{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:46:51Z","timestamp":1788382011883,"version":"build-2803163510"},"reference-count":192,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Ferroptosis, a recently discovered type of programmed cell death (PCD) distinguished by iron overload and lipid peroxidation, differs fundamentally from necrosis, apoptosis, and autophagy. Emerging evidence indicates that ferroptosis is deeply implicated in the disruption of the ocular microenvironment, wherein both structural and immune cells are significantly compromised. Rather than being an isolated cellular event, ferroptosis actively engages in a complex bidirectional crosstalk with the ocular immune system, driving neuroinflammation and tissue degeneration. In this review, we shift the paradigm from traditional disease-specific descriptions to the underlying microenvironmental interactions that dictate ocular health. Furthermore, we systematically evaluate the therapeutic potential of emerging interventions. Specifically, we highlight the latest breakthroughs in utilizing natural and dietary compounds as potent ferroptosis regulators. Crucially, we address current translational limitations by exploring advanced drug delivery systems, such as nanocarriers and hydrogels, designed to effectively overcome the blood-retinal barrier (BRB) and improve targeted efficacy. Ultimately, this review provides a comprehensive roadmap for advancing ferroptosis-targeted therapies from the laboratory to clinical ophthalmology.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1791087","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:10:55Z","timestamp":1774930255000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Ferroptosis and the eye: bridging the gap between cell death and vision preservation"],"prefix":"10.3389","volume":"17","author":[{"given":"Guangyu","family":"Zhu","sequence":"first","affiliation":[{"name":"Eye School of Chengdu University of TCM","place":["Chengdu, China"]},{"name":"Eye Health with Traditional Chinese Medicine Key Laboratory of Sichuan Province","place":["Chengdu, China"]},{"name":"Retinal Image Technology and Chronic Vascular Disease Prevention and Control and Collaborative Innovation Center","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nanjing Tongren Eye Center, Nanjing Tongren Hospital, School of Medicine, Southeast University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyu","family":"Han","sequence":"additional","affiliation":[{"name":"School of Medicine, Southeast University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Medicine, Southeast University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Eye School of Chengdu University of TCM","place":["Chengdu, China"]},{"name":"Eye Health with Traditional Chinese Medicine Key Laboratory of Sichuan Province","place":["Chengdu, China"]},{"name":"Retinal Image Technology and Chronic Vascular Disease Prevention and Control and Collaborative Innovation Center","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Shi","sequence":"additional","affiliation":[{"name":"Eye School of Chengdu University of TCM","place":["Chengdu, China"]},{"name":"Eye Health with Traditional Chinese Medicine Key Laboratory of Sichuan Province","place":["Chengdu, China"]},{"name":"Retinal Image Technology and Chronic Vascular Disease Prevention and Control and Collaborative Innovation Center","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Deng","sequence":"additional","affiliation":[{"name":"Eye School of Chengdu University of TCM","place":["Chengdu, China"]},{"name":"Eye Health with Traditional Chinese Medicine Key Laboratory of Sichuan Province","place":["Chengdu, China"]},{"name":"Retinal Image Technology and Chronic Vascular Disease Prevention and Control and Collaborative Innovation Center","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nanjing Tongren Eye Center, Nanjing Tongren Hospital, School of Medicine, Southeast University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Nanjing Tongren Eye Center, Nanjing Tongren Hospital, School of Medicine, Southeast University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejing","family":"Lu","sequence":"additional","affiliation":[{"name":"Eye School of Chengdu University of TCM","place":["Chengdu, China"]},{"name":"Eye Health with Traditional Chinese Medicine Key Laboratory of Sichuan Province","place":["Chengdu, China"]},{"name":"Retinal Image Technology and Chronic Vascular Disease Prevention and Control and Collaborative Innovation Center","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s2214-109x(20)30489-7","article-title":"Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to vision 2020: The right to sight: An analysis for the global burden of disease study","volume":"9","year":"2021","journal-title":"Lancet Glob Health"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00694-0","article-title":"Regulated cell death pathways in kidney disease","volume":"19","author":"Sanz","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.actbio.2025.08.018","article-title":"Regulated cell death-targeted ocular nanomedicine","volume":"205","author":"Ho","year":"2025","journal-title":"Acta Biomater"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B5","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","article-title":"Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies","volume":"9","author":"Zhou","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"B6","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1097\/hm9.0000000000000102","article-title":"Celastrol promotes apoptosis of breast cancer Mda-Mb-231 cells by targeting Hsdl2 %J acupuncture and herbal medicine","volume":"4","author":"Liu","year":"2024","journal-title":"Acupunct Herb Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13045-019-0720-y","article-title":"Ferroptosis, a new form of cell death: Opportunities and challenges in cancer","volume":"12","author":"Mou","year":"2019","journal-title":"J Hematol Oncol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12943-022-01530-y","article-title":"Ferroptosis in cancer therapy: A novel approach to reversing drug resistance","volume":"21","author":"Zhang","year":"2022","journal-title":"Mol Cancer"},{"key":"B9","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41419-022-04911-9","article-title":"Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury","volume":"13","author":"Qin","year":"2022","journal-title":"Cell Death Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41419-022-04775-z","article-title":"Interaction between macrophages and ferroptosis","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2022-006516","article-title":"Macrophage-inherited exosome excise tumor immunosuppression to expedite immune-activated