{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:51:27Z","timestamp":1781675487701,"version":"3.54.5"},"reference-count":242,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Heart failure following myocardial infarction (MI) is a major complication affecting long-term prognosis of patient, with its core pathological processes being ventricular pathological remodeling and fibrosis. This process is not merely simple scar formation, but is dominated by a continuous, dynamic, and intricate bidirectional dialogue between immune cells and cardiac stromal cells. This review systematically mapped the complex interactive networks between immune cells\u2014including neutrophils, macrophages, and lymphocytes\u2014and stromal cells such as cardiac fibroblasts, endothelial cells, and pericytes during the spatiotemporal evolution following MI. We emphasizes the key communication pathways involving cytokines, chemokines, fibrotic signals, and active signals from the microenvironment. And we mappied their spatiotemporal network governing the initiation and resolution of inflammation and fibrosis. Simultaneously, we explored how this network\u2019s imbalance shifts from essential repair responses to pathological fibrosis, ultimately leading to heart failure. Furthermore, we summarized novel therapeutic strategies targeting the immune-matrix axis, aiming to provide new perspectives and theoretical foundations for the precise prevention and treatment of heart failure following MI.<\/jats:p>","DOI":"10.3389\/fimmu.2026.1801258","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:52:48Z","timestamp":1781671968000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of the bidirectional regulatory network between immune cells and stromal cells in cardiac repair and fibrosis following myocardial infarction"],"prefix":"10.3389","volume":"17","author":[{"given":"Fuyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiying","family":"Liu","sequence":"additional","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruikang","family":"Liu","sequence":"additional","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohua","family":"Li","sequence":"additional","affiliation":[{"name":"China Academy of Chinese Medical Sciences Eye Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Guang\u2019anmen Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990-2019: Update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.0239","article-title":"Long-term outcomes in patients with severely reduced left ventricular ejection fraction undergoing percutaneous coronary intervention vs coronary artery bypass grafting","volume":"5","author":"Sun","year":"2020","journal-title":"JAMA Cardiol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.784215","article-title":"Long-term trends in the incidence of heart failure after myocardial infarction","volume":"118","author":"Velagaleti","year":"2008","journal-title":"Circulation"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e002667","DOI":"10.1161\/JAHA.115.002667","article-title":"Heart failure complicating acute myocardial infarction; burden and timing of occurrence: A nation-wide analysis including 86 771 patients from the Cardiovascular Disease in Norway (CVDNOR) project","volume":"5","author":"Sulo","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027600","article-title":"Impact of reperfusion on temporal immune cell dynamics after myocardial infarction","volume":"12","author":"Zhang","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118608","article-title":"Immune cell dynamics and their role in cardiac injury: Mechanisms and therapeutic implications","volume":"192","author":"Liu","year":"2025","journal-title":"BioMed Pharmacother"},{"key":"B7","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/s41467-021-20905-1","article-title":"Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction","volume":"12","author":"Tombor","year":"2021","journal-title":"Nat Commun"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202100752","article-title":"Single-cell RNA sequencing reveals the temporal diversity and dynamics of cardiac immunity after myocardial infarction","volume":"6","author":"Jin","year":"2022","journal-title":"Small Methods"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2797-4","article-title":"Cells of the adult human heart","volume":"588","author":"Litvinukova","year":"2020","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-025-00739-6","article-title":"Spatiotemporal dynamics of the cardioimmune niche during lesion repair","volume":"4","author":"Chan","year":"2025","journal-title":"Nat Cardiovasc Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1394137","article-title":"S100a8\/A9 proteins: Critical regulators of inflammation in cardiovascular diseases","volume":"11","author":"Sun","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.3390\/cells11121911","article-title":"Integrated analysis reveals S100a8\/a9 regulates autophagy and apoptosis through the MAPK and PI3K-AKT signaling pathway in the early stage of myocardial infarction","volume":"11","author":"Yi","year":"2022","journal-title":"Cells"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e155236","DOI":"10.1172\/jci.insight.155236","article-title":"Targeting IL-36 improves age-related coronary microcirculatory dysfunction and attenuates myocardial ischemia\/reperfusion injury in mice","volume":"7","author":"El-Awaisi","year":"2022","journal-title":"JCI Insight"},{"key":"B14","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.3390\/ijms25073983","article-title":"Neutrophil extracellular traps in cardiovascular and aortic disease: A narrative review on molecular mechanisms and therapeutic targeting","volume":"25","author":"Ibrahim","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2174\/0115701611345395241217053615","article-title":"Neutrophil elastase as a potential target in ischemia-reperfusion injury","volume":"23","author":"Tan","year":"2025","journal-title":"Curr Vasc Pharmacol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw002","article-title":"Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype","volume":"38","author":"Horckmans","year":"2017","journal-title":"Eur Heart J"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-024-10421-x","article-title":"The role of NETosis in heart failure","volume":"29","author":"Kostin","year":"2024","journal-title":"Heart Fail Rev"},{"key":"B18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/cvr\/cvw024","article-title":"Temporal neutrophil polarization following myocardial infarction","volume":"110","author":"Ma","year":"2016","journal-title":"Cardiovasc Res"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.708770","article-title":"Transcriptional profiling and functional analysis of N1\/N2 neutrophils reveal an immunomodulatory effect of S100A9-blockade on the pro-inflammatory N1 subpopulation","volume":"12","author":"Mihaila","year":"2021","journal-title":"Front Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.3390\/ani11041098","article-title":"Comparative phenotypic and functional analyses of the effects of IL-10 or TGF-beta on porcine macrophages","volume":"11","author":"Carta","year":"2021","journal-title":"Anim (Basel)"},{"key":"B21","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3390\/cells13030208","article-title":"Anti-inflammatory neutrophils reprogram macrophages toward a pro-healing phenotype with increased efferocytosis capacity","volume":"13","author":"Mihaila","year":"2024","journal-title":"Cells"},{"key":"B22","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1186\/s13287-025-04684-w","article-title":"Mesenchymal stromal cells modulate neutrophil phenotype via paracrine signals","volume":"16","author":"Cherry","year":"2025","journal-title":"Stem Cell Res