{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T05:06:54Z","timestamp":1775797614403,"version":"3.50.1"},"reference-count":250,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Sepsis is a major global cause of critical illness with high mortality. Sepsis-associated thrombocytopenia (SAT) is linked to markedly increased death risk and is a key indicator of poor prognosis. Although platelets are recognized as central players in the \u201cinflammation\u2013coagulation\u2013immunity\u201d network, most studies emphasize platelet counts rather than functional heterogeneity and underlying regulatory mechanisms, limiting the development of specific biomarkers and targeted therapies. Here, we characterize the \u201cdouble-edged\u201d role of platelets in sepsis. On the one hand, platelets recognize pathogens through pattern recognition receptors and exert anti-infective host defense functions; on the other hand, excessive platelet activation promotes endothelial injury and microthrombus formation through multiple signaling pathways and mediator release. These findings provide a concise framework linking platelet quantity, function, and mechanism in sepsis, and support the development of improved diagnostic and targeted treatment strategies.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1783001","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T04:25:39Z","timestamp":1775795139000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stratified assessment of platelets in sepsis: from dynamic counts to functional phenotypes"],"prefix":"10.3389","volume":"17","author":[{"given":"Yafei","family":"Liu","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College of Shandong University of Medicine","place":["Yantai, Shandong, China"]},{"name":"Department of Critical Care Medicine, Yantai Yuhuangding Hospital Affiliated to Qingdao University","place":["Yantai, Shandong, 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