{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:55:26Z","timestamp":1773392126717,"version":"3.50.1"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    A patient with systemic lupus erythematosus developed localized swelling with blistering after mosquito bites. A complete blood count showed eosinophils were 1.09 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L (13.9%). Total IgE was more than 5,000 KU\/L. Examination of the blister fluid showed very high levels of interleukin (IL)-1\u03b2, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17, tumor necrosis factor (TNF)-\u03b1, interferon (IFN)-\u03b1, and IFN-\u03b3 cytokines, while these serum cytokine levels were normal. After sterile extraction of the blister fluid, the inflammatory substances were removed, and the blister gradually disappeared. This might be a special manifestation after mosquito bites in a patient with a background of autoimmune diseases. Particular attention should be paid to patients with autoimmune diseases after insect bites.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1785094","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:48:27Z","timestamp":1773384507000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Localized hyperinflammatory response in the bulla after mosquito bites in a patient with systemic lupus erythematosus"],"prefix":"10.3389","volume":"17","author":[{"given":"Sainan","family":"Bian","sequence":"first","affiliation":[{"name":"Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]},{"name":"Beijing Key Laboratory of Precision Medical for Diagnosis and Treatment of Allergic Disease","place":["Beijing, China"]},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]},{"name":"Beijing Key Laboratory of Precision Medical for Diagnosis and Treatment of Allergic Disease","place":["Beijing, China"]},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases","place":["Beijing, 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