{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:22:49Z","timestamp":1790367769729,"version":"4.1.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Osteoarthritis (OA) is a chronic, progressive joint disease characterized by degenerative changes in articular cartilage, subchondral bone sclerosis, accompanied by synovitis and chondrocyte apoptosis. With the aging of society, it has become one of the major factors endangering the mobility of middle-aged and elderly people worldwide. The pathogenesis of OA remains unclear, and current treatments can only control symptoms without effectively repairing damaged cartilage. Ferroptosis, a novel form of programmed cell death proposed and confirmed in 2012, is characterized by iron-dependent accumulation of lipid peroxides, mitochondria-specific damage, and imbalance in antioxidant defense capacity. In recent years, it has been proven to be involved in regulating the process of cartilage degradation in OA. This review mainly focuses on the key biological processes of chondrocyte ferroptosis, elaborating on the interactions between iron homeostasis disorders, oxidative stress and inflammation, as well as the research progress on chondrocyte ferroptosis induced by dysregulation of important signaling pathways in the pathological environment of OA. In summary, it systematically analyzes the relationship between ferroptosis and other forms of programmed cell death, summarizes the research progress of OA therapeutic strategies targeting chondrocyte ferroptosis, and puts forward the existing contradictions and development trends in current research, aiming to provide new clues and directions for exploring the mechanism of OA occurrence and development and clinical personalized treatment.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1790918","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T05:19:31Z","timestamp":1774588771000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Research progress on the mechanism of chondrocyte ferroptosis in osteoarthritis"],"prefix":"10.3389","volume":"17","author":[{"given":"Ling","family":"Zhou","sequence":"first","affiliation":[{"name":"Orthopedics and Arthrology Department, Affiliated Sports Hospital of Chengdu Sport University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohua","family":"Ju","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Chengdu Sports University Affiliated Sports Hospital","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Sports Medicine and Health College, Chengdu Sports University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Fu","sequence":"additional","affiliation":[{"name":"Orthopedics and Arthrology Department, Affiliated Sports Hospital of Chengdu Sport University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruicheng","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Chengdu Medical College","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benxiang","family":"He","sequence":"additional","affiliation":[{"name":"Sichuan Academy of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Hu","sequence":"additional","affiliation":[{"name":"Sports Medicine and Health College, Chengdu Sports University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13134","article-title":"D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2\u03b1-dependent manner","volume":"54","author":"Zhou","year":"2021","journal-title":"Cell Prolif"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.12307\/2024.287","article-title":"Mechanism of ferroptosis in osteoarthritis and its traditional Chinese medicine interventions","volume":"28","author":"Gao","year":"2024","journal-title":"Chin. J. Tissue Eng. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.11958\/20221976","article-title":"Effect and its mechanism of emodin on the ferroptosis of chondrocytes in rats with knee osteoarthritis","volume":"51","author":"Wang","year":"2023","journal-title":"Tianjin Med. J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.12677\/jcpm.2024.34365","article-title":"Research progress of traditional Chinese medicine treatment of osteoarthritis based on the ferroptosis theory","volume":"3","author":"Yang","year":"2024","journal-title":"J. Clin. Personalized Med."},{"key":"B5","first-page":"2637","article-title":"Bioinformatic analysis and experimental validation of ferroptosis in osteoarthritis","volume":"27","author":"Li","year":"2023","journal-title":"Chin. J. Tissue Eng. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"11717","DOI":"10.1101\/2024.02.23.581510","article-title":"Mechanical confinement induces ferroptosis through mitochondrial dysfunction","volume":"16","author":"Zhou","year":"2025","journal-title":"Nat Commun"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2020.09.006","article-title":"Chondrocyte ferroptosis contribute to the progression of osteoarthritis","volume":"27","author":"A","year":"2021","journal-title":"J Orthop Translat"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-023-00282-0","article-title":"The role of ferroptosis in the pathogenesis of osteoarthritis","volume":"256","author":"Al-Hetty","year":"2023","journal-title":"J Membr Biol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1080\/26895293.2024.2391292","article-title":"Ferroptosis plays a role in osteoarthritis","volume":"17","author":"Altahla","year":"2024","journal-title":"All Life"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25158212","article-title":"Ferroptosis in arthritis: Driver of the disease or therapeutic option","volume":"25","author":"Bieri","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.12229","article-title":"METTL3 mediated ferroptosis in chondrocytes and promoted pain in KOA via HMGB1 m6A modification","volume":"48","author":"Bao","year":"2024","journal-title":"Cell Biol Int"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1202436","article-title":"Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies","volume":"14","author":"Cao","year":"2023","journal-title":"Front Immunol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-025-11273-w","article-title":"TPX2 promotes ferroptosis in LPS-induced C28\/I2 chondrocytes via NF-\u03baB p65-mediated downregulation of GPX4 and SLC7A11","volume":"52","author":"Chen","year":"2025","journal-title":"Mol Biol Rep"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1177\/00220345241242389","article-title":"Inflammation triggers chondrocyte ferroptosis in TMJOA via HIF-1alpha\/TFRC","volume":"103","author":"Chen","year":"2024","journal-title":"J Dent Res"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202502052","article-title":"PIEZO1-GPX4 axis mediates mechanical stress-induced vertebral growth plate dysplasia via ferroptosis activation","volume":"12","author":"Chen","year":"2025","journal-title":"Adv Sci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.s441350","article-title":"Systematic pharmacology and experimental validation to reveal the alleviation of Astragalus membranaceus regulating ferroptosis in osteoarthritis","volume":"18","author":"Chen","year":"2024","journal-title":"Drug Des Dev Ther"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-023-09991-6","article-title":"Chondroprotective effects of bone marrow mesenchymal stem cell-derived exosomes in osteoarthritis","volume":"56","author":"Cheng","year":"2024","journal-title":"J Bioenerg Biomembr"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02653-9","article-title":"Study on the mechanism of puerarin against osteoarthritis from ferroptosis based on network pharmacology and bioinformatics","volume":"397","author":"Deng","year":"2024","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2024.13425","article-title":"Quercetin attenuates the symptoms of osteoarthritis in vitro and in vivo by suppressing ferroptosis via activation of AMPK\/Nrf2\/Gpx4 signaling","volume":"31","author":"Dong","year":"2025","journal-title":"Mol Med Rep"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.12659\/msm.948290","article-title":"Impact of abnormal mechanical stress on chondrocyte death in osteoarthritis","volume":"31","author":"Du","year":"2025","journal-title":"Med Sci Monit"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1177\/00220345251313795","article-title":"FSP1\/S100A4-expressing stem\/progenitor cells are essential for temporomandibular joint growth and homeostasis","volume":"104","author":"Tuwatnawanit","year":"2025","journal-title":"J Dent Res"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-024-00668-8","article-title":"Exosomes-shuttled lncRNA SNHG7 by bone marrow mesenchymal stem cells alleviates osteoarthritis through targeting miR-485-5p\/FSP1 axis-mediated chondrocytes ferroptosis and inflammation","volume":"21","author":"Wang","year":"2024","journal-title":"Tissue Eng Regener Med"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.149733","article-title":"Mechanisms of chondrocyte regulated cell death in osteoarthritis: Focus on ROS-triggered ferroptosis, parthanatos, and oxeiptosis","volume":"705","author":"Fan","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/pep2.24394","article-title":"Relaxin-2 alleviated ferroptosis and inflammation in TNF-\u03b1-treated chondrocytes via regulating the Nrf2\/NF-\u03baB signaling pathway","volume":"117","author":"Fan","year":"2025","journal-title":"Biopolymers"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-024-05055-6","article-title":"Mechanisms of chondrocyte cell death in osteoarthritis: Implications for disease progression and treatment","volume":"19","author":"Guan","year":"2024","journal-title":"J Orthop Surg