{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:54:49Z","timestamp":1776664489194,"version":"3.51.2"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Skin-homing cutaneous lymphocyte-associated antigen (CLA)-expressing T cells play a key role in the pathogenesis of atopic dermatitis (AD) and psoriasis (Ps). We aimed to characterize the transcriptomic and epigenetic profiles of circulating CD4\n                      <jats:sup>+<\/jats:sup>\n                      CLA\n                      <jats:sup>+<\/jats:sup>\n                      and CD4\n                      <jats:sup>+<\/jats:sup>\n                      na\u00efve T cells from patients with AD and Ps to find shared and unique molecular signatures associated with the diseases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Circulating CD4\n                      <jats:sup>+<\/jats:sup>\n                      CLA\n                      <jats:sup>+<\/jats:sup>\n                      and CD4\n                      <jats:sup>+<\/jats:sup>\n                      na\u00efve T cells were sorted from the peripheral blood mononuclear cells of patients with AD (\n                      <jats:italic>n<\/jats:italic>\n                      = 11), those with Ps (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a010), and healthy individuals (\n                      <jats:italic>n<\/jats:italic>\n                      = 11), followed by assay for transposase-accessible chromatin sequencing (ATAC-seq) and mRNA sequencing and data analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Transcriptomic and epigenetic landscapes differed markedly between CD4\n                      <jats:sup>+<\/jats:sup>\n                      CLA\n                      <jats:sup>+<\/jats:sup>\n                      and CD4\n                      <jats:sup>+<\/jats:sup>\n                      na\u00efve T cells. In both AD and Ps, transcriptomic alterations within these cell populations were substantial, whereas changes in chromatin accessibility were relatively modest. In CLA\n                      <jats:sup>+<\/jats:sup>\n                      T cells, patients with AD and Ps exhibited altered expression of genes involved in T-cell activation, cell cycle, and JAK\u2013STAT signaling. These effects were more pronounced in AD, while a stronger association with innate immune activation was seen in Ps. Notably, CD4\n                      <jats:sup>+<\/jats:sup>\n                      na\u00efve T cells also exhibited disease-associated transcriptomic changes in both AD and Ps, including alterations in the JAK\u2013STAT pathway and changes in the expression of IL-2 receptor components. Epigenetic profiling further revealed disease-associated chromatin regions linked to transcription factors involved in immune regulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Both CD4\n                      <jats:sup>+<\/jats:sup>\n                      CLA\n                      <jats:sup>+<\/jats:sup>\n                      and CD4\n                      <jats:sup>+<\/jats:sup>\n                      na\u00efve T cells exhibit transcriptomic and epigenetic alterations in AD and Ps, suggesting the influence of the chronic inflammatory milieu leading to shared and disease-specific changes, including transcriptomic rewiring of the JAK\u2013STAT pathway in both diseases.\n                    <\/jats:p>\n                  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