{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:37:50Z","timestamp":1793813870700,"version":"4.6.1"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560986 , 81760516"],"award-info":[{"award-number":["82560986 , 81760516"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2023GXNSFBA026129"],"award-info":[{"award-number":["2023GXNSFBA026129"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      The impact of\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      ) on the gastrointestinal tract ecosystem has been widely investigated beyond the stomach. Researchers have made considerable progress in understanding the relationship between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection, gut microbiome dysbiosis, and systemic effects in recent years. This study aimed to explore the prospects and developing trends in the field of the\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2013gut microbiome nexus from a bibliometric perspective.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Articles were collected from the Web of Science Core Collection, Scopus, and PubMed (2000\u20132025) and analyzed using bibliometrix, VOSviewer, and CiteSpace. Analysis of 1,592 publications reveals a distinct three-phase evolutionary structure in the field.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and discussion<\/jats:title>\n                    <jats:p>\n                      Geographically led by China and the USA, the research focus has undergone a paradigm shift: evolving from an initial \u201cinfection and eradication\u201d phase, through a transitional \u201cdysbiosis and ecological intervention\u201d phase, to the current \u201ctumor\u2013immunity axis\u201d hotspot. Recent high-strength citation bursts for terms like \u201c\n                      <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                      \u201d and \u201cimmunity\u201d underscore this transformation, indicating that academic attention has moved beyond local gastric pathogen control to understanding\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2019s systemic role in modulating tumor microenvironments and therapeutic responses. This bibliometric analysis maps the field\u2019s rapid growth trajectory, highlighting its value for guiding future precision oncology and microecological strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1794021","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:21:19Z","timestamp":1776313279000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Worldwide research trends on the Helicobacter pylori\u2013gut microbiome nexus: a bibliometric analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Liwei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, 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Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiquan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengbin","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongbin","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, 923 Hospital of People's Liberation Army Joint Logistics Support Force","place":["Nanning, 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