume":"1870","author":"Miao","year":"2024","journal-title":"Bba-Mol Basis Dis"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1002\/art.42629","article-title":"METTL14-mediated m6A modification of TNFAIP3 involved in inflammation in patients with active rheumatoid arthritis","volume":"75","author":"Tang","year":"2023","journal-title":"Arthritis Rheumatol"},{"key":"B124","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s13018-025-05526-4","article-title":"METTL3-mediated methylation of RAC2 contributes to cell motility, oxidative stress and inflammation in TNF-\u03b1-stimulated rheumatoid arthritis fibroblast-like synovial cells","volume":"20","author":"Ren","year":"2025","journal-title":"J Orthop Surg Res"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.70065","article-title":"WTAP-mediated m6A modification of TRAIL-DR4 suppresses MH7A cell apoptosis","volume":"28","author":"Cui","year":"2025","journal-title":"Int J Rheum Dis"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2203318119","article-title":"RNA m6A demethylase ALKBH5 regulates the development of \u03b3\u03b4 T cells","volume":"119","author":"Ding","year":"2022","journal-title":"P Natl Acad Sci USA"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1038\/s41419-022-05479-0","article-title":"SMOC2 promotes aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis through transcriptional and post-transcriptional regulating MYO1C","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.05.087","article-title":"ALKBH5-YTHDF2 m6A modification axis inhibits rheumatoid arthritis progression by suppressing NLRP3","volume":"668","author":"Xiao","year":"2023","journal-title":"Biochem Bioph Res Co"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgae003","article-title":"Fat mass and obesity-associated protein inhibit the pathology of rheumatoid arthritis through the NSUN2\/SFRP1\/Wnt\/\u03b2-catenin signal axis","volume":"76","author":"Huang","year":"2024","journal-title":"J Pharm Pharmacol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13075-024-03290-0","article-title":"Fibroblast-like synoviocytes-derived exosomal circFTO deteriorates rheumatoid arthritis by enhancing N6-methyladenosine modification of SOX9 in chondrocytes","volume":"26","author":"Li","year":"2024","journal-title":"Arthritis Res Ther"},{"key":"B131","doi-asserted-by":"publisher","first-page":"167341","DOI":"10.1038\/ncomms2822","article-title":"FTO-mediated RNA m6A methylation regulates synovial aggression and inflammation in rheumatoid arthritis","volume":"1870","author":"Li","year":"2024","journal-title":"Bba-Mol Basis Dis"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2024.109929","article-title":"Hypoxia-induced ALKBH5 aggravates synovial aggression and inflammation in rheumatoid arthritis by regulating the m6A modification of CH25H","volume":"261","author":"Fan","year":"2024","journal-title":"Clin Immunol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5735279","article-title":"Decreased ALKBH5, FTO, and YTHDF2 in peripheral blood are as risk factors for rheumatoid arthritis","volume":"2020","author":"Luo","year":"2020","journal-title":"BioMed Res Int"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0303593","article-title":"IGF2BP3 regulates the expression of RRM2 and promotes the progression of rheumatoid arthritis via RRM2\/Akt\/MMP-9 pathway","volume":"19","author":"Ban","year":"2024","journal-title":"PloS One"},{"key":"B135","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/s41420-024-01988-3","article-title":"IGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritis","volume":"10","author":"Nan","year":"2024","journal-title":"Cell Death Discov"},{"key":"B136","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1080\/1547691x.2022.2067916","article-title":"Expression and clinical significance of the m6A reader YTHDF2 in peripheral blood mononuclear cells from rheumatoid arthritis patients","volume":"19","author":"Yao","year":"2022","journal-title":"J Immunotoxicol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1440398","article-title":"YTHDC1 regulates the migration, invasion, proliferation, and apoptosis of rheumatoid fibroblast-like synoviocytes","volume":"15","author":"Feng","year":"2024","journal-title":"Front Immunol"},{"key":"B138","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1007\/s10735-025-10656-4","article-title":"ALKBH5-mediated RNA m6A methylation regulates the migration, invasion, and proliferation of rheumatoid fibroblast-like