ferroptosis","volume":"11","author":"Wang","year":"2023","journal-title":"J Immunother Cancer"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1709354","article-title":"Redefining cell death: Ferroptosis as a game-changer in ophthalmology","volume":"16","author":"Wei","year":"2025","journal-title":"Front Immunol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-008554","article-title":"Mefloquine enhances the efficacy of anti-Pd-1 immunotherapy via Ifn-\u0393-Stat1-Irf1-Lpcat3-induced ferroptosis in tumors","volume":"12","author":"Tao","year":"2024","journal-title":"J Immunother Cancer"},{"key":"B14","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/imr.13235","article-title":"Ferroptosis in immunostimulation and immunosuppression","volume":"321","author":"Tang","year":"2024","journal-title":"Immunol Rev"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.Cd-19-0338","article-title":"Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of Slc7a11","volume":"9","author":"Lang","year":"2019","journal-title":"Cancer Discov"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3676","DOI":"10.1038\/s41467-022-31218-2","article-title":"Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity","volume":"13","author":"Wiernicki","year":"2022","journal-title":"Nat Commun"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1390263","article-title":"Emerging role of immunogenic cell death in cancer immunotherapy","volume":"15","author":"Arimoto","year":"2024","journal-title":"Front Immunol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuac071","article-title":"A double-edged sword with a therapeutic target: Iron and ferroptosis in immune regulation","volume":"81","author":"Ni","year":"2023","journal-title":"Nutr Rev"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/hm9.0000000000000120","article-title":"The Hemerocallis citrina extracts ameliorate radiation-induced ferroptosis in Lo2 cells through the Nrf2-Xct\/Gpx4 pathway %J acupuncture and herbal medicine","volume":"4","author":"Zhu","year":"2024","journal-title":"Acupunct Herb Med"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.Cir-20-0384","article-title":"Pharmacologic screening identifies metabolic vulnerabilities of Cd8(+) T cells","volume":"9","author":"Drijvers","year":"2021","journal-title":"Cancer Immunol Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.cell.2025.12.002","article-title":"Extracellular Gpx4 impairs antitumor immunity via dendritic Zp3 receptors","volume":"189","author":"Liu","year":"2026","journal-title":"Cell"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102463","article-title":"Inhibition of Apoc1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-Pd1 immunotherapy in hepatocellular carcinoma based on single-cell Rna sequencing","volume":"56","author":"Hao","year":"2022","journal-title":"Redox Biol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3892\/ijmm.2024.5369","article-title":"Role of microglia\/macrophage polarisation in intraocular diseases (review)","volume":"53","author":"Li","year":"2024","journal-title":"Int J Mol Med"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-024-02437-5","article-title":"Macrophage activation contributes to diabetic retinopathy","volume":"102","author":"Zhang","year":"2024","journal-title":"J Mol Med (Berl)"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13479","article-title":"Retinal microglia: Functions and diseases","volume":"166","author":"Fan","year":"2022","journal-title":"Immunology"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-276758","article-title":"Mice with hepcidin-resistant ferroportin accumulate iron in the retina","volume":"30","author":"Theurl","year":"2016","journal-title":"FASEB J"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.3390\/ijms24032420","article-title":"Cytochrome P450 1b1 expression regulates intracellular iron levels and oxidative stress in the retinal endothelium","volume":"24","author":"Song","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-28250","article-title":"Iron accumulates in retinal vascular endothelial cells but has minimal retinal penetration after Ip iron dextran injection in mice","volume":"60","author":"Shu","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103557","article-title":"Quercetin alleviates Lps\/Ie-Dap-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux","volume":"81","author":"Zhang","year":"2025","journal-title":"Redox Biol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"918","DOI":"10.3390\/antiox12040918","article-title":"The interplay between intracellular iron homeostasis and neuroinflammation in neurodegenerative diseases","volume":"12","author":"Lee","year":"2023","journal-title":"Antioxid (Basel)"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-024-02005-6","article-title":"Mesenchymal stem cells regulate microglial polarization via inhibition of the Hmgb1\/Tlr4 signaling pathway in diabetic retinopathy","volume":"47","author":"Tong","year":"2024","journal-title":"Inflammation"},{"key":"B32","doi-asserted-by":"publisher","first-page":"6715","DOI":"10.3390\/ijms23126715","article-title":"High-mobility group box 1 inhibitor Boxa alleviates neuroinflammation-induced retinal ganglion cell damage in traumatic optic neuropathy","volume":"23","author":"Peng","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.61.5.50","article-title":"Loss of high-mobility group box 1 (Hmgb1) protein in rods accelerates rod photoreceptor degeneration after retinal detachment","volume":"61","author":"Ross","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114192","article-title":"Inhibiting Hmgb1\/Ager\/Nf-\u03bab pathway prevents pro-inflammatory microglia polarization and protect photoreceptors in retinitis pigmentosa","volume":"149","author":"Hu","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1101\/gr.280554.125","article-title":"Molecular and genetic landscapes of retina and brain microglia in neurodegenerative diseases","volume":"35","author":"Ma","year":"2025","journal-title":"Genome Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41593-022-01221-3","article-title":"Microglia ferroptosis is regulated by Sec24b and contributes to neurodegeneration","volume":"26","author":"Ryan","year":"2023","journal-title":"Nat Neurosci"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.995084","article-title":"Iron metabolism mediates microglia susceptibility in ferroptosis","volume":"16","author":"Jiao","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102689","article-title":"Hiv-1 Tat-mediated microglial ferroptosis involves the Mir-204-Acsl4 signaling axis","volume":"62","author":"Kannan","year":"2023","journal-title":"Redox Biol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1186\/s40001-024-02163-1","article-title":"Elevation of Anxa1 associated with potential protective