{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:07:47Z","timestamp":1793315267630,"version":"4.5.0"},"reference-count":219,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Chronic Prostatitis\/Chronic Pelvic Pain Syndrome (CP\/CPPS), a prevalent urological and andrological condition among men of reproductive age, induces persistent pathological alterations. These alterations remodel the microenvironment of the prostate and reproductive tract through multiple pathways, thereby severely impairing sperm spermatogenesis, maturation, and function. By constructing a multidimensional interaction network encompassing \u201cinflammation-oxidation-endocrine-microbiota, \u201c this article elucidates the four core pathological mechanisms by which the CP\/CPPS microenvironment damages the full cycle of sperm development: (1) local inflammatory storms and immune cell infiltration hindering sperm development; (2) the collapse of the antioxidant defense system due to oxidative stress imbalance and excessive reactive oxygen species (ROS) generation; (3) metabolic homeostasis disruption in the spermatogenic microenvironment caused by neuroendocrine and biochemical disorders; and (4) sperm functional impairment resulting from heterogeneous alterations in the reproductive tract and gut microbiomes. This review systematically reveals the cascading impact of CP\/CPPS on the entire chain of \u201ctesticular spermatogenesis\u2013epididymal maturation\u2013fertilization capacitation.\u201d Furthermore, it posits that future research should focus on multi-omics mechanism resolution and shift towards a multi-target, precision combination intervention strategy of \u201canti-inflammation, antioxidation, endocrine regulation, and microecological reconstruction, \u201c providing a theoretical basis and translational direction for improving clinical reproductive outcomes in patients.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1793156","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T05:35:45Z","timestamp":1773207345000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Research progress on the multidimensional mechanisms underlying impaired spermatogenesis induced by pathological microenvironment remodeling in chronic prostatitis"],"prefix":"10.3389","volume":"17","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital of Zunyi Medical University (The First People\u2019s Hospital of Zunyi)","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital of Zunyi Medical University (The First People\u2019s Hospital of Zunyi)","place":["Zunyi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Urology, The Third Affiliated Hospital of Zunyi Medical University (The First People\u2019s Hospital of Zunyi)","place":["Zunyi, 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