Ther"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.3390\/cells10071676","article-title":"Role of neutrophils in cardiac injury and repair following myocardial infarction","volume":"10","author":"Ma","year":"2021","journal-title":"Cells"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.323658","article-title":"Repair of the infarcted heart: Cellular effectors, molecular mechanisms and therapeutic opportunities","volume":"134","author":"Hilgendorf","year":"2024","journal-title":"Circ Res"},{"key":"B25","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1146\/annurev-immunol-042617-053010","article-title":"Apoptosis and clearance of apoptotic cells","volume":"36","author":"Nagata","year":"2018","journal-title":"Annu Rev Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"764","DOI":"10.3390\/cells13090764","article-title":"Targeting interactions between fibroblasts and macrophages to treat cardiac fibrosis","volume":"13","author":"Yang","year":"2024","journal-title":"Cells"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.057549","article-title":"Cardiac resident macrophage-derived legumain improves cardiac repair by promoting clearance and degradation of apoptotic cardiomyocytes after myocardial infarction","volume":"145","author":"Jia","year":"2022","journal-title":"Circulation"},{"key":"B28","doi-asserted-by":"publisher","first-page":"879","DOI":"10.3390\/cells14120879","article-title":"Exogenous ubiquitin differentially modulates the phenotype and function of M1 and M2 macrophages","volume":"14","author":"Shook","year":"2025","journal-title":"Cells"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.yjmcc.2025.08.003","article-title":"Cell type specificity of Hippo-YAP signaling in cardiac development and disease","volume":"207","author":"Guan","year":"2025","journal-title":"J Mol Cell Cardiol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz336","article-title":"Cardiac monocytes and macrophages after myocardial infarction","volume":"116","author":"Peet","year":"2020","journal-title":"Cardiovasc Res"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115393","article-title":"IL4I1 attenuates myocardial infarction by inhibiting macrophage ferroptosis via the I3P\/AHR\/NRF2 signaling pathway","volume":"165","author":"Dong","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.trsl.2017.10.001","article-title":"Cardiac macrophage biology in the steady-state heart, the aging heart, and following myocardial infarction","volume":"191","author":"Ma","year":"2018","journal-title":"Transl Res"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.613116","article-title":"Non-genetic heterogeneity of macrophages in diseases-a medical perspective","volume":"8","author":"Gessain","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41590-018-0272-2","article-title":"Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction","volume":"20","author":"Dick","year":"2019","journal-title":"Nat Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1155\/mi\/9912957","article-title":"The dual role of macrophages in MIRI and MI by immunity and inflammation: Damage, repair, crosstalk, and therapy","volume":"2025","author":"Miao","year":"2025","journal-title":"Mediators Inflammation"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106116","article-title":"Inhibition of Dectin-1 in mice ameliorates cardiac remodeling by suppressing NF-kappaB\/NLRP3 signaling after myocardial infarction","volume":"80","author":"Li","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-025-05317-9","article-title":"Integrative single-cell and spatial transcriptome analysis reveals the functions of TREM2(high) macrophages and infarct border dynamics post-myocardial infarction","volume":"480","author":"Xiong","year":"2025","journal-title":"Mol Cell Biochem"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.7150\/thno.118014","article-title":"Macrophage-TREM2 promotes cardiac repair by restricting the infiltration of CD8(+) T cells via CXCL16-CXCR6 axis after myocardial infarction","volume":"15","author":"Zhang","year":"2025","journal-title":"Theranostics"},{"key":"B40","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s11658-020-00225-w","article-title":"Role of angiotensin-converting enzyme in myeloid cell immune responses","volume":"25","author":"Cao","year":"2020","journal-title":"Cell Mol Biol Lett"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107388","article-title":"Classical and nonclassical effects of angiotensin-converting enzyme: How increased ACE enhances myeloid immune function","volume":"300","author":"Bernstein","year":"2024","journal-title":"J Biol Chem"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.011244","article-title":"ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP","volume":"295","author":"Cao","year":"2020","journal-title":"J Biol Chem"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1278383","article-title":"Myeloid cell ACE shapes cellular metabolism and function in PCSK-9 induced atherosclerosis","volume":"14","author":"Cao","year":"2023","journal-title":"Front Immunol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad082","article-title":"Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor alpha and fundamentally changing lipid metabolism","volume":"119","author":"Cao","year":"2023","journal-title":"Cardiovasc Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1129007","article-title":"Single-cell landscape dissecting the transcription and heterogeneity of innate lymphoid cells in ischemic heart","volume":"14","author":"Jiang","year":"2023","journal-title":"Front Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00634","article-title":"Non-cytotoxic cardiac innate lymphoid cells are a resident and quiescent type 2-commited population","volume":"10","author":"Bracamonte-Baran","year":"2019","journal-title":"Front Immunol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.758272","article-title":"Innate lymphoid cells and myocardial infarction","volume":"12","author":"Yang","year":"2021","journal-title":"Front Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.004408","article-title":"Deleterious effect of the IL-23\/IL-17A axis and gammadeltaT cells on left ventricular remodeling after myocardial infarction","volume":"1","author":"Yan","year":"2012","journal-title":"J Am Heart Assoc"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.044164","article-title":"Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice","volume":"125","author":"Hofmann","year":"2012","journal-title":"Circulation"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.664457","article-title":"Cells of the immune system in cardiac remodeling: Main players in resolution of inflammation and repair after myocardial infarction","volume":"12","author":"Kologrivova","year":"2021","journal-title":"Front Immunol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The biological basis for cardiac repair after myocardial infarction: From inflammation to fibrosis","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ Res"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13325","article-title":"Signals that control MAIT cell function in healthy and inflamed human tissues","volume":"323","author":"Konecny","year":"2024","journal-title":"Immunol Rev"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1172\/JCI123859","article-title":"Myocardial infarction triggers cardioprotective antigen-specific T helper cell responses","volume":"129","author":"Rieckmann","year":"2019","journal-title":"J Clin Invest"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2323052121","article-title":"Injury-induced myosin-specific tissue-resident memory T cells drive immune checkpoint inhibitor myocarditis","volume":"121","author":"Kalinoski","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.584538","article-title":"Terminally