mechanism against ferroptosis and immune cell infiltration in age-related macular degeneration","volume":"29","author":"Chen","year":"2024","journal-title":"Eur J Med Res"},{"key":"B40","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s12951-024-02560-y","article-title":"Anti-ferroptosis exosomes engineered for targeting M2 microglia to improve neurological function in ischemic stroke","volume":"22","author":"Wang","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101789","article-title":"Protective role of microglial Ho-1 blockade in aging: Implication of iron metabolism","volume":"38","author":"Fern\u00e1ndez-Mend\u00edvil","year":"2021","journal-title":"Redox Biol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.05.001","article-title":"An ultrasound-activated nanoplatform remodels tumor microenvironment through diverse cell death induction for improved immunotherapy","volume":"370","author":"Ma","year":"2024","journal-title":"J Controlled Rel: Off J Controlled Rel Soc"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0462-8","article-title":"Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death","volume":"16","author":"Kapralov","year":"2020","journal-title":"Nat Chem Biol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180464","article-title":"Interleukin-6 regulates iron-related proteins through C-Jun N-terminal kinase activation in Bv2 microglial cell lines","volume":"12","author":"Zhou","year":"2017","journal-title":"PloS One"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.66.4.46","article-title":"Vitamin K1 alleviates retinal inflammation following acute ocular hypertension by modulating microglial ferroptosis","volume":"66","author":"Chen","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S372485","article-title":"Silica nanoparticles cause activation of Nlrp3 inflammasome in-vitro model-using microglia","volume":"17","author":"Hou","year":"2022","journal-title":"Int J Nanomed"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114171","article-title":"S100a8 regulates autophagy-dependent ferroptosis in microglia after experimental subarachnoid hemorrhage","volume":"357","author":"Tao","year":"2022","journal-title":"Exp Neurol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s13046-024-03235-0","article-title":"Ferroptosis and the tumor microenvironment","volume":"43","author":"Cui","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1170-y","article-title":"Cd8(+) T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.Cir-23-0083","article-title":"Long-read sequencing reveals alternative splicing-driven, shared immunogenic neoepitopes regardless of Sf3b1 status in uveal melanoma","volume":"11","author":"Yao","year":"2023","journal-title":"Cancer Immunol Res"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.65.1.42","article-title":"Tumor pigmentation does not affect light-activated belzupacap sarotalocan treatment but influences macrophage polarization in a murine melanoma model","volume":"65","author":"Ma","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.7150\/thno.63992","article-title":"The kinase Pdk1 regulates regulatory T cell survival via controlling redox homeostasis","volume":"11","author":"Feng","year":"2021","journal-title":"Theranostics"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.65.14.23","article-title":"Itaconate ameliorates experimental autoimmune uveitis by modulating Teff\/Treg cell imbalance via the Dnaja1\/Cdc45 axis","volume":"65","author":"Jiang","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B54","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s12974-022-02477-z","article-title":"Melatonin, an endogenous hormone, modulates Th17 cells via the reactive-oxygen species\/Txnip\/Hif-1\u03b1 axis to alleviate autoimmune uveitis","volume":"19","author":"Huang","year":"2022","journal-title":"J Neuroinflamm"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104382","article-title":"Metabolism-dependent ferroptosis promotes mitochondrial dysfunction and inflammation in Cd4(+) T lymphocytes in HIV-infected immune non-responders","volume":"86","author":"Xiao","year":"2022","journal-title":"EBioMedicine"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-024-01377-z","article-title":"A lipid atlas of human and mouse immune cells provides insights into ferroptosis susceptibility","volume":"26","author":"Morgan","year":"2024","journal-title":"Nat Cell Biol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088201","article-title":"T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration","volume":"9","author":"Cruz-Guilloty","year":"2014","journal-title":"PloS One"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-022-00883-0","article-title":"Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis","volume":"19","author":"Luoqian","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70253","article-title":"Ferroptosis of T cell in inflammation and tumour immunity","volume":"15","author":"Xia","year":"2025","journal-title":"Clin Transl Med"},{"key":"B60","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1186\/s12974-024-03323-0","article-title":"Regulatory T cell expansion prevents retinal degeneration in type 2 diabetes","volume":"21","author":"Llori\u00e1n-Salvador","year":"2024","journal-title":"J Neuroinflamm"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.4049\/immunohorizons.2000003","article-title":"Iron deprivation in human T cells induces nonproliferating accessory helper cells","volume":"4","author":"Berg","year":"2020","journal-title":"Immunohorizons"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102541","article-title":"Inhibition of ferroptosis promotes retina ganglion cell survival in experimental optic neuropathies","volume":"58","author":"Guo","year":"2022","journal-title":"Redox Biol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1422497","article-title":"Identification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy","volume":"15","author":"Li","year":"2024","journal-title":"Front Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1118391","article-title":"Identification and validation of ferroptosis-related genes and immune cell infiltration in thyroid associated ophthalmopathy","volume":"14","author":"Chen","year":"2023","journal-title":"Front Genet"},{"key":"B65","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3390\/diagnostics11020219","article-title":"A novel ferroptosis-associated gene signature to predict prognosis in patients with uveal melanoma","volume":"11","author":"Luo","year":"2021","journal-title":"Diagn (Basel)"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1103471","article-title":"Identification of hub genes and pathways of ferroptosis in Fusarium keratitis by bioinformatics