{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:16:08Z","timestamp":1778566568915,"version":"3.51.4"},"reference-count":114,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Antiphospholipid syndrome (APS) is an acquired systemic autoimmune disorder characterized clinically by recurrent arterial and venous thrombosis and\/or adverse pregnancy outcomes, and laboratory-defined by persistently positive antiphospholipid antibodies (aPLs). Neutrophils are the most abundant white blood cells in the circulation. In APS patients, aPLs abnormally activate neutrophils, causing them to transition from a quiescent state to a highly activated state, which is a central mechanism in disease pathogenesis. Neutrophil extracellular traps (NETs) are reticular structures composed of DNA, histones, and granular proteins released by neutrophils under stress conditions. As a crucial immune mechanism for neutrophil function, NETs play a vital role in anti-infection and immune responses. However, when overactivated or lacking inhibition, NETs can mediate the development of various diseases. Recent studies indicate that neutrophils and NETs occupy a central position in APS pathogenesis, promoting thrombosis and contributing to pathological processes such as placental dysfunction. This review summarizes the role of NETs in the development and progression of APS.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1800055","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:45:50Z","timestamp":1778564750000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of neutrophil extracellular traps in antiphospholipid syndrome"],"prefix":"10.3389","volume":"17","author":[{"given":"Chunyao","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youge","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Hospital of Inner Mongolia Medical University","place":["Hohhot, 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