synoviocytes","volume":"76","author":"Kuang","year":"2024","journal-title":"Arthritis Rheumatol"},{"key":"B139","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/s41413-025-00434-z","article-title":"IGF2BP3-mediated m6A modification of RASGRF1 promoting joint injury in rheumatoid arthritis","volume":"13","author":"Geng","year":"2025","journal-title":"Bone Res"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153871","article-title":"N6-methyladenosine modification of TGM2 mRNA contributes to the inhibitory activity of sarsasapogenin in rheumatoid arthritis fibroblast-like synoviocytes","volume":"95","author":"Lin","year":"2022","journal-title":"Phytomedicine"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-7-201310010-01004","article-title":"Systemic lupus erythematosus","volume":"172","author":"Kiriakidou","year":"2020","journal-title":"Ann Intern Med"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2013010026","article-title":"The pathogenesis of lupus nephritis","volume":"24","author":"Lech","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"B143","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12943-024-02041-8","article-title":"The role of RNA methylation in tumor immunity and its potential in immunotherapy","volume":"23","author":"Li","year":"2024","journal-title":"Mol Cancer"},{"key":"B144","doi-asserted-by":"publisher","first-page":"3098","DOI":"10.1186\/s10020-023-00643-4","article-title":"m6A methyltransferase METTL3 programs CD4(+) T-cell activation and effector T-cell differentiation in systemic lupus erythematosus","volume":"29","author":"Lu","year":"2023","journal-title":"Mol Med"},{"key":"B145","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1186\/s12916-024-03735-y","article-title":"METTL3 facilitates kidney injury through promoting IRF4-mediated plasma cell infiltration via an m6A-dependent manner in systemic lupus erythematosus","volume":"22","author":"Liu","year":"2024","journal-title":"BMC Med"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.2174\/1381612828666220617154204","article-title":"ALKBH5 expression could affect the function of T cells in systemic lupus erythematosus patients: A case-control study","volume":"28","author":"Deng","year":"2022","journal-title":"Curr Pharm Design"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-596920-8.50009-3","article-title":"FoxO1 deficiency in monocytic myeloid-derived suppressor cells exacerbates B cell dysfunction in systemic lupus erythematosus","volume":"77","author":"Tan","year":"2025","journal-title":"Arthritis Rheumatol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8193895","article-title":"Decreased peripheral blood ALKBH5 correlates with markers of autoimmune response in systemic lupus erythematosus","volume":"2020","author":"Luo","year":"2020","journal-title":"Dis Markers"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1298","article-title":"The study of METTL14, ALKBH5, and YTHDF2 in peripheral blood mononuclear cells from systemic lupus erythematosus","volume":"8","author":"Luo","year":"2020","journal-title":"Mol Genet Genom Med"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00430","article-title":"Disease activity-associated alteration of mRNA m5C methylation in CD4(+) T cells of systemic lupus erythematosus","volume":"8","author":"Guo","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.2147\/jir.s431628","article-title":"Diagnostic values of METTL1-related genes and immune characteristics in systemic lupus erythematosus","volume":"16","author":"Liu","year":"2023","journal-title":"J Inflammation Res"},{"key":"B152","doi-asserted-by":"publisher","first-page":"10599","DOI":"10.1038\/s41467-024-54941-4","article-title":"Aberrant METTL1-mediated tRNA m7G modification alters B-cell responses in systemic autoimmunity in humans and mice","volume":"15","author":"Wang","year":"2024","journal-title":"Nat Commun"},{"key":"B153","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nrrheum.2010.79","article-title":"Pathogenesis of ankylosing spondylitis","volume":"6","author":"Tam","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.748063","article-title":"The potential role of genetics, environmental factors, and gut dysbiosis in the aberrant non-coding RNA expression to mediate inflammation and osteoclastogenic\/osteogenic differentiation in ankylosing spondylitis","volume":"9","author":"Liao","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B155","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1615\/critreveukaryotgeneexpr.2024057127","article-title":"METTL17-mediated