differentiated CD4(+) T cells promote myocardial inflammaging","volume":"12","author":"Delgobo","year":"2021","journal-title":"Front Immunol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.079","article-title":"Myocardial infarction primes autoreactive T cells through activation of dendritic cells","volume":"18","author":"Van der Borght","year":"2017","journal-title":"Cell Rep"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00595.2019","article-title":"Monocytes prime autoreactive T cells after myocardial infarction","volume":"318","author":"DeBerge","year":"2020","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800618115","article-title":"T(reg) cells limit IFN-gamma production to control macrophage accrual and phenotype during skeletal muscle regeneration","volume":"115","author":"Panduro","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9483647","article-title":"Dynamic profile of CD4(+) T-cell-associated cytokines\/chemokines following murine myocardial infarction\/reperfusion","volume":"2019","author":"Yuan","year":"2019","journal-title":"Mediators Inflammation"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.001020","article-title":"Interleukin-13 deficiency aggravates healing and remodeling in male mice after experimental myocardial infarction","volume":"7","author":"Hofmann","year":"2014","journal-title":"Circ Heart Fail"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1331609","article-title":"Role of Treg cell subsets in cardiovascular disease pathogenesis and potential therapeutic targets","volume":"15","author":"Xia","year":"2024","journal-title":"Front Immunol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046789","article-title":"A unique population of regulatory T cells in heart potentiates cardiac protection from myocardial infarction","volume":"142","author":"Xia","year":"2020","journal-title":"Circulation"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1038\/s41467-021-21737-9","article-title":"Cytotoxic CD8(+) T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling","volume":"12","author":"Santos-Zas","year":"2021","journal-title":"Nat Commun"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-023-00585-7","article-title":"Immunogenicity of recombinant adeno-associated virus (AAV) vectors for gene transfer","volume":"37","author":"Arjomandnejad","year":"2023","journal-title":"BioDrugs"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3284","article-title":"B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction","volume":"19","author":"Zouggari","year":"2013","journal-title":"Nat Med"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.11.051","article-title":"Splenic marginal zone B lymphocytes regulate cardiac remodeling after acute myocardial infarction in mice","volume":"79","author":"Sun","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abg1046","article-title":"Inverted direct allorecognition triggers early donor-specific antibody responses after transplantation","volume":"14","author":"Charmetant","year":"2022","journal-title":"Sci Transl Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1093\/jimmun\/vkaf129","article-title":"MHC II-restricted presentation of soluble antigen by naive B cells is impaired upon engagement with membrane-associated antigen: A potential mechanism to mitigate autoreactivity","volume":"214","author":"Steiner","year":"2025","journal-title":"J Immunol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiad066","article-title":"Insights into the roles of IL-10-producing regulatory B cells in cardiovascular disorders: recent advances and future perspectives","volume":"114","author":"Zheng","year":"2023","journal-title":"J Leukoc Biol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s00395-021-00886-4","article-title":"Regulatory B cells improve ventricular remodeling after myocardial infarction by modulating monocyte migration","volume":"116","author":"Jiao","year":"2021","journal-title":"Basic Res Cardiol"},{"key":"B71","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3390\/jcdd5040056","article-title":"Endothelial contributions to zebrafish heart regeneration","volume":"5","author":"Fernandez","year":"2018","journal-title":"J Cardiovasc Dev Dis"},{"key":"B72","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1146\/annurev-physiol-021119-034527","article-title":"Cardiac fibroblast diversity","volume":"82","author":"Tallquist","year":"2020","journal-title":"Annu Rev Physiol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.06.024","article-title":"Fibroblasts: Origins, definitions, and functions in health and disease","volume":"184","author":"Plikus","year":"2021","journal-title":"Cell"},{"key":"B74","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.yjmcc.2015.11.002","article-title":"Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs)","volume":"94","author":"Turner","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00372.2009","article-title":"Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts","volume":"297","author":"Turner","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98215","article-title":"Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart","volume":"128","author":"Fu","year":"2018","journal-title":"J Clin Invest"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.588347","article-title":"Pivotal role of TGF-beta\/Smad signaling in cardiac fibrosis: Non-coding RNAs as effectual players","volume":"7","author":"Saadat","year":"2020","journal-title":"Front Cardiovasc Med"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2009.199","article-title":"Myocardial remodeling after infarction: the role of myofibroblasts","volume":"7","author":"van den Borne","year":"2010","journal-title":"Nat Rev Cardiol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.addr.2019.05.011","article-title":"Cardiac fibrosis - A short review of causes and therapeutic strategies","volume":"146","author":"Hinderer","year":"2019","journal-title":"Adv Drug Delivery Rev"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00540-z","article-title":"Fibroblasts as immune regulators in infection, inflammation and cancer","volume":"21","author":"Davidson","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"B81","article-title":"Aging and cardiac fibrosis","volume":"2","author":"Biernacka","year":"2011","journal-title":"Aging Dis"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-016-2431-9","article-title":"Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration","volume":"365","author":"Talman","year":"2016","journal-title":"Cell Tissue Res"},{"key":"B83","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.coi.2005.11.006","article-title":"Colony-stimulating factor-1 in immunity and inflammation","volume":"18","author":"Chitu","year":"2006","journal-title":"Curr Opin Immunol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.04.021","article-title":"Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer","volume":"54","author":"Buechler","year":"2021","journal-title":"Immunity"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.064155","article-title":"Cardiac pericytes acquire a fibrogenic phenotype and contribute to vascular maturation after myocardial infarction","volume":"148","author":"Alex","year":"2023","journal-title":"Circulation"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201712R","article-title":"Cardiac PDGFRalpha(+) interstitial cells generate spontaneous inward currents that contribute to excitability in the heart","volume":"37","author":"Zheng","year":"2023","journal-title":"FASEB J"},{"key":"B87","article-title":"Role of PDGFR-beta\/PI3K\/AKT signaling pathway in PDGF-BB induced myocardial fibrosis in rats","volume":"6","author":"Fan","year":"2014","journal-title":"Am J Transl