Res"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-55629-x","article-title":"Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-\u03baB p65\/GPX4 signaling pathway","volume":"14","author":"Han","year":"2024","journal-title":"Sci Rep"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2024.106618","article-title":"NS8593 inhibits chondrocyte ferroptosis and alleviates cartilage injury in rat adjuvant arthritis through TRPM7 \/ HO-1 pathway","volume":"174","author":"Hao","year":"2024","journal-title":"Int J Biochem Cell Biol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.2147\/jir.s514309","article-title":"Programmed cell death of chondrocytes, synovial cells, osteoclasts, and subchondral bone cells in osteoarthritis","volume":"18","author":"Huang","year":"2025","journal-title":"J Inflammation Res"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-023-00292-7","article-title":"Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways","author":"Li","year":"2023","journal-title":"\u9aa8\u7814\u7a76(\u82f1\u6587\u7248)"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphyss.2025.100039","article-title":"ATF4 transcriptionally activates NUPR1 to promote ferroptosis in chondrocytes and osteoarthritis development","volume":"75","author":"Kuang","year":"2025","journal-title":"J Physiol Sci"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/tox.24131","article-title":"ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis of chondrocytes via inhibition of the PI3K\/Akt pathway in mice with osteoarthritis","volume":"39","author":"Li","year":"2024","journal-title":"Environ Toxicol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185x.15297","article-title":"METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A modification of GPX4","volume":"27","author":"Liu","year":"2024","journal-title":"Int J Rheum Dis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-04483-0","article-title":"Baicalin inhibits IL-1\u03b2-induced ferroptosis in human osteoarthritis chondrocytes by activating Nrf-2 signaling pathway","volume":"19","author":"Liu","year":"2024","journal-title":"J Orthop Surg Res"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-024-01534-z","article-title":"Chondrocyte ferritinophagy as a molecular mechanism of arthritis\u2013a narrative review","volume":"83","author":"Liu","year":"2025","journal-title":"Cell Biochem Biophys"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/hae.70093","article-title":"Interleukin\u201010 mitigates chondrocyte ferroptosis associated with haemophilic arthropathy via modulation of the STAT3 signalling pathway","volume":"31","author":"Luo","year":"2025","journal-title":"Haemophilia"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70375","article-title":"KLF9, epigenetic silenced by DNMT1, promotes ERK-mediated ferroptosis of osteoarthritic chondrocytes through transcriptionally regulating CYP1B1","volume":"29","author":"Lv","year":"2025","journal-title":"J Cell Mol Med"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-025-11141-7","article-title":"Lycium barbarum polysaccharide alleviates osteoarthritis progression in mice DMM model by inhibiting chondrocytes ferroptosis and promoting the gut Lactobacillus\/Alistipes ratio","volume":"52","author":"Meng","year":"2025","journal-title":"Mol Biol Rep"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.09.006","article-title":"Transcriptional response of human articular chondrocytes treated with fibronectin fragments: an in vitro model of the osteoarthritis phenotype","volume":"29","author":"Reed","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103847","article-title":"Contribution of ferroptosis and GPX4's dual functions to osteoarthritis progression","volume":"76","author":"Miao","year":"2022","journal-title":"EBioMedicine"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2021.2000742","article-title":"Stigmasterol alleviates interleukin-1beta-induced chondrocyte injury by down-regulatingsterol regulatory element binding transcription factor 2 to regulateferroptosis","volume":"12","author":"Mo","year":"2021","journal-title":"Bioengineered"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1515\/tjb-2024-0185","article-title":"Targeting oxidative stress, iron overload and ferroptosis in bone-degenerative conditions","volume":"50","author":"Ren","year":"2025","journal-title":"Turkish J Biochem \/ Turk Biyokimya Dergisi"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110924","article-title":"Brevilin A attenuates cartilage destruction in osteoarthritis mouse model by inhibiting inflammation and ferroptosis via SIRT1\/Nrf2\/GPX4 signaling pathway","volume":"124","author":"Ruan","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"18","DOI":"10.2174\/0109298673280730231211092905","article-title":"Gossypol acetic acid alleviates the ferroptosis of chondrocytes