methods","volume":"13","author":"Teng","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13098-024-01301-3","article-title":"Two ferroptosis-specific expressed genes Nox4 and Parp14 are considered as potential biomarkers for the diagnosis and treatment of diabetic retinopathy and atherosclerosis","volume":"16","author":"Li","year":"2024","journal-title":"Diabetol Metab Syndr"},{"key":"B68","doi-asserted-by":"publisher","first-page":"13956","DOI":"10.1038\/s41598-023-41194-2","article-title":"Screening and identification of genes related to ferroptosis in keratoconus","volume":"13","author":"Wu","year":"2023","journal-title":"Sci Rep"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2022.108947","article-title":"Iron contributes to photoreceptor degeneration and M\u00fcller glia proliferation in the zebrafish light-treated retina","volume":"216","author":"Boyd","year":"2022","journal-title":"Exp Eye Res"},{"key":"B70","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12915-024-01932-y","article-title":"Pcyt1a deficiency disturbs fatty acid metabolism and induces ferroptosis in the mouse retina","volume":"22","author":"Wang","year":"2024","journal-title":"BMC Biol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2025.112464","article-title":"Single-cell RNA sequencing highlights a significant retinal M\u00fcller glial population in dry age-related macular degeneration","volume":"28","author":"Zeng","year":"2025","journal-title":"iScience"},{"key":"B72","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.freeradbiomed.2024.12.039","article-title":"Silicone oil, an intraocular surgical adjuvant, induces retinal ferroptosis","volume":"228","author":"Shimizu","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2024.114087","article-title":"Aqp4 regulates ferroptosis and oxidative stress of Muller cells in diabetic retinopathy by regulating Trpv4","volume":"439","author":"Chen","year":"2024","journal-title":"Exp Cell Res"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1155\/jdr\/1924668","article-title":"Upregulation of Sqstm1 regulates ferroptosis and oxidative stress in M\u00fcller cells of the diabetic neural retina by modulating Acsl4","volume":"2025","author":"Li","year":"2025","journal-title":"J Diabetes Res"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04496-8","article-title":"Resveratrol protects M\u00fcller cells against ferroptosis in the early stage of diabetic retinopathy by regulating the Nrf2\/Gpx4\/Ptgs2 pathway","volume":"62","author":"Wang","year":"2025","journal-title":"Mol Neurobiol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.4103\/nrr.Nrr-d-23-01540","article-title":"Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke","volume":"20","author":"Yang","year":"2025","journal-title":"Neural Regener Res"},{"key":"B77","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41531-025-00995-0","article-title":"Oligodendrocyte-astrocyte crosstalk in Parkinson's disease mediates neuronal ferroptosis via the Fgf signaling pathway","volume":"11","author":"Zhang","year":"2025","journal-title":"NPJ Parkinsons Dis"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-025-01467-x","article-title":"Metabolic reprogramming in astrocytes prevents neuronal death through a Uchl1\/Pfkfb3\/H4k8la positive feedback loop","volume":"32","author":"Xiong","year":"2025","journal-title":"Cell Death Differ"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2022.101093","article-title":"Cell fate decisions, transcription factors and signaling during early retinal development","volume":"91","author":"Diacou","year":"2022","journal-title":"Prog Retin Eye Res"},{"key":"B80","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1186\/s13287-024-04007-5","article-title":"Advances in retinal pigment epithelial cell transplantation for retinal degenerative diseases","volume":"15","author":"Liu","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"B81","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/s41419-022-05121-z","article-title":"Hypoxia aggravates ferroptosis in Rpe cells by promoting the Fenton reaction","volume":"13","author":"Henning","year":"2022","journal-title":"Cell Death Dis"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.101037","article-title":"Dynamic lipid turnover in photoreceptors and retinal pigment epithelium throughout life","volume":"89","author":"Lewandowski","year":"2022","journal-title":"Prog Retin Eye Res"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13490","article-title":"Intraocular iron injection induces oxidative stress followed by elements of geographic atrophy and sympathetic ophthalmia","volume":"20","author":"Liu","year":"2021","journal-title":"Aging Cell"},{"key":"B84","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/s41419-024-07150-2","article-title":"Retinal pigment epithelium-specific ablation of Gpx4 in adult mice recapitulates key features of geographic atrophy in age-related macular degeneration","volume":"15","author":"Azuma","year":"2024","journal-title":"Cell Death Dis"},{"key":"B85","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/s41419-021-03520-2","article-title":"Sodium iodate induces ferroptosis in human retinal pigment epithelium Arpe-19 cells","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis"},{"key":"B86","doi-asserted-by":"publisher","first-page":"116954","DOI":"10.1016\/j.taap.2024.116954","article-title":"Dual-specificity phosphatase 26 protects against kidney injury caused by ischaemia-reperfusion through restraint of Tak1-Jnk\/P38-mediated apoptosis and inflammation of renal tubular epithelial cells","volume":"487","author":"Xiang","year":"2024","journal-title":"Toxicol Appl Pharmacol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s11658-025-00700-2","article-title":"Exposure of A2e to blue light promotes ferroptosis in the retinal pigment epithelium","volume":"30","author":"Yang","year":"2025","journal-title":"Cell Mol Biol Lett"},{"key":"B88","doi-asserted-by":"publisher","first-page":"18949","DOI":"10.1038\/s41598-025-03757-3","article-title":"The role of Hmox1-mediated ferroptosis in blue light-induced damage to retinal pigment epithelium","volume":"15","author":"Ji","year":"2025","journal-title":"Sci Rep"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70195","article-title":"Superoxide activates ferroptosis via the Haber-Weiss reaction and enhances age-related macular degeneration","volume":"24","author":"Huang","year":"2025","journal-title":"Aging Cell"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102840","article-title":"Comparative mechanistic study of Rpe cell death induced by different oxidative stresses","volume":"65","author":"Tong","year":"2023","journal-title":"Redox Biol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102292","article-title":"Glia maturation factor-\u03b2 induces ferroptosis by impairing chaperone-mediated