{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:40:22Z","timestamp":1773916822449,"version":"3.50.1"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Vascular injury is a major contributor to the development of cardiovascular diseases. Following vascular damage, macrophages migrate to the injury site and, during the later stages of vascular repair, secrete cytokines such as interleukin-10 (IL-10) and transforming growth factor-\u03b21a (TGFB1A), thereby promoting vascular regeneration. Previous studies have demonstrated that macrophage recruitment to sites of tissue injury is mediated by the CXCR4A-CXCL12B signaling axis. In a screening of traditional Chinese medicinal herbs for cardiovascular therapeutic potential,\n                      <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                      root was identified as a promising source of bioactive compounds capable of enhancing vascular repair through modulation of the CXCR4A-CXCL12B axis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Establishing a vascular injury model in transgenic zebrafish lines\n                      <jats:italic>Tg<\/jats:italic>\n                      (\n                      <jats:italic>flk1<\/jats:italic>\n                      :eGFP;\n                      <jats:italic>gata1<\/jats:italic>\n                      :dsRed) using a two-photon microscopy laser system. Dynamic monitoring of vascular repair via two-photon microscopy. Evaluate macrophage migration capacity in a\n                      <jats:italic>Tg<\/jats:italic>\n                      (\n                      <jats:italic>mpeg1<\/jats:italic>\n                      :eGFP) zebrafish vascular injury model using confocal microscopy. Detection of\n                      <jats:italic>il-10<\/jats:italic>\n                      and\n                      <jats:italic>tgfb1a<\/jats:italic>\n                      expression released by macrophages via qPCR experiments. Detect CXCR4A-CXCL12B expression at the site of zebrafish vascular injury via fluorescence\n                      <jats:italic>in situ<\/jats:italic>\n                      hybridization coupled with antibody staining.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We confirm that compounds from the selected extract promote macrophage migration to vascular injury sites by upregulating the CXCR4A-CXCR12B signaling axis. This process accelerates repair of damaged blood vessels in zebrafish by inducing the release of cytokines such as\n                      <jats:italic>il-10<\/jats:italic>\n                      and\n                      <jats:italic>tgfb1a<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study confirms that\n                      <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                      , a traditional Chinese medicinal plant, is a valuable source of bioactive compounds with pro-angiogenic properties. Our findings provide scientific support for the traditional use of\n                      <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                      active components in treating vascular injuries.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1792022","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:23:46Z","timestamp":1773897826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Tanshinone IIA accelerates zebrafish venous vascular repair via macrophage recruitment through the CXCR4A\u2013CXCL12B signaling axis"],"prefix":"10.3389","volume":"17","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"Center for Tissue Engineering and Stem Cell Research, Translation Medicine Research Center, Guizhou Biomanufacturing Laboratory, Department of Immunology, School of Basic Medicine, Guizhou 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