{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:49:19Z","timestamp":1774424959468,"version":"3.50.1"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Muscle atrophy following anterior cruciate ligament reconstruction (ACLR) significantly impedes functional recovery, yet its underlying prognostic factors and potential cellular mechanisms remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a cohort of 26 ACLR patients, a correlation analysis was conducted between clinical characteristics and postoperative changes in quadriceps circumference. Single-cell RNA sequencing was performed to analyze cell composition and intercellular communication in immobilized muscle. Ligand\u2013receptor interactions were investigated using CellChat, and ferroptosis level was evaluated in fibro\/adipogenic progenitors (FAPs).\n                      <jats:italic>In vitro<\/jats:italic>\n                      experiments were conducted using apoptotic muscle satellite cells (MuSCs) conditioning medium to evaluate its effects on FAP activation and adipogenic differentiation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Preoperative muscle fat infiltration (MFI), C-reactive protein (CRP) level, and concurrent meniscus repair were independent predictors of quadriceps atrophy at 3 months post-ACLR. Single-cell analysis revealed increased proportions of MuSCs and FAPs in immobilized muscle with enhanced cross-talk. Conditioned medium from apoptotic MuSCs promoted FAP viability and adipogenic ability. Moreover, ferroptosis was suppressed in FAPs under immobilization, with several regulatory genes aberrantly regulated. Mechanistically, immobilization induced a coordinated shift in the ferroptosis regulatory network within FAPs, characterized by downregulation of pro-ferroptotic genes and upregulation of anti-ferroptotic genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Preoperative MFI and systemic inflammation are risk factors for quadriceps atrophy after ACLR. Apoptotic MuSCs may promote fat infiltration by activating FAPs through suppression of ferroptosis. These findings highlight potential therapeutic targets for mitigating muscle degeneration and improving recovery outcomes after ACLR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fimmu.2026.1796054","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:03:38Z","timestamp":1774418618000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative systemic inflammation and muscle fatty infiltration are prognostic factors for quadriceps atrophy following anterior cruciate ligament reconstruction"],"prefix":"10.3389","volume":"17","author":[{"given":"Hanyi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beijie","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiwu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]},{"name":"Shanghai General Hospital of Nanjing Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Sports Medicine and Arthroscopy, Fuyang People\u2019s Hospital Affiliated to Anhui Medical University","place":["Anhui, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]},{"name":"Shanghai General Hospital of Nanjing Medical University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaying","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1177\/03635465211060333","article-title":"Patient-reported outcome, return to sport, and revision rates 7-9 years after anterior cruciate ligament reconstruction: Results from a cohort of 2042 patients","volume":"50","author":"Randsborg","year":"2022","journal-title":"Am J Sport Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1177\/03635465251380293","article-title":"Sports participation 25 years after anterior cruciate ligament reconstruction: A prospective longitudinal study comparing patients with patellar tendon and hamstring tendon grafting to uninjured controls","volume":"53","author":"Keays","year":"2025","journal-title":"Am J Sport Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fspor.2025.1654873","article-title":"Anti-gravity treadmill training benefits the post-operative rehabilitation of ACL reconstruction and the effects on the muscular atrophy and balance ability: A cohort study and 1y follow-up","volume":"7","author":"Ma","year":"2025","journal-title":"Front Sport Act Liv"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.1016\/j.arthro.2024.12.004","article-title":"Earlier initiation of supervised physical rehabilitation is not associated with decreased arthrofibrosis after isolated arthroscopic anterior cruciate ligament reconstruction","volume":"41","author":"Rosenberg","year":"2025","journal-title":"Arthroscopy"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.arthro.2025.02.031","article-title":"Lower patient-reported outcomes after isolated anterior cruciate ligament reconstruction are associated with lower muscle strength rather than graft status during second-look arthroscopic evaluation","volume":"41","author":"Lee","year":"2025","journal-title":"Arthroscopy"},{"key":"B6","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s12178-025-09989-0","article-title":"Return to sport following ACL reconstruction","volume":"18","author":"Foley","year":"2025","journal-title":"Curr Rev Musculoskelet Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.knee.2025.02.008","article-title":"Quadriceps and hamstring muscles strength differences in adolescent and adult recreational athletes 6 months after autograft bone-patellar-tendon-bone anterior cruciate ligament