autophagic degradation of Acsl4 in early diabetic retinopathy","volume":"52","author":"Liu","year":"2022","journal-title":"Redox Biol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2022.101136","article-title":"Glaucomatous optic neuropathy: mitochondrial dynamics, dysfunction and protection in retinal ganglion cells","volume":"95","author":"Ju","year":"2023","journal-title":"Prog Retin Eye Res"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12828","article-title":"Anti-panoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model","volume":"73","author":"Ye","year":"2022","journal-title":"J Pineal Res"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1109\/tmi.2024.3380530","article-title":"Visible-light optical coherence tomography fibergraphy of the tree shrew retinal ganglion cell axon bundles","volume":"43","author":"Miller","year":"2024","journal-title":"IEEE Trans Med Imaging"},{"key":"B95","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41418-022-01046-4","article-title":"Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma","volume":"30","author":"Yao","year":"2023","journal-title":"Cell Death Differ"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.3390\/antiox12061173","article-title":"Melatonin alleviates retinal ischemia-reperfusion injury by inhibiting P53-mediated ferroptosis","volume":"12","author":"Zhang","year":"2023","journal-title":"Antioxid (Basel)"},{"key":"B97","doi-asserted-by":"publisher","first-page":"9892","DOI":"10.3390\/ijms24129892","article-title":"Various forms of programmed cell death are concurrently activated in the population of retinal ganglion cells after ischemia and reperfusion","volume":"24","author":"Dvoriantchikova","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2021.104427","article-title":"Proteomics analysis of N-methyl-D-aspartate-induced cell death in retinal and optic nerves","volume":"252","author":"Suo","year":"2022","journal-title":"J Proteomics"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.01.008","article-title":"Redox biology of regulated cell death in cancer: a focus on necroptosis and ferroptosis","volume":"134","author":"Florean","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1097\/js9.0000000000003213","article-title":"Inhibition of Mettl3-mediated m6a rna modification of Hmgcs1 protects retinal ganglion cells from glutamate excitotoxicity-induced ferroptosis in a rat model of glaucoma","volume":"111","author":"Wang","year":"2025","journal-title":"Int J Surg"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.391193","article-title":"P38 mapk inhibitor sb202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model","volume":"19","author":"Feng","year":"2024","journal-title":"Neural Regener Res"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70442","article-title":"Oral 7,8-dihydroxyflavone protects retinal ganglion cells by modulating the gut-retina axis and inhibiting ferroptosis via the indoleacrylic acid-ahr-aldh1a3-fsp1 pathway","volume":"31","author":"Zhou","year":"2025","journal-title":"CNS Neurosci Ther"},{"key":"B104","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.3390\/ijms23052626","article-title":"Deficiency in retinal tgf\u03b2 signaling aggravates neurodegeneration by modulating pro-apoptotic and map kinase pathways","volume":"23","author":"Bielmeier","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B105","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2147\/eb.S9078","article-title":"Energy metabolism of the visual system","volume":"2","author":"Wong-Riley","year":"2010","journal-title":"Eye Brain"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101469","article-title":"Ferrous but not ferric iron sulfate kills photoreceptors and induces photoreceptor-dependent rpe autofluorescence","volume":"34","author":"Shu","year":"2020","journal-title":"Redox Biol"},{"key":"B107","doi-asserted-by":"publisher","first-page":"100187","DOI":"10.1074\/jbc.RA120.015779","article-title":"Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance","volume":"296","author":"Chen","year":"2021","journal-title":"J Biol Chem"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.12.008","article-title":"Induction of ferroptosis by ho-1 contributes to retinal degeneration in mice with defective clearance of all-trans-retinal","volume":"194","author":"Chen","year":"2023","journal-title":"Free Radical Biol Med"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.12.007","article-title":"Inhibition of jnk signaling attenuates photoreceptor ferroptosis caused by all-trans-retinal","volume":"227","author":"Yang","year":"2025","journal-title":"Free Radic Biol Med"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.114187","article-title":"Activation of gsdme by all-trans-retinal increases sensitivity to photoreceptor ferroptosis","volume":"21","author":"Yang","year":"2025","journal-title":"Int J Biol Sci"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406343","article-title":"Quantum dots-caused retinal degeneration in zebrafish regulated by ferroptosis and mitophagy in retinal pigment epithelial cells through inhibiting spliceosome","volume":"11","author":"Zheng","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.7150\/thno.99484","article-title":"Photoreceptor-targeted extracellular vesicles-mediated delivery of cul7 sirna for retinal degeneration therapy","volume":"14","author":"Guo","year":"2024","journal-title":"Theranostics"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.4103\/nrr.Nrr-d-23-01741","article-title":"Contribution of ferroptosis and slc7a11 to light-induced photoreceptor degeneration","volume":"21","author":"Huang","year":"2026","journal-title":"Neural Regener Res"},{"key":"B114","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.3390\/cells10092302","article-title":"Corneal epithelial stem cells-physiology, pathophysiology and therapeutic options","volume":"10","author":"Ruan","year":"2021","journal-title":"Cells"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.10.409","article-title":"Phenylarsine oxide induced corneal injury involves oxidative stress mediated unfolded protein response and ferroptotic cell death: Amelioration by nac","volume":"209","author":"Kandhari","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2025.117438","article-title":"Unveiling the acute toxic pathology and transcriptomic signature of ocular exposure to phosgene oxime using an in vivo mouse model: A novel pilot study","volume":"502","author":"Okoyeocha","year":"2025","journal-title":"Toxicol Appl Pharmacol"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.124764","article-title":"Yap o-glcnacylation contributes to corneal epithelial cell ferroptosis under cigarette smoke exposure","volume":"360","author":"Zhang","year":"2024","journal-title":"Environ pollut"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.12141","article-title":"Glutathione peroxidase 4 plays an important role in oxidative homeostasis and wound repair in corneal epithelial cells","volume":"6","author":"Sakai","year":"2016","journal-title":"FEBS Open Bio"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.66.6.28","article-title":"Corneal sensory denervation causes epithelial ferroptosis and delayed healing in mice","volume":"66","author":"Wang","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1441196","article-title":"Urolithin a alleviates cell senescence by inhibiting ferroptosis and enhances corneal epithelial wound healing","volume":"11","author":"Guo","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"B121","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3390\/pharmaceutics15010118","article-title":"A novel ferroptosis inhibitor uamc-3203, a potential treatment for corneal epithelial wound","volume":"15","author":"Balla","year":"2022","journal-title":"Pharmaceutics"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10276","article-title":"Ferrostatin-1-loaded liposome for treatment of corneal alkali burn via targeting ferroptosis","volume":"7","author":"Wang","year":"2022","journal-title":"Bioeng Transl Med"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.65.14.12","article-title":"Atg5-mediated lipophagy induces ferroptosis in corneal epithelial cells in dry eye disease","volume":"65","author":"Zuo","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.66.5.23","article-title":"Autophagy impairment-derived sqstm1 accumulation promotes ferroptosis in corneal epithelial cells through acsl4 in dry eye","volume":"66","author":"Zhang","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1407659","article-title":"Astaxanthin activated the slc7a11\/gpx4 pathway to inhibit ferroptosis and enhance autophagy, ameliorating dry eye disease","volume":"15","author":"Hou","year":"2024","journal-title":"Front Pharmacol"},{"key":"B126","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41420-022-01141-y","article-title":"Ferrostatin-1 alleviates tissue and cell damage in diabetic retinopathy by improving the antioxidant capacity of the xc(-)-gpx4 system","volume":"8","author":"Shao","year":"2022","journal-title":"Cell Death Discov"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167530","article-title":"Tmco1 promotes ferroptosis and ecm deposition in glaucomatous trabecular meshwork via erk1\/2 signaling","volume":"1871","author":"Zhang","year":"2025","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202507526","article-title":"Iron-chelating and ros-scavenging polymers with thioketal and thioether bonds delivering ferroptosis inhibitor lip-1 provide a triple therapeutic strategy for retina ganglion cells in acute glaucoma","volume":"37","author":"Zhang","year":"2025","journal-title":"Adv Mater"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2025.102893","article-title":"The role of lactate metabolism in retinoblastoma tumorigenesis and ferroptosis resistance","volume":"95","author":"Zhang","year":"2025","journal-title":"Tissue Cell"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1626907","article-title":"\u03b1-lipoic acid mitigates age-related macular degeneration via ferroptosis: Integrative multi-omics and network pharmacology","volume":"16","author":"Zhang","year":"2025","journal-title":"Front Pharmacol"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117569","article-title":"Selenomethionine alleviates t-2 toxin-induced articular chondrocyte ferroptosis via the system xc(-)\/gsh\/gpx4 axis","volume":"290","author":"Yu","year":"2025","journal-title":"Ecotoxicol Environ Saf"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1552228","article-title":"Neuroprotective effects of ethanol extraction from rubia yunnanensis diels on chronic cerebral hypoperfusion: Modulation of the system xc-\/gsh\/gpx4 axis to alleviate oxidative stress and ferroptosis","volume":"16","author":"Cheng","year":"2025","journal-title":"Front Pharmacol"},{"key":"B133","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.chembiol.2025.04.002","article-title":"N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4","volume":"32","author":"Zheng","year":"2025","journal-title":"Cell Chem Biol"},{"key":"B134","doi-asserted-by":"publisher","first-page":"600","DOI":"10.3390\/ijms22020600","article-title":"Superior properties of n-acetylcysteine ethyl ester over n-acetyl cysteine to prevent retinal pigment epithelial cells oxidative damage","volume":"22","author":"Tosi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2025.09.025","article-title":"Oral acetylcysteine and the risk of age-related macular degeneration: A retrospective cohort study","volume":"133","author":"Tsai","year":"2026","journal-title":"Ophthalmology"},{"key":"B136","doi-asserted-by":"publisher","first-page":"4783","DOI":"10.3390\/ijms23094783","article-title":"Ferroptosis and apoptosis are involved in the formation of l-selenomethionine-induced ocular defects in zebrafish embryos","volume":"23","author":"Gao","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2320655121","article-title":"The crl3(kctd10) ubiquitin ligase-usp18 axis coordinately regulates cystine uptake and ferroptosis by modulating slc7a11","volume":"121","author":"Zhou","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"B138","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1210\/clinem\/dgac163","article-title":"Insights into ferroptosis: Targeting glycolysis to treat graves' orbitopathy","volume":"107","author":"Ma","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"B139","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/s41419-021-04307-1","article-title":"Nrf2 attenuates ferroptosis-mediated iir-ali by modulating tert and slc7a11","volume":"12","author":"Dong","year":"2021","journal-title":"Cell Death Dis"},{"key":"B140","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3390\/antiox12010045","article-title":"Dimethyl fumarate protects retinal pigment epithelium from blue light-induced oxidative damage via the nrf2 pathway","volume":"12","author":"Shimizu","year":"2022","journal-title":"Antioxid (Basel)"},{"key":"B141","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.3390\/antiox10091466","article-title":"The effects of two nrf2 activators, bardoxolone methyl and omaveloxolone, on retinal ganglion cell survival during ischemic optic neuropathy","volume":"10","author":"Chien","year":"2021","journal-title":"Antioxid (Basel)"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.178175","article-title":"Protective efficacy and mechanism of gypenosides against diabetic cataracts via the ferroptosis pathway: A study based on network pharmacology","volume":"1007","author":"Pei","year":"2025","journal-title":"Eur J