in osteoarthritis by inhibiting GPX4 methylation","volume":"32","author":"Shang","year":"2025","journal-title":"Curr Med Chem"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1002\/marc.202400495","article-title":"A novel curcumin\u2010loaded nanoplatform alleviates osteoarthritis by inhibiting chondrocyte ferroptosis","volume":"46","author":"Sheng","year":"2025","journal-title":"Macromol Rapid Commun"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122768","article-title":"Reactive oxygen species-sensitive fenofibrate-loaded dextran nanoparticles in alleviation of osteoarthritis","volume":"347","author":"Sheng","year":"2025","journal-title":"Carbohydr Polym"},{"key":"B46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2147\/jir.s479186","article-title":"The multifaceted protective role of nuclear factor erythroid 2-related factor 2 in osteoarthritis: Regulation of oxidative stress and inflammation","volume":"17","author":"Sheng","year":"2024","journal-title":"J Inflammation Res"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.101092","article-title":"Screen of FDA-approved drug library identifies vitamin K as anti-ferroptotic drug for osteoarthritis therapy through Gas6","volume":"15","author":"Shi","year":"2025","journal-title":"J Pharm Anal"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70405","article-title":"cZFP609 tethering BiP alleviates cartilage degradation in osteoarthritis via remedying aberrant ER\u2010mitochondrial contacts","volume":"6","author":"Song","year":"2025","journal-title":"MedComm"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18228","article-title":"Geniposidic acid alleviates osteoarthritis progression through inhibiting inflammation and chondrocytes ferroptosis","volume":"28","author":"Sun","year":"2024","journal-title":"J Cell Mol Med"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202402134rr","article-title":"Inhibition of ASIC1a reduces ferroptosis in rheumatoid arthritis articular chondrocytes via the p53\/NRF2\/SLC7A11 pathway","volume":"39","author":"Tang","year":"2025","journal-title":"FASEB J"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202504768","article-title":"Functionalized biomimetic nanoparticles targeting the IL-10\/IL-10Ralpha\/glycolytic axis in synovial macrophages alleviate cartilage degeneration in osteoarthritis","volume":"12","author":"Li","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114400","article-title":"Unraveling the crucial role of SDF-1 in osteoarthritis progression: IL6\/HIF-1alpha positive feedback and chondrocyte ferroptosis","volume":"152","author":"Yang","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1186\/s13018-025-05894-x","article-title":"The effect of lactate dehydrogenase B and its mediated histone lactylation on chondrocyte ferroptosis during osteoarthritis","volume":"20","author":"Zhang","year":"2025","journal-title":"J Orthop Surg Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000003325","article-title":"Mechanism of osteoarthritis treatment by exosomes","volume":"138","author":"Wang","year":"2025","journal-title":"Chin Med J"},{"key":"B55","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1089\/ars.2022.0141","article-title":"Selective clearance of senescent chondrocytes in osteoarthritis by targeting excitatory amino acid transporter protein 1 to induce ferroptosis","volume":"39","author":"Wen","year":"2023","journal-title":"Antioxidants Redox Signal"},{"key":"B56","doi-asserted-by":"publisher","first-page":"000","DOI":"10.1016\/j.intimp.2025.115111","article-title":"Paeoniflorin mitigates iron overload-induced osteoarthritis by suppressing chondrocyte ferroptosis via the p53\/SLC7A11\/GPX4 pathway","volume":"162","author":"Wu","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1604652","article-title":"Ferroptosis in osteoarthritis: metabolic reprogramming, immunometabolic crosstalk, and targeted intervention strategies","volume":"16","author":"Xia","year":"2025","journal-title":"Front Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.intimp.2024.112010","article-title":"Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11\/GPX4 signaling","volume":"133","author":"Xiao","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2024.105918","article-title":"Britanin alleviates chondrocyte ferroptosis in osteoarthritis by regulating the Nrf2-GPX4 axis","volume":"17","author":"Xiong","year":"2024","journal-title":"Arabian J Chem"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-024-01574-8","article-title":"Sirt1 overexpression inhibits chondrocyte ferroptosis via Ftl deacetylation to suppress the development of osteoarthritis","volume":"43","author":"Xiong","year":"2025","journal-title":"J Bone Miner Metab"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0328139","article-title":"Curcumin inhibits