reconstruction: A retrospective study","volume":"54","author":"Turati","year":"2025","journal-title":"Knee"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1177\/0363546520960108","article-title":"Rate of force development remains reduced in the knee flexors 3 to 9 months after anterior cruciate ligament reconstruction using medial hamstring autografts: A cross-sectional study","volume":"48","author":"Nielsen","year":"2020","journal-title":"Am J Sport Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.knee.2023.06.006","article-title":"Persistence of neuromuscular activation deficit in the lower limb at 3-years of follow-up after ACL reconstruction surgery","volume":"43","author":"Zunzarren","year":"2023","journal-title":"Knee"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2025.106544","article-title":"Performance across the isokinetic velocity spectrum: Interpretation for individuals after anterior cruciate ligament reconstruction","volume":"126","author":"Culiver","year":"2025","journal-title":"Clin Biomech (Bristol)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1123\/jsr.2016-0141","article-title":"MRI-based assessment of lower-extremity muscle volumes in patients before and after ACL reconstruction","volume":"27","author":"Norte","year":"2018","journal-title":"J Sport Rehabil"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.asmr.2025.101191","article-title":"Thigh muscle volume remains decreased on 3-dimensional magnetic resonance imaging at minimum of 5 years after patellar tendon but not allograft anterior cruciate ligament reconstruction","volume":"7","author":"Hunter","year":"2025","journal-title":"Arthrosc Sport Med Rehabil"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1177\/03635465241313235","article-title":"Quantifying muscle volume deficits among 38 lower extremity muscles in collegiate football athletes after anterior cruciate ligament reconstruction","volume":"53","author":"Ito","year":"2025","journal-title":"Am J Sport Med"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1177\/23259671231194593","article-title":"Older age, poor preoperative quadriceps muscle strength, and residual pain as risk factors for poor quadriceps muscle strength recovery at 1 year after ACL reconstruction: A TMDU MAKS study of 402 patients","volume":"11","author":"Hasegawa","year":"2023","journal-title":"Orthop J Sport Med"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1113\/JP286815","article-title":"CSF1-R inhibition attenuates posttraumatic osteoarthritis and quadriceps atrophy following ligament injury","volume":"603","author":"Keeble","year":"2025","journal-title":"J Physiol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.198","article-title":"Interactions between muscle stem cells, mesenchymal-derived cells and immune cells in muscle homeostasis, regeneration and disease","volume":"6","author":"Farup","year":"2015","journal-title":"Cell Death Dis"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/jor.25933","article-title":"Transcriptional evidence for transient regulation of muscle regeneration by brown adipose transplant in the rotator cuff","volume":"42","author":"Gui","year":"2024","journal-title":"J Orthop Res"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.875611","article-title":"Gut metabolite urolithin A inhibits osteoclastogenesis and senile osteoporosis by enhancing the autophagy capacity of bone marrow macrophages","volume":"13","author":"Tao","year":"2022","journal-title":"Front Pharmacol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115664","article-title":"Oxidative stress: Roles in skeletal muscle atrophy","volume":"214","author":"Zhang","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1177\/1941738120944256","article-title":"Muscle atrophy after ACL injury: Implications for clinical practice","volume":"12","author":"Lepley","year":"2020","journal-title":"Sport Health"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.K.00692","article-title":"Evaluation of muscle size and fatty infiltration with MRI nine to eleven years following hamstring harvest for ACL reconstruction","volume":"94","author":"Snow","year":"2012","journal-title":"J Bone Joint Surg Am"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1113\/JP279595","article-title":"Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction","volume":"598","author":"Biltz","year":"2020","journal-title":"J Physiol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-010-0081-2","article-title":"Skeletal muscle fat infiltration: Impact of age, inactivity, and exercise","volume":"14","author":"Marcus","year":"2010","journal-title":"J Nutr Health Aging"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14202260","article-title":"Sex differences in fat distribution and muscle fat infiltration in the lower extremity: A retrospective diverse-ethnicity 7T MRI study in a research institute setting in the USA","volume":"14","author":"Johnson","year":"2024","journal-title":"Diag (Basel)"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.171","article-title":"Cell death, clearance and immunity in the skeletal muscle","volume":"23","author":"Sciorati","year":"2016","journal-title":"Cell Death Differ"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125334","article-title":"Non-fibro-adipogenic pericytes from human embryonic stem cells attenuate degeneration of the chronically injured mouse muscle","volume":"4","author":"Mosich","year":"2019","journal-title":"JCI