Pharmacol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124758","article-title":"Gypenoside a-loaded mpeg-plga nanoparticles ameliorate high-glucose-induced retinal microvasculopathy by inhibiting ferroptosis","volume":"666","author":"Chen","year":"2024","journal-title":"Int J Pharm"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110684","article-title":"Astaxanthin ameliorates oxidative stress in lens epithelial cells by regulating gpx4 and ferroptosis","volume":"383","author":"Kong","year":"2023","journal-title":"Chem Biol Interact"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2024.117214","article-title":"Resveratrol alleviates reactive oxygen species and inflammation in diabetic retinopathy via sirt1\/hmgb1 pathway-mediated ferroptosis","volume":"495","author":"Peng","year":"2025","journal-title":"Toxicol Appl Pharmacol"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114978","article-title":"1,8-cineole ameliorates diabetic retinopathy by inhibiting retinal pigment epithelium ferroptosis via ppar-\u03b3\/txnip pathways","volume":"164","author":"Liu","year":"2023","journal-title":"Biomed Pharmacother = Biomed Pharmacother"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2025.124059","article-title":"Structural characterization and protective effects of a glucuronogalactomannan from tetrastigma hemsleyanum against diabetic retinopathy via targeting ferroptosis pathway","volume":"366","author":"Zhou","year":"2025","journal-title":"Carbohydr Polym"},{"key":"B148","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/s41419-025-07497-0","article-title":"The role of vitamin k and its antagonist in the process of ferroptosis-damaged rpe-mediated cnv","volume":"16","author":"Dai","year":"2025","journal-title":"Cell Death Dis"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1543575","article-title":"Melatonin protects retinal pigment epithelium cells against ferroptosis in amd via the pi3k\/akt\/mdm2\/p53 pathway","volume":"16","author":"Wu","year":"2025","journal-title":"Front Pharmacol"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166969","article-title":"Melatonin protects photoreceptor cells against ferroptosis in dry amd disorder by inhibiting gsk-3b\/fyn-dependent nrf2 nuclear translocation","volume":"1870","author":"Zhi","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16272","article-title":"Interferon-\u03b3 induces retinal pigment epithelial cell ferroptosis by a Jak1-2\/Stat1\/Slc7a11 signaling pathway in age-related macular degeneration","volume":"289","author":"Wei","year":"2022","journal-title":"FEBS J"},{"key":"B152","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/j.molcel.2025.02.016","article-title":"Spatial control of m(6)a deposition on enhancer and promoter rnas through co-acetylation of Mettl3 and H3k27 on chromatin","volume":"85","author":"Huang","year":"2025","journal-title":"Mol Cell"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-025-01610-3","article-title":"Prmt5-mediated arginine methylation stabilizes Gpx4 to suppress ferroptosis in cancer","volume":"27","author":"Fan","year":"2025","journal-title":"Nat Cell Biol"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2026.1765089","article-title":"Ferroptosis in diabetic retinopathy: from pathogenic mechanisms to translational prospects","volume":"17","author":"Jiang","year":"2026","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101971","article-title":"Ho-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration","volume":"43","author":"Tang","year":"2021","journal-title":"Redox Biol"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c00595","article-title":"Exploring the mechanisms of the ferroptosis-related gene Tgfbr1 in autoimmune uveitis based on machine learning models","volume":"10","author":"Zhang","year":"2025","journal-title":"ACS Omega"},{"key":"B157","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.3390\/ijms26052334","article-title":"Sodium iodate-induced ferroptosis in photoreceptor-derived 661w cells through the depletion of Gsh","volume":"26","author":"Chen","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B158","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1080\/15548627.2022.2062887","article-title":"Increased Lcn2 (Lipocalin 2) in the Rpe decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry Amd","volume":"19","author":"Gupta","year":"2023","journal-title":"Autophagy"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124614","article-title":"Deferasirox nanosuspension loaded dissolving microneedles for ocular drug delivery","volume":"664","author":"Faizi","year":"2024","journal-title":"Int J Pharm"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.67.1.46","article-title":"Digoxin attenuates ocular hypertension and protects trabecular meshwork cells via ferroptosis inhibition","volume":"67","author":"Zhou","year":"2026","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1608975","article-title":"Ferroptosis in ocular diseases: mechanisms, crosstalk with other cell death pathways, and therapeutic prospects","volume":"12","author":"Huang","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411172","article-title":"Corneal mucin-targeting liposome nanoplatforms enable effective treatment of dry eye diseases by integrated regulation of ferroptosis and inflammation","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401613","article-title":"Melanin-like nanomedicine functions as a novel Rpe ferroptosis inhibitor to ameliorate retinal degeneration and visual impairment in dry age-related macular degeneration","volume":"13","author":"Huang","year":"2024","journal-title":"Adv Healthc Mater"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202504907","article-title":"Dual ferroptosis-inhibitory and antifungal therapy for fungal keratitis using a defect-adhesive thermoresponsive hydrogel","volume":"15","author":"Wang","year":"2026","journal-title":"Adv Healthc Mater"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103354","article-title":"Phytic acid-loaded polyvinyl alcohol hydrogel promotes wound healing of injured corneal epithelium through inhibiting ferroptosis","volume":"76","author":"Gong","year":"2024","journal-title":"Redox Biol"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-04832-6","article-title":"Retinal Pigment Epithelium and Monocytes' Mitochondrial Control of Ferroptosis and Its Relevance to Age-Related Macular Degeneration","volume":"62","author":"Singh","year":"2025","journal-title":"Mol Neurobiol"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.639851","article-title":"Slc7a11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting Rpe Ferroptosis and Vegf Production","volume":"9","author":"Zhao","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2024.01.019","article-title":"Ferroptosis Contributes to Microvascular