Res"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v17.i11.112484","article-title":"HIF-1alpha modulates beta-catenin pathway to enhance the survival and angiogenesis of PBMSCs under hypoxia environment","volume":"17","author":"Wang","year":"2025","journal-title":"World J Stem Cells"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1039\/c7bm00891k","article-title":"Collagen-binding VEGF targeting the cardiac extracellular matrix promotes recovery in porcine chronic myocardial infarction","volume":"6","author":"Shi","year":"2018","journal-title":"Biomater Sci"},{"key":"B90","doi-asserted-by":"publisher","first-page":"e44816","DOI":"10.7554\/eLife.44816","article-title":"Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming","volume":"8","author":"Galvez-Santisteban","year":"2019","journal-title":"Elife"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.7150\/thno.37678","article-title":"Cardio-renal exosomes in myocardial infarction serum regulate proangiogenic paracrine signaling in adipose mesenchymal stem cells","volume":"10","author":"Gao","year":"2020","journal-title":"Theranostics"},{"key":"B92","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","article-title":"Signaling pathways and targeted therapy for myocardial infarction","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2023.117487","article-title":"ICAM-1 and VCAM-1: Gatekeepers in various inflammatory and cardiovascular disorders","volume":"548","author":"Singh","year":"2023","journal-title":"Clin Chim Acta"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118415","article-title":"New insights into endothelial cell physiology and pathophysiology","volume":"190","author":"Jozkowiak","year":"2025","journal-title":"BioMed Pharmacother"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.798699","article-title":"Endocan: A key player of cardiovascular disease","volume":"8","author":"Chen","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"B96","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1152\/physrev.00022.2002","article-title":"Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells","volume":"83","author":"Mann","year":"2003","journal-title":"Physiol Rev"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"Forstermann","year":"2012","journal-title":"Eur Heart J"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1146399","article-title":"Cellular heterogeneity and stem cells of vascular endothelial cells in blood vessel formation and homeostasis: Insights from single-cell RNA sequencing","volume":"11","author":"Wakabayashi","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6558060","article-title":"Programmed cell death of endothelial cells in myocardial infarction and its potential therapeutic strategy","volume":"2022","author":"Wu","year":"2022","journal-title":"Cardiol Res Pract"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00913-y","article-title":"The role of cardiac pericytes in health and disease: therapeutic targets for myocardial infarction","volume":"21","author":"Avolio","year":"2024","journal-title":"Nat Rev Cardiol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1038\/s41467-020-17740-1","article-title":"Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination","volume":"11","author":"Muhl","year":"2020","journal-title":"Nat Commun"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab200","article-title":"Progress in cardiac research: from rebooting cardiac regeneration to a complete cell atlas of the heart","volume":"117","author":"Davidson","year":"2021","journal-title":"Cardiovasc Res"},{"key":"B103","doi-asserted-by":"publisher","first-page":"e10036","DOI":"10.7554\/eLife.10036","article-title":"Pericytes are progenitors for coronary artery smooth muscle","volume":"4","author":"Volz","year":"2015","journal-title":"Elife"},{"key":"B104","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41368-020-0086-6","article-title":"Gap junction-mediated cell-to-cell communication in oral development and oral diseases: a concise review of research progress","volume":"12","author":"Liu","year":"2020","journal-title":"Int J Oral Sci"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.948541","article-title":"The protective effect of pericytes on vascular permeability after hemorrhagic shock and their relationship with Cx43","volume":"13","author":"He","year":"2022","journal-title":"Front Physiol"},{"key":"B106","doi-asserted-by":"publisher","first-page":"652722","DOI":"10.1101\/2025.05.07.652722","article-title":"Pericyte and endothelial cell responses within murine cerebral capillaries after blood flow cessation","volume":"5","author":"Abdelazim","year":"2025","journal-title":"bioRxiv"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1111\/eci.14204","article-title":"The fate and role of the pericytes in myocardial diseases","volume":"54","author":"Frangogiannis","year":"2024","journal-title":"Eur J Clin Invest"},{"key":"B108","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/ni.2477","article-title":"Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs","volume":"14","author":"Stark","year":"2013","journal-title":"Nat Immunol"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1735526100","article-title":"Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading","volume":"100","author":"Rong","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1168339","article-title":"Hypoxia-inducible factor activation promotes osteogenic transition of valve interstitial cells and accelerates aortic valve calcification in a mice model of chronic kidney disease","volume":"10","author":"Csiki","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3959845","article-title":"Mechanism of hypoxia-mediated smooth muscle cell proliferation leading to vascular remodeling","volume":"2022","author":"Huang","year":"2022","journal-title":"BioMed Res Int"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.07.097","article-title":"Smooth muscle cells from abdominal aortic aneurysms are unique and can independently and synergistically degrade insoluble elastin","volume":"60","author":"Airhart","year":"2014","journal-title":"J Vasc Surg"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.315937","article-title":"Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease","volume":"126","author":"Abbate","year":"2020","journal-title":"Circ Res"},{"key":"B114","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s40119-018-0104-3","article-title":"A review of interleukin-1 in heart disease: where do we stand today","volume":"7","author":"Szekely","year":"2018","journal-title":"Cardiol Ther"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.07.785","article-title":"Complicated pericarditis: understanding risk factors and pathophysiology to inform imaging and treatment","volume":"68","author":"Cremer","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.927061","article-title":"NLRP3 inflammasome: the rising star in cardiovascular diseases","volume":"9","author":"Zheng","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B117","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/imr.12621","article-title":"Overview of the IL-1 family in innate inflammation and acquired immunity","volume":"281","author":"Dinarello","year":"2018","journal-title":"Immunol Rev"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2021.110141","article-title":"Interleukin-18 accelerates cardiac inflammation and dysfunction during ischemia\/reperfusion injury by transcriptional activation of CXCL16","volume":"87","author":"Zhao","year":"2021","journal-title":"Cell Signal"},{"key":"B119","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s11886-018-1067-7","article-title":"Tumor necrosis factor-alpha in heart failure: an updated review","volume":"20","author":"Schumacher","year":"2018","journal-title":"Curr