Insight"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166865","article-title":"Degeneration in ACL injured knees with and without reconstruction in relation to muscle size and fat content-data from the osteoarthritis initiative","volume":"11","author":"Jungmann","year":"2016","journal-title":"PloS One"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24479","article-title":"Association of quadriceps strength symmetry and surgical status with clinical osteoarthritis five years after anterior cruciate ligament rupture","volume":"74","author":"Arhos","year":"2022","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1075357","article-title":"Periarticular muscle status affects in vivo tibio-femoral joint loads after total knee arthroplasty","volume":"11","author":"Winkler","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13395-024-00365-z","article-title":"Fully-automated segmentation of muscle and inter-\/intra-muscular fat from magnetic resonance images of calves and thighs: An open-source workflow in Python","volume":"14","author":"Tam","year":"2024","journal-title":"Skelet Muscle"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.12.011","article-title":"Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis","volume":"31","author":"Kang","year":"2024","journal-title":"Cell Stem Cell"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.70115","article-title":"Slo1 deficient myoblast exosomes-derived miR-222-3p inhibits osteogenic differentiation via targeting of STAT3","volume":"16","author":"Wang","year":"2025","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-006-0197-6","article-title":"Skeletal muscle atrophy increases cell proliferation in mice gastrocnemius during the first week of hindlimb suspension","volume":"97","author":"Ferreira","year":"2006","journal-title":"Eur J Appl Physiol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26199333","article-title":"In vitro and in vivo comparative analysis of muscle regenerative processes induced by different microcurrent waveforms in skeletal muscle atrophy","volume":"26","author":"Lee","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B35","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12964-019-0461-0","article-title":"TAM receptors, phosphatidylserine, inflammation, and cancer","volume":"17","author":"Burstyn-Cohen","year":"2019","journal-title":"Cell Commun Signal"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-025-02548-7","article-title":"Role of aberrant activated fibro\/adipogenic progenitors and suppressed ferroptosis in disused skeletal muscle atrophy and fatty infiltration","volume":"103","author":"Tan","year":"2025","journal-title":"J Mol Med (Berl)"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1023314","article-title":"Xiaoaiping injection combined with chemotherapy for advanced gastric cancer: An updated systematic review and meta-analysis","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Pharmacol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.4149\/BLL_2021_078","article-title":"Neutrophil-to-lymphocyte ratio, past, present and future perspectives","volume":"122","author":"Zahorec","year":"2021","journal-title":"Bratisl Lek Listy"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2023.112084","article-title":"C-reactive protein, but not neutrophil-lymphocyte ratio, is inversely associated with muscle strength only in older men: NHANES 1999-2002","volume":"173","author":"Lobo","year":"2023","journal-title":"Exp Gerontol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"3669","DOI":"10.1038\/s41598-024-54056-2","article-title":"Neutrophil-to-lymphocyte ratio is associated with sarcopenia risk in overweight maintenance hemodialysis patients","volume":"14","author":"Nie","year":"2024","journal-title":"Sci Rep"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11092656","article-title":"Sarcopenia and myosteatosis are associated with neutrophil to lymphocyte ratio but not Glasgow prognostic score in colorectal cancer patients","volume":"11","author":"Aro","year":"2022","journal-title":"J Clin Med"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232315039","article-title":"Inflammaging: implications in sarcopenia","volume":"23","author":"Antu\u00f1a","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101682","article-title":"Bidirectional roles of skeletal muscle fibro-adipogenic progenitors in homeostasis and disease","volume":"80","author":"Chen","year":"2022","journal-title":"Ageing Res Rev"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2024.05.020","article-title":"Myosteatosis is closely associated with sarcopenia and significantly worse outcomes in patients with cirrhosis","volume":"81","author":"Di Cola","year":"2024","journal-title":"J Hepatol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s42003-023-04504-y","article-title":"MME(+) fibro-adipogenic progenitors are the dominant adipogenic population during fatty infiltration in human skeletal muscle","volume":"6","author":"Fitzgerald","year":"2023","journal-title":"Commun Biol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2316544121","article-title":"Reciprocal communication between FAPs and muscle cells via distinct extracellular vesicle miRNAs in muscle regeneration","volume":"121","author":"Yu","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"B47","doi-asserted-by":"publisher","first-page":"jrm00153","DOI":"10.2340\/16501977-2794","article-title":"Increased satellite cell apoptosis