{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:05:09Z","timestamp":1780380309180,"version":"3.54.1"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>SAPHO syndrome is a rare autoimmune disorder, and the occurrence of renal involvement in this condition is even more uncommon. We report the case of a 43-year-old male patient with SAPHO syndrome, who initially presented with palmoplantar pustulosis and pain in the chest wall and sternoclavicular joints, accompanied by proteinuria and microscopic hematuria. He was admitted to the hospital due to headache, lower limb edema, and elevated serum creatinine. Renal biopsy revealed stage II membranous nephropathy combined with analgesic nephropathy. Following treatment, his symptoms resolved, and at one-year follow-up, proteinuria had nearly achieved clinical complete remission, with stable renal function.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1784305","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:41:48Z","timestamp":1780378908000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["SAPHO syndrome with membranous nephropathy and analgesic-induced nephropathy: a case report"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuxin","family":"Qiao","sequence":"first","affiliation":[{"name":"Clinical College of Traditional Chinese Medicine, Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical College of Traditional Chinese Medicine, Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical College of Traditional Chinese Medicine, Inner Mongolia Medical University","place":["Hohhot, China"]},{"name":"Department of Rheumatology and Immunology, Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/mr\/roab103","article-title":"SAPHO syndrome and pustulotic arthro-osteitis","volume":"32","author":"Kishimoto","year":"2022","journal-title":"Mod Rheumatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.04.030","article-title":"Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome - a challenging diagnosis not to be missed","volume":"72","author":"Zimmermann","year":"2016","journal-title":"J Infect"},{"key":"B3","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1186\/s13052-020-00933-1","article-title":"SAPHO syndrome: the supposed trigger by isotretinoin, the efficacy of adalimumab and the specter of depressive disorder: a case report","volume":"46","author":"Luzzati","year":"2020","journal-title":"Ital J Pediatr"},{"key":"B4","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s10238-025-01750-8","article-title":"Clinicopathological features and renal outcomes in patients with IgA nephropathy secondary to psoriasis","volume":"25","author":"He","year":"2025","journal-title":"Clin Exp Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.2150","article-title":"Recurrent unilateral headache associated with SAPHO syndrome","volume":"53","author":"Tsugawa","year":"2014","journal-title":"Intern Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.5692\/clinicalneurol.52.106","article-title":"Headache as a manifestation of SAPHO syndrome with a lesion extending to the dura mater, parietal bone, and temporal muscle","volume":"52","author":"Uematsu","year":"2012","journal-title":"Rinsho Shinkeigaku"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.4.0693","article-title":"Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome presenting as a primary calvarial lesion. 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