Cardiol Rep"},{"key":"B120","doi-asserted-by":"publisher","first-page":"e125074","DOI":"10.1172\/jci.insight.125074","article-title":"Fibroblast-specific deletion of interleukin-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction","volume":"5","author":"Bageghni","year":"2019","journal-title":"JCI Insight"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01285.2008","article-title":"IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice","volume":"297","author":"Yu","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B122","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.cyto.2010.10.002","article-title":"Effects of interleukin-18 on cardiac fibroblast function and gene expression","volume":"53","author":"Fix","year":"2011","journal-title":"Cytokine"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1042\/CS20200402","article-title":"IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture","volume":"134","author":"Ghali","year":"2020","journal-title":"Clin Sci (Lond)"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1177\/15353702231198075","article-title":"Roles of IL-33 in the pathogenesis of cardiac disorders","volume":"248","author":"Jiang","year":"2023","journal-title":"Exp Biol Med (Maywood)"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044582","article-title":"Cytokine mRNA degradation in cardiomyocytes restrains sterile inflammation in pressure-overloaded hearts","volume":"141","author":"Omiya","year":"2020","journal-title":"Circulation"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319077","article-title":"Interleukin-6 signaling and anti-interleukin-6 therapeutics in cardiovascular disease","volume":"128","author":"Ridker","year":"2021","journal-title":"Circ Res"},{"key":"B127","doi-asserted-by":"publisher","first-page":"F1000","DOI":"10.12688\/f1000research.26058.1","article-title":"Interleukin-6 signalling in health and disease","volume":"9","author":"Rose-John","year":"2020","journal-title":"F1000Res"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.08.013","article-title":"Interleukin-17A mediates cardiomyocyte apoptosis through Stat3-iNOS pathway","volume":"1863","author":"Su","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-014-1176-8","article-title":"IL-17A promotes ventricular remodeling after myocardial infarction","volume":"92","author":"Zhou","year":"2014","journal-title":"J Mol Med (Berl)"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.112185","article-title":"Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-kappaB","volume":"126","author":"Verma","year":"2012","journal-title":"Circulation"},{"key":"B131","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1161\/CIRCRESAHA.108.188243","article-title":"IL-10 inhibits inflammation and attenuates left ventricular remodeling after myocardial infarction via activation of STAT3 and suppression of HuR","volume":"104","author":"Krishnamurthy","year":"2009","journal-title":"Circ Res"},{"key":"B132","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.yjmcc.2015.04.003","article-title":"Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function","volume":"84","author":"Kain","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00888","article-title":"Tuning the cytokine responses: an update on interleukin (IL)-4 and IL-13 receptor complexes","volume":"9","author":"Junttila","year":"2018","journal-title":"Front Immunol"},{"key":"B134","doi-asserted-by":"publisher","first-page":"e172702","DOI":"10.1172\/jci.insight.172702","article-title":"IL-13 promotes functional recovery after myocardial infarction via direct signaling to macrophages","volume":"9","author":"Alvarez-Argote","year":"2024","journal-title":"JCI Insight"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00310.2022","article-title":"Interleukin 4\/13 signaling in cardiac regeneration and repair","volume":"323","author":"Bakhshian Nik","year":"2022","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175293","article-title":"IL-37 improves mice myocardial infarction via inhibiting YAP-NLRP3 signaling mediated macrophage programming","volume":"934","author":"Wang","year":"2022","journal-title":"Eur J Pharmacol"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.696605","article-title":"Current understanding of IL-37 in human health and disease","volume":"12","author":"Su","year":"2021","journal-title":"Front Immunol"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.894002","article-title":"Effects of IL-38 on macrophages and myocardial ischemic injury","volume":"13","author":"Li","year":"2022","journal-title":"Front Immunol"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121534109","article-title":"IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist","volume":"109","author":"van de Veerdonk","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"B140","doi-asserted-by":"publisher","first-page":"e004406","DOI":"10.1161\/JAHA.116.004406","article-title":"Interleukin-37 and dendritic cells treated with interleukin-37 plus troponin I ameliorate cardiac remodeling after myocardial infarction","volume":"5","author":"Zhu","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321787","article-title":"IL-37 attenuates platelet activation and thrombosis through IL-1R8 pathway","volume":"132","author":"Chen","year":"2023","journal-title":"Circ Res"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcab011","article-title":"IL-37-a putative therapeutic agent in cardiovascular diseases","volume":"115","author":"McCurdy","year":"2022","journal-title":"QJM"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1590\/S1679-45082015RB3438","article-title":"Chemokines and immunity","volume":"13","author":"Palomino","year":"2015","journal-title":"Einstein (Sao Paulo)"},{"key":"B144","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.cophys.2020.10.004","article-title":"Chemokines in cardiac fibrosis","volume":"19","author":"Li","year":"2021","journal-title":"Curr Opin Physiol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1042\/CS20170009","article-title":"Monocyte subtypes and the CCR2 chemokine receptor in cardiovascular disease","volume":"131","author":"Franca","year":"2017","journal-title":"Clin Sci (Lond)"},{"key":"B146","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s12265-020-10006-7","article-title":"Chemokines in myocardial infarction","volume":"14","author":"Chen","year":"2021","journal-title":"J Cardiovasc Transl Res"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-023-01222-3","article-title":"Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF\/CCL2\/CCR2 and phenotype switching","volume":"45","author":"Shen","year":"2024","journal-title":"Acta Pharmacol Sin"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104744","article-title":"Interleukin-34-NF-kappaB signaling aggravates myocardial ischemic\/reperfusion injury by facilitating macrophage recruitment and polarization","volume":"95","author":"Zhuang","year":"2023","journal-title":"EBioMedicine"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1611023114","article-title":"beta2-adrenergic receptor-dependent chemokine receptor 2 expression regulates leukocyte recruitment to the heart following acute injury","volume":"113","author":"Grisanti","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B150","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1089\/jir.2023.0132","article-title":"C-C motif chemokine 2 regulates macrophage polarization and contributes to myocardial infarction healing","volume":"44","author":"Chen","year":"2024","journal-title":"J Interferon Cytokine Res"},{"key":"B151","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13073-025-01456-2","article-title":"Rare damaging CCR2 variants are associated with lower lifetime cardiovascular risk","volume":"17","author":"Georgakis","year":"2025","journal-title":"Genome Med"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.114009","article-title":"Downregulation of CCR2 reduces ventricular remodeling after myocardial infarction by splenic nerve neuromodulation in acute and chronic rat models","volume":"148","author":"Jin","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.05.009","article-title":"Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure","volume":"45","author":"Husberg","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr221","article-title":"Detrimental effect of fractalkine on myocardial ischaemia and heart failure","volume":"92","author":"Xuan","year":"2011","journal-title":"Cardiovasc Res"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23894","article-title":"The fractalkine receptor CX(3)CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes","volume":"52","author":"Karlmark","year":"2010","journal-title":"Hepatology"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.028442","article-title":"CCL17 protects against viral myocarditis by suppressing the recruitment of regulatory T cells","volume":"12","author":"Feng","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-023-04822-z","article-title":"The interplay between T lymphocytes and macrophages in myocardial ischemia\/reperfusion injury","volume":"479","author":"Li","year":"2024","journal-title":"Mol Cell Biochem"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202400839R","article-title":"Overview of multifunctional Tregs in cardiovascular disease: From insights into cellular functions to clinical implications","volume":"38","author":"Kumar","year":"2024","journal-title":"FASEB J"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055888","article-title":"CCL17 aggravates myocardial injury by suppressing recruitment of regulatory T cells","volume":"145","author":"Feng","year":"2022","journal-title":"Circulation"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2011.06.008","article-title":"Human cardiac fibroblasts express ICAM-1, E-selectin and CXC chemokines in response to proinflammatory cytokine stimulation","volume":"43","author":"Turner","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu138","article-title":"CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycans","volume":"103","author":"Saxena","year":"2014","journal-title":"Cardiovasc Res"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.199471","article-title":"Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction","volume":"105","author":"Bujak","year":"2009","journal-title":"Circ Res"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090759","article-title":"CCR5 signaling suppresses inflammation and reduces adverse remodeling of the infarcted heart, mediating recruitment of regulatory T cells","volume":"176","author":"Dobaczewski","year":"2010","journal-title":"Am J Pathol"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr127","article-title":"CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice","volume":"33","author":"Montecucco","year":"2012","journal-title":"Eur Heart J"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.3390\/biomedicines9111532","article-title":"CCR6 deficiency increases infarct size after murine acute myocardial infarction","volume":"9","author":"Schumacher","year":"2021","journal-title":"Biomedicines"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00212","article-title":"The CXCL12\/CXCR4 chemokine ligand\/receptor axis in cardiovascular disease","volume":"5","author":"Doring","year":"2014","journal-title":"Front Physiol"},{"key":"B167","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.3390\/ijms25021082","article-title":"The role of pro-inflammatory cytokines in the pathogenesis of cardiovascular disease","volume":"25","author":"Zhang","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00140","article-title":"The role of the TGF-beta superfamily in myocardial infarction","volume":"6","author":"Hanna","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu053","article-title":"Integrins alphavbeta5 and alphavbeta3 promote latent TGF-beta1 activation by human cardiac fibroblast contraction","volume":"102","author":"Sarrazy","year":"2014","journal-title":"Cardiovasc Res"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2007","article-title":"Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function","volume":"87","author":"Spinale","year":"2007","journal-title":"Physiol Rev"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)63764-9","article-title":"Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1","volume":"164","author":"Shephard","year":"2004","journal-title":"Am J Pathol"},{"key":"B172","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00395-021-00863-x","article-title":"Cytokines as therapeutic targets for cardio- and cerebrovascular diseases","volume":"116","author":"Liberale","year":"2021","journal-title":"Basic Res Cardiol"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.2.1209","article-title":"Oxidants selectively reverse TGF-beta suppression of proinflammatory mediator production","volume":"176","author":"Xiao","year":"2006","journal-title":"J Immunol"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2025.152553","article-title":"Redox-architected signaling networks in cardiac fibrosis","volume":"781","author":"Zhang","year":"2025","journal-title":"Biochem Biophys Res Commun"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.949030","article-title":"Signaling pathways and therapeutic approaches in post-myocardial infarction fibrosis","volume":"31","author":"Ba","year":"2025","journal-title":"Med Sci Monit"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202501610","article-title":"Lung-derived small extracellular vesicles containing miR-15a-5p\/miR-96-5p promote myocardial fibrosis in hypertrophic cardiomyopathy via targeting SMAD7","volume":"21","author":"Long","year":"2025","journal-title":"Small"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301843","article-title":"TGF-beta: guardian of T cell function","volume":"191","author":"Oh","year":"2013","journal-title":"J Immunol"},{"key":"B178","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1089\/ars.2016.6953","article-title":"Gliptins suppress inflammatory macrophage activation to mitigate inflammation, fibrosis, oxidative stress, and vascular dysfunction in models of nonalcoholic steatohepatitis and liver fibrosis","volume":"28","author":"Wang","year":"2018","journal-title":"Antioxid Redox Signal"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10561","article-title":"TGF-beta induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.2741\/3573","article-title":"Transforming growth factor-beta signaling and tumor angiogenesis","volume":"14","author":"Pardali","year":"2009","journal-title":"Front Biosci (Landmark Ed)"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000022166.74073.f8","article-title":"Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression","volume":"90","author":"Hou","year":"2002","journal-title":"Circ Res"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2011.07.006","article-title":"Deletion of discoidin domain receptor 2 does not affect smooth muscle cell adhesion, migration, or proliferation in response to type I collagen","volume":"21","author":"Hou","year":"2012","journal-title":"Cardiovasc Pathol"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.23.090506.123337","article-title":"Hyaluronan in tissue injury and repair","volume":"23","author":"Jiang","year":"2007","journal-title":"Annu Rev Cell Dev Biol"},{"key":"B184","doi-asserted-by":"publisher","first-page":"153","DOI":"10.3390\/biom15020153","article-title":"Unraveling elastic fiber-derived signaling in arterial aging and related arterial