{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:38:47Z","timestamp":1773041927649,"version":"3.50.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A combination of local and systemic therapies is used to treat inguinal lymph node metastases post-penile cancer surgery. This multimodal approach may include surgery, chemotherapy, radiotherapy, and immunotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>We describe an 89-year-old male with a history of penile cancer status post resection, who presented with multiple metastases to the left inguinal lymph nodes confirmed by pathological biopsy. The patient was treated with a combination of radiotherapy and Pembrolizumab. Following this combined modality therapy, he experienced symptomatic relief and achieved a progression-free survival exceeding 38 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case suggests that concurrent radiotherapy plus Pembrolizumab may achieve durable remission in elderly, chemotherapy-intolerant, metastatic PSCC, but verification in more patients is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1783437","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:48:12Z","timestamp":1773038892000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiotherapy combined with immunotherapy achieves clinical complete response in elderly metastatic penile cancer: a case 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