in vastus lateralis muscle after anterior cruciate ligament reconstruction","volume":"53","author":"Parstorfer","year":"2021","journal-title":"J Rehabil Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S511521","article-title":"Therapeutic implications of traditional Chinese medicine in clinically relevant diseases: Perspectives from microRNA-modulated apoptotic signaling","volume":"19","author":"Xu","year":"2025","journal-title":"Drug Des Devel Ther"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111270","article-title":"Environmental contaminant BPA causes intestinal damage by disrupting cellular repair and injury homeostasis in vivo and in vitro","volume":"137","author":"Wang","year":"2021","journal-title":"BioMed Pharmacother"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14412","article-title":"Human umbilical cord derived mesenchymal stem cells overexpressing HO-1 attenuate neural injury and enhance functional recovery by inhibiting inflammation in stroke mice","volume":"30","author":"Yang","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"B51","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12951-023-01969-1","article-title":"Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials","volume":"21","author":"Yu","year":"2023","journal-title":"J Nanobiotechnol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110304","article-title":"Arsenic trioxide promotes ERK1\/2-mediated phosphorylation and degradation of BIM(EL) to attenuate apoptosis in BEAS-2B cells","volume":"369","author":"Liang","year":"2023","journal-title":"Chem Biol Interact"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2121-3","article-title":"Metabolites released from apoptotic cells act as tissue messengers","volume":"580","author":"Medina","year":"2020","journal-title":"Nature"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3390\/biology9010021","article-title":"Apoptotic bodies: Particular extracellular vesicles involved in intercellular communication","volume":"9","author":"Battistelli","year":"2020","journal-title":"Biol (Basel)"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13531","article-title":"Apoptotic bodies inhibit inflammation by PDL1-PD1-mediated macrophage metabolic reprogramming","volume":"57","author":"Jiang","year":"2024","journal-title":"Cell Prolif"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12434","article-title":"Functional diversity of apoptotic vesicle subpopulations from bone marrow mesenchymal stem cells in tissue regeneration","volume":"13","author":"Zhang","year":"2024","journal-title":"J Extracell Vesicles"},{"key":"B57","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1038\/s41419-021-03883-6","article-title":"Emerging understanding of apoptosis in mediating mesenchymal stem cell therapy","volume":"12","author":"Fu","year":"2021","journal-title":"Cell Death Dis"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116406","article-title":"Mechanistic and therapeutic perspectives of miRNA-PTEN signaling axis in cancer therapy resistance","volume":"226","author":"Wu","year":"2024","journal-title":"Biochem Pharmacol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111998","article-title":"Identification of TAP1 as a T-cell related therapeutic target in gastric cancer by mediating oxalipliatin-related synergistic enhancement of immunotherapy","volume":"132","author":"Zhao","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23502","article-title":"ACL injury reduces satellite cell abundance and promotes fibrogenic cell expansion within skeletal muscle","volume":"35","author":"Fry","year":"2017","journal-title":"J Orthop Res"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00035","article-title":"Cellular and morphological alterations in the vastus lateralis muscle as the result of ACL injury and reconstruction","volume":"98","author":"Noehren","year":"2016","journal-title":"J Bone Joint Surg Am"},{"key":"B62","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12575-020-00130-8","article-title":"Isolation and quantification of blood apoptotic bodies, a non-invasive tool to evaluate apoptosis in patients with ischemic stroke and neurodegenerative diseases","volume":"22","author":"Serrano-Heras","year":"2020","journal-title":"Biol Proced Online"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c03517","article-title":"Apoptotic extracellular vesicles ameliorate multiple myeloma by restoring Fas-mediated apoptosis","volume":"15","author":"Wang","year":"2021","journal-title":"ACS Nano"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba2987","article-title":"Chimeric apoptotic bodies functionalized with natural membrane and modular delivery system for inflammation modulation","volume":"6","author":"Dou","year":"2020","journal-title":"Sci Adv"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2020.06.003","article-title":"A tale of two moieties: Rapidly evolving CRISPR\/Cas-based genome editing","volume":"45","author":"Yang","year":"2020","journal-title":"Trends Biochem Sci"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1796054\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:03:39Z","timestamp":1774418619000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1796054\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":65,"alternative-id":["10.3389\/fimmu.2026.1796054"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1796054","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,25]]},"article-number":"1796054"}}