diseases","volume":"15","author":"Wang","year":"2025","journal-title":"Biomolecules"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.815356","article-title":"The elastin receptor complex: an emerging therapeutic target against age-related vascular diseases","volume":"13","author":"Tembely","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2429","article-title":"Effect of elastin-derived peptides on the production of tissue inhibitor of metalloproteinase-1, -2, and -3 and the ratios in various endothelial cell lines","volume":"9","author":"Siemianowicz","year":"2015","journal-title":"Exp Ther Med"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00153.2006","article-title":"Cardiac myofibroblasts differentiated in 3D culture exhibit distinct changes in collagen I production, processing, and matrix deposition","volume":"291","author":"Poobalarahi","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1159\/000493217","article-title":"Signaling mechanisms of myofibroblastic activation: outside-in and inside-out","volume":"49","author":"Zent","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"B189","doi-asserted-by":"publisher","first-page":"45","DOI":"10.14715\/cmb\/2018.64.3.8","article-title":"Human podocytes responses to alternatively spliced extra domain A fibronectin in culture","volume":"64","author":"Madne","year":"2018","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1021\/nn4058984","article-title":"Hippo pathway effectors control cardiac progenitor cell fate by acting as dynamic sensors of substrate mechanics and nanostructure","volume":"8","author":"Mosqueira","year":"2014","journal-title":"ACS Nano"},{"key":"B191","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.3390\/cells8121607","article-title":"Mechanotransduction in the cardiovascular system: from developmental origins to homeostasis and pathology","volume":"8","author":"Garoffolo","year":"2019","journal-title":"Cells"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12498","article-title":"New insights into YAP\/TAZ nucleo-cytoplasmic shuttling: new cancer therapeutic opportunities","volume":"13","author":"Shreberk-Shaked","year":"2019","journal-title":"Mol Oncol"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00005.2014","article-title":"The biology of YAP\/TAZ: hippo signaling and beyond","volume":"94","author":"Piccolo","year":"2014","journal-title":"Physiol Rev"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201802725RRR","article-title":"Mechanosensitive transcriptional coactivators MRTF-A and YAP\/TAZ regulate nucleus pulposus cell phenotype through cell shape","volume":"33","author":"Fearing","year":"2019","journal-title":"FASEB J"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14242","article-title":"Inhibiting leukocyte-endothelial cell interactions by Chinese medicine Tongxinluo capsule alleviates no-reflow after arterial recanalization in ischemic stroke","volume":"29","author":"Liu","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109816","article-title":"Neutrophil signaling during myocardial infarction wound repair","volume":"77","author":"Daseke","year":"2021","journal-title":"Cell Signal"},{"key":"B197","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/s41392-023-01452-1","article-title":"Macrophages in immunoregulation and therapeutics","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070885","article-title":"The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions","volume":"204","author":"Nahrendorf","year":"2007","journal-title":"J Exp Med"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.74","article-title":"Characterization of CD8(+)CD57(+) T cells in patients with acute myocardial infarction","volume":"12","author":"Tae Yu","year":"2015","journal-title":"Cell Mol Immunol"},{"key":"B200","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/apm.13094","article-title":"Interleukin-9-secreting CD4(+) T cells regulate CD8(+) T cells cytotoxicity in patients with acute coronary syndromes","volume":"129","author":"Gang","year":"2021","journal-title":"APMIS"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.649244","article-title":"Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes","volume":"114","author":"Yang","year":"2006","journal-title":"Circulation"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140672","article-title":"Activated regulatory T-cells attenuate myocardial ischaemia\/reperfusion injury through a CD39-dependent mechanism","volume":"128","author":"Xia","year":"2015","journal-title":"Clin Sci (Lond)"},{"key":"B203","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00395-019-0746-x","article-title":"Neutrophil proteome shifts over the myocardial infarction time continuum","volume":"114","author":"Daseke","year":"2019","journal-title":"Basic Res Cardiol"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1177\/1074248421989570","article-title":"Nucleolin improves heart function during recovery from myocardial infarction by modulating macrophage polarization","volume":"26","author":"Tang","year":"2021","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"B205","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cmet.2019.09.010","article-title":"Roles of regulatory T cells in tissue pathophysiology and metabolism","volume":"31","author":"Campbell","year":"2020","journal-title":"Cell Metab"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1126761","article-title":"Targeting regulatory T cells for cardiovascular diseases","volume":"14","author":"Wang","year":"2023","journal-title":"Front Immunol"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.07.018","article-title":"Innate lymphoid cells promote recovery of ventricular function after myocardial infarction","volume":"78","author":"Yu","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00646-w","article-title":"Transforming growth factor-beta in myocardial disease","volume":"19","author":"Frangogiannis","year":"2022","journal-title":"Nat Rev Cardiol"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.110203","article-title":"Cellular crosstalk in fibrosis: Insights into macrophage and fibroblast dynamics","volume":"301","author":"Froom","year":"2025","journal-title":"J Biol Chem"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1126\/science.abm0594","article-title":"CAR T cells produced in vivo to treat cardiac injury","volume":"375","author":"Rurik","year":"2022","journal-title":"Science"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036065","article-title":"Dysfunctional and proinflammatory regulatory T-lymphocytes are essential for adverse cardiac remodeling in ischemic cardiomyopathy","volume":"139","author":"Bansal","year":"2019","journal-title":"Circulation"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.116.003688","article-title":"Activated T lymphocytes are essential drivers of pathological remodeling in ischemic heart failure","volume":"10","author":"Bansal","year":"2017","journal-title":"Circ Heart Fail"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.037931","article-title":"Transient receptor potential vanilloid 4 calcium-permeable channel contributes to valve stiffening in aortic stenosis","volume":"14","author":"Dutta","year":"2025","journal-title":"J Am Heart Assoc"},{"key":"B214","doi-asserted-by":"publisher","first-page":"e100492","DOI":"10.15252\/embj.2018100492","article-title":"Length-independent telomere damage drives post-mitotic cardiomyocyte senescence","volume":"38","author":"Anderson","year":"2019","journal-title":"EMBO J"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63309-3","article-title":"Targeted deletion of CC chemokine receptor 2 attenuates left ventricular remodeling after experimental myocardial infarction","volume":"165","author":"Kaikita","year":"2004","journal-title":"Am J