Dysfunction in Diabetic Retinopathy","volume":"194","author":"Liu","year":"2024","journal-title":"Am J Pathol"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112800","article-title":"Trim46 Contributes to High Glucose-Induced Ferroptosis and Cell Growth Inhibition in Human Retinal Capillary Endothelial Cells by Facilitating Gpx4 Ubiquitination","volume":"407","author":"Zhang","year":"2021","journal-title":"Exp Cell Res"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2025.110656","article-title":"Yap1 Aggravates Hyperglycemia-Induced Retinal Capillary Endothelial Cells Injury Via Ferroptosis and Inflammation Regulation","volume":"261","author":"Liu","year":"2025","journal-title":"Exp Eye Res"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2025.110576","article-title":"Pcbp1 Modulates Cellular Iron Homeostasis Via Targeting Hif-1\u03b1\/Ho-1 Pathway and Alleviates High-Glucose-Induced Ferroptosis in Hrmecs","volume":"259","author":"Yang","year":"2025","journal-title":"Exp Eye Res"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-025-02544-x","article-title":"Flotillin- 1 Ameliorates Experimental Diabetic Retinopathy by Inhibiting Ferroptosis in Blood-Retinal Barrier","volume":"103","author":"Zhang","year":"2025","journal-title":"J Mol Med (Berl)"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.10.296","article-title":"Role of Ferroptosis in Mitochondrial Damage in Diabetic Retinopathy","volume":"225","author":"Malaviya","year":"2024","journal-title":"Free Radic Biol Med"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.2147\/opth.S521660","article-title":"Trap1 Improves Diabetic Retinopathy by Preserving Mitochondrial Function","volume":"19","author":"Li","year":"2025","journal-title":"Clin Ophthalmol"},{"key":"B175","doi-asserted-by":"publisher","first-page":"12753","DOI":"10.3390\/ijms232112753","article-title":"Neuroprotective Effects of Transferrin in Experimental Glaucoma Models","volume":"23","author":"Youale","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.66.5.26","article-title":"Ferroptosis Contributes to Retinal Ganglion Cell Loss in Glast Knockout Mouse Model of Normal Tension Glaucoma","volume":"66","author":"Ye","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.2147\/eb.S434280","article-title":"Ggt1 Suppresses the Development of Ferroptosis and Autophagy in Mouse Retinal Ganglion Cell through Targeting Gclc","volume":"15","author":"Xu","year":"2023","journal-title":"Eye Brain"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00173.2024","article-title":"Ion Channel Piezo1 Induces Ferroptosis of Trabecular Meshwork Cells: A Novel Observation in the Pathogenesis in Primary Open Angle Glaucoma","volume":"327","author":"Liu","year":"2024","journal-title":"Am J Physiol Cell Physiol"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.66.3.25","article-title":"Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis through a Ros\/Nox4\/Smad3 Axis","volume":"66","author":"Wang","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117397","article-title":"Ferroptosis Is Involved in the Damage of Ocular Lens under Long-Term Pm(2.5) Exposure in Rat Models and Humans","volume":"288","author":"Sheng","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"B181","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.freeradbiomed.2021.02.010","article-title":"Aging Lens Epithelium Is Susceptible to Ferroptosis","volume":"167","author":"Wei","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.11.020","article-title":"Glycine Recalibrates Iron Homeostasis of Lens Epithelial Cells by Blocking Lysosome-Dependent Ferritin Degradation","volume":"210","author":"Wang","year":"2024","journal-title":"Free Radical Biol Med"},{"key":"B183","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3390\/ijms26010307","article-title":"Jag1\/Notch Pathway Inhibition Induces Ferroptosis and Promotes Cataractogenesis","volume":"26","author":"Ni","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2025.110601","article-title":"A Novel Protein Encoded by Hsa_Circ_0068626 Contributes to Age-Related Cataract Via the P62\/Keap1\/Nrf2 Signaling Pathway-Mediated Ferroptosis","volume":"260","author":"Chen","year":"2025","journal-title":"Exp Eye Res"},{"key":"B185","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1186\/s12886-023-03205-8","article-title":"Lens Epithelium Cell Ferroptosis Mediated by M(6)a-Lncrna and Gpx4 Expression in Lens Tissue of Age-Related Cataract","volume":"23","author":"Wang","year":"2023","journal-title":"BMC Ophthalmol"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101417","article-title":"Peroxiredoxin-1 Regulates Lipid Peroxidation in Corneal Endothelial Cells","volume":"30","author":"Lovatt","year":"2020","journal-title":"Redox Biol"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2024.110180","article-title":"Mir-23a-3p Targets Pten as a Novel Anti-Ferroptosis Regulator in Fuchs Endothelial Corneal Dystrophy","volume":"250","author":"Chi","year":"2025","journal-title":"Exp Eye Res"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.66.4.23","article-title":"Iron-Sulfur Clusters and Iron Responsive Element Binding Proteins Mediate Iron Accumulation in Corneal Endothelial Cells in Fuchs Dystrophy","volume":"66","author":"Hartness","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16491","article-title":"A Highly Selective Inhibitor of Discoidin Domain Receptor-1 (Ddr1-in-1) Protects Corneal Epithelial Cells from Yap\/Acsl4-Mediated Ferroptosis in Dry Eye","volume":"181","author":"Dai","year":"2024","journal-title":"Br J Pharmacol"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.63.10.3","article-title":"Akr1c1 Protects Corneal Epithelial Cells against Oxidative Stress-Mediated Ferroptosis in Dry Eye","volume":"63","author":"Zuo","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115625","article-title":"Ferroptosis Induced by Dcps Depletion Diminishes Hepatic Metastasis in Uveal Melanoma","volume":"213","author":"Jin","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"B192","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41420-023-01773-8","article-title":"1,4-Dihydroxy Quininib Activates Ferroptosis Pathways in Metastatic Uveal Melanoma and Reveals a Novel Prognostic Biomarker Signature","volume":"10","author":"Tonelotto","year":"2024","journal-title":"Cell Death Discov"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1791087\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T04:10:58Z","timestamp":1774930258000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1791087\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":192,"alternative-id":["10.3389\/fimmu.2026.1791087"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1791087","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,31]]},"article-number":"1791087"}}