inhibition of M1 macrophage polarization alleviates the progression of ankylosing spondylitis","volume":"35","author":"Lv","year":"2025","journal-title":"Crit Rev Eukar Gene"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109838","article-title":"METTL14-m6A-FOXO3a axis regulates autophagy and inflammation in ankylosing spondylitis","volume":"257","author":"Chen","year":"2023","journal-title":"Clin Immunol"},{"key":"B157","doi-asserted-by":"publisher","first-page":"5373","DOI":"10.1038\/s41467-021-25710-4","article-title":"TNF-\u03b1-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis","volume":"12","author":"Xie","year":"2021","journal-title":"Nat Commun"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.1314","article-title":"Identification of key genes with abnormal RNA methylation modification and selected m6A regulators in ankylosing spondylitis","volume":"12","author":"Wu","year":"2024","journal-title":"Immun Inflammation Dis"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v17.i3.98911","article-title":"Fat mass and obesity-associated protein in mesenchymal stem cells inhibits osteoclastogenesis via lnc NORAD\/miR-4284 axis in ankylosing spondylitis","volume":"17","author":"Liu","year":"2025","journal-title":"World J Stem Cells"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2024.08.172","article-title":"The role of N6-methyladenosine(m(6)A) mediated LncRNA DDIT3 upregulation in chondrocyte ferroptosis in ankylosing spondylitis","volume":"48","author":"Wang","year":"2025","journal-title":"Asian J Surg"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113670","article-title":"ALKBH5 controlled autophagy of peripheral blood mononuclear cells by regulating NRG1 mRNA stability in ankylosing spondylitis","volume":"144","author":"Xie","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B162","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1186\/s12967-025-06607-y","article-title":"YTHDF3 regulates IL32 mRNA stability to promote osteogenic differentiation of bone mesenchymal stem cells in ankylosing spondylitis","volume":"23","author":"Zhou","year":"2025","journal-title":"J Transl Med"},{"key":"B163","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41584-023-00932-6","article-title":"Genetics and epigenetics of primary Sj\u00f6gren syndrome: implications for future therapies","volume":"19","author":"Thorlacius","year":"2023","journal-title":"Nat Rev Rheumatol"},{"key":"B164","doi-asserted-by":"publisher","first-page":"3523","DOI":"10.1038\/s41467-021-23472-7","article-title":"A new molecular classification to drive precision treatment strategies in primary Sj\u00f6gren\u2019s syndrome","volume":"12","author":"Soret","year":"2021","journal-title":"Nat Commun"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e3821","article-title":"Primary Sjogren syndrome","volume":"344","author":"Ramos-Casals","year":"2012","journal-title":"Bmj-Brit Med J"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.959388","article-title":"The potential role of RNA N6-methyladenosine in primary Sj\u00f6gren\u2019s syndrome","volume":"9","author":"Xiao","year":"2022","journal-title":"Front Med-Lausanne"},{"key":"B167","doi-asserted-by":"publisher","first-page":"5242287","DOI":"10.1155\/2022\/5242287","article-title":"N6-Methyladenosine regulator-mediated RNA methylation is involved in primary Sj\u00f6gren\u2019s syndrome immunoinfiltration","volume":"2022","author":"He","year":"2022","journal-title":"Dis Markers"},{"key":"B168","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s12886-023-02988-0","article-title":"Increased METTL3 expression and m6A RNA methylation may contribute to the development of dry eye in primary Sj\u00f6gren\u2019s syndrome","volume":"23","author":"Ma","year":"2023","journal-title":"BMC Ophthalmol"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24860","article-title":"Significance of N6-methyladenosine RNA methylation regulators in diagnosis and subtype classification of primary Sj\u00f6gren\u2019s syndrome","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.949206","article-title":"Alterations of m6A RNA methylation regulators contribute to autophagy and immune infiltration in primary Sj\u00f6gren\u2019s syndrome","volume":"13","author":"Cheng","year":"2022","journal-title":"Front Immunol"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e28645","article-title":"Integrated analysis of m6A regulator-mediated RNA methylation modification patterns and immune characteristics in Sj\u00f6gren\u2019s