Pathol"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1535703","article-title":"Navarixin alleviates cardiac remodeling after myocardial infarction by decreasing neutrophil infiltration and the inflammatory response","volume":"16","author":"Hu","year":"2025","journal-title":"Front Pharmacol"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104656","article-title":"Comparative efficacy and mechanism of action of cardiac progenitor cells after cardiac injury","volume":"25","author":"Gunasekaran","year":"2022","journal-title":"iScience"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110511","article-title":"Celastrol relieves myocardial infarction-induced cardiac fibrosis by inhibiting NLRP3 inflammasomes in rats","volume":"121","author":"Fan","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177621","article-title":"Calycosin treats acute myocardial infarction via NLRP3 inflammasome: Bioinformatics, network pharmacology and experimental validation","volume":"997","author":"Yuan","year":"2025","journal-title":"Eur J Pharmacol"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03602-w","article-title":"Quercetin is a potential therapy for post-infarction NETosis formation","volume":"398","author":"Goshovska","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2022.2093598","article-title":"Astragaloside IV attenuate MI-induced myocardial fibrosis and cardiac remodeling by inhibiting ROS\/caspase-1\/GSDMD signaling pathway","volume":"21","author":"Zhang","year":"2022","journal-title":"Cell Cycle"},{"key":"B222","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1002\/ptr.7592","article-title":"Berberine plays a cardioprotective role by inhibiting macrophage Wnt5a\/beta-catenin pathway in the myocardium of mice after myocardial infarction","volume":"37","author":"Tian","year":"2023","journal-title":"Phytother Res"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8237681","article-title":"Electroacupuncture improves cardiac function via inhibiting sympathetic remodeling mediated by promoting macrophage M2 polarization in myocardial infarction mice","volume":"2024","author":"Peng","year":"2024","journal-title":"Mediators Inflammation"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2025.1562285","article-title":"Electroacupuncture posttreatment attenuates the inflammatory injury in rats after MIRI through PPARgamma\/NF-kappab pathway","volume":"12","author":"Jiang","year":"2025","journal-title":"Front Cardiovasc Med"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2021.12.036","article-title":"Acellular biomaterial modulates myocardial inflammation and promotes endogenous mechanisms of postinfarct cardiac repair","volume":"165","author":"Vasanthan","year":"2023","journal-title":"J Thorac Cardiovasc Surg"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.784041","article-title":"Curcumin ameliorates cardiac fibrosis by regulating macrophage-fibroblast crosstalk via IL18-P-SMAD2\/3 signaling pathway inhibition","volume":"12","author":"Zhao","year":"2021","journal-title":"Front Pharmacol"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.2174\/1381612828666211224152440","article-title":"Sodium tanshinone IIA sulfonate improves adverse ventricular remodeling post-MI by reducing myocardial necrosis, modulating inflammation, and promoting angiogenesis","volume":"28","author":"Zhang","year":"2022","journal-title":"Curr Pharm Des"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1038\/nature24676","article-title":"IL-11 is a crucial determinant of cardiovascular fibrosis","volume":"552","author":"Schafer","year":"2017","journal-title":"Nature"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202501619","article-title":"Trans-organ early intervention for myocardial infarction based on bone marrow-homing biomimetic nanomedicine","volume":"15","author":"Jiang","year":"2025","journal-title":"Adv Healthc Mater"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.11.016","article-title":"Neutrophil membrane-camouflaged nanoparticles alleviate inflammation and promote angiogenesis in ischemic myocardial injury","volume":"23","author":"Han","year":"2023","journal-title":"Bioact Mater"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbae145","article-title":"Neutrophil-derived apoptotic body membranes-fused exosomes targeting treatment for myocardial infarction","volume":"12","author":"Wang","year":"2025","journal-title":"Regener Biomater"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S420301","article-title":"Intranasal delivery of endothelial cell-derived extracellular vesicles with supramolecular gel attenuates myocardial ischemia-reperfusion injury","volume":"18","author":"Wang","year":"2023","journal-title":"Int J Nanomed"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13654","article-title":"miR-21 promotes cardiac fibroblast-to-myofibroblast transformation and myocardial fibrosis by targeting Jagged1","volume":"22","author":"Zhou","year":"2018","journal-title":"J Cell Mol Med"},{"key":"B234","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.canlet.2019.03.015","article-title":"Metabolic reprogramming of macrophages during infections and cancer","volume":"452","author":"Wang","year":"2019","journal-title":"Cancer Lett"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2956","article-title":"Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages","volume":"15","author":"Huang","year":"2014","journal-title":"Nat Immunol"},{"key":"B236","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3390\/biomedicines10020319","article-title":"Metformin inhibits ROS production by human M2 macrophages via the activation of AMPK","volume":"10","author":"Nassif","year":"2022","journal-title":"Biomedicines"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.915903","article-title":"Sinapic acid attenuated cardiac remodeling after myocardial infarction by promoting macrophage M2 polarization through the PPARgamma pathway","volume":"9","author":"Yang","year":"2022","journal-title":"Front Cardiovasc Med"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2025.124083","article-title":"Dapagliflozin attenuates post-infarction fibrosis via cardiomyocyte protection and fibroblast inhibition","volume":"383","author":"Xu","year":"2025","journal-title":"Life Sci"},{"key":"B239","doi-asserted-by":"publisher","first-page":"4401","DOI":"10.3390\/ijms22094401","article-title":"Phosphatidylserine supplementation as a novel strategy for reducing myocardial infarct size and preventing adverse left ventricular remodeling","volume":"22","author":"Schumacher","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnves.2025.100032","article-title":"S-palmitoylation: A novel player in cancer and its emerging therapeutic implications","volume":"1","author":"Wang","year":"2025","journal-title":"Cell Invest"},{"key":"B241","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s11658-025-00776-w","article-title":"Palmitoylation: an emerging therapeutic target bridging physiology and disease","volume":"30","author":"Li","year":"2025","journal-title":"Cell Mol Biol Lett"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301244","article-title":"Extracellular matrix\/glycopeptide hybrid hydrogel as an immunomodulatory niche for endogenous cardiac repair after myocardial infarction","volume":"10","author":"Kong","year":"2023","journal-title":"Adv Sci (Weinh)"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1801258\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:52:55Z","timestamp":1781671975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2026.1801258\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":242,"alternative-id":["10.3389\/fimmu.2026.1801258"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2026.1801258","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]},"article-number":"1801258"}}