{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:19:51Z","timestamp":1790705991412,"version":"4.1.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Oral lichen planus (OLP), known as a common and chronic mucosal inflammatory disease. Due to its potential for cancerous transformation, this disease has long been a subject of significant concern. Its pathogenesis is that an unknown antigen activates oral keratinocytes and antigen-presenting cells (APCs) in the epithelium, leading to a T cell-mediated immune response. This study investigates the regulatory role of HIF-1\u03b1 transcription factor and the potential role of autophagy in a simulated OLP inflammatory cell model. In this study, by comparing the control group with the model group, we observed a notable up-regulation of\n                    <jats:italic>HIF1A<\/jats:italic>\n                    mRNA expression. Additionally, both the autophagy marker protein LC3-II and its substrate p62 exhibited abnormal accumulation, suggesting that autophagy is impaired at the lysosomal degradation stage. Furthermore, mechanistic studies have shown that HIF-1\u03b1 leads to dysfunction of the autophagy-lysosomal pathway by inhibiting the expression of lysosomal-related genes, while knockdown of HIF-1\u03b1 alleviates the disruption of autophagic and promotes the improvement of cell activity. In experiments with\n                    <jats:italic>C. elegans<\/jats:italic>\n                    , stimulation with\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    lipopolysaccharide (\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    LPS) shortens worms\u2019 lifespan, but knocking down the\n                    <jats:italic>hif-1<\/jats:italic>\n                    gene reverses this effect. Similarly, deletion of the key autophagy genes\n                    <jats:italic>bec-1<\/jats:italic>\n                    and\n                    <jats:italic>lgg-1<\/jats:italic>\n                    reduces worm survival rates. Results indicate that HIF-1\u03b1 plays a vital role in regulating autophagy-lysosomal function and cellular homeostasis. In summary, the excessively high expression of HIF-1\u03b1 aggravates cellular and systemic damage by impairing autophagy-lysosomal function in OLP. Conversely, the targeted inhibition of HIF-1\u03b1 restores autophagy function, suggesting a potential therapeutic strategy.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2026.1789261","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:21:44Z","timestamp":1776140504000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypoxia inducible factor 1 subunit alpha mediates autophagy disorder of oral lichen planus by regulating lysosomal pathway"],"prefix":"10.3389","volume":"17","author":[{"given":"Xie","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Oral Diseases Research, School of Stomatology, Zunyi Medical University","place":["Zunyi, Guizhou, China"]},{"name":"Institute of Life Sciences, Zunyi Medical University","place":["Zunyi, Guizhou, 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