syndrome","volume":"10","author":"Yin","year":"2024","journal-title":"Heliyon"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2023.110650","article-title":"Involvement of RNA methylation modification patterns mediated by m7G, m6A, m5C and m1A regulators in immune microenvironment regulation of Sj\u00f6gren\u2019s syndrome","volume":"106","author":"Liu","year":"2023","journal-title":"Cell Signal"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2024.103341","article-title":"EZH2 promotes B-cell autoimmunity in primary Sjogren\u2019s syndrome via METTL3-mediated m6A modification","volume":"149","author":"Yang","year":"2024","journal-title":"J Autoimmun"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2025.123884","article-title":"M6A modification of RRM2 drives B cell hyperactivity in primary Sj\u00f6gren\u2019s syndrome","volume":"379","author":"Yang","year":"2025","journal-title":"Life Sci"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1383\/medc.30.10.36.28247","article-title":"Systemic sclerosis","volume":"390","author":"Denton","year":"2017","journal-title":"Lancet"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu155","article-title":"Epigenetics, the holy grail in the pathogenesis of systemic sclerosis","volume":"54","author":"Altorok","year":"2015","journal-title":"Rheumatology"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2023.147989","article-title":"Characteristics of N6-methyladenosine (m6A) regulators and role of FTO\/TNC in scleroderma","volume":"894","author":"Yu","year":"2024","journal-title":"Gene"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1148","article-title":"Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3-mediated N6-methyladenosine modification of ICAM2 mRNA in fibroblast-like synoviocytes","volume":"12","author":"Chen","year":"2022","journal-title":"Clin Transl Med"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c01570","article-title":"Small-molecule inhibitors targeting RNA m6A modifiers for cancer therapeutics: Latest advances and future perspectives","volume":"68","author":"Tang","year":"2025","journal-title":"J Med Chem"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.843358","article-title":"Potential target analysis of triptolide based on transcriptome-wide m6A methylome in rheumatoid arthritis","volume":"13","author":"Fan","year":"2022","journal-title":"Front Pharmacol"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01965-2","article-title":"Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages","volume":"37","author":"Sturgess","year":"2023","journal-title":"Leukemia"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.cd-23-0007","article-title":"Inhibition of METTL3 results in a cell-intrinsic interferon response that enhances antitumor immunity","volume":"13","author":"Guirguis","year":"2023","journal-title":"Cancer Discov"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.115300","article-title":"3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line","volume":"28","author":"Malacrida","year":"2020","journal-title":"Bioorgan Med Chem"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.04.019","article-title":"YTHDF2 inhibition potentiates radiotherapy antitumor efficacy","volume":"41","author":"Wang","year":"2023","journal-title":"Cancer Cell"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224916","article-title":"Unmet need in rheumatology: reports from the Advances in Targeted Therapies meeting, 2023","volume":"83","author":"Winthrop","year":"2024","journal-title":"Ann Rheum Dis"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1080\/08830185.2023.2280544","article-title":"RNA methylation: A potential therapeutic target in autoimmune disease","volume":"43","author":"Li","year":"2024","journal-title":"Int Rev Immunol"},{"key":"B187","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.jot.2025.05.004","article-title":"N6-methyladenosine and intervertebral disc degeneration: Advances in detection and pathological insights","volume":"53","author":"Liu","year":"2025","journal-title":"J Orthop Transl"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1779307\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:35:26Z","timestamp":1777613726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1779307\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":187,"alternative-id":["10.3389\/fimmu.2026.1779307"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1779307","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"article-number":"1779307"}}