ferroptosis through dessuccinylation of SIRT5-associated ACSL4 protein, and plays a chondroprotective role in osteoarthritis","volume":"20","author":"Xu","year":"2025","journal-title":"PloS One"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13018-022-03225-y","article-title":"Metformin alleviates osteoarthritis in mice by inhibiting chondrocyte ferroptosis and improving subchondral osteosclerosis and angiogenesis","volume":"17","author":"Yan","year":"2022","journal-title":"J Orthop Surg Res"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1002\/ccs3.70027","article-title":"Nuclear binding SET domain 1 alleviates cartilage ferroptosis in knee osteoarthritis by upregulating the kr\u00fcppel-like factor 9\/autophagy-related 14 pathway via H3K36me2 modification","volume":"19","author":"Yang","year":"2025","journal-title":"J Cell Commun Signaling"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156382","article-title":"Calcipotriol suppresses GPX4-mediated ferroptosis in OA chondrocytes by blocking the TGF-\u03b21 pathway","volume":"171","author":"Yang","year":"2023","journal-title":"Cytokine"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-3175974\/v1","article-title":"Angelica sinensis polysaccharide protects chondrocytes from ferroptosis in osteoarthritis","author":"Yin","year":"2023"},{"key":"B66","doi-asserted-by":"publisher","first-page":"000","DOI":"10.1016\/j.cellsig.2024.111399","article-title":"LncRNA HOXA11-AS intercepts the POU2F2-mediated downregulation of SLC3A2 in osteoarthritis to suppress ferroptosis","volume":"124","author":"Yu","year":"2024","journal-title":"Cell Signal"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-6630","article-title":"SCD1 deficiency exacerbates osteoarthritis by inducing ferroptosis in chondrocytes","volume":"11","author":"Yu","year":"2023","journal-title":"\u8f6c\u5316\u533b\u5b66\u5e74\u9274"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.4c01980","article-title":"Coixol-loaded hydrogels promote osteochondral defect repair via modulation of ferroptosis and autophagy in chondrocytes","volume":"11","author":"Zhang","year":"2025","journal-title":"ACS Biomater Sci Eng"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-025-10450-2","article-title":"Role and mechanism of lncRNA ZEB1-AS1 endogenous competition for miR-365a-3p targeting NRF2 in ferroptosis in articular chondrocytes","volume":"56","author":"Zhang","year":"2025","journal-title":"J Mol Histol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2025.13502","article-title":"Salidroside ameliorates lipopolysaccharideinduced ferroptosis in chondrocytes via regulation of the sirt1\/foxo1 axis","volume":"31","author":"Zhang","year":"2025","journal-title":"Mol Med Rep"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-024-09567-5","article-title":"OGT promotes the ferroptosis of chondrocytes in osteoarthritis development via O-GlcNAcylation modification of ACSF2","volume":"73","author":"Zhang","year":"2025","journal-title":"Immunol Res"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1539092","article-title":"Asperosaponin VI suppresses ferroptosis in chondrocytes and ameliorates osteoarthritis by modulating the Nrf2\/GPX4\/HO-1 signaling pathway","volume":"16","author":"Zhang","year":"2025","journal-title":"Front Pharmacol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03179-4","article-title":"Sappanone a alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis via activating the SIRT1\/Nrf2 signaling pathway","volume":"397","author":"Zhang","year":"2024","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2023.12.047","article-title":"P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability","volume":"212","author":"Zheng","year":"2024","journal-title":"Free Radical Biol Med"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.01.010","article-title":"Antioxidant taurine inhibits chondrocyte ferroptosis through upregulation of OGT\/Gpx4 signaling in osteoarthritis induced by anterior cruciate ligament transection","volume":"77","author":"Zhou","year":"2025","journal-title":"J Adv Res"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.04.012","article-title":"Interplay between lipid dysregulation and ferroptosis in chondrocytes and the targeted therapy effect of metformin on osteoarthritis","volume":"69","author":"Zou","year":"2025","journal-title":"J Adv Res"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1790918\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T05:19:35Z","timestamp":1774588775000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1790918\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":76,"alternative-id":["10.3389\/fimmu.2026.1790918"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1790918","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]},"article-number":"1790918"}}